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Analysis of Pathway Activity in Primary Tumors and NCI60 Cell Lines Using Gene Expression Profiling Data

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Genomics, Proteomics & Bioinformatics 2007年第1期5卷 15-24页

作者： Xing-Dong Feng Shu-Guang Huang Jian-Yong Shou Bi-Rong Liao Jonathan M. Yingling Xiang Ye Xi Lin Lawrence M. Gelbert Eric W. Su Jude E. Onyia Shu-Yu Li Integrative Biology Lilly Research Laboratories Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 USA Global Discovery ＆ development Statistics Lilly Research Laboratories Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 USA Cancer Discovery research Lilly Research Laboratories Eli Lilly and Company Lilly Corporate Center Indianapolis IN 46285 USA

To determine cancer pathway activities in nine types of primary tumors and NCI60 cell lines, we applied an in silico approach by examining gene signatures reflective of consequent pathway activation using gene expression data. Supervised learning approaches predicted that the Ras pathway is active in -70% of lung adenocarcinomas but inactive in most squamous cell carcinomas, pulmonary carcinoids, and small cell lung carcinomas. In contrast, the TGF-β, TNF-α, Src, Myc, E2F3, and β-catenin pathways are inactive in lung adenocarcinomas. We predicted an active Ras, Myc, Src, and/or E2F3 pathway in significant percentages of breast cancer, colorectal carcinoma, and gliomas. Our results also suggest that Ras may be the most prevailing oncogenic pathway. Additionally, many NCI60 cell lines exhibited a gene signature indicative of an active Ras, Myc, and/or Src, but not E2F3, β-catenin, TNF-α, or TGF-β pathway. To our knowledge, this is the first comprehensive survey of cancer pathway activities in nine major tumor types and the most widely used NCI60 cell lines. The ＂gene expression pathway signatures＂ we have defined could facilitate the understanding of molecular mechanisms in cancer development and provide guidance to the selection of appropriate cell lines for cancer research and pharmaceutical compound screening.

关键词： cancer pathways gene expression profiling supervised learning classification

Genomic alterations and molecular subtypes of gastric cancers in Asians

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Chinese Journal of Cancer 2016年第8期35卷 403-409页

作者： Xiang S.Ye Chunping Yu Amit Aggarwal Christoph Reinhard Lilly(China) R&D Center Lilly research laboratories Lilly Corporate CenterEli Lilly and Company

Gastric cancer(GC) is a highly heterogenic disease,and it is the second leading cause of cancer death in the *** chemotherapies are not very effective for GC,which often presents as an advanced or metastatic disease at *** options are limited,and the prognosis for advanced GCs is *** landscape of genomic alterations in GCs has recently been characterized by several international cancer genome programs,including studies that focused exclusively on GCs in *** studies identified major recurrent driver mutations and provided new insights into the mutational heterogeneity and genetic profiles of *** analysis of gene expression data by the Asian Cancer research Group(ACRG) further uncovered four distinct molecular subtypes with well-defined clinical features and their intersections with actionable genetic alterations to which targeted therapeutic agents are either already available or under clinical *** this article,we review the ACRG GC *** also discuss the implications of the genetic and molecular findings from various GC genomic studies with respect to developing more precise diagnoses and treatment approaches for GCs.

关键词： Gastric cancer Cancer genome Molecular subtyping Heterogeneity Oncogenic drivers Targeted therapy

development of a physiologically relevant dripping analytical method using simulated nasal mucus for nasal spray formulation analysis

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Journal of Pharmaceutical Analysis 2016年第5期6卷 283-291页

作者： Tina Masiuk Parul Kadakia Zhenyu Wang Respiratory Product development Merck Research Laboratories Merck & Co.Inc.

Current methods for nasal spray formulations have been elementary evaluating the dripping characteristics of a formulation and have not assessed the behavior of the nasal formulation in the presence of varying types of mucus depending on the indication or diseased state. This research investigated the effects of nasal mucus on the dripping behavior of nasal formulations and focused on developing an improved in vitro analytical test method that is more physiologically relevant in characterizing nasal formulation dripping behavior. Method development was performed using simulated nasal mucus preparations for both healthy and diseased states as coatings for the dripping experiment representing a wide range of viscosity. Factors evaluated during development of this in vitro test method included amount of mucus, application of mucus, drying times, and compatibility of the mucus on a C18 Thin Layer Chromatography(TLC) substrate. The dripping behavior of nasal formulations containing a range of 1%Avicel to 3.5% Avicel was assessed by actuating the nasal spray on a perpendicular TLC plate coated with either healthy or diseased simulated nasal mucus. After actuation of the nasal spray, the dripping of the formulation on the coated TLC plate was measured after the plate was repositioned vertically. The method that was developed generated reproducible results on the dripping behavior of nasal formulations and provided critical information about the compatibility of the formulation with the nasal mucus for different diseased states, aiding in nasal spray formulation development and physical characterization of the nasal spray.

