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Epidemiological, Clinical and Evolutionary Aspects of Human African Trypanosomiasis in Children in Nola

Open Journal of pediatrics 2024年第2期14卷 344-358页

作者： Brice Olivier Bogning Mejiozem Gaspard Tékpa Synthia Ningatoloum Nazita Jocelyn Tony Nengom Danebera Lydie Verlaine Carine Judith Kiteze Nguinzanémou Rostand Juste Koyangboi Kombaya Iris Vanessa Gaspiet Sonny Jean Chrysostome Gody complexe Hospitalier pédiatrique de bangui Bangui République Centrafricaine Service des Maladies Infectieuses H&#244pital de l’Amitié Bangui République Centrafricaine Faculté des Sciences de la Santé de l’Université de bangui Bangui République Centrafricaine Centre Hospitalo Universitaire Communautaire de Bangui Bangui République Centrafricaine Faculté de Médecineet des Sciences Biomédicales Université de Yaoundé 1 Yaoundé Cameroun

Background: Human African trypanosomiasis (HAT) occurs in three historical foci in the Central African Republic. Objective: To describe the morbi-mortality of childhood HAT in rural Central African Republic with the aim of early management. Methods: descriptive and analytic cross-sectional study conducted from January 1, 2017 to March 30, 2018 at Nola prefectural hospital. This study was included all children seen as outpatients and/or hospitalized in the pediatric wards, in whom the diagnosis of HAT was confirmed. Statistical analysis was performed using Epi-info software. Results: Forty children were included from Bilolo (60%), Nola (30%) and Salo (10%). The sex ratio was 0.66 with a median age of 8.65 ± 12.48 years. Fever (82.5%), nocturnal insomnia (75%), daytime somnolence (67.5%), headache (65%), polyarthralgia (62.5%), convulsions 52.5% (n = 21), tremor (27.5%), trypanidism (7.5%) and delirium (2.5%) were the main functional signs. Examination signs were adenopathy (52.5%), paresthesia (30%), decreased cutaneous-abdominal reflexes (25%) and osteoarticular reflexes (17.5%), hyperesthesia (20%), extrapyramidal hypertonia (15%) and depression (2.5%). The children were in the lymphatic-blood phase in 65% of cases, and meningoencephalitis in 35%. pentamidine was administered in 65% of cases. Four children died and 6 had neurological sequelae. There was an association between age under 5, Bilolo’s focus, the children’s history and the severity of the disease. Age under 5, gender, household, children’s activity, history and occurrence of sequelae were also associated. Conclusion: HAT remains a permanent threat to Central African children. Any clinical presentation combining long-term infectious signs and unexplained neurological or neuropsychological disorders must be treated with caution.

关键词： Morbidity-Mortality Child HAT Nola CAR

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Epidemiological, Clinical, Bacteriological and Evolutionary profiles of Bacterial Meningitis in Children in bangui (CAR)

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Open Journal of pediatrics 2023年第4期13卷 553-561页

作者： Synthia Ningatoloum Nazita Simplice Cyriaque Kango Carine Judith Kiteze Nguinzanémou Rostand Juste Koyangboi Kombaya Iris Vanessa Gaspiet Sonny Brice Olivier Bogning Mejiozem Franck Houndjahoue Jean Chrysostome Gody Centre Hospitalo Universitaire Communautaire de Bangui Bangui République Centrafricaine Faculté des Sciences de la Santé de l’Université de bangui Bangui République Centrafricaine complexe Hospitalo Universitaire Pédiatrique de Bangui Bangui République Centrafricaine

Background: Bacterial meningitis is a major public health problem worldwide due to its severity. It is a vaccine-preventable disease. Methodology: It was a retrospective descriptive study conducted at the pediatric Teaching Hospital of bangui from June 2019 to May 2021. Children aged 1 month to 15 years hospitalized for bacterial meningitis were included in the study. Data were entered and analyzed using Stata/IC version 16.1. Results: Of 2490 patients hospitalized during the study period, 122 (4.9%) had bacterial meningitis. The patients were male in 54.92% of cases with a sex ratio of 1.21. The mean age was 35.95 months ± 49.16. Most of the patients (84.42%) came directly from home. The average consultation delay was 3.4 days ± 2.6. The vaccination coverage was 56.55%. The CSF study isolated germs from 24 patients (19.67%), the main ones being S. pneumoniae (75%) and H. influenzae (16.67%). Ceftriaxone was prescribed alone or in combination in all cases as first-line treatment. The average duration of antibiotic therapy was 8.95 days. The mortality rate was 27.87% and 12.30 % of patients had sequelae. Conclusion: Bacterial meningitis is common in bangui and still poses a public health problem despite the introduction of new vaccines in the EpI. Improving vaccination coverage and raising awareness for early consultation could improve the situation.

