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A decade of Changes in the Transportation of passengers： What Are the Factors That Affected the demand？

Journal of Traffic and Transportation Engineering 2016年第6期4卷 299-311页

作者： Francisco Gildemir Ferreira Da silva sergio Aquino de souza curso de Finanvas--FEAAC Universidade Federal do Ceara Vila Uniao CEP: 60410-691 Brazil curso de p6s-graduaao em economia Universidade Federal do Ceara Segundo Andar CEP: 60.020-181 Brazil

Ten years of financial stability in Brazilian economy have gone. In this period, the regional transportation of passengers suffered exogenous impacts： economical crises, airport crises and great proportions＇ accidents, as well as impacts which were intern to the system： institutional changes （liberation of tariff promotions, many companies establishing themselves and also coming to bankruptcy）, creation of regulating institutions in the air transportation as well as the land transportation. Theoretically, it is expected that these changes have generated impacts in the demand for trips, since an environment regulated with more flexible prices and higher amounts of companies would generate a competitive environment in which the companies could struggle to attract their demand. On the other hand, the impacts which are exogenous to the system can generate responses in the sense of restoring the balance of demand. Thus, based on the theoretical experience, this article aims at analyzing empirically, through categorical variables, if there were impacts on the demand for regional trips in Brazil due to the internal or external changes. In order to perform this, monthly data from January, 1999 to december, 2009 are utilized and estimates are calculated making use of sUR （seemingly unrelated regressions）. As a result, we have the meaning of the internal and external impacts related to air and land transports, identifying that the worldwide economic crisis generated an impact at the level of the demand for transportation and also that the flexibility of tariffs allowed by ANTT （Ag^ncia Nacional de Transportes Terrestres） had an equal impact on the demand for land transportation.

关键词： seemingly unrelated regressions passengers transport demand analysis.

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Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats:a preliminary study

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Neural Regeneration Research 2018年第12期13卷 2160-2163页

作者： Viviane Rostirola Elsner Laura Reck Cechinel Louisiana Carolina Ferreira de Meireles Karine Bertoldi Ionara Rodrigues siqueira programa de pós-Graduacao em Ciências Biológicas:Fisiologia Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul programa de pós-Graduacao em Biociências e Reabilitacao Centro Universitário Metodista-IPA curso de Fisioterapia Centro Universitário Metodista-IPA

Although the involvement of gender in epigenetic machinery in peripheral tissues during the neonatal period has been suggested, the gender-related epigenetic profile of brain areas during the adolescent period is rarely exploited. Furthermore, the influence of time of day on hippocampal acetylation marks has been demonstrated in young adult and aged rats; however, there are no studies reporting epigenetic changes in the adolescent period. Therefore, this study aimed to investigate the effects of gender on hippocampal DNA methyltransferase 1 content and histone deacetylase（HDAC） activity of adolescent rats at different time points, specifically early morning and afternoon. Both epigenetic markers increased significantly in the hippocampi of female rats compared to the male group, an indicator of reduced transcriptional activity. In addition, HDAC activity during the early morning was higher compared to afternoon groups in both male and female rats, while DNA methyltransferase 1 content was not altered by the time of day. Our findings demonstrate that hippocampal DNA methylation and histone acetylation status can be influenced by gender during the adolescent period, while the time of the day impacts HDAC activity.

关键词： adolescent rats DNA methyltransferase 1 histone deacetylase hippocampus time of the day gender epigenetic marks

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Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study

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Neural Regeneration Research 2021年第5期16卷 805-812页

作者： Viviane Rostirola Elsner Lucieli Trevizol Isadora de Leon Marcos da silva ThaynáWeiss Milena Braga Daniela pochmann Amanda stolzenberg Blembeel Caroline Dani Elenice Boggio curso de Fisioterapia do Centro Universitário Metodista-IpA Porto AlegreRSBrasil programa de pós-Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IpA Porto AlegreRSBrasil programa de pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of ***,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these *** exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different ***,little is reported on this in post-stroke *** purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FEs)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke *** this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FEs group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and *** intervention,higher Berg Balance scale scores were obtained in the EXE+FEs group than in the EXE alone *** was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FEs *** intervention,a better cognitive performance was found in both groups compared with before the *** intervention,the Timed Up and Go test scores were higher in the EXE+FEs group than in the EXE alone *** addition,the intervention induced lower levels of lipid *** intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FEs group,compared with the

