检索结果-南通市图书馆

Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo

Protein & Cell 2011年第4期2卷 333-346页

作者： Sharyn Bayne He Li Margaret E.E.Jones Alex R.Pinto Michelle van Sinderen Ann Drummond Evan R.Simpson Jun-Ping Liu Department of Immunology Central Eastern Clinical SchoolMonash UniversityVictoria 3800Australia Prince Henry’s Institute of Medical Research Clayton VIC 3168Australia current address:Research Services M459The University of Western Australia35 Stirling HighwayCRAWLEY WA 6009Australia current address:Murdoch Children’s Research Institute Royal Children’s HospitalParkvilleVic 3052Australia

Estrogen is implicated as playing an important role in aging and tumorigenesis of estrogen responsive tissues;however the mechanisms underlying the mitogenic actions of estrogen are not fully *** we report that estrogen deficiency in mice caused by targeted disruption of the aromatase gene results in a signi-ficant inhibition of telomerase maintenance of telomeres in mouse ovaries in a tissue-specific *** inhibition entails a significant shortening of telomeres and compromised proliferation in the follicular granulosa cell compartment of *** expression analysis showed decreased levels of proto-oncogene c-Myc and the telomerase catalytic subunit,telomerase reverse transcriptase(TERT),in response to estrogen *** replacement therapy led to increases in TERT gene expression,telomerase activity,telomere length and ovarian tissue growth,thereby reinstating ovary development to normal in four *** data demonstrate for the first time that telomere maintenance is the primary mechanism mediating the mitogenic effect of estrogen on ovarian granulosa cell proliferation by upregulating the genes of c-Myc and TERT in *** deficiency or over-activity may cause ovarian tissue aging or tumorigenesis,respectively,through estrogen regulation of telomere remodeling.

关键词： estrogen telomerase reverse transcriptase(TERT) telomeres ovary mice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dairy sheep production research at the University of Wisconsin-Madison,USA-a review

引用

Journal of Animal science and Biotechnology 2014年第2期5卷 127-138页

作者： David L Thomas Yves M Berger Brett C McKusick Claire M Mikolayunas University of Wisconsin-Madison Department of Animal Sciences Spooner Agricultural Research Station current address:Merial Ltd Midwest Organic Services Association ViroquaWisconsinUSA

Commercial milking of sheep is a new agricultural industry in the United States starting approximately 30 yr ago. The industry is still small, but it is growing. The majority of the sheep milk is used in the production of specialty cheeses. The United States is the major importer of sheep milk cheeses with 50 to 60% of annual world exports coming to the United States during the past 20 yr. Therefore, there is considerable growth potential for the industry in the United States. The only dairy sheep research flock in North America is located at the Spooner Agricultural Research Station of the University of Wisconsin-Madison. The research program started in 1993 and has been multifaceted; dealing with several areas important to commercial dairy sheep farmers. The East Friesian and Lacaune dairy breeds were compared and introduced to the industry through the research program. Both dairy breeds produced significantly more milk than traditional meat-wool breeds found in the U.S., but the two breeds differed in their production traits. East Friesian-cross ewes produced more lambs and slightly more milk than Lacaune-cross ewes whereas Lacaune-cross ewes produced milk with a higher percentage of fat and protein than East Friesian-cross ewes. Lactation physiology studies have shown that ewes with active corpora lutea have increased milk yields, oxytocin release during milking is required to obtain normal fat percentages in the milk, large udder cisterns of dairy ewes can allow for increased milking intervals, and short daylengths during late pregnancy results in increased milk yield. In the nutrition area, legume-grass pastures and forages with a higher percentage of legume will result in increased milk production. Grazing ewes respond to additional supplementation with increased milk yield, but it is important to match the supplement to the quality of the grazing. Ewes on high quality legume-grass pastures that are high in rumen degradable protein respond with increased milk

关键词： Dairy sheep East Friesian Grazing Lacaune Lactation physiology Nitrogen efficiency RDP RUP Supplementation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Runaway electrons during subnanosecond breakdowns in high-pressure gases

引用

High Voltage 2016年第4期1卷 181-191页

作者： Victor F.Tarasenko Mikhail I.Lomaev Dmitry V.Beloplotov Dmitry A.Sorokin Institute of High current Electronics Siberian Branch Russian Academy of Science2/3 Akademicheskii Ave.Tomsk 634055Russia

