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Impact of microbial communities from tropical soils on the mobilization of trace metals during dissolution of cinnabar ore

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Journal of Environmental Sciences 2017年第6期29卷 122-130页

作者： Clarisse Balland-Bolou-Bi Benjamin Turc Vanessa Alphonse Noureddine Bousserrhine UniversitéParis-Est crùteil Val de Marne institute of Ecology and Enuironmental Sciences of Paris(UMR 7618)61 auenue du Général De Gaulle94010 Créteil cedexFrance

Biodissolution experiments on cinnabar ore （mercury sulphide and other sulphide minerals, such as pyrite） were performed with microorganisms extracted directly from soil. These experiments were carried out in closed systems under aerobic and anaerobic conditions with 2 different soils sampled in French Guyana. The two main objectives of this study were （1） to quantify the ability of microorganisms to mobilize metals （Fe, A1, Hg） during the dissolution of cinnabar ore, and （2） to identify the links between the type and chemical properties of soils, environmental parameters such as season and the strategies developed by indigenous microorganisms extracted from tropical natural soils to mobilize metals, Results indicate that microbial communities extracted directly from various soils are able to （1） survive in the presence of cinnabar ore, as indicated by consumption of carbon sources and, （2） leach Hg from cinnabar in oxic and anoxic dissolution experiments via the acidification of the medium and the production of low molecular mass organic acids （LMMOAs）. The dissolution rate of cinnabar in aerobic conditions with microbial communities ranged from 4.8 x 10-4 to 2.6 x 10-3 μmol/m2/day and was independent of the metabolites released by the microorganisms. In addition, these results suggest an indirect action by the microorganisms in the cinnabar dissolution. Additionally, because iron is a key element in the dynamics of Hg, microbes were stimulated by the presence of this metal, and microbes released LMMOAs that leached iron from iron-bearing minerals, such as pyrite and oxy-hydroxide of iron, in the mixed cinnabar ore.

关键词： Low molecular mass organic acidsCinnabar oreMicrobial communitiesTropical soils

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Semiology:A Comparative Science of Institutions

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Language and Semiotic Studies 2022年第1期8卷 6-15页

作者： Rossana de Angelis UniversitéParis-Est créteil France

The Saussurian notion of semiology is closely linked to that of *** fact,in Saussure’s words,“systems of signs” are “social institutions”.Furthermore,language is conceived as a “special system” in relation to others “in the set of semiological facts”.Among different semiological systems,writing also occupies a special *** there is a real difference between language and writing,we could look for it in the power of externalization,which confers to writing a sort of exemplarity among the other *** we will see in this article,writing reveals the process of institutionalization itself,as well as the rational sociality of reasoning institutions and the irrational sociality of unreasoning institutions as ***,which is the discipline studying these phenomena and their differences,can be considered as a comparative science of institutions.

关键词： semiology language writing institution signs systems

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Influence of random uncertainties of anisotropic fibrous model parameters on arterial pressure estimation

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Applied Mathematics and Mechanics(English Edition) 2013年第5期34卷 529-540页

作者： A.EDDHAHAK-OUNI I.MASSON F.MOHAND-KACI M.ZIDI Arts et Mtiers ParisTech(ENSAM-ESTP/IRC) Institut de Recherche en ConstructibilitUniversit Paris-Est Crteil Centre de Recherches Chirurgicales Facult de MdecineUniversit Paris-Est Crteil

This paper deals with a stochastic approach based on the principle of the maximum entropy to investigate the effect of the parameter random uncertainties on the arterial pressure. Motivated by a hyperelastic, anisotropic, and incompressible constitutive law with fiber families, the uncertain parameters describing the mechanical behavior are considered. Based on the available information, the probability density functions are attributed to every random variable to describe the dispersion of the model parameters. Numerous realizations are carried out, and the corresponding arterial pressure results are compared with the human non-invasive clinical data recorded over a mean cardiac cycle. Furthermore, the Monte Carlo simulations are performed, the convergence of the probabilistic model is proven. The different realizations are useful to define a reliable confidence region, in which the probability to have a realization is equM to 95%. It is shown through the obtained results that the error in the estimation of the arterial pressure can reach 35% when the estimation of the model parameters is subjected to an uncertainty ratio of 5%. Finally, a sensitivity analysis is performed to identify the constitutive law relevant parameters for better understanding and characterization of the arterial wall mechanical behaviors.

