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Transplantation of human hepatocytes into tolerized genetically immunocompetent rats

World Journal of Gastroenterology 2001年第3期7卷 324-330页

作者： EdwinC.Ouyang CatherineH.wu CherieWalton KittichaiPromrat georgey.wu department of medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterRm. AM-045263 Farmington AvenueFarmingtonCT 06030 correspondence to:george y.wu.m.d. Ph.D.Department of Medicine.Division of Gastroenterology-Hepatology.University of Connecticut I lealth CenterRm.AM-045.263 Farmington Avenue.FarmingtonC T 06030

AIm: To determine whether normal genetically immunocompetent rodent hosts could be manipulated to accept human hepatocyte transplants with long term survival without immunosuppression. mETHOdS: Tolerance towards human hepatocytes was established by injection of primary human hepatocytes or Huh7 human hepatoma cells into the peritoneal cavities of fetal rats. Corresponding cells were subsequently transplanted into newborn rats via intrasplenic injection within 24h after birth. RESULTS: mixed lymphocyte assays showed that spleen cells from non-tolerized rats were stimulated to proliferate when exposed to human hepatocytes, while cells from tolerized rats were not. Injections made between 15 d and 17 d of gestation produced optimal tolerization. Transplanted human hepatocytes in rat livers were visualized by immunohistochemical staining of human albumin. By dot blotting of genomic dNA in livers of tolerized rats 16 weeks after hepatocyte transplantation, it was found that approximately 2.5 X 10(5) human hepatocytes survived per rat liver. Human albumin mRNA was detected in rat livers by RT-PCR for 15 wk, and human albumin protein was also detectable in rat serum. CONCLUSION: Tolerization of an immuno-competent rat can permit transplantation, and survival of functional human hepatocytes.

关键词： Albumins Animals Cell Line, Transformed disease models, Animal Female Gene Expression Graft Survival Hepatitis Hepatoblastoma Hepatocytes Humans Immune Tolerance Immunocompetence Liver Liver Neoplasms Lymphocyte Culture Test, mixed microscopy, Confocal Pregnancy RNA, messenger Rats Rats, Sprague-dawley Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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An Intermediate-field Fast Radio Burst model and the Quasi-periodic Oscillation

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Research in Astronomy and Astrophysics 2023年第3期23卷 93-99页

作者： Jie-Shuang Wang Xinyu Li Zigao dai Xuefeng wu max-Planck-Institut für Kernphysik Saupfercheckweg 1D-69117 HeidelbergGermany Canadian Institute for Theoretical Astrophysics 60 St George StTorontoON M5R 2M8Canada Perimeter Institute for Theoretical Physics 31 Caroline Strect North.watcrlooOntarioN2L 2Y5Canada department of Astronomy University of Science and Technology of ChinaHefei20026China School of Astronomy and Space Science Nanjing UniversityNanjng 210023.China Purple mountain Observatory Chinese Academy of SciencesNanjing 210023China

Quasi-periodic oscillation(QPO)signals are discovered in some fast radio bursts(FRBs)such as FRB 20191221A,as well as in the X-ray burst associated with the galactic FRB from SGR 1935+*** revisit the intermediatefield FRB model where the radio waves are generated as fast-magnetosonic waves through magnetic reconnection near the light *** current sheet in the magnetar wind is compressed by a low frequency pulse emitted from the inner magnetosphere to trigger magnetic *** incorporating the wave dynamics of the magnetosphere,we demonstrate how the FRB frequency,the single pulse width,and luminosity are determined by the period,magnetic field,QPO frequency and quake energetics of the *** find that this model can naturally and self-consistently interpret the X-ray/radio event from SGR 1935+2154 and the QPO in *** can also explain the observed wide energy range of repeating FRBs in a narrow bandwidth.

关键词： periodic field narrow

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Prediction of energy resolution in the JUNO experiment

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Chinese Physics C 2025年第1期49卷 35-59页

