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Brain activity following esophageal acid infusion using positron emission tomography

World Journal of Gastroenterology 2010年第43期16卷 5481-5489页

作者： Shigeyuki Kobayashi Yasuhiko Abe Manabu Tashiro Tomoyuki Koike Katsunori Iijima Akira Imatani Shuichi Ohara Satoshi Watanabe Shin Fukudo Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Division of cyclotron Nuclear Medicine Cyclotron and Radioisotope Center Tohoku University Division of Behavioral Medicine Tohoku University Graduate School of Medicine

AIM: To investigate symptoms and brain activity following esophageal acid infusion. METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2) and distilled water (pH 7) were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of ***: The severity of heartburn following each infusion showed a step-wise increase with increasing acidity of the perfusate. The heartburn scores were significantly higher in the second pH 1 infusion compared with the first infusion. Acid and distilled water infusion induced activation of various brain areas such as the anterior insula, temporal gyrus, and anterior/ posterior cingulate cortex. At pH 1 or 2, in particular, activation was observed in some emotion-related brain areas such as the more anterior part of the anterior cingulate cortex, parahippocampal gyrus, or the temporal pole. Strong activation of the orbitofrontal cortex was found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms. CONCLUSION: Emotion-related brain areas were activated by esophageal acid stimulation. The orbitofrontal area might be involved in symptom processing, with esophageal sensitization induced by repeated acid stimulation.

关键词： Esophageal acid infusion Brain imaging Positron emission tomography

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An advanced partitioning process for key elements separation from high level liquid waste

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Science China Chemistry 2012年第9期55卷 1726-1731页

作者： WEI YueZhou WANG XinPeng LIU RuiQin WU Yan USUDA Shigekazu ARAI Tsuyoshi School of Nuclear Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China cyclotron and radioisotope center Tohoku University Aoba-ku Sendai 980-8578 Japan Shibaura Institute of Technology Koto-ku Tokyo 135-8548 Japan

To separate MA （Am, Cm） and some fission product elements （FPs） such as Tc, Pd, Cs and Sr from high level liquid waste （HLLW） systematically, we have been studying an advanced aqueous partitioning process, which uses selective adsorption as the separation method. For this process, we prepared several novel adsorbents which were immobilized in a porous sili- c^polymer composite support （SiO2-P）. Adsorption and separation behavior of various elements was studied experimentally in detail. Small scale separation tests using simulated HLLW solutions were carried out. Pd（II） was strongly adsorbed by the AR-01 anion exchanger and effectively eluted off by using thiourea. Successful separation of Pd（ll） from simulated HLLW was achieved. Te（VII） also exhibited strong adsorption on AR-01 and could be eluted off by using U（IV） as a reductive eluent. Am（Ⅲ） presented significantly high adsorbability and selectivity onto R-BTP/SiOz-P adsorbents over various FPs including Ln（Ⅲ）. The R-BTP adsorbents were fairly stable in 3 M HNO3, but instable against 7-irradiation-3M HNO3. An advanced par- titioning process consisting of three separation columns for the target elements separation from HLLW was proposed and the obtained experiment results indicated that the proposed process is essentially feasible.

关键词： HLLW minor actinides fission products separation novel adsorbents extraction chromatography ion exchange waste minimization valuable elements utilization

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Magnetic Moment of the 3/2+ State in 165Ho

Magnetic Moment of the 3/2+ State in 165Ho

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作者： M.Tanigaki Y.Ohkubo A.Taniguchi S.Izumi T.Shinozuka Graduate School of Science Tohoku University cyclotron and radioisotope center Tohoku University

INTRODUCTION:Electromagnetic moments of nuclei are important physical quantities not only for nuclear structure studies,but also for the investigation of the electromagnetic structures in *** values of electromagnetic moments of radioactive nuclei are essential especially for probe nuclei of rare-earth elements in ferromagnetic materials through hyperfine interactions since it is difficult to apply the conventional NMR technique due to their very high resonance frequencies and shallow skin *** such example is

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内皮源性缩血管因子花生四烯酸代谢物的作用多样性(英文)

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Acta Pharmacologica Sinica 2003年第11期24卷 3-7+110页

作者： KURAHASHI Kazuyoshi,NISHIHASHI Tsuyoshi,TRANDAFIR Cristina Corina,WANG Ai-Min,MURAKAMI Shizuka,JI Xu Pharmacology Division radioisotope Research center Kyoto University Kyoto 606-8501 Japan Pharmacology Division radioisotope Research center Kyoto University Kyoto 606-8501 Japan Pharmacology Division radioisotope Research center Kyoto University Kyoto 606-8501 Japan Pharmacology Division radioisotope Research center Kyoto University Kyoto 606-8501 Japan Pharmacology Division radioisotope Research center Kyoto University Kyoto 606-8501 Japan Pharmacology Division radioisotope Research center Kyoto University Kyoto 606-8501 Japan

