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Cytochrome P45026A1 Contributes to the Maintenance of Neuropathic pain

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Neuroscience Bulletin 2024年第3期40卷 293-309页

作者： De-Li Cao Ling-Jie Ma Bao-Chun Jiang Qiang Gu Yong-Jing Gao Institute of pain Medicine and Special Environmental Medicine Co-innovation Center of NeuroregenerationNantong UniversityNantong226019China Nantong University Medical School Nantong226001China Department of pain management The Affiliated Hospital of Nantong UniversityNantong226001China

The cytochrome P450 proteins(CYP450s)have been implicated in catalyzing numerous important biological reactions and contribute to a variety of ***26A1,a member of the CYP450 family,carries out the oxidative metabolism of retinoic acid(RA),the active metabolite of vitamin *** we report that CYP26A1 was dramatically upregulated in the spinal cord after spinal nerve ligation(SNL).CYP26A1 was mainly expressed in spinal neurons and *** analysis displayed that the content of all-trans-RA(at-RA),the substrate of CYP26A1,was reduced in the spinal cord on day 7 after *** of CYP26A1 by siRNA or inhibition of CYP26A1-mediated at-RA catabolism by talarozole relieved the SNL-induced mechanical allodynia during the maintenance phase of neuropathic *** also reduced SNL-induced glial activation and proinflammatory cytokine production but increased anti-inflammatory cytokine(IL-10)*** RA receptors RARα,RXRβ,and RXRγwere expressed in spinal neurons and glial *** promoter of Il-10 has several binding sites for RA receptors,and at-RA directly increased Il-10 mRNA expression in ***,intrathecal IL-10 attenuated SNL-induced neuropathic pain and reduced the activation of astrocytes and ***,the inhibition of CYP26A1-mediated at-RA catabolism alleviates SNL-induced neuropathic pain by promoting the expression of IL-10 and suppressing glial ***26A1 may be a potential therapeutic target for the treatment of neuropathic pain.

关键词： CYP26A1 Microglia Astrocytes ERK P38 IL-10 Neuropathic pain

Laser speckle contrast imaging to predict the effect of temporary spinal cord stimulation in postherpetic neuralgia patients: A prospective observational study

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 69-75页

作者： Xiang Huang Dacheng Tang Pan Chen Lumiao Chen Xiaohong Li Xiaoping Wang Department of pain management The First A±liated Hospital Jinan University Guang ZhouGuangdong 510630P.R.China Department of pain management The First People's Hospital of Foshan Foshan City Guangdong 528000P.R.China

Temporary spinal cord stimulation(tSCS)can effectively reduce the pain and severity of postherpetic neuralgia(PHN).However,there are no effective and objective methods for predicting the effects of tSCS on *** speckle contrast imaging(LSCI)is frequently used in neurology to evaluate the effectiveness of *** assess the accuracy of LSCI in predicting the impact of tSCS on PHN,14 adult patients receiving tSCS treatments for spinal nerve-innervated(C6-T2)PHN participated in this observational *** analog scale(VAS)assessments and LSCI bloodflow images of the-ngers were recorded after the tSCS *** results showed that the VAS scores of all patients decreased ***,the bloodflow index(BFI)values were signi-cantly higher than they were before the *** bloodflow and pain alleviation were positively ***-ndings indicated that spinal nerve PHN(C6-T2)was signi-cantly reduced by *** alleviation by tSCS was positively correlated with increased bloodflow in the *** effect of tSCS on PHN may thus be predicted using an independent and consistent indicator such as LSCI.

关键词： Laser speckle contrast imaging temporary spinal cord stimulation postherpetic neuralgia

Complex Regional pain Syndrome: Outpatient pain management in the Chronic Setting: A Case Report

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Open Journal of Anesthesiology 2024年第5期14卷 137-144页

作者： Julie Chege Ngugi Kinyungu ITAV pain management Medical School University of Nairobi New York USA ITAV pain management Donald and Barbara Zucker School of Medicine at Hofstra/Northwell New York USA

Background: Complex Regional pain Syndrome (CRPS), previously known as reflex sympathetic dystrophy and causalgia, is a neuropathic pain condition that usually develops after an injury to an extremity. CRPS can be a debilitating condition with high levels of pain and reduced function. Aim: This case report aims to discuss the multimodal approach in the management of a patient who presented with ongoing poorly controlled pain secondary to CRPS from an injury that happened years prior. Case Presentation: A 45-year-old female was involved in a motor vehicle accident where her right leg was injured. She underwent several surgeries and developed CRPS that significantly reduced her mobility and quality of life. She presented to the pain clinic years after her initial injury and a multimodal regimen was started for her resulting in significantly improved function. Conclusion: CRPS can be a severely debilitating condition. While early diagnosis and management are important, ongoing management in the outpatient chronic pain setting is important in maintaining a good level of function.