作者： Angel Abusleme Thomas Adam Kai Adamowicz Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Joao Pedro Athayde marcondes de André didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi davide Basilico Eric Baussan marco Bellato marco Beretta Antonio Bergnoli daniel Bick Lukas Bieger Svetlana Biktemerova Thilo Birkenfeld Iwan Blake david Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai yanke Cai Zhiyan Cai Stéphane Callier Steven Calvez Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Vanessa Cerrone Jinfan Chang yun Chang Auttakit Chatrabhuti Chao Chen Guoming Chen Pingping Chen Shaomin Chen Xin Chen yiming Chen yixue Chen yu Chen Zelin Chen Zhangming Chen Zhiyuan Chen Zikang Chen Jie Cheng yaping Cheng yuChin Cheng Alexander Chepurnov Alexey Chetverikov davide Chiesa Pietro Chimenti yen-Ting Chin Po-Lin Chou Ziliang Chu Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux marta Colomer molla Selma Conforti di Lorenzo Alberto Coppi daniele Corti Simon Csakli Chenyang Cui Flavio dal Corso Olivia dalager Jaydeep datta Christophe de La Taille Zhi deng Ziyan deng Xiaoyu ding Xuefeng ding yayun ding Bayu dirgantara Carsten dittrich Sergey dmitrievsky Tadeas dohnal dmitry dolzhikov Georgy donchenko Jianmeng dong Evgeny doroshkevich Wei dou marcos dracos Frédéric druillole Ran du Shuxian du Katherine dugas Stefano dusini Hongyue duyang Jessica Eck Timo Enqvist Andrea Fabbri Ulrike Fahrendholz Lei Fan Jian Fang Wenxing Fang dmitry Fedoseev Li-Cheng Feng Qichun Feng Federico Ferraro Amélie Fournier Fritsch Fritsch Haonan Gan Feng Gao Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Nunzio Giudice maxim Gonchar Guanghua Gong Hui Gong yuri Gornushkin marco Grassi maxim Gromov Vasily Gromov minghao G yerevan Physics Institute YerevanArmenia Université Libre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil millennium Institute for SubAtomic Physics at the High-energy Frontier(SAPHIR) ANIDChile Pontificia Universidad Católica de Chile SantiagoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National

This paper presents an energy resolution study of the JUNO experiment,incorporating the latest knowledge acquired during the detector construction *** determination of neutrino mass ordering in JUNO requires an exceptional energy resolution better than 3% at 1 *** achieve this ambitious goal,significant efforts have been undertaken in the design and production of the key components of the JUNO *** factors affecting the detection of inverse beta decay signals have an impact on the energy resolution,extending beyond the statistical fluctuations of the detected number of photons,such as the properties of the liquid scintillator,performance of photomultiplier tubes,and the energy reconstruction *** account for these effects,a full JUNO simulation and reconstruction approach is *** enables the modeling of all relevant effects and the evaluation of associated inputs to accurately estimate the energy *** results of this study reveal an energy resolution of 2.95% at 1 ***,this study assesses the contribution of major effects to the overall energy resolution *** analysis serves as a reference for interpreting future measurements of energy resolution during JUNO data ***,it provides a guideline for comprehending the energy resolution characteristics of liquid scintillator-based detectors.

关键词： energy resolution liquid scintillator detector JUNO simulation reconstruction

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Families of dothideomycetes

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Fungal diversity 2013年第6期63卷 1-313页

作者： Kevin d.Hyde E.B.Gareth Jones Jian-Kui Liu Hiran Ariyawansa Eric Boehm Saranyaphat Boonmee Uwe Braun Putarak Chomnunti Pedro W.Crous dong-Qin dai Paul diederich Asha dissanayake mingkhuan doilom Francesco doveri Singang Hongsanan Ruvishika Jayawardena James d.Lawrey yan-mei Li yong-Xiang Liu Robert Lücking Jutamart monkai Lucia muggia matthew P.Nelsen Ka-Lai Pang Rungtiwa Phookamsak Indunil C.Senanayake Carol A.Shearer Satinee Suetrong Kazuaki Tanaka Kasun m.Thambugala Nalin N.Wijayawardene Saowanee Wikee Hai-Xia wu ying Zhang Begoña Aguirre-Hudson S.Aisyah Alias AndréAptroot Ali H.Bahkali Jose L.Bezerra d.Jayarama Bhat Erio Camporesi Ekachai Chukeatirote Cécile Gueidan david L.Hawksworth Kazuyuki Hirayama Sybren de Hoog Ji-Chuan Kang Kerry Knudsen Wen-Jing Li Xing-Hong Li Zou-yi Liu Ausana mapook Eric H.C.mcKenzie Andrew N.miller Peter E.mortimer Alan J.L.Phillips Huzefa A.Raja Christian Scheuer Felix Schumm Joanne E.Taylor Qing Tian Saowaluck Tibpromma dhanushka N.Wanasinghe yong Wang Jian-Chu Xu Supalak yacharoen Ji-ye yan min Zhang Key Laboratory for Plant Biodiversity and Biogeography of East Asia(KLPB) Kunming Institute of BotanyChinese Academy of ScienceKunming 650201Yunnan China World Agroforestry Centre East Asia NodeHeilongtanKunming 650201China Institute of Excellence in Fungal Research Chiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Institute Ocean Earth Sciences Kuala Lumpur 50603SelangorMalaysia department of Botany and microbiology King Saudi UniversityRiyadhSaudi Arabia 42 Longacre drive LivingstonNJ 07039USA Institut für Biologie Bereich Geobotanik und Botanischer GartenHerbariumMartin-Luther-UniversitätNeuwerk 2106099 Halle(Saale)Germany CBS-KNAW Fungal Biodiversity Centre Uppsalalaan 83584CT UtrechtThe Netherlands musée National d’histoire Naturelle 25 rue Munster2160 LuxembourgLuxembourg Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesBeijing 100097People’s Republic of China Via dei Funaioli 22 57126 LivornoItaly department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA International Fungal Research and development Centre Key Laboratory of Resource Insect Cultivation&Utilization State Forestry AdministrationKunming 650224People’s Republic of China The Research Institute of Resource Insects Chinese Academy of ForestryKunming 650224People’s Republic of China Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Science and Education Integrative Research(Botany)The Field Museum1400 South Lake Shore DriveChicagoIL 60605-2496USA Institute of Plant Sciences University of GrazHolteigasse 68010 GrazAustria department of Life Science University of TriesteVia L.Giorgieri 10TriesteItaly Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Institute ofmarine Biology and Center of Excellence for the Oceans Taiwan