Vascular endothelium releases vasocontracting and/or vasorelaxing substances. Here, we report the diversity of endothelium-derived vasocontracting factors（EDCFs）, arachidonic acid metabolites, and discuss the pathophysiological significance. In the canine basilar artery and the rabbit intrapulmonary artery, acetylcholine-induced contractions（ACh-induced EDC） are due to endothelial thromboxane A2（TXA2）（TXA2-type）. The ACh-induced EDC in the rabbit coronary artery is due to endothelial leukotrienes（LTs）（LTs-type）. In addition, in the rat coronary artery, nicotine and noradrenaline（NAd）-induced EDCs are due to endothelial COX-metabolites（COX metabolite-type）. These arachidonic acid metabolites derived from endothelium（activation by vasoactive substances including ACh, NAd and nicotine） cause a contraction of vascular smooth muscle cells and may disturb the local circulation. These EDCFs （TXA2, LTs and COX-metabolites） may be involved in the pathophysiology of cardiovascular immuno-inflammatory diseas

关键词：内皮花生四烯酸脑动脉冠状血管

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Evaluation study on properties of a macroporous silica-based CMPO extraction resin to be used forminor actinides separation from high level liquid waste

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Nuclear Science and Techniques 2011年第1期22卷 18-24页

作者： LIU Ruiqin WEI Yuezhou Daisuke Tozawa XU Yuanlai Shigekazu Usuda Hiromichi Yamazaki Keizo Ishii Yuichi Sano Yoshikazu Koma School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China cyclotron and radioisotope center Tohoku UniversityAoba 6-3Aramaki-Aoba-kuSendaiMiyagi980-8578Japan Japan Atomic Energy Agency (JAEA) TokaiIbaraki319-1195Japan

Basic properties of a silica-based octyl(phenyl)-N,N-diisobutylcarbamoyl-methylphosphine oxide (CMPO) extraction resin (CMPO/SiO2-P) was *** behavior for some rare earth elements (RE) which are constituents of high level liquid waste (HLLW) and the long-term stability of the extraction resin in nitric acid solution were *** CMPO extraction resin was significantly stable in 3 mol·L?1 HNO3 solution at ***,the RE(III) were efficiently separated from non-adsorptive fission product (FP) elements such as Sr(II) in a column experiment using a highly nitric acid *** separation behaviors of the elements are considered to result from the difference in their adsorption and elution selectivity based on the complex formation with *** was no strong dependency of RE(III) separation efficiency on feed solution flow *** from the perspectives of the acid-resistant behavior of CMPO extraction resin and the elution kinetics for the metal ions with the extraction resin,the CMPO extraction resin can be used in the modified MAREC process for HLLW partitioning.

关键词：萃取树脂高放废液锕系元素分离性能大孔硅提取基础选择性吸附

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Challenges to develop single-column MA(Ⅲ) separation from HLLW using R-BTP type adsorbents

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Science China Chemistry 2012年第9期55卷 1732-1738页

作者： USUDA Shigekazu WEI YueZhou LIU RuiQin LI Zheng XU YuanLai WU Yan KIM Seongyun cyclotron and radioisotope center Tohoku UniversityAoba 6-3AramakiAoba-kuSendai 980-8578Japan School of Engineering Tohoku UniversityAoba 6-6-01-2AramakiAoba-kuSendai 980-8578Japan School of Nuclear Science and Engineering Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

In order to directly separate trivalent minor actinides （MA： Am, Cm） from fission products （FP） containing rare earths （RE） in high level radioactive liquid waste （HLLW）, the authors have challenged to develop a simplified MA separation process by extraction chromatography using a single column. Attention has been paid to a new type of nitrogen-donor ligands, R-BTP （2,6-bis（5,6-dialkyl-1,2,4-triazin-3-yl） pyridine, R： alkyl group） as an extractant because it shows high extraction selectivity for Am（Ⅲ） over RE（Ⅲ）. It is known that the R-BTP ligands show different properties such as adsorbability and stability by hav- ing different alkyl groups. Therefore, some novel adsorbents were prepared by impregnating different types of R-BTP ligands （isohexyl-, isoheptyl- and cyheptyl-BTP） and a similar ligand to the R-BTP, ATP （2,6-bis（l-aryl-lH-tetrazol-5-yl）pyridines）, into the porous silica/polymer support （SiOrP particles）. This work deals with comparison in adsorption and desorption prop- erties of Am and some FP in HNO3 solution onto such R-BTP type adsorbents, as well as chemical and radiolytic stability of the adsorbents. Then the possibility of a single-column separation of MA from main FP was pursued by evaluating the results of column experiments using the most promising adsorbent （isohexyl-BTP/SiO2-P） under temperature control. In addition, elu- tion behaviors of U and Pd were also estimated.