关键词： cognition epigenetic exercise functional electrical stimulation functional mobility oxidative stress stroke WalkAide

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Amprolium exposure alters mice behavior and metabolism in vivo

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Animal Models and Experimental Medicine 2018年第4期1卷 272-281页

作者： Juliana Oliveira Moraes samara Dias Cardoso Rodrigues Leidiano Martins pereira Rita de Cássia Noronha Medeiros Clarissa Amorim silva de Cordova Fabiano Mendes de Cordova programa de pós-Gradua??o em sanidade Animal e saúde pública nos Trópicos Universidade Federal do Tocantins curso de Medicina Veterinária Universidade Federal do Tocantins curso de Medicina Universidade Federal do Tocantins

Background: Thiamine deficiency(TD) models have been developed, mainly using the thiamine analog pyrithiamine. Other analogs have not been used in rodents. We aimed to evaluate the effects and mechanisms of intraperitoneal(ip) amprolium-induced TD in mice. We also evaluated the associated pathogenesis using antioxidant and anti-inflammatory compounds(Trolox, dimethyl sulfoxide).Methods: Male mice were separated into two groups, one receiving a standard diet(control animals), and the other a TD diet(deficient groups) for 20 days. Control mice were further subdivided into three groups receiving daily ip injections of saline(NaCl0.9%; Cont group), Tolox(Tr group) or dimethyl sulfoxide(DMsO; Dmso group). The three TD groups received amprolium(Amp group), amprolium and Trolox(Amp+Tr group), or amprolium and DMsO(Amp+Dmso group). The animals were subjected to behavioral tests and then euthanized. The brain and viscera were ***: Amprolium exposure induced weight loss with hyporexia, reduced the behavioral parameters(locomotion, exploratory activity, and motor coordination), and induced changes in the brain(lower cortical cell viability) and liver(steatosis). Trolox co-treatment partially improved these conditions, but to a lesser extent than ***: Amprolium-induced TD may be an interesting model, allowing the deficiency to develop more slowly and to a lesser extent. Amprolium exposure also seems to involve oxidative stress and inflammation, suggested as the main mechanisms of cell dysfunction in TD.

关键词： brain dimethyl sulfoxide thiamine deficiency Trolox

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Effects of a multimodal exercise protocol on functional outcomes,epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults:a quasi-experimental pilot study

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Neural Regeneration Research 2021年第12期16卷 2479-2485页

作者： Iasmin Fraga Camila Weber Wériton Baldo Galiano Lucio Iraci Mariana Wohlgemuth Gabriela Morales Camila Cercato Juliana Rodriguez Daniela pochmann Caroline Dani pérsia Menz Adriane Dal Bosco Viviane Rostirola Elsner programa de pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil curso de Fisioterapia do Centro Universitário Metodista-IpA Porto AlegreRSBrasil programa de pós-Graduação em Biociências e Reabilitação Centro Universitário Metodista-IPAPorto AlegreRSBrasil physiotherapist working in Long-Term InstitutionsPorto AlegreRSBrasil

