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Geochemical elements in suspended particulate matter of Ensenada de La paz Lagoon,Baja California peninsula,mexico:Sources,distribution,mass balance and ecotoxicological risks

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Journal of Environmental Sciences 2024年第2期136卷 422-436页

作者： Sandra Soledad morales-García pilar de Acacia pérez-Escamilla Suresh Babu Sujitha pichaimani Godwyn-paulson Andrés Felipe Zuniga-Cabezas muthuswamy ponniah Jonathan Instituto politécnico Nacional(IpN) Centro Mexicano para la Producción más Limpia(CMPL)Av.Acueducto s/nCol.Barrio la Laguna TicománDel Gustavo A.MaderoC.P.07340Ciudad de MéxicoMexico Instituto politécnico Nacional(IpN) Escuela Superior de Ingeniería y Arquitectura(ESIA)Unidad Ticomán***án 600Delg.Gustavo A.MaderoC.P.07340Ciudad de México(CDMX)Mexico Instituto politécnico Nacional(IpN) Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo(CIIEMAD)Calle 30 de Junio de 1520Barrio la Laguna TicománDel.Gustavo A.MaderoC.P.07340Ciudad de MéxicoMéxico

The present study aimed to evaluate multi-element concentrations(Al,As,Ca,Cd,Co,Cr,Cu,Fe,mg,mn,mo,Ni,pb,Sr)in suspended particulate material(Spm)collected from Ensenada de La paz(ELp)lagoon,Baja California Sur,mexico in two different periods(September and may)to comprehend their origin,geochemical behavior,mass transfer and associated ecotoxicological *** 24 hr variation coefficient of volumetric Spm levels were found to be 51.7%in September and 40.5%in may,signifying the effects of oceanic *** calculated enrichment factor(EF)values for all the studied elements were of higher magnitude because of the high surface area and oxide nature of Spm,and in this study,mo had the highest EF of 46.77 probably due to its origin from continental *** the ecotoxicological perspective,the integrated toxic risk index revealed low toxic risk to the benthic ***,the mean-ERm-Quotient calculated using the particulate concentrations of As,Cd,Cr,Cu,Ni,pb indicated 9%probability of toxicity to *** comprehensive geochemical and ecotoxicological assessment of particulate metal concentrations in the ELp lagoon signify low to moderate contamination.

关键词： Suspended particulate material Heavy metals Risk assessment mass transfer Ensenada de La paz

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Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia michael J.Bannon Irma Alicia martínez-dávila Luis O.Soto-Rojas david Reyes-Corona Lourdes Escobedo minerva maldonado-Berny mE Gutierrez-Castillo Armando J.Espadas-Alvarez manuel A.Fernandez-parrilla Juan U.mascotte-Cruz Cp Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar daniel martinez-Fong departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico department of pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de patogénesis molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de medicina para la Educación y desarrollo y la Investigación Científica de Iztacala(Red mEdICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico departamento de Biología molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

parkinsonism by unilateral,intranigralβ-sitosterolβ-d-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-d-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-d-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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Freeze-thaw cycles and associated geomorphology in a post-glacial environment:current glacial,paraglacial,periglacial and proglacial scenarios at pico de Orizaba volcano,mexico

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Journal of mountain Science 2024年第6期21卷 1954-1977页

作者： Víctor SOTO Carlos m.WELSH R. Kenji YOSHIKAWA Hugo deLGAdO GRANAdOS Centro de Ciencias de la Tierra Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water and Environmental Research Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México department of Earth and Environmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial history of pico de Orizaba indicates that during the Last Glacial maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m *** retraction of the glacier has left behind an intense climatic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geomorphological processes are represented by the fragmentation of the bedrock that occupies the upper parts of the *** is a notable lack of studies regarding the fragmentation and erosion occurring in tropical high mountains,and the associated geomorphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m asl,through continuous monitoring of surface ground *** results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and *** was found that the paraglacial zone presents an intense drop of temperature,of up to~9℃ in only sixty *** rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the main factor of the constant slope dynamics that occur at the *** activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the temperature presents a certain degree of stability,until reaching the proglacial zone,where cycles are almost non-existent,and therefore there is no gelifraction *** geomorphological processes have resulted in significant alterations to the mountain slopes,which can have severe consequences in terms of risk and water.

关键词： Freeze-Thaw Gelifraction mountain mechanical erosion periglacial geomorphology postglacial scenarios

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morbidity and mortality of Acute Renal Failure in COVId-19 patients in Intensive Care According to Waves/Variant: Case of the Grand Hôpital de l’Est Francilien Site de meaux

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Open Journal of Internal medicine 2024年第1期14卷 16-29页

