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male genitourinary schistosomiasis-related symptoms among long-term Western African migrants in spain: a prospective population-based screening study

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Roure sílvia Vallès Xavier pérez-Quílez Olga López-mu?oz israel chamorro Anna Abad Elena Valerio Lluís soldevila Laura Espa?a sergio Hegazy Alaa H. A. Fernández-Rivas Gema Gorriz Ester Herena Dolores Oliveira mário miralles maria carme conde carmen montero-Alia Juan José Fernández-pedregal Elia miranda-sánchez Jose Llibre Josep m. isnard mar Bonet Josep maria Estrada Oriol prat núria clotet Bonaventura The schisto-stop study group international Health program (pROsics) Barcelona North Metropolitan Territorial Directorate for Infectious Diseases Catalan Institute for Health CAP La Salut Passatge dels Encants S/N Badalona Spain Fundació Lluita contra les infeccions c/Can Ruti s/n Badalona Spain infectious Diseases Department Hospital Universitari Germans Trias i Pujol c/Can Ruti s/n Badalona Spain Germans Trias i pujol Research institute c/Can Ruti s/n Badalona Spain microbiology Department Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain Department of Genetics and microbiology Universitat Autònoma de Barcelona c/Can Ruti s/n Badalona Spain Faculty of medicine University of Asyut El Fateh Assiut Governorate Egypt Department of Urology Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain canovelles primary Health care Unit Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Indústria Canovelles Spain primary Health care Unit mataró-(Rocafonda-palau) Barcelona North Metropolitan Health Directorate Catalan Institute for Health Camí Ral el Ravalet Mataró Barcelona Spain Barcelona north metropolitan primary care Directorate Catalan Institute for Health Ctra. de Barcelona Sabadell Barcelona Spain Directorate for innovation and interdisciplinary cooperation Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain irsicaixa-AiDs Research institute Hospital Universitari Germans Trias i Pujol University Hospital c/Can Ruti s/n Badalona Spain infectious Diseases Directorate Barcelona North Metropolitan Health Directorate Catalan Institute for Health C/Can Ruti S/N Badalona Spain

Background schistosomiasis is highly endemic in sub-saharan Africa and frequently imported to Europe. male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical signs and symptoms among long-term African migrants in a non-endemic European country using a serology *** We carried out a prospective, community-based cross-sectional study of adult male migrants from sub-saharan Africa living in *** serology tests and microscopic urine examinations were carried out, and clinical data were obtained from an electronic medical record search and a structured *** We included 388 adult males, mean age 43.5 years [standard Deviation (sD) = 12.0, range: 18–76]. The median time since migration to the European Union was 17 [interquartile range (iQR): 11–21] years. The most frequent country of origin was senegal (n = 179, 46.1%). Of the 338, 147 (37.6%) tested positive forschistosoma. parasite eggs were present in the urine of only 1.3%. nine genitourinary clinical items were significantly associated with positiveschistosoma serology results: pelvic pain (45.2%;OR = 1.57, 95%ci: 1.0–2.4), pain on ejaculation (14.5%;OR = 1.85, 95%ci: 1.0–3.5), dyspareunia (12.4%;OR = 2.45, 95%ci: 1.2–5.2), erectile dysfunction (9.5%;OR = 3.10, 95%ci: 1.3–7.6), self-reported episodes of infertility (32.1%;OR = 1.69, 95%ci: 1.0–2.8), haematuria (55.2%;OR = 2.37, 95%ci: 1.5–3.6), dysuria (52.1%;OR = 2.01, 95%ci: 1.3–3.1), undiagnosed syndromic sTis (5.4%), and orchitis (20.7%;OR = 1.81, 95%ci: 1.0–3.1). clinical signs tended to *** Urogenital clinical signs and symptoms are prevalent among male African long-term migrants with a positiveschistosoma serology results. Genital involvement can be frequent even among those with long periods of non-residence in their sub-saharan African countries of origin. Further research is needed to develop diagnostic tools and validate therapeutic approaches to

关键词： schistosomiasis chronic schistosomiasis Urogenital schistosomiasis male genital schistosomiasis Longterm migrant

