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Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

Oncology Research 2025年第1期33卷 171-184页

作者： GENGYUN SUN YIPING ZHENG JIANFENG CAI JIE GAO LIE DONG XIANGBIN ZHANG YINGHUI HUANG department of Respiratory and critical care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei230022China department of Respiratory and critical care Medicine Nanping First Hospital Affiliated to Fujian Medical UniversityNanping353006China

Background:Long noncoding RNA,LINC01106 exhibits high expression in lung adenocarcinoma(LUAD)tumor tissues,but its functional role and regulatory mechanism in LUAD cells remain ***:LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was *** cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor *** downstream transcription factors and molecular mechanism were determined using the Human transcription factor database(TFDB)database and Gene Expression Profiling Interactive Analysis(GEPIA)***,the impact of linc01106 on autophagy was analyzed by determining the expression of autophagy-related genes(ATGs)in LUAD ***:Our results showed that LINC01106 exhibited upregulation in both LUAD tissues and cell *** silencing of LINC01106 demonstrated a suppressive effect on tumorigenesis in a xenograft mouse model of ***,LINC01106 was found to recruit TATA-binding protein-associated factor 15(TAF15),an RNA-binding protein,thereby enhancing the mRNA stability of TEA domain transcription factor 4(TEAD4).In turn,TEAD4 served as a transcription factor that bound to the LINC01106 promoter and regulated its *** assays indicated that LINC01106 promoted autophagy in LUAD cells by upregulating the expression of autophagy-related genes(ATGs).The silencing of LINC01106 in LUAD cells inhibited autophagy,and cell proliferation,and promoted apoptosis,which all were effectively reversed by ATG5 ***:Overall,LINC01106,transcriptionally activated by TEAD4,interacts with TAF15 to promote the stability of TEAD4 and upregulates the expression of ATGs,promoting malignancy of LUAD cells.

关键词： LINC01106 TAF15 TEAD4 ATG5 Lung adenocarcinoma(LUAD) Non-small cell lung cancer(NSCLC)

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CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGHUA SONG HUA LIU department of Respiratory and critical care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China department of Emergency The People’s Hospital of RugaoNantong226500China department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

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NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS

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Chinese Chemical Letters 2025年第2期36卷 337-343页

作者： Xiaoshuai Wu Bailei Wang Yichen Li Xiaoxuan Guan Mingjing Yin Wenquan Lv Yin Chen Fei Lu Tao Qin Huyang Gao Weiqian Jin Yifu Huang Cuiping Li Ming Gao Junyu Lu Intensive care Unit The Second Affiliated Hospital of Guangxi Medical University department of critical care Medicine The Ninth Affiliated Hospital of Guangxi Medical University Life Sciences Institute Guangxi Medical University department of Emergency The First Affiliated Hospital of Guangxi Medical University College & Hospital of Stomatology Guangxi Medical University Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction Guangxi Medical University

Acute lung injury(ALI) was characterized by excessive reactive oxygen species(ROS) levels and inflammatory response in the lung. Scavenging ROS could inhibit the excessive inflammatory response, further treating ALI. Herein, we designed a novel nanozyme(P@Co) comprised of polydopamine(PDA) nanoparticles(NPs) loading with ultra-small Co, combining with near infrared(NIR) irradiation, which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI. For lipopolysaccharide(LPS) induced macrophages, P@Co + NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels, decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α) as well as inducing macrophage M2 directional polarization. Significantly, it displayed the outstanding activities of lowering acute lung inflammation, relieving diffuse alveolar damage, and up-regulating heat shock protein 70(HSP70) expression, resulting in synergistic enhanced ALI therapy effect. It offers a novel strategy for the clinical treatment of ROS related diseases.