关键词： Nasal spray Nasal spray dripping method Nasal mucus Nasal formulation dripping

development of ^(153)Sm-bleomycin as a possible therapeutic complex

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Nuclear Science and Techniques 2010年第3期21卷 165-170页

作者： BAHRAMI-SAMANI Ali GHANNADI-MARAGHEH Mohammad JALILIAN Amir Reza YOUSEFNIA Hassan MORADKHANI Sedigheh BOLOURINOVIN Fatemeh Faculty of Nuclear Engineering and Physics Amir Kabir University Radiopharmaceutical research and development laboratories Nuclear Science and Technology Research InstituteTehranIran

Due to interesting therapeutic properties of ^(153)Sm and antineoplastic antibiotic,bleomycin(BLM), ^(153)Sm-bleomycin(^(153)Sm-BLM) was developed as a possible therapeutic compound using ^(153)SmCl_3 and *** ^(153)SmCl_3 was obtained by thermal neutron flux(5×10^(13)n·cm^(-2)·s^(-1))of an enriched ^(152)Sm_2O_3 sample,dissolved in acidic *** optimized conditions(room temperature,45 min,0.1 mg bleomycin for 740-3700 MBq ^(153)SmCl_3) a radiochemical purity over 98%was obtained shown by HPLC(Specific activity = 55 TBq/mM).The ^(153)SmCl_3 and ^(153)Sm-BLM were administered into wild-type rats up to 96 h followed by *** SPECT imaging of labeled compound in wild-type rats was performed and significant image pattern was observed for a radiolabeled bleomycin *** ^(153)Sm-BLM is a potential therapeutic compound and our experiments on this compound have shown satisfactory quality,and stability suitable for future therapeutic studies.

关键词：博莱霉素治疗性高效液相色谱法钐抗肿瘤抗生素放射化学纯度管理局 SPECT

Quantum counterfactuality with identical particles

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Communications in Theoretical Physics 2023年第6期75卷 59-65页

作者： Vinod N Rao Anindita Banerjee R Srikanth Theoretical Sciences Division Poornaprajna Institute of Scientific ResearchBidalurBengaluru—562164India Graduate Studies Manipal Academy of Higher EducationManipal—576104India Centre of development of Advanced Computing Corporate Research and DevelopmentPune—411008India

Quantum self-interference enables the counterfactual transmission of information,whereby the transmitted bits involve no particles traveling through the *** this work,we show how counterfactuality can be realized even when the self-interference is replaced by interference between identical ***,the facet of indistinguishability called forth here is associated with first-order coherence,and is different from the usual notion of indistinguishability associated with the(anti-)commutation relations of mode *** an experimental perspective,the simplest implementation of the proposed idea can be realized by slight modifications to existing protocols for differential-phase-shift quantum key distribution or interaction-free measurement.

关键词： quantum cryptography counterfactuality indistinguishability

research of Rolling Super Heavy H-Beam from ***

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Research of Rolling Super Heavy H-Beam from ***

边界元法及层状介质岩体在地表及岩层移动计算中的应用

第七届(2009)中国钢铁年会

作者： Yoshiaki Kusaba corporate research ＆ development laboratories Sumitorno MetalJapan

＜正＞Super Heavy H-beam with 1,000-1,200 mm web-height and 400 mm flange width is difficult to be produced by hot-rolling. The authors researched to develop the new rolling method for H 1000 - 1200×400 mm especially with thick flange from slabs:250 mm×1600 mm by using FEM simulation and model test rolling with special designed grooves of the breakdown mill and universal mills.

关键词： Super Heavy H-beam Groove-rolling Universal Mill-Rolling

来源： cnki会议评论

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煤炭学报 2004年第2期29卷 150-154页

作者：范之望 corporate Headquarters research and development DBMS Uhlandstraβe 12

引进了一种特殊的、易于计算操作的横观各向同性体———层状介质来描述岩体,并利用计算实例指出层状介质岩体的重要性和合理性.应用实例表明,对德国煤矿的深部开采,采用介质各向异性的强度为0 05～0 01较适宜.

关键词：边界元法层状介质岩体地表及岩层移动位移不连续法

Construction and Characterization of an Atmospheric Simulation Smog Chamber

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Advances in Atmospheric Sciences 2007年第2期24卷 250-258页

作者：武山吕子峰郝吉明赵喆李俊华 Hideto TAKEKAWA Hiroaki MINOURA Akio YASUDA Department of Environmental Science and Engineering Tsinghua University Toyota Central research and development laboratories Nagakute Aichi480-1192Japan

Currently, air pollution in Beijing has become a complex problem with two types of source pollutants： coal smoke and photochemical smog. Furthermore the maximum hourly mean concentration of O3 increases continuously, especially in the summer. In order to simulate the photochemical reaction, develop an air quality simulation model and further improve the air quality of Beijing, a precisely temperature-controlled, indoor, smog chamber facility was designed and constructed at Tsinghua University. Characterization experiments have been carried out to acquire the basic parameters of the smog chamber, such as the wall loss rates of NO2, NO, O3, C3H6 and particulate matter （PM）, the intensity of ultraviolet （UV） light in the chamber, the reactivity of the purified air and the reproducibility of the experimental results. The results indicate that the facility performs up to specifications, and can meet the demands required for simulating the photochemical reaction. The effect of high primary contaminated PM on the formation of ozone and secondary organic aerosol （SOA） is under investigation.

关键词： photochemical smog smog chamber construction characterization experiments SOA

Basic research on Phase Relation between Mold Flux Composition and Cuspidine

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Basic Research on Phase Relation between Mold Flux Compositi...