关键词： Bacterial Meningitis Child bangui

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Epidemiological, Clinical and Anatomopathological Aspects of Cancers in Central African Republic Children

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Open Journal of pediatrics 2022年第5期12卷 841-849页

作者： Jess Elio Kosh Komba palet Cyriaque Simplice Kango Carine Kiteze Nguinzanemou Marie Christine Awa Sépou Yanza Marie Colette Nganda Bangue Barbara Ouansaba Mouhamadou Ousmane Jean Chrysostome Gody Boniface Koffi complexe pédiatrique de bangui Bangui République Centrafricaine Faculté des Sciences de la Santé de l’Université de bangui Bangui République Centrafricaine Laboratoire National de Biologie Clinique et de Santé publique Bangui République Centrafricaine

Objectives: To determine the epidemiological, clinical and anatomopathological aspects of childhood cancer in CAR. patients and Methods: This was a retrospective study carried out from May 2015 to May 2018, at the Center Hospitalier Universitaire pédiatrique de bangui (CHUpB). The study population consisted of patients aged under 15 followed in the UHOpB for malignant tumors on clinical, radiological or ultrasound suspicion of malignancy and confirmed or not by histology or biology. A questionnaire was used to collect the data which was analyzed using SpSS11.0 software. Results: During the study period, we collected 107 cases of childhood cancer. The annual hospital incidence was 1.27% in 2016;1.93% in 2017 and 1.50% in 2018 The average monthly frequency of patients followed is 35.66. The intensity of pain assessed in the 99 patients ranged from 02/10 to 09/10 with an average of 5.41/10. The mean duration of the disease was 3.3 months with extremes at 1.2 months and 36 months. A predominance of comorbidity with HIV is 41.66%. Histologically diagnosed malignant tumors are dominated by 30.4% Burkitt’s lymphoma. Conclusion: Data on cancer incidence are scarce in developing countries and for the most part are hospital statistics. In CAR, it will be important to set up a national register for collecting information.

关键词： Cancer Child Epidemiology Central African Republic

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Risk Factors of Early Neonatal deaths in pediatric Teaching Hospital in bangui, Central African Republic

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Open Journal of pediatrics 2021年第4期11卷 840-853页

作者： Jean Chrysostome Gody Moyen Engoba Brice Olivier Bogning Mejiozem Lydie Verleine Danebera Evodie pierrette Kakouguere Marie Collette Nganda Bangue Carine Judith Kiteze Nguinzanemou Romuald Belly de Dieu Komangoya Kpembi petula Waraka Dusie Lesly Ngoyoli Mbode Mireille Mande Djapou Ghislain Franck Houndjahoue George Moyen Centre Hospitalier Universitaire pédiatrique de bangui (CHUpB) Bangui République Centrafricaine Université Marien Ngouabi Brazzaville Congo Médecins avec l’Afrique CUAMM International NGO Padova Italie

Background: The neonatal mortality rate in the Central African Republic (CAR) is 42.3 per 1000 live births in 2017, indicating that CAR is with the highest number of newborn deaths. Objective: Tpan>he objective is to clarify the risk factors of neonatal deaths in this area. Methodology: A case-control study with retrospective data collection. Targets were newborns >7 days, hospitalized and dead (cases), and newborns admitted after the respective case during the study period and discharged before the 7p>thp> day of life. This study was carried out between 2016 and 2018 in the neonatal unit of the “Complexe Hospitalier Universitaire Pédiatrique de Bangui” (CHUPB), the only national hospital for newborns care in the CAR. Results: We included 902 newborns, with 451 cases of early neonatal death and 451 controls. 4168 newborns were admitted to the neonatology unit with 621 early death cases;a lethality rate of 14.9%. Early neonatal deaths factors were: newborns with low birth weight (OR = 22.59;95% CI [15.93 - 32.04];pan> P pan style="font-family:Verdana;">25 years (OR = 2.08;95% CI [1.58 - 2.73];p port (O

关键词： Early Neonatal Mortality Risk Factors CHUpB CAR

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