Epigenetic changes have been shown to be associated with both aging process and aging-related *** is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life of institutionalized older adults,however,the molecular mechanisms involved are not *** purpose of this pilot study was to investigate the effects of a multimodal exercise intervention on functional outcomes,cognitive performance,quality of life(QOL),epigenetic markers and brain-derived neurotrophic factor(BDNF)levels among institutionalized older adult ***(n=8)without dementia who were aged 73.38±11.28 years and predominantly female(87.5%)were included in this quasi-experimental pilot study.A multimodal exercise protocol(cardiovascular capacity,strength,balance/agility andﬂexibility,perception and cognition)consisted of twice weekly sessions(60 minutes each)over 8 ***(Berg scale),mobility(Timed Up and Go test),functional capacity(six-Minute Walk test),cognitive function(Mini-Mental state Examination)and QOL(the World Health Organization Quality of Life-BREF scale questionnaire)were evaluated before and after the *** sample(15 mL)was also collected before and after intervention for analysis of biomarkers global histone H3 acetylation and brain-derived neurotrophic factor *** improvements were observed in cognitive function,balance,mobility,functional capacity and QOL after the *** addition,a tendency toward an increase in global histone H3 acetylation levels was observed,while brain-derived neurotrophic factor level remained *** study provided evidence that an 8-week multimodal exercise protocol has a significant effect on ameliorating functional outcomes and QOL in institutionalized older adult *** addition,it was also able to promote cognitive improvement,which seems to be partially related to histone hyperacetylation *** Ethics Research Com

关键词： aging balance brain-derived neurotrophic factor cognition epigenetics physical exercise quality of life risk of falling

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Effect of mini-cutting size on adventitious rooting and morphophysiological quality of Ilex paraguariensis plantlets

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Journal of Forestry Research 2021年第2期32卷 815-822页

作者： Nathalia pimentel denise Gazzana Janaina de Fatima spanevello Kelen Haygert Lencina Dilson Antônio Bisognin programa de pós-Graduação em Engenharia Florestal Centro de Ciências Rurais da Universidade Federal de Santa MariaAvenida Roraima1000Santa MariaRS 97105-900Brazil curso de Graduação em Agronomia Centro de Ciências Rurais da Universidade Federal de Santa MariaAvenida Roraima1000Santa MariaRS 97105-900Brazil departamento de Fitotecnia Centro de Ciências RuraisUniversidade Federal de Santa MariaAv.Roraima1000Santa MariaRS 97105-900Brazil

As the energizing and therapeutic effects of infusions of mate(Ilex paraguariensis ***.-Hil)leaves are increasingly recognized,rising global consumption is also increasing the demand for plantlets with high genetic and morphological ***-cuttings are an alternative for clonal plantlets;however,more details are needed on factors that affect the success of this ***,toward maximizing production,we evaluated adventitious rooting competence of mini-cuttings of different sizes and the morphophysiological quality of the resultant ***(one bud;length up to 2.5 cm),medium(multiple buds;length 2.6–5.0 cm),and large(multiple buds;length 5.1–10.0 cm)mini-cuttings were planted in a mixture of commercial substrate,vermiculite,and coarse sand(1:1:1 v:v:v),grown in a humidity chamber,then evaluated after 45,60,75,and 90 days for survival,percentage of callus and shoot formation,number and length of shoots,percentage of rooted cuttings,and number and length of *** rooted mini-cuttings were then cultivated in commercial substrate and subsurface soil(2:1 v:v)and evaluated after 30,60,90 and 120 days of cultivation for morphophysiology of the plantlets,percentage of survival,number of leaves,shoot height,stem diameter,and ratio of shoot height to stem *** 120 days,the plantlets were evaluated for the ratio of shoot and root dry mass,total length,surface area,total volume,and mean diameter of roots and Dickson quality *** rooting of the mini-cuttings and the morphophysiological quality of the plantlets were not influenced by the size of the vegetative ***,single-bud mini-cuttings have similar adventitious rooting competence,and result in plantlets with adequate morphophysiological quality,based upon leaf development,shoot height,stem diameter and length,and surface area,volume and diameter of ***-bud mini-cuttings up to 2.5 cm long can thus be used to maximize production of mate plantlets by mini-c

关键词： Aquifoliaceae Clonal forestry Mini-cutting technique plantlet production Vegetative propagation

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Aquatic exercise program-modulated oxidative stress markers in patients with parkinson's disease

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Neural Regeneration Research 2020年第11期15卷 2067-2072页