关键词： arterial pressure non-invasive clinical data hyperelasticity anisotropy random confidence region

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Dual angiogenesis and PD-1 blockade in hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 350-352页

作者： Julien Calderaro Département de Pathologie Centre Hospitalier Universitaire Henri MondorAssistance Publique Hôpitaux de ParisCréteilFrance Inserm U955 Team 18UniversitéParis-Est CréteilCréteilFrance

Hepatocellular carcinoma(HCC)is the fourth leading cause of cancer related-death worldwide and its incidence is rising in most western countries(1).

关键词： death carcinoma hepatocellular

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Longitudinal analysis of quantitative biomarkers using projection-resolved OCT angiography in retinal vein occlusion

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Annals of Eye Science 2021年第2期6卷 19-31页

作者： Alexandra Miere Donato Colantuono Camille Jung Agnès Glacet-Bernard Severine Becuwe Eric Petit Eric Souied Department of Ophthalmology Centre Hospitalier Intercommunal de CréteilUniversitéParis EstCréteilFrance Laboratory of Images Signals and Intelligent Systems Laboratory(LISSI/EA 3956)University Paris-EstCréteilFrance Clinical Research Center GRC Maculaand Biological Ressources CenterCentre Hospitalier Intercommunal de CréteilCréteilFrance UNIACT NeurospinISVFJCEAGif-sur-YvetteFrance

Background:To evaluate a fully automated vascular density(VD),skeletal density(SD)and fractal dimension(FD)method for the longitudinal analysis of retinal vein occlusion(RVO)eyes using projection-resolved optical coherence tomography angiography(OCTA)images and to evaluate the association between these quantitative variables and the visual prognosis in RVO ***:Retrospective longitudinal observational case *** presenting with RVO to creteil University Eye Clinic between October 2014 and December 2018 and healthy controls were retrospectively *** 1 consisted of central RVO(crVO)eyes,group 2 consisted of eyes with branch RVO(BRVO)and group 3 of healthy control *** acquisitions(AngioVue RTVue XR Avanti,Optovue,Inc.,Freemont,CA)were performed at baseline and last follow up ***,SD,and FD analysis were computed on OCTA superficial and deep vascular complex(SVC,DVC)images at baseline and final follow up using an automated *** regression was performed to find if and which variable(VD,SD,FD)was predictive for the visual ***:Forty-one eyes,of which 21 consecutive eyes of 20 RVO patients(13 crVO in group 1,8 BRVO in group 2),and 20 eyes of 20 healthy controls were *** the level of SVC,VD and FD were significantly lower in RVO eyes compared to controls(P<0.0001 and P=0.0008 respectively).Best-corrected visual acuity(BCVA)at last follow-up visit was associated with baseline VD(P=0.013),FD(P=0.016),and SD(P=0.01)at the level of the SVC,as well as with baseline FD at the DVC level(P=0.046).Conclusions:Baseline VD,SD,and FD are associated with the visual outcome in RVO *** parameters seem valuable biomarkers and may help improve the evaluation and management of RVO patients.