The parameters of runaway electrons produced in nanosecond high-voltage discharges in different gases(air,nitrogen,sulphur hexafluoride,krypton,argon,methane,neon,hydrogen,helium)at atmospheric and higher pressure were *** optical analysis was also performed to investigate the ionisation dynamics in diffuse discharges in nitrogen and nitrogen-containing *** breakdown of a point-to-plane gap by nanosecond(≃2 ns)high-voltage(≃200 kV)pulses of negative voltage polarity and gas pressure above 0.1 MPa,a supershort avalanche electron beam(SAEB)was detected by a collector behind the flat *** pressure>0.1 MPa of nitrogen and other gases it is shown that the maximum pressure for SAEB registration decreases with increasing the voltage pulse rise ***,to detect a SAEB at atmospheric and higher gas pressure,one should use voltage pulses with an amplitude of hundred kilovolts and rise time of∼1 ns and *** experimental research in the dynamics of optical radiation from the discharge plasma shows that the breakdown in which runaway electrons are produced develops as an ionisation wave.

关键词： wave. gases fluoride

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surface alloying of Al films/Ti substrate based on high-current pulsed electron beams irradiation

引用

Rare Metals 2014年第2期33卷 155-160页

作者： Xian-Xiu Mei Jian-Qiang Fu Xiao-Na Li V.P.Rotshtein N.N.Koval Teng-Cai Ma Key Laboratory of Materials Modification by Laser Ion and Electron Beams Ministry of Education Dalian University of Technology Institute of High current Electronics Siberian Branch Russian Academy of Sciences

Ti–Al surface alloy was fabricated using a cyclic pulsed liquid-phase mixing of predeposited 100 nm Al film with a-Ti substrate by low-energy high-current electron beam. Electron probe micro-analysis（EPMA）,grazing incidence X-ray diffraction analysis（GIXRD）,transmission electron microscopy（TEM）, and nanoindentation were used to investigate the characterization of Ti–Al surface alloy. The experimental results show that the thickness of alloy layer is ＊3 lm, and the content of Al in the ＊1 lm thickness surface layer is ＊60 at%. The tetragonal TiAl and TiAl2intermetallics were synthesized at the top surface, which have nanocrystalline *** main phase formed in the ＊2.5 lm thick surface is TiAl, and there are few TiAl2and Ti3Al phase for the *** is enhanced in the alloyed layer. The nanohardness of Ti–Al surface alloy increased significantly compared with a-Ti substrate due to the nanostructure and enhanced dislocation. Since the e-beam remelted repeatedly, the Ti–Al surface alloy mixed sufficiently with Ti substrate. Moreover, there is no obvious boundary between the alloyed layer and substrate.

关键词： Ti–Al surface alloy layer High-current pulse electron beam irradiation Microstructural characterization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Monolithic GaAs/Si V-groove depletion-type optical phase shifters integrated in a 300 mm Si photonics platform

引用

Photonics Research 2022年第6期10卷 1509-1516页

作者： YOUNGHYUN KIM DIDIT YUDISTIRA BERNARDETTE KUNERT MARINA BARYSHNIKOVA REYNALD ALCOTTE CENK IBRAHIM OZDEMIR SANGHYEON KIM SEBASTIEN LARDENOIS PETER VERHEYEN JORIS VAN CAMPENHOUT MARIANNA PANTOUVAKI IMEC Heverlee B-3001Belgium current address:Department of Photonics and Nanoelectronics BK21 FOUR ERICA-ACE CenterHanyang UniversityAnsan 15588Republic of Korea current address:School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

We demonstrate monolithically integrated n-GaAs/p-Si depletion-type optical phase shifters fabricated on a 300 mm wafer-scale Si photonics *** measured the phase shifter performance using Mach–Zehnder modulators with the GaAs/Si optical phase shifters in both arms.A modulation efficiency of V_(π)L as low as 0.3 V·cm has been achieved,which is much lower compared to a carrier-depletion type Si optical phase shifter with pn *** propagation loss is relatively high at.5 d B∕mm,the modulator length can be reduced by the factor of.2 for the same optical modulation amplitude of a Si reference Mach–Zehnder modulator,owing to the high modulation efficiency of the shifters.