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Dynamical study of varicella-zoster virus model in sense of mittag-Leffler kernel

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international Journal of Biomathematics 2024年第3期17卷 153-183页

作者： Qura Tul Ain Aziz Khan Thabet Abdeljawad J.F.Gomez-Aguilar saleem Riaz Department of mathematics Guizhou University GuiyangGuizhou 550025P.R.China Department of mathematics and sciences prince sultan University p.O.Bor 66833 11586 RiyadhSaudi Arabia Department of medical Research china medical University Taichung 40402Taiwan cOnAcyT-Tecnologico nacional de mécico/cEniDET interior internado palmira s/n Col.Palmira C.P.62490CuernavacaMorelosMécico IConsejo Academico Universidad Virtual CNCIMonterreyMécico school of Automation northwestern polytechnical University 170072 Xian P.R.China

The primary varicella-zoster virus(VzV)infection that causes chickenpox(also known as varicella),spreads quickly among people and,in severe circumstances,can cause to fever and *** this paper,the mittag-Leffler fractional operator is used to examine the mathematical representation of the *** fractional-order differential equations are created in terms of the disease's dynamical analysis such as s:susceptible,V:Vaccinated,E:Exposed,i:infectious and R:*** derive the existence criterion,positive solution,Hyers-Ulam stability,and boundedness of results in order to examine the suggested fractional-order model's ***,some numerical examples for the VzV model of various fractional orders are shown with the aid of the generalized Adams-Bashforth-moulton approach to show the viability of the obtained results.

关键词： Varicella-zoster virus model Hyers-Ulam stability ABc fractional operator schauder fix point theory numerical analysis

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porphyrins,phthalocyanines,and related covalent-organic frameworks in the photochemical and electrochemical water splitting:A review

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particuology 2024年第7期90卷 236-265页

作者： Oxana V.Kharissova Yolanda peña méndez Boris i.Kharisov Aleksandr Lnikolaev Edith Luévano-Hipólito Lucy T.González Universidad Autónoma de nuevo León Ave.Universidad s/nSan Nicolás de los GarzaNuevo León66455Mexico Department of chemistry Moscow State UniversityVorobievy HillsMoscowRussia cOnAcYT-Universidad Autónoma de nuevo León Facultad de Ingeniería Civil-Departamento de Ecomateriales y EnergíaCd.UniversitariaC.P.66455San Nicolás de los GarzaNLMexico Tecnologico de monterrey Escuela de Ingeniería y CienciasMonterreyNuevo León 64890Mexico Tecnologico de monterrey Centro del AguaMonterreyNuevo León 64890Mexico

in this review,the possibilities of photochemical and electrochemical water splitting(Ws)using porphyrins,phthalocyanines,related macrocycles,and their metal complexes are *** efforts are being carried out in order to develop novel and cheap methods for water decomposition to generate inexhaustible greener energy sources(molecular hydrogen)instead of oil and *** processes of Ws in heterogeneous and homogeneous media require novel photo-and electrocatalysts,in particular those on macrocycle basis.A high Ws efficiency has been observed for porphyrins and phthalocyanines,showing their suitability both for HER and OER processes are available using these relative compounds for Ws *** can be used in photocatalytic and electrocatalytic Ws processes both in their free forms or as metal porphyrins/porphyrinates,mainly loaded on various inorganic materials,such as Au nps,c_(3)n_(4),Gap,KTaO_(3),Gap,and so on,as part of porphyrin-containing polymers or on electrode surface as modifying coatings,being sometimes better than commercial catalysts,such as pt/*** H2 evolution can be considerably depended on the shape of porphyrin particles;in particular,porphyrin nanowires can yield up to 20 times more H2 than its *** certain cases,both HER and OER can be driven in the same electrolyte using metal *** capacity of metal porphyrins to generate ROs(in particular,singlet oxygen 1O_(2))under ultrasonic treatment is known and can be successfully used for H_(2)O_(2) and O_(2) *** can be used in similar processes in free form or as composites with inorganic or organic counterparts,being immobilized on nanocarbons,metal oxides and salts,or simply dissolved in water acting in a homogeneous *** additional use of ultrasound can lead to better results due to the synergistic effect of the sonochemical treatment and ***-organic frameworks are also applied for Ws purposes and are mainly based