关键词： Retinal vein occlusion(RVO) vascular density(VD) optical coherence tomography angiography(OCTA) fractal dimension(FD) image analysis

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Acute lung injury in mechanically ventilated patients with epidermal necrolysis:an exposed-unexposed retrospective cohort study

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Burns & Trauma 2020年第1期8卷 30-33页

作者： S.Lalevée J.Catano S.Ingen-Housz-Oro M.Surenaud J.Tran Van Nhieu F.Schlemmer I.Bendib A.Mekontso-Dessap S.Hue N.de Prost Service de dermatologie AP-HPhoital Henri MondorCréteilFrance UniversitéParis Est créteil INSERM U955IMRBF-94010 CréteilFrance Service de Médecine Intensive Réanimation Hoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France EA7379 EpidermE UPECCréteilFrance Centre de référence des dermatoses bulleuses toxiques et toxidermies graves TOXIBUL CréteilFrance Service d’Anatomopathologie AP-HPhoital Henri MondorCréteilFrance Unitéde Pneumologie Service de Médecine Intensive RéanimationHoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France Groupe de Recherche Clinique CARMAS Facultéde Santéde CréteilUniversitéParis Est CréteilCréteil Cedex 94010France AP-HP Département d’Hématologie et d’Immunologie biologiquesGroupe hospitalouniversitaire Chenevier MondorAssistance Publique-Hoitaux de Paris F-94010 CréteilFrance

To the Editor,During the acute phase of epidermal necrolysis(EN,including Stevens-Johnson syndrome and toxic epidermal necrolysis),mucosal lesions involving the tracheo-bronchial tract have been reported[1,2]and approximately one in four EN patients develop acute respiratory failure and require endotracheal intubation and mechanical ventilation(MV)support[3].Asymptomatic respiratory sequelae may be detected on pulmonary function tests after the acute phase in as much as 50%of EN patients,possibly related to pulmonary lesions that occurred at the acute phase[4].

关键词： acute patients respiratory

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Interleukin-17 mediates liver progenitor cell transformation into cancer stem cells through downregulation of miR-122

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Cancer Biology & Medicine 2018年第S1期15卷 14-15页

作者： Imène Gasmi CamiliaMachou AurélieRodrigues Julien Calderaro Benoit Rousseau Arthur Brouillet Christophe Rodriguez Vanessa Demontant Guillaume Gricourt Alain Luciani Jean-Michel Pawlotsky Fouad Lafdil Université Paris-Est-créteil CréteilFrance INSERMU955 VirusesHepatology and CancersHopital Henri MondorCréteilFrance Institut Universitaire de France(IUF) ParisFrance

Objective:Cancer stem cells(CSCs)have been the focus of several studies because oftheir involvement in cancer initiation and *** were identified in 28%to 50%of hepatocellular carcinomas(HCCs).The origin of CSCs is still unclear,but it has been recently suggested that CSCs could originate from the transformation of liver progenitor cells(LPCs)during chronic liver inflammation.

关键词： Interleukin-17 mediates liver

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Immunopathogenesis of idiopathic nephrotic syndrome

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Cellular & Molecular Immunology 2022年第12期19卷 1429-1431页

作者： B.Savas F.Fofana S.Le Gouvello A.Pawlak D.Sahali M.Ollero UniversitéParis Est(UPEC) Facultéde SantéUMRS 955CréteilF-94010France AP-HP Groupe Henri-Mondor Albert-ChenevierService de NéphrologieCréteilF-94010France

Idiopathic nephrotic syndrome(INS)describes a group of rare glomerular diseases characterized by massive proteinuria and hypoalbuminemia in the absence of glomerular inflammatory lesions or immunoglobulin *** includes two main entities based on kidney biopsy findings:minimal-change nephrotic syndrome(MCNS)and focal segmental glomerulosclerosis(FSGS).The treatment of INS relies on steroids and/or immunosuppressive drugs(calcineurin inhibitors,cyclophosphamide,mycophenolate mofetil,and rituximab).