关键词： R-BTP/SiO2-P type adsorbents single-column separation trivalent minor actinides (MA) adsorbability and stability fission products (FP) rare earths (RE) temperature control

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Fluorescent spectrum study of fluorescein binding to the interior of silica nanocapsules in various solvents

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生物物理学报 2009年第S1期25卷 299-300页

作者： Hirokazu Miyoshi radioisotope Research center The University of Tokushima Kuramoto-cho 3-18-15 Tokushima 770-8503 Japan

Porous silica nanocapsules with 20% 3-aminopropyltrimethoxysilane (APS)-bound 6-carboxy-fluorescein (APS-fluorescein) and 80% APS molecules adsorbed on the surface

关键词： Fluorescent spectrum study of fluorescein binding to the interior of silica nanocapsules in various solvents XL

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Constraints on symmetry energy and n/p effective mass splitting with improved quantum molecular dynamics model

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Nuclear Science and Techniques 2013年第5期24卷 13-18页

作者： ZHANG Yingxun LI Zhuxia ZHAO Kai LIU Hang TSANG M B China Institute of Atomic Energy National Superconducting cyclotron Laboratory Michigan State University Texas Advanced Computing center University of TexasAustin

A new version of improved quantum molecular dynamics model that includes standard Skyrme interactions has been *** on the new code,four commonly used parameter sets,SLy4,SkI2,SkM*and Gs are adopted in the improved quantum molecular dynamics model and the isospin sensitive observables,namely isospin transport ratios,single and double ratios of the yields of neutrons and protons are *** isospin transport ratios are strongly sensitive to the slope of symmetry energy,and are not very sensitive to the nucleon effective mass *** the other hand,the high energy neutrons and protons yields ratios from reactions at different incident energies provide a good observable to the momentum dependence of nucleon effective mass *** comparing our calculations with the data,we find that the constrained L value(the slope of density dependence of symmetry energy) is about ~46 MeV when the Skyrme type interaction is considered in transport models,and the isospin diffusion data prefer to mn*>mp*,but it is not a strong constraint with deep χ2minimum.

关键词：量子分子动力学模型核子有效质量对称能 Skyrme相互作用分裂密度依赖性入射能量运输模型

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Sustained release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA

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生物物理学报 2009年第S1期25卷 297-298页

作者： Hirokazu Miyoshi radioisotope Research center The University of Tokushima Kuramoto-cho 3-18-15 Tokushima 770-8503 Japan

The use of nanotechnology in drug delivery is a rapidly expanding field. Biodegradable or nontoxic nanomaterials have the most promising application potentials in nanomedicine.

关键词： Sustained release of methyl viologen from a novel nanoparticle delivery system with double shells of silica and PLGA SiO

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Potassium transporter KUP9 participates in K+distribution in roots and leaves under low K+stress

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Stress Biology 2022年第1期2卷 60-70页

作者： Taro Yamanashi Takeshi Uchiyama Shunya Saito Taiki Higashi Hayato Ikeda Hidetoshi Kikunaga Mutsumi Yamagami Yasuhiro Ishimaru Nobuyuki Uozumi Department of Biomolecular Engineering Graduate School of EngineeringTohoku UniversitySendai 980‑8579Japan Research center for Electron Photon Science Tohoku UniversitySendai 980‑0826Japan cyclotron and radioisotope center Tohoku UniversitySendai 980‑8578Japan Institute for Environmental Sciences RokkashoKamikitaAomori 039‑3212Japan

Potassium(K)is a major essential element in plant cells,and KUP/HAK/KT-type K+transporters participate in the absorption of K+into roots and in the long-distance transport to above-ground *** Arabidopsis thaliana,KUP9 is involved in the transport of K+and Cs+in *** this study,we investigated KUP9 function in relation to the K+status of the *** expression of KUP9 was upregulated in older leaves on K+-depleted medium,compared to the expression of the other 12 KUP genes in the KUP/HAK/KT family in *** grown on low K+medium,the kup9 mutant had reduced chlorophyll content in seedlings and chlorosis in older rosette ***-specific expression of KUP9 determined by KUP9 promoter:GUS assay depended on the K+status of the plants:In K+sufficient medium,KUP9 was expressed in the leaf blade towards the leaf tip,whereas in K+depleted medium expression was mainly found in the *** accordance with this,K+accumulated in the roots of kup9 *** short-term 43K+tracer measurement showed that 43K was transferred at a lower rate in roots and shoots of kup9,compared to the wild *** data show that KUP9 participates in the distribution of K+in leaves and K+absorption in roots under low K+conditions.

关键词： Potassium KUP9 Arabidopsis thaliana KUP/HAK/KT

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