关键词： GaAs/Si modulator optical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stochastic Augmented-Based Dual-Teaching for Semi-Supervised Medical Image Segmentation

引用

Computers, Materials & Continua 2025年第1期82卷 543-560页

作者： Hengyang Liu Yang Yuan Pengcheng Ren Chengyun Song Fen Luo School of Computer science and Engineering Chongqing University of TechnologyChongqing400054China College of Artificial Intelligence Chongqing Technology and Business UniversityChongqing400067China

Existing semi-supervisedmedical image segmentation algorithms use copy-paste data augmentation to correct the labeled-unlabeled data distribution ***,current copy-paste methods have three limitations:(1)training the model solely with copy-paste mixed pictures from labeled and unlabeled input loses a lot of labeled information;(2)low-quality pseudo-labels can cause confirmation bias in pseudo-supervised learning on unlabeled data;(3)the segmentation performance in low-contrast and local regions is less than *** design a Stochastic Augmentation-Based Dual-Teaching Auxiliary Training Strategy(SADT),which enhances feature diversity and learns high-quality features to overcome these *** be more precise,SADT trains the Student Network by using pseudo-label-based training from Teacher Network 1 and supervised learning with labeled data,which prevents the loss of rare labeled *** introduce a bi-directional copy-pastemask with progressive high-entropy filtering to reduce data distribution disparities and mitigate confirmation bias in *** the mixed images,Deep-Shallow Spatial Contrastive Learning(DSSCL)is proposed in the feature spaces of Teacher Network 2 and the Student Network to improve the segmentation capabilities in low-contrast and local *** this procedure,the features retrieved by the Student Network are subjected to a random feature perturbation *** two openly available datasets,extensive trials show that our proposed SADT performs much better than the state-ofthe-art semi-supervised medical segmentation *** only 10%of the labeled data for training,SADT was able to acquire a Dice score of 90.10%on the ACDC(Automatic Cardiac Diagnosis Challenge)dataset.

关键词： Semi-supervised medical image segmentation contrastive learning stochastic augmented

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CD4＋VEGFR1HIGH T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice

引用

Cellular & Molecular Immunology 2015年第5期12卷 592-603页

作者： Jin-Young Shin Department of Microbiology and Immunology Seoul National University College of Medicine Seoul South Korea Department of Biomedical sciences Seoul National University College of Medicine Seoul South Korea Xenotransplantation Research Center Seoul National University College of Medicine Seoul South Korea Cancer Research Institute Seoul National University College of Medicine Seoul South Korea J.Y. Shin's current address is Biopharmaceutical Quality Management Division Ministry of Food and Drug Safety 187 Osongsaengmyeong2-ro Osong-eup Heungduk-gu Cheungju-si Chungbuk 363-700 South Korea J.H. Lim's current address is Department of Clinical Pathobiochemistry Faculty of Medicine Technische UniversitSt Dresden Dresden 01307 Germany Y.H. Kim's current address is Department of Microbiology Kyungpook National University School of Medicine 680 Gukchaebosang-ro Jung-gu Daegu 700-842 South Korea H.S. Cho's current address is Department of Pathology University of Massachusetts Medical School MA 01655 USA S.H. Hong's current address is Division of Immunology and Rheumatology Emory University School of MedicineGA 30322 USA

Regulatory T cells （Tregs） are a specialized subpopulation of T cells that control the immune response and thereby maintain immune system homeostasis and tolerance to self-antigens. Many subsets of CD4＋ Tregs have been identified, including Foxp3~, Trl, Th3, and Foxp3neg iT（R）35 cells. In this study, we identified a new subset of CD4＋VEGFR1high Tregs that have immunosuppressive capacity. CD4＋VEGFRlhigh T cells, which constitute approximately 1.0% of CD4＋ T cells, are hyporesponsive to T-cell antigen receptor stimulation. Surface marker and FoxP3 expression analysis revealed that CD4＋VEGFR1high T cells are distinct from known Tregs. CD4＋VEGFR1high T cells suppressed the proliferation of CD4＋CD25- T cell as efficiently as CD4＋CD25high natural Tregs in a contact-independent manner. Furthermore, adoptive transfer of CD4＋VEGFR1＋ T cells from wild type to RAG-2-deficient C57BL/6 mice inhibited effector T-cell-mediated inflammatory bowel disease. Thus, we report CD4＋ VEGFR1high T cells as a novel subset of Tregs that regulate the inflammatory response in the intestinal tract.