关键词： porphyrins phthalocyanines cOFs Water splitting photocatalysis Electrocatalysis

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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor cilleros-mañé Laia Just-Borràs marta Balanyà-segura Aleksandra polishchuk Laura nadal marta Tomàs carolina silvera-simón manel m.santafé maria A.Lanuza Unitat d’Histologia i neurobiologia(UHneurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and c(pKA and pKc)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75nTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the pKA/pKc activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and p/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the n-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

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Journal of sport and Health science 2024年第4期13卷 537-547页

作者： Jacqueline Josee van ierssel Olivia Galea Kirsten Holte caroline Luszawski Elizabeth Jenkins Jennifer O’neil carolyn A Emery Rebekah mannix Kathryn schneider Keith Owen Yeates Roger Zemek children’s Hospital of Eastern Ontario Research institute OttawaON K1H 8L1Canada The centre for Health Activity and Rehabilitation ResearchUniversity of OtagoDunedin 9016New Zealand sport injury prevention Research centre Faculty of KinesiologyUniversity of CalgaryCalgaryAB T2N 1N4Canada Alberta children’s Hospital Research institute University of calgary CalgaryAB T2N 1N4Canada Hotchkiss Brain institute University of CalgaryCalgaryAB T2N 4N1Canada Department of psychology University of CalgaryCalgaryAB T2N 1N4Canada g Faculty of MedicineUniversity of OttawaOttawaON K1H 8M5Canada school of Rehabilitation sciences University of OttawaOttawaON K1H 8M5Canada Bruyere Research institute OttawaON K1N 5C8Canada Departments of pediatrics and Emergency medicine Harvard Medical SchoolBostonMA 02115USA Departments of pediatrics and Emergency medicine University of OttawaOttawaON K1H 8M5Canada

purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RcTs)of non-pharmacological interventions following ***:We searched mEDLinE,Embase,psycinfo,cinAHL,and Web of science up to may *** reviewers independently screened studies and assessed reporting completeness using the Template for intervention Description and Replication(TiDieR),consensus on Exercise Reporting Template(cERT),and international consensus on Therapeutic Exercise and Training(i-cOnTEnT)*** information was sought my study authors where reporting was *** of bias(ROB)was assessed with the cochrane ROB-2 *** examining non-pharmacological interventions following ***:We included 89 RcTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck *** scores were:TiDieR 9/12(75%;interquartile range(iQR)=5;range:5-12),cERT 17/19(89%;iQR=2;range:10-19),and i-cOnTEnT 6/7(86%;iQR=1;range:5-7).percentage of studies completely reporting all items was TiDieR 35%(31/89),cERT 24%(5/21),and i-cOnTEnT 10%(2/21).studies were more completely reported after publication of TiDieR(t_(87)=2.08;p=0.04)and cERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TiDieR:rs=0.27;p=0.01;cERT:r_(s)=-0.44;p=0.06;i-cOnTEnT:r_(s)=-0.17;p=0.48)or ROB(TiDieR:rs=0.11;p=0.31;cERT:rs=0.04;p=0.86;i-cOnTEnT:rs=0.12;p=0.60).conclusion:RcTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified *** completeness improved after TiDieR and cERT publication,but p

关键词： concussion intervention Randomized controlled trial systematic review

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Association between mental Disorders and subsequent medical conditions

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四川生理科学杂志 2024年第4期46卷 217-217页

