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Automated deformation monitoring for urban subway tunnelling risk assessment: a case study from the Wuhan Metro line 12

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Journal of Earth Science 2024年

作者： Yuyong Jiao Jianfeng Qi Hongbin An Luyi Shen Fei Zheng Zhi Li You Zhang Lingling He Faculty of Engineering， China University of Geosciences (Wuhan) Wuhan Metro inc. School of Civil and Hydraulic Engineering， Huazhong University of Science and Technology China Railway Construction Investment Group Corporation Ltd. Department of Civil Engineering， Monash University

Monitoring deformation is of critical importance for tunnel boring projects. This importance is further amplified for the metro construction project that involves boring beneath or near susceptible civil infrastructures. Here， we present a case study that uses robotic total station to preform automated deformation monitoring inside a tunnel during the excavation. Further， enabled with the Internet of Things technology， the monitoring data are streamlined through wireless internet access points and processed by a remote control center. A complete suite of software is deployed that can 1. process the monitoring data automatically. 2. set different triggering threshold reflecting various levels of hazardous inc.dents. 3. storing the data for further analysis that visualize the data， quantify overall risk levels and conduct predictive modelling. Built upon this automated system， a triage of risk response protocol is established that preforms reactive treatment according to the levels of reported hazards. A de-risk process， involving third party review， is also established. Overall， this report demonstrates our effort in monitoring the tunnel’s deformation with an automated system to save cost and reduce human induced errors. This report can be a useful reference for other engineers preforming metro tunneling tasks.

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新时期民营企业创新文化建设的策略

现代企业文化 2024年第4期 13-15页

作者：刘君 Jfood Group Holding inc.

在市场经济开放发展的背景下，民营企业在市场经济当中的地位日益突出，对于国家经济发展产生了深远的影响。企业文化建设对于民营企业发展有着至关重要的作用，良好的企业文化能整合企业内部力量，促使企业不断向前迈进。因此，在新时... 详细信息

在市场经济开放发展的背景下，民营企业在市场经济当中的地位日益突出，对于国家经济发展产生了深远的影响。企业文化建设对于民营企业发展有着至关重要的作用，良好的企业文化能整合企业内部力量，促使企业不断向前迈进。因此，在新时期发展中，民营企业应当明确创新文化建设的意义，找出创新文化发展过程中面对的问题，进而采取有效的策略，大力推动新时期民营企业创新文化建设，不断夯实企业运行发展基础，改善经营发展态势，促进国家整体经济水平的提升。

关键词：新时期民营企业创新文化建设策略

Ursolic acid inhibiting excessive reticulophagic flux contributes to alleviate ochratoxin A-induced endoplasmic reticulum stress- and mitochondrial-mediated apoptosis

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Food Science and Human Wellness 2024年

作者： Huiqiong Deng Wenying Chen Lingyun Han Boyang Zhang Xun Luo Song Yao Hongwei Wang Yao Zhou Shuangchao Liu Xiao Li Shen School of Public Health， Zunyi Medical University Chongqing Fuling District Center for Disease Control and Prevention Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes Research and Development Department，Allife Medicine inc.

Foods and animal feeds frequently become contaminated with the nephrotoxic ochratoxin A (OTA). Our prior research has indicated that ursolic acid (UA)， which is widely present in fruits and medicinal plants， has the potential to alleviate nephrotoxicity triggered by OTA. Additionally， excessive induction of endoplasmic reticulum (ER)-phagy exacerbates OTA-induced apoptosis. Therefore， further investigation is essential to comprehend whether UA can mitigate OTA-induced apoptosis by influencing ER-phagy. This objective is accomplished through a series of experiments involving assessments of cell viability， apoptosis， fluorescence microscopy， and western blot analysis. The outcomes of these experiments reveal that pre-treatment with 4 μmol/L UA for 2 h can markedly reverse the elevated apoptotic rate， the co-localization of ER and lysosomes， and the protein expressions of GRP78， p-eIF2α， Chop， Bax， and Bak， as well as the reduced cell viability and the protein expressions of Lonp1， Trap1， p62， Tex264， FAM134B， Bcl-2， and Bcl-xl， all caused by exposure to 1 μmol/L OTA for 24 h in human proximal tubule epithelial-originated kidney-2 (HK-2) cells (P inc.eased expression of LC3B-II induced by OTA is further amplified by UA pre-treatment (P < 0.05). In conclusion， OTA triggers a harmful feedback loop between ER stress (ERS) and excessive ER-phagy， thereby further promoting ERS- and mitochondrial-mediated apoptosis in vitro. However， this effect is significantly mitigated by UA through the inhibition of autophagosome-lysosome fusion， consequently blocking the excessive ER-phagic flux.