dothideomycetes comprise a highly diverse range of fungi characterized mainly by asci with two wall layers(bitunicate asci)and often with fissitunicate *** species are saprobes,with many asexual states comprising important plant *** are also endophytes,epiphytes,fungicolous,lichenized,or lichenicolous *** occur in terrestrial,freshwater and marine habitats in almost every part of the *** accept 105 families in dothideomycetes with the new families Anteagloniaceae,Bambusicolaceae,Biatriosporaceae,Lichenoconiaceae,muyocopronaceae,Paranectriellaceae,Roussoellaceae,Salsugineaceae,Seynesiopeltidaceae and Thyridariaceae introduced in this *** family is provided with a description and notes,including asexual and asexual states,and if more than one genus is included,the type genus is also *** family is provided with at least one figure-plate,usually illustrating the type genus,a list of accepted genera,including asexual genera,and a key to these genera.A phylogenetic tree based on four gene combined analysis add support for 64 of the families and 22 orders,including the novel orders,dyfrolomycetales,Lichenoconiales,Lichenotheliales,monoblastiales,Natipusillales,Phaeotrichales and *** paper is expected to provide a working document on dothideomycetes which can be modified as new data comes to *** is hoped that by illustrating types we provide stimulation and interest so that more work is carried out in this remarkable group of fungi.

关键词： Acrospermales Asterinales Botryosphaeriales Capnodiales dothideales dyfrolomycetales Hysteriales Jahnulales Lichenoconiales Lichenotheliales microthyriales monoblastiales myriangiales mytilinidiales Natipusillales Patellariales Phaeotrichales Phylogeny Pleosporales Strigulales Taxonomy Trypetheliales Tubeufiales Type species Venturiales

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CEPC Technical design Report

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Radiation detection Technology and methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An daniele Paolo Anderle Stefan Antusch yasuo Arai Andrej Arbuzov Abdesslam Arhrib mustafa Ashry Sha Bai yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade yong Ban Tripamo Bandyopadhyay Shou-Shan Bao desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev michele Bertucci Xiao-Jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter michela Biglietti Shalva Bilanishvili deng Binglin denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert maarten Boonekamp marcello Borri Angelo Bosotti Vincent Boudry mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai wujun Cai yijian Cai yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti yimin Che yuzhi Che Bin Chen danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-yuan Chen Kai Chen mali Chen mingjun Chen mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen ye Chen ying Chen yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella d'Anzi Ling-yun dai Xinchen dai Xuwen dai Antonio de maria Nicola de Filippis Christophe de La Taille Francesca de mori Chiara de Sio Elisa del Core Shuangxue deng Wei-Tian deng Zhi deng Ziyan deng Bhupal dev Tang dewen Biagio di micco Ran ding Siqin dingl yadong ding Haiyi dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTd Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPm(AmU/IPhU&CNRS/INP) Marseille dalian minzu University DalianLiaoning dalian University of Technology Department of PhysicsDalian deutsches Elektronen-Synchrotron dESy Hamburg dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(dLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 mW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 mW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical design Report(TdR)follows the Preliminary Conceptual design Report(Pre-CdR,2015)and the Conceptual design Report(CdR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&d and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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