关键词： nephrotic drugs pathogenesis

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Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners

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Cellular & Molecular Immunology 2021年第9期18卷 2165-2176页

作者： Yeni Ait Ahmed Yaojie Fu Robim M.Rodrigues Yong He Yukun Guan Adrien Guillot Ruixue Ren Dechun Feng Juan Hidalgo Cynthia Ju Fouad Lafdil Bin Gao Laboratory of Liver Diseases National Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthBethesdaMDUSA UniversitéParis-Est-créteil CréteilFrance Universitat Autònoma de Barcelona BarcelonaSpain Department of Anesthesiology McGovern Medical SchoolUniversity of Texas Health Science Center at HoustonHoustonTXUSA INSERM U955 Institut Mondor de Recherche BiomédicaleCréteilFrance Institut Universitaire de France(IUF) ParisFrance

Kupffer cells(KCs),which are liver-resident macrophages,originate from the fetal yolk sac and represent one of the largest macrophage populations in the ***,the current data on the origin of the cells that restore macrophages during liver injury and regeneration remain ***,we address the question of whether liver macrophage restoration results from circulating monocyte infiltration or local KC proliferation in regenerating livers after partial hepatectomy(PHx)and uncover the underlying *** using several strains of genetically modified mice and performing immunohistochemical analyses,we demonstrated that local KC proliferation mainly contributed to the restoration of liver macrophages after *** KC proliferation was impaired in Il6-knockout(KO)mice and restored after the administration of IL-6 protein,whereas KC proliferation was not affected in Il4-KO or Csf2-KO *** source of IL-6 was identified using hepatocyte-and myeloid-specific Il6-KO mice and the results revealed that both hepatocytes and myeloid cells contribute to IL-6 production after ***,peak KC proliferation was also impaired in myeloid-specific Il6 receptor-KO mice after PHx,suggesting that IL-6 signaling directly promotes KC *** using several inhibitors to block the IL-6 signaling pathway revealed that sirtuin 1(SIRT1)contributed to IL-6-mediated KC proliferation in *** deletion of the Sirt1 gene in myeloid cells,including KCs,impaired KC proliferation after *** conclusion,our data suggest that KC repopulation after PHx is mainly driven by local KC proliferation,which is dependent on IL-6 and SIRT1 activation in KCs.

关键词： IL-6 Sirtuin 1 Liver regeneration Kupffer cells Myeloid cells

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Coverage rates for diphtheria,tetanus,poliomyelitis,and pertussis age-specific booster recommendations in France:2018 update of the real-world cohort analysis

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Infectious Medicine 2023年第1期2卷 51-56页

作者： Régis Verdier Clarisse Marchal Manon Belhassen Marie Le Pannerer Nicole Guiso Robert Cohen Sanofi LyonFrance PELyon(Pharmaco Epidemiology Lyon) LyonFrance Independent Expert ParisFrance UniversitéParis Est IMRB-GRC GEMINICréteilFrance Clinical Research Center(crC) Centre Hospitalier Intercommunal de CréteilCréteilFrance GPIP Pediatric Infectious Disease GroupFrance ACTIV Pediatric Clinical and Therapeutical Association of the Val de MarneSaint-Maur des FossésFrance UnitéCourt Séjour Petits NourrissonsService de NéonatologieCentre Hospitalier Intercommunal de CréteilCréteilFrance

The French National Immunization Program was updated in 2013 for vaccination against diphtheria,tetanus,per-tussis,and *** previous findings on the evolution of age-specific booster vaccination coverage rates(Vcrs)up to 2017 suggested suboptimal vaccination coverages due to the pre-2013 recommendation-residual vaccination *** the current analysis,we evaluated all age-specific booster Vcr and distribution of age at vaccination visits in *** this retrospective observational cohort study,the cumulative booster Vcrs were updated at all vaccination visits up to 2018 among the people who were eligible for a booster vaccination,using a 1/97th random sample of French national healthcare reimbursement *** cumulative booster Vcr for individuals from all age groups increased from 2017 to 2018,except for 85-years-old vaccination *** of the individuals from all age groups were vaccinated(boosted)with a vaccine containing the pertussis *** 2018,sharp peaks corresponding to the recommended ages for booster vaccination visits were observed for individuals aged 6,11 to 13,25,45,and 65 *** study reiterates suboptimal coverages in France and implies the need for booster vaccination throughout life for the protection of the population.

关键词： Booster vaccine DTaP-IPV France Pertussis National Immunisation Programme Vaccination coverage rate

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