作者： natalie c momen From the national center for Register-based Research (n.c.m. O.P.-R. E.A. M.K.C. S.D. J.-C.P.G.D. T.M.L. P.B.M. K.L.M. C.B.P. L.V.P. B.V. N.W. J.J.M.) Center for Integrated Register-based Research (E.A. P.B.M. C.B.P.) the Departments of Biomedicine-Human Genetics (A.D.B.) and Public Health (M.K.C. M.F.-G. K.M.I. M.V. A.P.) the Center for Integrative Sequencing (A.D.B.) and the Big Data Center for Environment and Health (C.B.P.) Aarhus University the Lundbeck Foundation Initiative for Integrative Psychiatric Research (E.A. A.D.B. S.D. O.M. P.B.M. K.L.M. M.N. C.B.P. L.V.P. A.J.S. B.V. T.W.) the Center for Genomics and Personalized Medicine (A.D.B.) the Department of Neurology (J.-C.P.G.D.) and the Research Unit Department of Psychosis (O.M.) Aarhus University Hospital and the Research Unit for General Practice (M.F.-G. A.R.R. M.V. A.P.) Aarhus the Copenhagen Research Center for Mental Health Mental Health Center Copenhagen Copenhagen University Hospital (M.E.B. M.N. H.J.S.) Psychiatric Center Copenhagen (L.V.K.) Faculty of Health and Medical Sciences (L.V.K.) the Department of Clinical Medicine (T.W.) and the Lundbeck Foundation GeoGenetics Center GLOBE Institute (T.W.) University of Copenhagen Copenhagen and the Institute of Biological Psychiatry Mental Health Center Sankt Hans Mental Health Services Capital Region Roskilde (A.J.S. T.W.) - all in Denmark the National Drug and Alcohol Research Centre University of New South Wales Sydney (L.D.) the Department of General Practice Melbourne Medical School University of Melbourne Melbourne VIC (J.M.G.) and the Queensland Brain Institute (C.C.W.L. S.S. J.J.M.) Queensland Centre for Mental Health Research the Park Centre for Mental Health (C.C.W.L. S.S. T.J.S. H.A.W. J.J.M.) and the School of Public Health Faculty of Medicine (H.A.W.) University of Queensland Brisbane - all in Australia the Departments of Psychology (P.J.) and Developmental Psychology (A.M.R.) Heymans Institute and the I

Background:persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical ***:We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016,for a total of 83.9 million person-years.

关键词： conditions milli population

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Recent Advances in the catalytic Functionalization of “Electrophilic” indoles

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chinese Journal of chemistry 2020年第3期38卷 287-294页

作者： Alessandro cerveri marco Bandini Dipartimento di chimica"Giacomo ciamician"-Alma moter studiorum Universita di Bologna Via Selmi 240126 BolognaItaly consorzio c.i.n.m.p.i.s.via selmi 2 40126 BolognaItaly

When "dark"is bright:the scarcely explored electrophilic profile of the indolyl core(dark side)continues to inspire developments in organic synthesis by means of new catalytic *** advancements in the field enabled mol... 详细信息

关键词： chemistry. catalytic heterocyclic

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Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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Food science and Human Wellness 2024年

作者： Emily p.Laveriano-santos sara castro-Barquero camila Arancibia-Riveros Ana maría Ruiz-León Rosa casas Ramón Estruch patricia Bodega mercedes de miguel Amaya de cos-Gandoy Jesús martínez-Gómez Gloria santos-Beneit Juan m.Fernández-Alvira Rodrigo Fernández-Jiménez Rosa m.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and michael A.Wiener cardiovascular institute icahn school of medicine at mount sinai Department de nutrició ciències de l'Alimentació i Gastronomia XiA Facultat de Farmàcia i ciències de l'alimentació institut de Recerca en nutrició i seguretat Alimentària (insA-UB) Universitat de Barcelona Department of internal medicine Hospital clínic institutd'investigacions Biomèdiques August pi i sunyer (iDiBAps) University of Barcelona consorcio ciBER m.p.Fisiopatología de la Obesidad y nutrición (ciBERObn) instituto de salud carlos iii (isciii) mediterranean Diet Foundation 5. Foundation for science Health and Education (sHE) 6. centro nacional de investigaciones cardiovasculares (cnic) ciBER de Enfermedades cardiovasculares (ciBERcV) 9. Hospital Universitario clínico san carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the si! program for secondary schools trial (ncT03504059). (poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (Wc) age-sex z-score， blood pressure (Bp) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower Wc z-scores (β=-0.09， 95%ci=-0.09;-0.08， p-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%ci=-0.12;-0.09， p-for trend=0.206)， and HDL-c (β=-1.52， 95%ci=-2.90;-0.14， p-for trend=0.108)， after multivariable adjustment. The Wc z-scores (β=-0.11， 95%ci=-0.19;-0.03， p-for trend=0.013) and HDL-c (β=-2.16， 95%ci=-3.78;-0.53， p-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower Wc z-score (β=-0.14， 95%ci=-0.26;-0.02， p-for trend=0.011) and TG levels (β=-8.83， 95%ci=-12.37;-5.30， p-for trend nd the highest quintile of stilbene intake with lower BG (β=-1.83， 95%ci= -3.103;-0.64， p-for trend nd TG (β=-3.22， 95%ci= -4.95;-1.49， p-for trend=0.034)， and with higher HDL-c (β=2.328， 95%ci= 1.40;3.17， p-for trend=0.466) compared to the lowest quintile. conclusion: A higher intake of (poly)phenols， espe

