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Biomarkers of end of shift exposure to disinfection byproducts in nurses

Journal of Environmental Sciences 2017年第8期29卷 217-223页

作者： Solomon Ioannou Xanthi D.Andrianou Pantelis Charisiadis Konstantinos C.Makris cyprus international Institute for Environmental and Public Health Cyprus University of Technology Limassol 3041 Cyprus

Increased disinfectant use commonly takes place in hospitals and other health care settings. A cross-sectional study among active nurses in two Cypriot public hospitals（n = 179） was conducted to examine the prevalence of exposure to disinfection byproducts（DBPs）, such as trihalomethanes（THMs） using both self-reported information and biomarker *** objectives of this study were to： i） quantify the magnitude and variability of occupational exposure to disinfectants/DBPs in nurses, ii） generate job exposure matrices（JEM） and job task exposure matrices（JTEM） for disinfectants, and iii） assess the major determinants of urinary THMs in nurses. End of shift urinary total THM values showed high variability among the nurses, but did not differ between hospitals. The disinfectant group of alcohols/phenols was used by 〉 98% of nurses, followed by octenidine（82%）, iodine and chlorine（39%, each）,chlorhexidine（25%）, formaldehyde（12%）, hydrogen peroxide（11%）, and peracetic acid/ammonia/quaternary ammonium compounds（QACs）, all being 〈 8% each. Chlorine use during the past 24 hr was associated with significantly（p 〈 0.05） lower brominated THMs（Br THMs） after adjusting for age, gender and BMI, while a positive association was shown for TCM and the sum of all THMs（TTHMs）, albeit not significant. Nurses were exposed to nearly double the levels of TTHMs and BrT HMs（median and IQR, 1027 [560, 2475] ng/g and 323 [212,497] ng/g, respectively） when compared to those of the general population（552 [309,989] ng/g and 152 [87,261] ng/g, respectively）. This was the first occupational health dataset reporting measurements of biomarkers of end of shift exposures to disinfectants/DBPs.

关键词： Nurses Disinfectants Disinfection Exposure Biomarker Job exposure matrix Healthcare

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A global harmony search algorithm for finding optimal capacitor location and size in distribution networks

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Journal of Central South university 2015年第5期22卷 1748-1761页

作者： Reza Sirjani Melkamu Gamene Bade cyprus international university Faculty of Engineering Nicosia Northern Cyprus Mersin 10 Turkey

Shunt capacitors are broadly applied in distribution systems to scale down power losses, improve voltage profile and boost system capacity. The amount of capacitors added and location of deployment in the system highly determine the advantage of compensation. A novel global harmony search(GHS) algorithm in parallel with the backward/ forward sweep power flow technique and radial harmonic power flow was used to investigate the optimal placement and sizing of capacitors in radial distribution networks for minimizing power loss and total cost by taking account load unbalancing, mutual coupling and harmonics. The optimal capacitor placement outcomes show that the GHS algorithm can reduce total power losses up to 60 k W and leads to more than 18% of cost saving. The results also demonstrate that the GHS algorithm is more effective in minimization of power loss and total costs compared with genetic algorithm(GA), particle swarm optimization(PSO) and harmony search(HS) algorithm. Moreover, the proposed algorithm converges within 800 iterations and is faster in terms of computational time and gives better performance in finding optimal capacitor location and size compared with other optimization techniques.

关键词： optimal capacitor placement harmonics unbalancing harmony search algorithm

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Unravel the potential of zinc oxide nanoparticle-carbonized sawdust matrix for removal of lead(Ⅱ) ions from aqueous solution

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Chinese Journal of Chemical Engineering 2021年第1期34卷 92-102页

作者： Racheal Aigbe Doga Kavaz Department of Environmental Science Cyprus International UniversityNicosiaMersin 10Turkey Environmental Research Centre Cyprus International UniversityNicosiaMersin 10Turkey Department of Bioengineering Cyprus International UniversityNicosiaMersin 10Turkey