关键词： Acute lung injury M2 directional polarization Nanozyme NIR driven ROS scavenging

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Chinese clinical practice consensus for device-supported treatment in adults with post-cardiac arrest syndrome(2024 Edition)

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World Journal of Emergency Medicine 2025年第1期16卷 3-9页

作者： Chuanbao Li Shengchuan Cao Yue Zheng Mengzhi Zong Haitao Zhang Xuezhong Yu Feng Xu Yuguo Chen the Chinese Clinical Practice Consensus for Device-supported Treatment in Adults with Post-cardiac Arrest Syndrome Work group department of Emergency Medicine Chest Pain CenterShandong Provincial Clinical Research Center for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinan 250012China department of critical care Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China State Key Laboratory of Complex Severe and Rare Diseases Emergency DepartmentPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China 不详

During cardiac arrest (CA),severe ischemia and hypoxia occur in tissues and organs of the entire body,inflammatory cytokines are released,and ischemiareperfusion injury occurs after the return of spontaneous circulation (ROSC),leading to multiple organ dysfunction in the body;this condition is called post-CA syndrome(PCAS).^([1])According to the BASeline Investigation of Out-of-Hospital Cardiac Arrest (BASIC-OHCA) study,the crude incidence of emergency medical service (EMS)-assessed OHCA was 95.7 per 100,000 individuals,and only1.2%of those individuals survived to hospital discharge or30 d after being resuscitated by the EMS in China.

关键词： cardiac organs return

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Novel flangeless video laryngoscope for limited mouth opening

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World Journal of critical care Medicine 2025年第1期14卷 118-121页

作者： Mohd Mustahsin Harshita Singh Division of critical care Medicine Department of Anaesthesiology and Critical CareEra UniversityLucknow 226003Uttar PradeshIndia department of Anaesthesiology Era UniversityLucknow 226003Uttar PradeshIndia

Airway management plays a crucial role in providing adequate oxygenation and ventilation to patients during various medical procedures and *** patients have a limited mouth opening due to factors such as trauma,inflammation,or anatomical abnormalities airway management becomes challenging.A commonly utilized method to overcome this challenge is the use of video laryngoscopy(VL),which employs a specialized device equipped with a camera and a light source to allow a clear view of the larynx and vocal *** overcomes the limitations of direct laryngoscopy in patients with limited mouth opening,enabling better visualization and successful *** types of VL blades are *** devised a novel flangeless video laryngoscope for use in patients with a limited mouth opening and then tested it on a manikin.

关键词： Video laryngoscope Difficult intubation Intubation Airway management Laryngoscopy

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A smart finger patch with coupled magnetoelastic and resistive bending sensors

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Journal of Semiconductors 2025年第1期46卷 194-203页

作者： Ziyi Dai Mingrui Wang Yu Wang Zechuan Yu Yan Li Weidong Qin Kai Qian School of Integrated Circuits Shandong UniversityJinan 250100China department of Mechanical Engineering University of AucklandAuckland 1010New Zealand department of Urology Qilu Hospital of Shandong UniversityJinan 250100China Shenzhen Research Institute of Shandong University Shenzhen 518000China department of critical care Medicine Qilu hospital of Shandong universityJinan 250100China

In the era of Metaverse and virtual reality(VR)/augmented reality(AR),capturing finger motion and force interactions is crucial for immersive human-machine *** study introduces a flexible electronic skin for the index finger,addressing coupled perception of both state and process in dynamic tactile *** device integrates resistive and giant magnetoelastic sensors,enabling detection of surface pressure and finger joint *** e-skin identifies three phases of finger action:bending state,dynamic normal force and tangential force(sweeping).The system comprises resistive carbon nanotubes(CNT)/polydimethylsiloxane(PDMS)films for bending sensing and magnetoelastic sensors(NdFeB particles,EcoFlex,and flexible coils)for pressure *** inward bending resistive sensor,based on self-assembled microstructures,exhibits directional specificity with a response time under 120 ms and bending sensitivity from 0°to 120°.The magnetoelastic sensors demonstrate specific responses to frequency and deformation magnitude,as well as sensitivity to surface roughness during sliding and material *** system’s capability is demonstrated through tactile-based bread type and condition recognition,achieving 92%*** intelligent patch shows broad potential in enhancing interactions across various fields,from VR/AR interfaces and medical diagnostics to smart manufacturing and industrial automation.

