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Antioxidants Enzymes Activities and NO Levels in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis—A comparative Study

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Journal of Biosciences and Medicines 2024年第2期12卷 50-59页

作者： Natalia Cristina Aparecida Ribeiro e Ribeiro Anderson Martins Tavares Jaslana Hainfellner da Silva João Paulo Lima Daher Salim Kanaan Luciene de Carvalho Cardoso-Weide Laboratory of Neuroplasticity Neurobiology Department Biology Institute Federal Fluminense University Rio de Janeiro Brazil Postgraduate Program in Medical Sciences School of Medicine Federal Fluminense University Rio de Janeiro Brazil School of Biology UNIVERSO—Salgado de Oliveira University Rio de Janeiro Brazil Department of pathology Faculty of Medicine Federal Fluminense University Rio de Janeiro Brazil

It consists of a retrospective study with twenty-two individuals diagnosed with DRC: fourteen HD and eight CAPD, followed up in the dialysis center of Antonio Pedro University Hospital (HUAP) of Fluminense Federal University (UFF), between 2015 and 2017. Fifteen healthy control (HC) subjects were included, without diagnosed CKD. Patients with HIV positive, hepatitis A, B, and C, pregnant, cancer, smokers, alcoholics and those exposed to X-rays in the last 3 months, were excluded. Objectives: As oxidative stress and endothelial dysfunction may be linked to the higher prevalence of CVD in CKD patients, we measured the activities of the antioxidants enzymes: SOD and GPx and total NO levels in the plasma and serum of end-stage CKD patients undergoing dialysis therapy, comparing with the HC group. Methods: Quantification of NO levels was performed by fluorometric kit, while activities of SOD and GPx were determined using kinetic methods. Results: We found higher plasma SOD activity in HD (8.58 U/ml) and CAPD (10.14 U/ml), compared to C (3.73 U/ml) group, while GPx activity was decreased in HD (115.38 nmol/h/ml) and CAPD (122.76 nmol/h/ml) groups compared to HC group (275.83 nmol/h/ml). Total serum NO concentration was decreased in HD (14.09 pmol/μl) and CAPD (10.26 pmol/μl), compared to non-CKD patients (49.65 pmol/μl). Conclusion: Decreased total serum NO and GPx activities may lead to endothelial dysfunction and consequently a higher prevalence of CVD in CKD patients.

关键词： Hemodialysis CAPD SOD GPx NO

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Genome-wide identification, classification, and expression profiling of serine esterases and other esterase-related proteins in the tobacco hornworm, Manduca sexta

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Insect Science 2023年第2期30卷 338-350页

作者： Zelong Miao Chao Xiong Xiaolong Cao Tisheng Shan Qiao Jin Haobo Jiang Department of Entomology and Plant pathology Oklahoma State UniversityOklahomaStillwaterUSA

Serine esterases(SEs)are hydrolases that catalyze the conversion of carboxylic esters into acids and *** and carboxylesterases constitute two major groups of *** over a hundred of insect genomes are known,systematic identification and classification of SEs are rarely performed,likely due to large size and complex composition of the gene family in each *** their key roles in lipid metabolism and other physiological processes,we have categorized 144 *** SEs and SE homologs(SEHs),114 of which contain a motif of *** sequence alignment and phylogenetic tree analysis have revealed 39 neutral lipases(NLs),3 neutral lipase homologs(NLHs),11 acidic lipases(ALs),3 acidic lipase homologs(ALHs),a lipase-3,a triglyceride lipase,a monoglyceride lipase,a hormone-sensitive lipase,and a GDSL ***-three carboxylesterase genes encode 29α-esterases(AEs),12 AEHs(e.g.,SEH4-1–3),20 feruloyl esterases(FEs),2 FEHs,2β-esterases(BEs),2 integument esterases(IEs),1 IEH,4 juvenile hormone esterases,2 acetylcholinesterases,gliotactin,6 neuroligins,neurotactin,and an uncharacteristic esterase *** addition to these GXSXG proteins,we have identified 26 phospholipases and 13 *** profiling of these genes in specific tissues and stages has provided insights into their functions including digestion,detoxification,hormone processing,neurotransmission,reproduction,and developmental *** summary,we have established a framework of information on SEs and related proteins in *** to stimulate their research in the model species and comparative investigations in agricultural pests or disease vectors.