作者： Khazy Anga Ariel makembi Éric Amisi Éric delpierre Vivien Hong Tuan Ha Wilfrid mbombo Jean Claude mubenga dan Kankonde Chris Nsituavibidila Lionel diyamona Noelly mukuna Gracia Likinda Tharcisse mabiala martin mukenga médard Bula-Bula Berthe Barhayiga département d’Anesthésie Réanimation Université de Kinshasa Kinshasa République démocratique du Congo Service de Réanimation Grand H&ocircpital de l’Est Francilien Meaux France département de médecine Interne Université de Kinshasa Kinshasa République démocratique du Congo Service d’Anesthésie Réanimation Centre Hospitalier Monkole Kinshasa République démocratique du Congo department of Anaesthesia and Intensive Care H&ocircpital Général de Référence de Kinshasa Kinshasa République démocratique du Congo department of Anaesthesia and Intensive Care Université Protestante du Congo Kinshasa République démocratique du Congo

Introduction: The incidence of acute renal failure (ARF) varies between 20% and 40% of cases for COVId-19 patients admitted to the intensive care unit, with very high mortality, but heterogeneous according to the different epidemic waves, probably due to the genetic variant phenomenon of the virus. The aim of this study is to determine the morbidity and mortality of COVId-19 patients admitted with ARF to the intensive care unit of the Grand H?pital Est Francilien (GHEF) according to the waves and variants. methods: Cross-sectional observational study of COVId-19 patients with ARF admitted to the intensive care unit of the GHEF site in meaux covering the period from march 1p>stp> 2020 to december, 31p>stp> 2021. per-hospitalisation and outcome data were collected and analysed with SpSS version 25.0 software using the Chi-square or Fischer’s exact test or Student’s t-test and logistic regression for p Results: A total of 86 patients were included. The mean age was higher (70 ± 8.5) in patients in the fourth wave than in the other waves (p = 0.015), with male predominance in all waves without significant difference. Co-morbidities: hypertension, diabetes, heart disease, dyslipidaemia and arrhythmia complete with fibrillation were present in all waves. The majority of patients were classified as KdIGO 1 for the different waves (1st: 61.9%, 2nd: 86.5%, 3rd: 80%, and 4th: 75%), with the same trend according to variant (alpha: 80%, beta: 75%, delta: 81.3%, omicron: 75%). mortality by the wave was: 1st: 28.5%, 2nd: 37.5%, 3rd: 23% and 4th: 11%) and by variant: alpha: 24.2%, beta: 44.8%, delta: 20.7%, omicron: 10.3%). Overall mortality was 33.7%. Case fatality was higher in the fourth wave. Hypertension, shock, failure to recover renal function, acute lung oedema, ventilator-associated lung disease and hyperkalaemia were factors associated with mortality (p Conclusion: Acute renal failure is common in COVId-19 patients admitted to the intensive care unit, and m

关键词： mortality COVId-19 morbidity Renal Failure Intensive Care Unit

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Risk Factors for Neonatal mortality at the Institute of Nutrition and Child Health of the donka/Guinea-Conakry National Hospital

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Open Journal of pediatrics 2024年第2期14卷 327-337页

作者： Bangoura mmah Aminata Kolié Ouo Ouo Camara Salématou Hassimiou Baldé mariama Bangoura Kaba diop mamadou moustapha Camara Emmanuel diallo Fatoumata Binta doukouré mamadou Aliou mamadou mouctar Sow Bémy pé Néabey Institut de Nutrition et de Santé de l’Enfant Conakry Guinea Service de pédiatrie Hô pital National Donka Conakry Guinea Service de pédiatrie Hô pital National d’Ignace Deen Conakry Guinea

Introduction: The birth of a baby is a moment of joy and celebration. However, the neonatal period is a very delicate phase of life. Neonatal mortality rates remain high in low-income countries. In Guinea, after 20 years, this rate has fallen from 34.2% in 1998 to 32% in 2018. Objective: To identify the main risk factors for neonatal mortality. methods: This was an observational, analytical case-control study, lasting 6 months from January 1 to June 30, 2019, conducted at the Institut de Nutrition et de la Santé de l’Enfant (INSE) at donka National Hospital. Results: We collected 242 cases and 242 controls, i.e. a total of 484 records. 748 patients were registered, with 32.35% deaths. 82.86% of deaths occurred in the early neonatal period. Statistical analysis revealed the main risk factors: prematurity (RQ 7.39 95% CI 3.27 - 16.61 p = 0.0000003), hypothermia (RQ 2.29 95% CI 1.51 - 3.46 p = 0.0001), acute fetal distress (RQ 2.13 95% CI 1.33 - 3.43 p = 0.0016), low birth weight (QR 1.91 95% CI 1.12 - 3.24 p = 0.016), home birth (QR 3.26 95% CI 1.25 - 8.46 p = 0.015). Conclusion: Neonatal mortality is a health problem in the INSE neonatology department. To reduce the mortality rate in this referral facility, it is essential to equip it and provide ongoing training for staff.