关键词： human machine interface flexible sensor wearable sensor giant magnetoelastic effect inward bending sensor

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Improving gastrointestinal scoring systems for predicting short-term mortality in critically ill patients

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World Journal of Gastroenterology 2025年第5期31卷 137-139页

作者： Shane Moore Noel E Donlon department of Anaesthesia and critical care University Hospital LimerickLimerick V94MunsterIreland department of Upper Gastrointestinal Surgery St James HospitalDublin D09LeinsterIreland

Shen et al’s retrospective study aims to compare the utility of two separate scoring systems for predicting mortality attributable to gastrointestinal(GI)injury in critically ill patients[the GI Dysfunction Score(GIDS)and the Acute Gastroin-testinal Injury(AGI)grade].The authors note that this study is the first proposal that suggests an equivalence between the ability of both scores to predict mor-tality at 28 days from intensive care unit(ICU)*** et al retrospec-tively analysed an ICU cohort of patients utilising two physicians administering both the AGI grade and GIDS score,using electronic healthcare records and ICU *** these physicians disagreed about the scores,the final decision as to the scores was made by an associate chief physician,or chief *** note that the primary reason for the development of GIDS was to create a clear score for GI dysfunction,with minimal subjectivity or inter-operator *** subjectivity inherent to the older AGI grading system is what ultimately led to the development of GIDS in *** ensuring consensus between physicians administering the AGI,Shen et al have controlled for one of this grading systems biggest *** have concerns,however,that this does not represent the real-world challenges associated with applying the AGI compared to the newer GIDS,and wonder if this arbitration process had not been instituted,would the two scoring systems remain equivalent in terms of predicted mortality?

关键词： Gastrointestinal injury critical care Patient mortality prediction Gastrointe-stinal Dysfunction Score Acute Gastrointestinal Injury grade Intensive care unit scoring systems

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.Thomas M.Brandon Westover Can Zhang department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Early prediction cardiac arrest in intensive care units:the value of laboratory indicator trends

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World Journal of Emergency Medicine 2025年第1期16卷 67-70页

作者： Wentao Sang Jiaxin Ma Xuan Zhang Shuo Wu Chang Pan Jiaqi Zheng Wen Zheng Qiuhuan Yuan Jian Zhang Jingjing Ma Feng Xu department of Emergency Medicine Qilu HospitalShandong UniversityJinan 250012China Chest Pain Center Qilu HospitalShandong UniversityJinan 250012China Shandong Provincial Clinical Research Center for Emergency and critical care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Emergency and critical care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu HospitalShandong UniversityJinan 250012China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical Sciencesthe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu HospitalShandong UniversityJinan 250012China

The incidence of in-hospital cardiac arrest (IHCA) has increased over the past decade,with more than half occurring in intensive care units (ICUs).^([1])ICU cardiac arrest (ICU-CA)presents unique challenges,with worse outcomes than those in monitored wards,highlighting the need for early detection and intervention.^([2])Up to 80%of patients exhibit signs of deterioration hours before IHCA.^([3])Although early warning scores based on vital signs are useful,their eff ectiveness in ICUs is limited due to abnormal physiological parameters.^([4])Laboratory markers,such as sodium,potassium,and lactate,are predictive of poor outcomes,^([5])but static measurements may not capture the patient’s *** in laboratory indicators,such as variability and extremes,may offer better predictive value.^([6])This study aimed to evaluate ICU-CA predictive factors,with a focus on vital signs and trends of laboratory indicators.

关键词： prediction signs arrest

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Obesity paradox in patients with community-acquired pneumonia:Have you fully considered the confounding factors?

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World Journal of Clinical Cases 2025年第9期13卷 53-55页

作者： Jin-Ke Sun Hui Tian department of Pulmonary and critical care Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000Shandong ProvinceChina department of critical care Medicine Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

There exists a notion that there is an obesity paradox in the prognosis of community-acquired *** other words,obese individuals with communityacquired pneumonia have a better *** study by Wang et al supports this claim,but we believe that the obesity paradox should not be proposed hastily as it is influenced by numerous subjective and objective confounding factors.

关键词： Community-acquired pneumonia Mortality Body mass index Overweight Obesity paradox

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