关键词： Chronic Regional pain Syndrome (CRPS) Multimodal management Chronic pain Sequelae

Thoracic spinal cord injury and paraplegia caused by intradural cement leakage after percutaneous kyphoplasty: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1837-1843页

作者： Zi Mao Zhi-Hong Xiong Jun-Feng Li Department of pain management The Affiliated Hospital of Yunnan UniversityKunming 650000Yunnan ProvinceChina Department of Medical Administration The Affiliated Hospital of Yunnan UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Percutaneous kyphoplasty(PKP)is a pivotal intervention for osteoporotic fractures,pathological vertebral compression fractures,and vertebral bone *** its efficacy,the procedure presents challenges,notably complications arising from intradural cement *** and accurate diagnosis,coupled with emergent intervention is imperative to improve patient *** case report illuminates the intricacies and potential complications associated with PKP,emphasizing the critical need for vigilant monitoring,prompt diagnosis,and immediate intervention to mitigate adverse *** SUMMARY A 58-year-old male patient,experiencing a T7 osteoporosis-related pathological compression fracture,underwent PKP at a local *** weeks postprocedure,the patient developed paraplegic and dysuric symptoms,necessitating emergency decompression *** improvement was achieved,marked by the restoration of muscle strength,sensation,and *** PKP Intradural cement leakage following PKP is unusual and potentially *** imaging examinations,urgent evaluation,and the decompression surgery are essential,which help alleviate symptoms associated with spinal damage,markedly improving the overall prognosis.

关键词： Percutaneous kyphoplasty Intradural cement leakage Complication Decompression surgery Case report

Effects of flue gas desulfurization gypsum and clover planting on qualities of soil and winter jujube in coastal saline-alkali orchard of north China

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Soil Ecology Letters 2024年第1期6卷 141-152页

作者： Qi Shao Xuejing Xia Guihua Li Hui Li Jitong Lin Yanhong Lou Quangang Yang Hui Wang Zhongchen Yang Hong Pan Yuping Zhuge National Engineering Research Centerfor Efficient Utilization of Soil and Fertilizer Resources College of Resources and EnvironmentShandong Agricultural UniversityTai'an271018China Tai'an City management comprehensive Service Center Tai'an 271021China

Flue gas desulfurization gypsum and clover planting alleviated the soil salinization *** pH and total phosphorus affected the bacterial *** phosphorus affected the fungal *** gas desulfurization gypsum and clover planting improved jujube *** coastal area of Shandong Province,characterized by coastal saline tidal soil,is one of the main production areas of winter jujube in ***,the low soil fertility and poor soil structure in jujube orchard restricted the development of the jujube *** objectives of this study were to 1)evaluate the effect of application of flue gas desulfurization(FGD)gypsum and clover planting on soil quality improvement and soil microbial community structure of jujube orchard;2)investigate the effects of two measures on the nutrition and quality of winter *** results showed that FGD gypsum reduced the soil total salt content by 65.6%,and clover planting increased the soil organic matter content by 30.7%,which effectively alleviated the soil salinization stress and improved the soil *** pH and total phosphorus(TP)were the main determinants influencing bacterial community composition,and TP was the dominant factor of the fungal community composition in the saline-alkali ***,FGD gypsum addition and clover planting significantly increased the sugar degree and Vc content of winter jujube,thus improved jujube quality,and further contributed to the ecological sustainable development of winter jujube industry.