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Applying Earth Observation Technologies to Economic Consequence Modeling:A Case Study of COVID‑19 in Los Angeles County,California

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International Journal of Disaster Risk Science 2024年第1期15卷 18-31页

作者： Fynnwin Prager Marina T.Mendoza Charles K.Huyck Adam Rose Paul Amyx Gregory Yetman Kristy F.Tiampo California State University Dominguez HillsCarsonCA 90747USA ImageCat Inc.Long BeachCA 90802USA University of Southern California Los AngelesCA 90015USA CIESIN–Center for International Earth Science Information Network Columbia UniversityPalisadesNY 10964USA Cooperative Institute for Research in Environmental Sciences(CIRES) University of Colorado BoulderBoulderCO 80309USA

Earth observation(EO) technologies,such as very high-resolution optical satellite data available from Maxar,can enhance economic consequence modeling of disasters by capturing the fine-grained and real-time behavioral responses of businesses and the *** investigated this unique approach to economic consequence modeling to determine whether crowd-sourced interpretations of EO data can be used to illuminate key economic behavioral responses that could be used for computable general equilibrium modeling of supply chain repercussions and resilience *** applied our methodology to the COVID-19 pandemic experience in Los Angeles County,California as a case *** also proposed a dynamic adjustment approach to account for the changing character of EO through longer-term disasters in the economic modeling *** found that despite limitations,EO data can inc.ease sectoral and temporal resolution,which leads to significant differences from other data sources in terms of direct and total impact *** findings from this analytical approach have important implications for economic consequence modeling of disasters,as well as providing useful information to policymakers and emergency managers,whose goal is to reduce disaster costs and to improve economic resilience.

关键词： Computable general equilibrium models COVID-19 Disaster economic impacts Earth observation Economic consequence analysis Los Angeles County

Building a Stronger Foundation for Web3:Advantages of 5G Infrastructure

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ZTE Communications 2024年第2期22卷 3-10页

作者： FENG Jianxin PAN Yi WU Xiao TripleLab Shenzhen 518000China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China WhiteMatrix inc. Nanjing 210031China

The emergence of Web3 technologies promises to revolutionize the Internet and redefine our interactions with digital assets and *** essay explores the pivotal role of 5G infrastructure in bolstering the growth and potential of *** focusing on several crucial aspects—network speed,edge computing,network capacity,security and power consumption—we shed light on how 5G technology offers a robust and transformative foundation for the decentralized future of the *** to delving into the specifics,we undertake a technical review of the historical progression and development of Internet and telecommunication technologies.

关键词： Web3 5G blockchain decentralized application infrastructure

Genomic profiling of colorectal cancer in large-scale Chinese patients:amplification and somatic mutations in ERBB2

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Oncology Research 2024年第9期32卷 1429-1438页

作者： YUZHI LIU EVELYNE BISCHOF ZHIQIN CHEN JIAHUAN ZHOU BEI ZHANG DING ZHANG YONG GAO MING QUAN Department of Oncology Shanghai East HospitalTongji University School of MedicineShanghaiChina State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteDepartment of OncologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Jiangsu Hengrui Pharmaceuticals Co. Ltd.ShanghaiChina D Medicines inc. ShanghaiChina

Objectives:Human epidermal growth factor receptor 2(HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer(mCRC)patients with HER2 amplification,but are not satisfactory in cases of HER2 mutant ***:Consequently,further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2(ERBB2)is *** genomic profiling was conducted on 2454 Chinese CRC cases to evaluate genomic alterations in 733 cancer-related genes,tumor mutational burden,microsatellite instability,and programmed death ligand 1(PD-L1)***:Among 2454 CRC patients,85 cases(3.46%)exhibited ERBB2 amplification,and 55 cases(2.24%)carried ERBB2 mutation.p.R678Q(28%),p.V8421(24%),and p.S310F/Y(12%)were the most prevalent of the 16 detected mutation *** comparison to the ERBB2 altered(alt)group,KRAS/BRAF mutations were more prevalent in ERBB2 wild-type(wt)samples(ERBB2wt ***2alt,KRAS:50.9%vs.25.6%,p<0.05;BRAF:8.5%vs.2.3%,p<0.05).32.7%(18/55)of CRCs with ERBB2 mutation exhibited microsatellite instability high(MSI-H),while no cases with HER2 amplification displayed *** genes varied between ERBB2 copy number variation(CNV)and ERBB2 single nucleotide variant(SNV);TP53 alterations tended to co-occur with ERBB2 amplification(92.3%)as opposed to ERBB2 mutation(58.3%).KRAS and PIK3CA alterations were more prevalent in ERBB2 SNV cases(KRAS/PIK3CA:45.8%/31.2%)compared to ERBB2 amplification cases(KRAS/PIK3CA:14.1%/7.7%).Conclusion:Our study delineates the landscape of HER2 alterations in a large-scale cohort of CRC patients from *** findings enhance our understanding of the molecular features of Chinese CRC patients and offer valuable implications for further investigation.