关键词： inflammatory bowel disease regulatory T cells suppression vascular endothelial growth factor receptor 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in therapies using mesenchymal stem cells and their exosomes for treatment of peripheral nerve injury:state of the art and future perspectives

引用

Neural Regeneration Research 2025年第11期20卷 3151-3171页

作者： Fatima Aldali Chunchu Deng Mingbo Nie Hong Chen Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

“Peripheral nerve injury”refers to damage or trauma affecting nerves outside the brain and spinal *** nerve injury results in movements or sensation impairments,and represents a serious public health *** severed peripheral nerves have been effectively joined and various therapies have been offered,recovery of sensory or motor functions remains limited,and efficacious therapies for complete repair of a nerve injury remain *** emerging field of mesenchymal stem cells and their exosome-based therapies hold promise for enhancing nerve regeneration and *** stem cells,as large living cells responsive to the environment,secrete various factors and *** latter are nano-sized extracellular vesicles containing bioactive molecules such as proteins,microRNA,and messenger RNA derived from parent mesenchymal stem *** have pivotal roles in cell-to-cell communication and nervous tissue function,offering solutions to changes associated with cell-based *** ongoing investigations,mesenchymal stem cells and mesenchymal stem cell-derived exosome-based therapies are in the exploratory stage.A comprehensive review of the latest preclinical experiments and clinical trials is essential for deep understanding of therapeutic strategies and for facilitating clinical *** review initially explores current investigations of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in peripheral nerve injury,exploring the underlying ***,it provides an overview of the current status of mesenchymal stem cell and exosomebased therapies in clinical trials,followed by a comparative analysis of therapies utilizing mesenchymal stem cells and ***,the review addresses the limitations and challenges associated with use of mesenchymal stem cell-derived exosomes,offering potential solutions and guiding future directions.

关键词： clinical trials exosome extracellular vesicles mesenchymal stem cells nerve regeneration peripheral nerve injury pre-clinical experiments

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

引用

Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang Yan Li Libo Chen Handong Jiao Zhijing Yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Semiconductor doping

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Non-linear Radical Additions-Coupling Polymerization of Monovinyl Monomers towards Polymer Networks: Theory, Tunability and Heritable Architecture

引用

Chinese Journal of Polymer science 2022年第12期40卷 1623-1630,I0008页

作者： Li-Mei Ren Cheng-Lin Li Qi Wang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science&Engineering Zhejiang UniversityHangzhou 310027China current address:Zhejiang University-University of Edinburgh Institute Zhejiang University School of Medicineand Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310027China

Exploring new polymerization strategy for current available monomers is a big challenge in polymer science. Here we re-investigate radical polymerization of monovinyl monomer(MVM) initiated by uniform branched polyfunctional initiator(PFI), which is termed non-linear radical additions-coupling polymerization(NLRAs CP). In NLRAs CP, both addition and coupling reactions of radical contribute to the construction of the polymer chains, which leads to continuous growth of branch topology. Theoretical analysis of NLRAs CP predicts that the gelation is determined by the functionality of PFI(a), the extent of initiation of the PFI(q) and the termination factor of radical(φ). NLRAs CPs of styrene and methyl methacrylate promoted by Cu(0)/MeTREN or Mn_(2)(CO)_(10)/visible light were conducted. After the cleavage of incorporated PFI fragment or junctions in the network, the network was transformed to linear chains having almost the same structure as segmental chains in the precursor network. This allows the reverse deducing the network structure from its cleaved products. It has been proven that NLRAs CP includes stepwise initiation of PFI, chain-growth of segmental chains and successive endlinking of macroradicals derived from PFI. The three parameters related to the gelation process, a, q and φ, were adjusted via binary PFI, the feed ratio of [Mn_(2)(CO)_(10)]/[PFI] and addition of non-homopolymerizable comonomer respectively. The minimum values of a and q, and the minimum amount of comonomer required for gelation were determined,which can be applied to estimate φ of various macroradicals. NLRAs CP opens a general and facile strategy for synthesis of a variety of polymer networks with heritable architecture by one-pot polymerization of various MVMs.

关键词： Non-linear radical additions-coupling polymerization Monovinyl monomer Polyfunctional initiator Polymer network Theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：