Zinc oxide nanoparticles(ZnOnp) are molecular nanoparticles synthesized by a chemical precipitation method from zinc nitrate tetrahydrate and sodium *** sawdust(CSD) was prepared from sawdust obtained from a local wood *** matrix of both provides a better material as an *** present study applied the functionality of ZnOnp,CSD,and ZnOnp-CSD matrix as adsorbent materials for the removal of Pb(Ⅱ) ions from aqueous *** method of batch process was employed to investigate the potential of the *** influence of pH,contact time,initial concentration of adsorbate,the dosage of adsorbents,and the temperature of adsorbate-adsorbent mixture on the adsorption capacity were *** adsorption isotherm studies indicate that both Freundlich and Langmuir isotherms were suitable to express the experimental data obtained with theoretical maximum adsorption capacities(q_(m)) of 70.42,87.72,and 92.59 mg·g^(-1) for the adsorption of Pb(Ⅱ) ions onto ZnOnp,CSD,and ZnOnp-CSD matrix,*** separation factors(R_(L)) calculated showed that the use of the adsorbents for the removal of Pb(Ⅱ) ions is a feasible process with R_(L) <*** thermodynamic parameters obtained revealed that the processes are endothermic,feasible,and spontaneous in nature at 25-50℃.Evaluation of the kinetic model elected that the processes agreed better with pseudo-second order where the values of rate constant(k_2) obtained for the adsorption of Pb(Ⅱ) ions onto ZnOnp,CSD,and ZnOnp-CSD matrix are 0.00149,0.00188,and 0.00315 g·mg^(-1)·min^(-1),*** reusability potential examined for four cycles indicated that the adsorbents have better potential and economic value of reuse and the ZnOnp-CSD matrix indicates improved adsorbent material to remove Pb(Ⅱ) ions from aqueous solution.

关键词： Zinc oxide nanoparticles Carbonized saw dust Matrix Batch process Reusability potential

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Avoid Suspicious Route of Blackhole Nodes in MANET’s:Using A Cooperative Trapping

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Computer Systems Science & Engineering 2023年第5期45卷 1901-1915页

作者： Abdllkader Esaid Mary Agoyi Department of Computer Engineering Faculty of EngineeringCyprus International UniversityNicosiaCyprus Information Technology Department School of Applied SciencesCyprus International UniversityNicosiaCyprus

Mobile Ad hoc Network(MANET)is decentralized wireless network and can communicate without existing infrastructure in many *** is vulnerable to various attacks that affect its performance such as blackhole *** attacker,inject fault routing information to persuade the source node to select the path with malicious node as the shortest *** eliminate malicious nodes from launching any collaborative attack.A cooperative Trapping Approach(CTA)was proposed based on modifying Ad-hoc On-demand Distance Vector(AODV)routing protocol and trapping the malicious nodes by responding to the trap request *** approach aims to eliminate and rule out both single and collaborative malicious blackhole nodes from any *** approach realizes a backward tracking mechanism to perform the elimination *** proposed algorithm(CTA)was executed using NS-2 network *** performance metrics that has been considered to evaluate the performance of the proposed algorithm such as throughput,end to end delay,packet delivery ratio,and consuming *** experimental results have shown the performance metrics of the proposed approach outperformed other state of at algorithms.

关键词： AODV Blackhole MANET Malicious node

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The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang Yuan Liang Yixue Gu international Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen Beijing international Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration

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Neural Regeneration Research 2025年第8期20卷 2317-2318页

作者： Francesco Angelucci Jakub Hort Memory Clinic Department of NeurologySecond Faculty of MedicineCharles University and Motol University HospitalPragueCzech Republic international Clinical Research Centre St.Anne’s University HospitalBrnoCzech Republic

Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the *** pathology involves a series of cognitive,behavioral,and neurological ... 详细信息

关键词： degeneration elevated pathology

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Person-Dependent Handwriting Verification for Special Education Using DeepLearning

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Intelligent Automation & Soft Computing 2023年第4期36卷 1121-1135页

作者： Umut Zeki Tolgay Karanfiller Kamil Yurtkan Department of Computer Engineering Cyprus International UniversityHaspolatNicosiaNorthern CyprusMersin 10Turkey Computer and Instructional Technology Teacher Education Cyprus International UniversityHaspolatNicosiaNorthern CyprusMersin 10Turkey

Individuals with special needs learn more slowly than their peers and they need repetitions to be ***,in crowded classrooms,it is dif-ﬁcult for a teacher to deal with each student *** problem can be overcome by using supportive education ***,the majority of such applications are not designed for special education and therefore they are not efﬁcient as *** education students differ from their peers in terms of their development,characteristics,and educational qualiﬁ*** handwriting skills of individuals with special needs are lower than their *** makes the task of Handwriting Recognition(HWR)more difﬁ*** over-come this problem,we propose a new personalized handwriting veriﬁcation sys-tem that validates digits from the handwriting of special education *** system uses a Convolutional Neural Network(CNN)created and trained from *** data set used is obtained by collecting the handwriting of the students with the help of a tablet.A special education center is visited and the handwrittenﬁgures of the students are collected under the supervision of special education *** system is designed as a person-dependent system as every student has their writing ***,the system achieves promising results,reaching a recognition accuracy of about 94%.Overall,the system can verify special educa-tion students’handwriting digits with high accuracy and is ready to integrate with a mobile application that is designed to teach digits to special education students.