关键词： Colorectal cancer ERBB2 HER2 Human epidermal growth factor receptor 2 Genetic profiling Precision oncology

Accurate Distinc.ion of Weak and Strong AC Grids for Emerging Hierarchical-Infeed LCC-UHVDC Systems

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 772-777页

作者： Hao Xiao Xianzhong Duan Yi Zhang Department of Electrical and Computer Engineering University of ManitobaWinnipeg R3T 2N2ManitobaCanada State Key Laboratory of Advanced Electromagnetic Engineering and Technology Hubei Electric Power Security and High Efficiency Key LaboratorySchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina RTDS Technologies inc. Winnipeg R3T 2E1ManitobaCanada

Distinc.ion of weak and strong AC grids for emerging hierarchical-infeed LCC-UHVDC systems is important for planning and operation departments. However, accuracy of earlier distinc.ion methods is limited as they were developed by empirical reasoning without rigorous theoretical analysis. Hence in this letter, hierarchical-infeed interactive effective short-circuit ratio (HIESCR) index is first used for strength evaluation of HIDC systems with complex inter-inverter interactions considered. Boundary HIESCR (BHIESCR) is also introduced in the proposed distinc.ion method of weak and strong AC grids. That is, weak (or strong) AC grids are, respectively, identified when HIESCR is less (or greater) than BHIESCR. Second, it is shown BHIESCR remains almost unchanged as 3.0 versus various system parameters and rated operation variables based on rigorous theoretical analysis. This salient feature makes the proposed method more accurate than earlier methods. Finally, the proposed method is validated by simulations based on the PSCAD/EMTDC program.

关键词： Hierarchical-Infeedinteractive effective short-circuit ratio hierarchical-infeed LCC-UHVDC systems inter-inverter interactions strong AC grids weak AC grids

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SiP的模块化发展趋势

电子与封装 2024年第7期24卷 21-28页

作者： William Koh Pacrim Technology inc. IrvineCA 92602

系统级封装(SiP)技术已广泛应用于移动设备、可穿戴设备、健康和医疗设备、人工智能(AI)、物联网(IoT)和汽车电子。SiP采用异构集成的方式,将各种芯片和元件集成到一个封装中,以实现特定功能,并具有节省电路板空间、简化布局设计和降低... 详细信息

系统级封装(SiP)技术已广泛应用于移动设备、可穿戴设备、健康和医疗设备、人工智能(AI)、物联网(IoT)和汽车电子。SiP采用异构集成的方式,将各种芯片和元件集成到一个封装中,以实现特定功能,并具有节省电路板空间、简化布局设计和降低制造成本等优势。随着电子组件的小型化发展方向不断持续,一些SiP已经发展成为模块或系统级模块(SiM),可以直接连接并安装到器件中。回顾了SiP从多芯片模块(MCM)、多芯片封装(MCP)到高级芯粒封装和共封装光学器件(CPO)的演变。未来几年,更多的SiP将变成SiM,直接连接器件或系统。

关键词：系统级封装系统级模块多芯片模块

Fundamental Study on Response Properties of Structures Constructed on Lunar Regolith

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Open Journal of Earthquake Research 2024年第1期13卷 27-40页

作者： Yuji Miyamoto Takaharu Nakano Toshio Kobayashi Department of Architecture and Civil Engineering Fukui University of Technology Fukui Japan Graduate School of Engineering Osaka University Osaka Japan SANSEI Inc. Tokyo Japan

The Artemis Program, for constructing the lunar base, is in progress. How to design and construct architectural and civil engineering structures in the lunar environment has become an important issue. The lunar surface is covered with soft sand, called regolith, and it is required to protect lunar bases and structures, as well as internal precision equipment, against vibrational disturbances such as moonquakes and meteorite collisions. Therefore, in this study, the static and cyclic triaxial compression tests of the regolith simulant were conducted. The reference strain and equivalent damping factor of the regolith simulant were smaller compared to sandy soil on Earth. In addition, a shaking table test using model specimens was conducted on the response properties of regolith ground alone and structures set on regolith ground. The buried foundation and pile foundation notably suppressed the horizontal response attributed to the rocking component compared to a direct foundation.

关键词： Lunar Development Regolith Soil-Structure Interaction Triaxial Compression Test Shaking Table Test