关键词： Neonatal mortality INSE Guinea-Conakry

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metal-modulated epitaxy of mg-doped Al_(0.80)In_(0.20)N-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-Gutiérrez Enrique Campos-González máximo López-López Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInN layers doped with mg by plasma-assisted molecular beam epitaxy(pAmBE).AlInN was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(mmE)with a thickness of 180 nm on Si(111)substrates using AlN as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRd).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XpS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInN layers were studied for use as the electron-blocking layer(EBL)in LEd *** varied the Al composition in the EBL from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SILVACO *** results from this study highlight the importance and capability of producing high-quality mg-doped p-AlInN layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInN dUV-LEd EBL simulation

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High CO_(2)permeation using a new Ce_(0.85)Gd_(0.15)O_(2-δ)-LaNiO_(3)composite ceramic–carbonate dual-phase membrane

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Journal of Environmental Sciences 2024年第6期140卷 219-229页

作者： daniela González-Varela JFrancisco Gómez-García Gustavo Tavizon Heriberto pfeiffer Instituto de Investigaciones en materiales Universidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico departamento de Física y Química Teórica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico 不详

This work shows the synthesis,characterization and evaluation of dense-ceramic membranes made of Ce_(0.85)Gd_(0.15)O_(2-δ)-LaNiO_(3)(CG-LN)composites,where the fluorite-perovskite ratio(CG:LN)was varied as follows:75:25,80:20 and 85:15 wt.%.Supports were initially characterized by XRd,SEm and electrical conductivity(using vacuum and oxygen atmospheres),to determine the composition,microstructural and ionic-electronic conductivity ***,supports were infiltrated with an eutectic carbonates mixture,producing the corresponding dense dual-phase membranes,in which CO_(2)permeation tests were ***,CO_(2)permeation experiments were performed from 900 to 700℃,in the presence and absence of oxygen(flowed in the sweep membrane side).Results showed that these composites possess high CO_(2)permeation properties,where the O_(2)addition significantly improves the ionic conduction on the sweep membrane ***,the GC80-LN20 composition presented the best results due to the following physicochemical characteristics:high electronic and ionic conductivity,appropriate porosity,interconnected porous channels,as well as thermal and chemical stabilities between the composite support and carbonate phases.

关键词： CO_(2)permeation doped CeO_(2) LaNiO_(3) Impedance Ceramic carbonate membrane

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Hypothalamic circuits and aging:keeping the circadian clock updated

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Neural Regeneration Research 2024年第9期19卷 1919-1928页

作者： Rosa Vázquez-Lizarraga Lucia mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-montoya Erick Carreño-Vázquez Ricardo Orozco-Solis Instituto Nacional de medicina Genómica(INmEGEN) México CityMéxico Centro de Investigacíon sobre el Envejecimiento Centro de Investigacíon y de Estudios Avanzados(CIE-CINVESTAV)México CityMéxico Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México UNAMMéxico CityMéxico

Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of *** on aged animal models have unveiled a progressive discoordination at multiple regulatory levels,including transcriptional,translational,and post-translational processes,resulting from cellular stress and circadian *** circadian clock emerges as a key regulator,sustaining physiological homeostasis and promoting healthy aging through timely molecular coordination of pivotal cellular processes,such as stem-cell function,cellular stress responses,and inter-tissue communication,which become disrupted during *** the crucial role of hypothalamic circuits in regulating organismal physiology,metabolic control,sleep homeostasis,and circadian rhythms,and their dependence on these processes,strategies aimed at enhancing hypothalamic and circadian function,including pharmacological and non-pharmacological approaches,offer systemic benefits for healthy *** brain-directed drug administration represents a promising avenue for effectively targeting specific brain regions,like the hypothalamus,while reducing side effects associated with systemic drug delivery,thereby presenting new therapeutic possibilities for diverse age-related conditions.

关键词： aging astrocytes cellular stress responses circadian clock hypothalamus intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis

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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto doncel-pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain medical Research Unit for Neurological diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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A neural branch-and-price for truck scheduling in cross-docks

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Science China mathematics 2024年第6期67卷 1341-1358页

作者： Rahimeh Neamatian monemi Shahin Gelareh Nelson maculan Wei-Kun Chen Sharkey predictim Globe Villeneuve d’Ascq59650France département R&T IUT de BéthuneUniversitéd’ArtoisBéthuneF-62000France Federal University of Rio de Janeiro COPPE-PESCRio de JaneiroRJ 21941-972Brazil School of mathematics and Statistics Beijing Institute of TechnologyBeijing100081China

In this paper,we address the complex problem of dock-door assignment and truck scheduling within cross-docking *** is a problem that requires frequent resolution throughout the operational day,as disruptions often invalidate the optimal *** the problem's highly combinatorial nature,finding an optimal solution demands significant computational time and ***,the distribution of data across problem instances over a lengthy planning horizon remains consistently stable,with minimal concern regarding distribution *** factors collectively establish the problem as an ideal candidate for a learn-to-optimize solution *** propose a dantzig-Wolfe reformulation,solving it via both a conventional branch-and-price approach and a neural branch-and-price approach,the latter of which employs imitation ***,we introduce some classes of valid inequalities to enhance and refine the pricing problem through a branch-and-cut *** computational experiments demonstrate that this methodology is not only feasible but also presents a viable alternative to the traditional branch-and-price algorithms typically utilized for such challenges.

关键词： cross-docking mILp modeling dantzig-Wolfe decomposition graph convolutional network

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