关键词： saline-alkali soils winter jujube bacterial community fungal community fue gas desulfurization gypsum clover planting

Molecular compositions and sources of organic aerosols at a rural site on the Guanzhong Plain,Northwest China:The importance of biomass burning

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Particuology 2024年第6期89卷 44-56页

作者： Yali Liu Minxia Shen Haijiao Liu Wenting Dai Weining Qi Yifan Zhang Lu Li Yue Cao Xin Wang Xiao Guo Yingkun Jiang Jianjun Li State Key Laboratory of Loess and Quaternary Geology Key Lab of Aerosol Chemistry and PhysicsInstitute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China Xi'an Institute for Innovative Earth Environment Research Xi'an 710061China National Observation and Research Station of Regional Ecological Environment Change and comprehensive management in the Guanzhong Plain ShaanxiChina

The concentration of PM_(2.5)has considerably reduced in recent years,but remains relatively high in *** particular,the increasing contribution of organic compounds to PM_(2.5)generates popular pressure for further reductions,resulting in an urgent need to study organic aerosol(OA).To investigate the molecular composition and source contribution of OA in the rural area of the Guanzhong Plain,Northwest China,PM_(2.5)samples were collected during 3–23 August 2016 and 5–20 January 2017 and studied for more than 100 organic tracer *** mean concentration of total measured organic compounds is 662±296 ng/m^(3)in summer and 3258±1925 ng/m^(3)in *** is the most abundant single compound found throughout the sampling period,which is a crucial tracer for biomass burning emissions,preliminary suggesting that biomass burning is an essential source of *** summer,organic compounds such as lipid compounds,sugar compounds,and polycyclic aromatic hydrocarbons(PAHs),more come from higher plants,wood burning,vehicle exhausts,plastic waste,and other direct emission *** PAHs(OPAHs),nitrophenols,and phthalic acids more come from the atmosphere through the oxidation reaction of aromatic precursors,especially photochemical ***,in winter,most of the increases in concentrations of organic compounds are attributed to biomass *** analysis of a haze event(14–19 January 2017)during the winter sampling period shows that the increases in the concentration of organic compounds are unaccompanied by strong secondary formation under lower relative humidity(49.1%±13.5%).The main reason for the growth of OA in this haze event is the accumulation of primary OA(POA).The source apportionment by the positive matrix factorization(PMF)model shows that biomass burning(37.1%)is the primary source of OA in the rural regions of the Guanzhong Plain,especially in winter(40.6%).The contribution of secondary formation decreases from 26.0%in summer t

关键词： Organic aerosol Molecular composition Seasonal variation Source apportionment Guanzhong Plain

A strategy to synthesize phosphorus-containing nickel phyllosilicate whiskers to enhance the flame retardancy of epoxy composites with excellent mechanical and dry-friction properties

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 39-50页

作者： Shibin Nie Zongquan Zhao Yuxuan Xu Wei He Wenli Zhai Jinian Yang School of Public Security and Emergency management Anhui University of Science and TechnologyHefei231131China School of Safety Science and Engineering Anhui University of Science and TechnologyHuainan232001China School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China Institute of Energy Hefei Comprehensive National Science CenterHefei230000China

To enhance the fire safety and wear resistance of epoxy,phosphorus-containing nickel phyllosilicate whiskers(FP-NiPS)were synthesized using a facile hydrothermal technology,with 9,10-dihydro-9-oxa-10-phosphaphenanthrene as the organic *** impacts of FP-NiPS on the thermal stability,flame retardancy,and mechanical and tribological properties of EP composites were *** findings demonstrated that 5 wt%FP-NiPS elevated the limiting oxygen index of the EP composite from 23.8%to 28.4%,achieving a V-0 rating during vertical burning ***-NiPS could enhance the thermal stability of epoxy resin(EP)and facilitate the development of a dense and continuous carbon layer,thereby significantly improving the fire safety of the EP *** FP-NiPS led to an 8.2%increase in the tensile strength and a 38.8%increase in the elastic modulus of the EP composite,showing outstanding mechanical ***,FP-NiPS showed remarkable potential in enhancing the wear resistance of *** wear rate of 1 wt%FP-NiPS is 2.34×10^(−5) mm^(3)·N^(−1)·m^(−1),a decrease of 66.7%compared to *** work provides a novel promising modification method to enhance the fire safety,mechanical and wear resistance properties of EP.