作者： Caroline Dani Isabel Teixeira proenca Jessica Marinho pamela peccin Ivy Reichert Vital da silva simone Nique Vera striebel Daniela pochmann Viviane Rostirola Elsner programa de pos Graduacao em Biociencias e Reabilitacao do Centro Universitario Metodista-IpA Porto AlegreRSBrazil curso de Fisioterapia do Centro Universitario Metodista-IpA Porto AlegreRSBrazil programa de pos Graduacao em Ciencias Biologicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil programa de pos Graduacao em Farmacologia e Terapeutica Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil

parkinson's disease is a neurodegenerative *** stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this *** exercise can regulate oxidative *** purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with parkinson's *** aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise *** results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with parkinson's *** with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first *** results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme *** results could better help understand the target of oxidative stress in parkinson's *** study was approved by the Ethics Committee of Centro Universitário Metodista IpA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).

关键词： antioxidant enzyme antioxidants aquatic exercise exercise therapies neurodegenerative disease oxidative stress parkinson's disease

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<i>schistosoma mansoni</i>: phytochemical Effect on Aquatic Life Cycle

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Open Journal of Veterinary Medicine 2015年第6期5卷 127-132页

作者： Ronaldo de Carvalho Augusto Gabriela Friani Maurício Carvalho de Vasconcellos Maria de Lurdes de Azevedo Rodrigues Clélia Christina Mello-silva Laboratório de Avaliaç &atilde o e promoç &atilde o da saúde Ambiental Instituto Oswaldo Cruz Funda&ccedil &atilde o Oswaldo Cruz Rio de Janeiro Brasil departamento de parasitologia Animal Curso de Pós-Gradua&ccedil &atilde o em Ciências Veterinárias Universidade Federal Rural do Rio de Janeiro Seropédica Brasil

Background: Two aspects need to be considered for schistosomiasis control: morbidity and transmission. In this context, many soluble substances have been tested and Euphorbia milii latex is one of the most promising Brazilian molluscicides. phytochemical studies involving simulation of the applicability of this latex on all aquatic forms of the s. mansoni life cycle are rare in the literature. The aim of this work was to evaluate the effect of E. milii latex on s. mansoni in the egg, miracidium and different developmental stages in Biomphalaria glabrata. Methods: The laboratory study was designed to simulate the different forms of exposure of the life cycle stages of s. mansoni to the LC50 of E. milii latex;we tested the exposition from four situations of s. mansoni contact with the latex and observed the exposure on different snails’ infection stage too. All snails were analyzed weekly for cercarial shedding and reproductive biology. Results: The results showed that contact of s. mansoni eggs and miracidia with the LC50 of E. milii negatively influenced the development of the parasite life cycle in the intermediate host, with consequent reduction of cercarial shedding. The exposure of infected snails affected the reproductive biology and cercarial shedding in all intra-mollusk development stages of s. mansoni, but the reduction was greater in the first, fourth, fifth, sixth, seventh and eighth weeks of infection. The LC50 of E. milii latex had toxic action on eggs and miracidia, and the number of cercariae shed by snails during the study period declined by about 80%. Conclusions: We can conclude that the use of natural biodegradable compounds containing low concentrations of substances already characterized as having eco-toxico- logical potential can be an important tool to reduce the transmission of schistosomiasis.

关键词： schistosomiasis Cercariae Miracidia Eggs Euphorbia milii

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Red Onion (Allium Cepa L.) Methanolic Extract Increases Extracellular Nucleotide Hydrolysis in Rat serum

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Open Journal of Applied sciences 2020年第12期10卷 864-876页

作者： Janayne Luihan silva Bruno Quintanilha Faria Vinícius Marques Arruda Fernanda Cardoso da silva Joyce Ferreira da Costa Guerra Cristina Ribas Fürstenau Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Belo Horizonte Brazil curso de Biotecnologia Universidade Federal de Uberlandia Patos de Minas Brazil programa de pós-graduaç o em Biotecnologia Instituto de Biotecnologia Universidade Federal de Uberlandia Patos de Minas Brazil Centro de Ciências Naturais e Humanas Universidade Federal do ABC Santo André Brazil