关键词： Special education deep learning convolutional neural network handwriting veriﬁcation handwriting digit veriﬁcation person-dependent training handwriting recognition

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Sensitivity Analysis of COVID-19 in Mediterranean Island

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Computer Modeling in Engineering & Sciences 2022年第1期130卷 133-148页

作者： Ahmet Savasan Bilgen Kaymakamzade Nezihal Gokbulut Evren Hincal Elcin Yoldascan Near East university Faculty of Arts and SciencesNicosia99138North Cyprus Near East university Mathematics Research CenterNicosia99138North Cyprus cyprus international university Faculty of MedicineNicosia99138North Cyprus

The aim of this study is to examine the progress of the worldwide pandemic *** authors,we have decided to analyze the situation of COVID-19 onMediterranean islandwith accurate *** this purpose,amathematical model is constructed and proposed by dividing the whole population into sensible and suitable *** study captures the dates February 01 till May 15,*** the control of the spread of disease,vaccination and infection rates are compared and *** calculations and comparison,MatLab software is *** of the data that are used are taken from the Ministry of *** effect of parameters is examined with sensitivity ***,with this analysis,values of parameters are ***,by using the constructed model,the effect of vaccine on infected individuals is analyzed *** a result,it is concluded that the studied part of the island is late for the control of the disease via *** can be explained by two main reasons;vaccinating the people that are not inmobilitymost of the time(aged people and people with chronic diseases)and getting the vaccine ***,the results showed that this rate and distribution of vaccines would not be enough to control the pandemic on the island.

关键词： COVID-19 vaccination mathematical model basic reproduction number island sensitivity analysis

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Optimum Calcination Condition of Waste Stabilized Adobe for Alkali Activated High Volume Adobe-Slag Binder Cured at Room Temperature

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Journal of Renewable Materials 2022年第5期10卷 1269-1285页

作者： Brya Aldawoodi Salaheddin Sabri Abdulmounem Alchekh Wis Department of Civil Engineering Cyprus International UniversityHaspolatNorth Cyprusvia Mersin 10Turkey Kocaeli university Kocaeli41380Turkey

This study aims to determine the most convenient calcination temperature and calcination duration of wastestabilized Adobe(AB)to produce a new alkali-activated ***-stabilized Adobe mainly consists of soil,CaCO3 as a stabilizer,and straw(for strengthening).The availability of raw materials for making Adobe presents the waste-stabilized Adobe as a potential product for a new alkali-activated ***-stabilized Adobe collected from an abandoned damaged building in the village of Inonu in Northern cyprus,ground and calcined at the following temperatures:450,550,650,750,850,and 950℃.The calcination at each temperature was held for different durations 1,3,5,and 7 *** and calcined waste stabilized Adobe structures were investigated using XRF,TGA-DTA,XRD,FTIR,and *** technical and environmental views related to energy consumption,waste stabilized Adobe calcined at 750℃ for 1 h presented the most promising results regarding the production of a new precursor for alkali-activated *** study also presents the effect of ground granulated blast furnace slag(GGBFS)usage on the fresh and hardened properties of optimum calcined AB-based alkali-activated pastes cured at room *** was used to partially replace AB to form a binary composite raw material system and seven experimental groups were designed according to replacement levels of 0%,5%,10%,15%,20%,25%and 30%(by mass).Alkali-activated high volume waste-stabilized Adobe-slag pastes prepared using Na2SiO3-to-NaOH ratio of 2 and 12 M concentration of Sodium *** fresh property as flowability and the hardened property as the compressive strength of the alkali-activated pastes with different GGBFS contents were *** results indicated that the incorporation of GGBFS increased the flowability of fresh alkali-activated pastes.A 28-day compressive strength of 43.75 MPa can be obtained by a 30%replacement level of GGBFS.

关键词： Waste stabilized adobe calcination alkali activation compressive strength room temperature curing

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