关键词： nickel phyllosilicate epoxy resin flame retardant wear resistance mechanical property

Development of international guidelines by Tuina practitioners for specific acupoints of paediatrics Tuina(2022 version)

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1044-1051页

作者： LAN Xiaoxue SUN Yanan WENG Zhiwen WANG Yue ZHANG Ying LIANG Yuanwen GU Sirui ZHOU Rong CHEN Qianji JIA Baolin BO Han WANG Fangying HE Qiang ZHANG Jie TAN Jiang YE Xingzhu WANG Xiyou YU Changhe CHEN Hong Department of Tuina and pain management the First Clinical DepartmentBeijing University of Chinese Medicine Department of Traditional Chinese Medicine Xuanwu HospitalCapital Medical University Department of Tuina and pain management Dongzhimen Hospital of Beijing University of Chinese Medicine Department of Encephalopathy Beijing Huairou Hospital of Traditional Chinese Medicine Yungang Community Health Service Center China Aerospace Science & Industry Corporation of 731 Hospital Department of Pediatrics China-Japan Friendship Clinical SchoolBeijing University of Chinese Medicine Department of Pediatrics the Second Clinical Medical College of Beijing University of Chinese Medicine Shenzhen Luohu Hospital of Traditional Chinese Medicine Department of Chinese Medicine Raffles Medical Group Department of Traditional Chinese Medicine Beiing Children's HospitalCapital Medicine UniversityNational Center for Children's Health Anzhen Community Health Service Center L. Ac. Ancient Healing Center Frederick Department of Tuina and pain management Dongzhimen HospitalBeijing University of Chinese Medicine

OBJECTIVE: To establish a standardized framework encompassing the precise locations, manipulations,functions and indications of specific acupoints in the field of paediatric Tuina. METHODS: The development of consensus involved three distinct stages. Initially, a list of paediatric Tuina specific acupoints was compiled based on an extensive literature review, which was subsequently supplemented through expert interviews. In the second stage, the Delphi method was employed to assess the significance of acupoint locations, manipulations, functions, and indications. In situations where the questionnaire survey failed to yield agreement or when the experts held reservations, the nominal group approach was utilized during the expert consensus meeting. The final version of the technical standardized material was ultimately determined during an expert consensus conference. After undergoing external peer review and evaluation, the completed draft was prepared for public dissemination RESULTS: The comprehensive list identified a total of 66 specific acupoints. The location and manipulation questionnaire consisted of 156 items based on the literature database, while the function and indication questionnaire contained 116 items. Two rounds of Delphi surveys were conducted for the location and manipulation category, and another two rounds of Delphi surveys were conducted for the function and indication category. During the experts consensus meeting The panel of experts conducted in-depth discussions on 61 questions, resulting in the formulation of technical guidelines for the locations, manipulations, functions, and indications of 64 paediatric Tuina acupoints. Subsequently, the research team compiled and edited the draft of the technical guidelines for acupoints of paediatric Tuina, which was finalized after external review and feedback. CONCLUSION: This study successfully established the recognized technical standards for practitioners of paediatric Tuina, thereby standardizi

关键词： Child Delphi technique Tuina acupoint guideline international paediatrics

Ultrasound-Guided Superior Gluteal Nerve Hydrodissection in the Treatment of Deep Gluteal Syndrome

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pain Studies and Treatment 2024年第3期12卷 49-53页

作者： Janai Puckett Roisin Hosie Dominic Harmon Medical School University of Limerick Limerick Ireland pain management Centre University Hospital Limerick Limerick Ireland

Background: Deep gluteal syndrome is a common cause of posterior hip pain. It results from peripheral nerves, such as the sciatic or superior gluteal nerve, being compressed in the deep gluteal space. Hydrodissection is a novel technique for the treatment of nerve pain due to entrapment. The use of hydrodissection for the treatment of deep gluteal syndrome has not been reported. Methods: A case report involved a 42-year-old female presenting with deep gluteal syndrome. Case report: We report, with patient consent, an ultrasound-guided superior gluteal nerve hydrodissection method used for treating the deep gluteal syndrome. A previously healthy 42-year-old female patient sought medical attention due to persistent left gluteal pain. Trials of joint injections, physiotherapy, and epidural blocks were unsuccessful. Hydrodissection under ultrasound-guidance allowed separation of the fascial plane in areas with significant neural innervation. We targeted the superior gluteal nerve with hydrodissection offering the patient immediate and persistent relief from her symptoms. Conclusion: Ultrasound-guided hydrodissection of the superior gluteal nerve offers an effective and novel diagnostic and treatment option for deep gluteal syndrome.

关键词： Superior Gluteal Nerve Deep Gluteal Syndrome Lower Limb Radicular pain Deep Gluteal Space Hydrodissection Ultrasound