Ectonucleotidases are enzymes involved in nucleotides metabolism. The amount of circulating nucleotides may modulate distinct pathophysiological processes in the vasculature, including platelet aggregation and vascular tone. Onion (em>Allium cepaem> L.) phenolic compounds modulate enzymatic activity. The present study evaluated the total phenolic content of red onion methanolic extract, its antioxidant capacity, and its ability to interfere in nucleotides hydrolyses in rat serum. Total phenolic content was determined with the Folin-Ciocalteau reagent using gallic acid as a standard, while total flavonoid content was obtained through the aluminum chloride colorimetric method with quercetin as a standard. Antioxidant capacity was evaluated from the ability of the extract to scavenge ABTsstrong>·strong>+ and DppHstrong>·strong> radicals. ATp, ADp, AMp, and p-Nph-5'-TMp hydrolyses were colorimetrically determined in response to different onion extract concentrations (0, 125, 250, 500, or 1000 μg/mL). phenolic content of the extract was 54.35 mg GAE 100 gsup>-1sup> sample, while flavonoid content was 7.22 mg quercetin gsup>-1sup> sample. The IC50 value for ABTsstrong>·strong>+ was 374.13 ± 7.52 μg/mL, while it was 440.29 ± 15.17 μg/mL for DppHstrong>·strong>. Red onion extract increased ADp and p-Nph-5'-TMp hydrolysis. The results confirmed that red onion contains high content of antioxidant, mainly flavonoids, and high antioxidant capacity. Additionally, biochemical studies suggest that the increased ADp breakdown may be important to regulate vascular processes. As it occurs for other enzymes, the antioxidant capacity of onion extract may neutralize reactive oxygen species (ROs) formation and favor ectonucleotidase activity and the hydrolysis of ADp, a major platelet agonist.

关键词： Red Onion Flavonoids Reactive Oxygen species Ectonucleotidases Vascular Homeostasis

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Historical Evolution of the Trophic and Limnological Relationships in the Itaipu Reservoir:Top-Down and Bottom-Up Effects upon Fish production

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Advances in Bioscience and Biotechnology 2015年第6期6卷 390-407页

作者： Rinaldo Antonio Ribeiro Filho Miguel petrere Junior Angelo Antonio Agostinho simone Friderigi Benassi Julia Myriam de Almeida pereira Edson Kiyoshi Okada curso de Engenharia de pesca Universidade Estadual Paulista(Unesp)RegistroBrazil programa de pos Graduacao em Diversidade Bilogica e Conservacao Universidade Federal de Sao Carlos(UFSCar)SorocabaBrazil programa de pos Graduacao em sustentabilidade em Ecossistemas Marinhos e Costeiros UNISANTASantosBrazil departamento de Biologia Nucleo de Pesquisas em LimnologiaIctiologia e AquiculturaUniversidade Estadual de MaringaParanaBrazil Divisao de Reservatorio(MARR.CD) Itaipu BinacionalFoz do IguaçuBrazil

Many experimental studies have contributed to the development of the theory of trophic chains in lacustrine habitats. They have revealed the important role played by fish, a subject that has been mostly ignored by limnological studies for the past few decades. Most of these studies were developed in Europe and in the United states. The general applicability of this theory has not yet been tested in subtropical and tropical habitats. In spite of controversies, the bottom-up: top-down trophic cascade hypotheses are the most adopted conceptual models. In this context, we examined if these hypotheses may be corroborated by data from the subtropical Itaipu Reservoir. A negative effect was verified between water transparency and total suspended solids. The detritivorous fish exerted a controlling effect on chlorophyll-a concentrations. Bottom-up effects were detected in four trophic levels, and top-down was detected in just one trophic level. The limnological variates influenced the chlorophyll-a concentration, which indicated that the lnTKN plus the effect of the quarter and the reservoir zone (and their interaction) were important.

关键词： Reservoir Trophic Cascade Top-Down Bottom-Up Limnology Biotic Community

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