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Fully integrated and broadband si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERiO ViTALi THALÍA DOmÍnGUEZ BUciO HAO LiU JOsÉmAnUEL LUQUE GOnZÁLEZ FRAnciscO JURADO-ROmERO ALEJAnDRO ORTEGA-mOÑUX GLEnn cHURcHiLL JAmEs c.GATEs JAmEs HiLLiER niKOLAOs KALFAGiAnnis DAniELE mELATi JEns H.scHmiD iLARiA cRisTiAni pAVEL cHEBEn J.GOnZALO WAnGÜEmERT-pÉREZ ÑiGO mOLinA-FERnÁnDEZ FREDERic GARDEs cOsimO LAcAVA pERiKLis pETROpOULOs Optoelectronics Research centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research institute(TELmA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain school of science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of materials science and Engineering University of IoanninaIoannina 45110Greece centre de nanosciences et de nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and photonics Research center National Research Council CanadaOttawaOntario K1A 0R6Canada

intermodal four-wave mixing(FWm)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWm,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWm-based system.

关键词： scattering pump modal

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superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of pediatrics 2024年第4期20卷 353-370页

作者： Jaime s.Rosa Duque samuel m.s.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng mu Yuet chung Tsun ming Lau manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.Tsang sara chaothai Tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos m.T.Lee Jennifer H.Y.Lam sau man chan Wilfred H.s.Wong issan Y.s.Tam masashi mori sophie A.Valkenburg malik peiris Wenwei Tu Yu Lung Lau Department of paediatrics and Adolescent medicine The University of Hong KongHong KongChina school of public Health The University of Hong KongHong KongChina HKU‑pasteur Research pole School of Public HealthThe University of Hong KongHong KongChina Research institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of microbiology and immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for immunology and infection c2i Hong KongChina

Background Optimising the immunogenicity of cOViD-19 vaccines to improve their protection against disease is *** dosing by intradermal(iD)administration has been shown to be equally immunogenic as intramuscular(im)administration for several vaccines,but the immunogenicity of iD inactivated whole severe acute respiratory syndrome coronavirus 2(sARs-coV-2)at the full dose is *** study(ncT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by iD over im administration in *** participants aged 11–17 years received two doses of im or iD vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(im-cc versus iD-cc)and post-dose 3(imccc versus iD-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** spike protein(s)immunoglobulin G(igG),s-receptor-binding domain(RBD)igG,s igG Fcγreceptor iiia(FcγRiiia)-binding,snm[sum of individual(s),nucleocapsid protein(n),and membrane protein(m)peptide pool]-specific interleukin-2(iL-2)+cD4^(+),snm-specific iL-2^(+)cD8^(+),s-specific iL-2^(+)cD8^(+),n-specific iL-2^(+)cD4^(+),n-specific iL-2^(+)cD8^(+)and m-specific iL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for iD-cc compared to im-cc,whereas igG avidity was *** iD-ccc,s-RBD igG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(pRnT90),pRnT50,s igG avidity,s igG FcγRiiia-binding,m-specific iL-2^(+)cD4^(+),interferon-γ+cD8^(+)and iL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for im-cc,iD-cc,im-ccc and iD-ccc,*** iD groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and m-specific T-cell responses by iD inactivated sARscoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 immunity intradermal Vaccine

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