关键词： carboxylesterase esterase lipase phospholipase phylogenetic analysis RNA-Seq thioesterase

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Evidences supporting the vascular etiology of post-double balloon enteroscopy pancreatitis: Study in porcine model

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World Journal of Gastroenterology 2017年第34期23卷 6201-6211页

作者： Rafael Latorre Octavio López-Albors Federico Soria Esther Morcillo Pilar Esteban Enrique Pérez-Cuadrado-Robles Enrique Pérez-Cuadrado-Martínez Department of Anatomy and comparative pathology University of Murcia Minimally Invasive Surgery Centre Jesús Usón Department of Gastroenterology Small Bowel UnitMorales Meseguer Hospital

Double balloon enteroscopy(DBE) is an endoscopic technique broadly used to diagnose and treat small bowel diseases. Among the associated complications of the oral DBE, post-procedure pancreatitis has taken the most attention due to its gravity and the thought that it might be associated to the technique itself and anatomical features of the pancreas. However, as the etiology has not been clarified yet, this paper aims to review the published literature and adds new results from a porcine animal model. Biochemical markers, histological sections and the vascular perfusion of the pancreas were monitored in the pig during DBE practice. A reduced perfusion of the pancreas and bowel, the presence of defined hypoxic areas and disseminated necrotic zones were found in the pancreatic tissue of pigs. All these evidences contribute to support a vascular distress as the most likely etiology of the post-DBE pancreatitis.

关键词：加倍汽球 enteroscopy 胰动物模型胰腺炎猪

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SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages

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Cellular & Molecular Immunology 2022年第2期19卷 210-221页

作者： Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijing 100005China NHC Key Laboratory of Human Disease comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceCAMS and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesCAMS and Peking Union Medical CollegeBeijingChina Department of pathology Institute of Basic Medical SciencesCAMS and Peking Union Medical CollegeBeijingChina Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China

Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising ***,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a potential therapeutic agent against SARS-CoV-2 *** administered AO-MPs dexterously navigate the anatomical and biological features of the lungs to enter the alveoli and are taken up by alveolar macrophages(AMs).Then,AO-MPs increase the endosomal pH but decrease the lysosomal pH in AMs,thus escorting bound SARS-CoV-2 from phago-endosomes to lysosomes for *** pH regulation is attributable to oxidized cholesterol,which is enriched in AO-MPs and translocated to endosomal membranes,thus interfering with proton pumps and impairing endosomal *** addition to promoting viral degradation,AO-MPs also inhibit the proinflammatory phenotype of AMs,leading to increased treatment efficacy in a SARS-CoV-2-infected mouse model without side *** findings highlight the potential use of AO-MPs to treat SARS-CoV-2-infected patients and showcase the feasibility of MP therapies for combatting emerging respiratory viruses in the future.

关键词： SARS-CoV-2 microparticles Alveolar macrophages Endosomes Lysosomes

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Airway administration of bisphosphate and dexamethasone inhibits SARS-CoV-2 variant infection by targeting alveolar macrophages

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1375-1378页

作者： Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Jiangning Liu Chuan Qin Wei-Min Tong Bo Huang Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical College100005 BeijingChina NHC Key Laboratory of Human Disease comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceCAMS and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina Department of pathology Institute of Basic Medical SciencesCAMS and Peking Union Medical CollegeBeijingChina Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&Technology430030 WuhanChina

Dear Editor,Alveolar macrophages(AMs)are among the first immune cells to encounter SARS-CoV-2 during an infection due to their abundant numbers and physical location in the ***,the reaction of AMs to SARS-CoV-2 has a profound impact on the outcome of the *** most cases,AMs can release cytokines and prime adaptive T-and B-cell immune responses to resolve the infection.

关键词： infection alveolar release

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Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant

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Signal Transduction and Targeted Therapy 2022年第1期7卷 28-30页

作者： Zhenfeng Wang Yabo Zhou Linlin Bao Dan Li Jiadi Lv Dianheng Wang Shunshun Li Wei-Min Tong Jiangning Liu Chuan Qin Bo Huang Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical College100005 BeijingChina NHC Key Laboratory of Human Disease comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceCAMS and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina Department of pathology Institute of Basic Medical SciencesCAMS and Peking Union Medical CollegeBeijingChina Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&Technology430030 WuhanChina

Dear Editor,Genetic variant Delta(B.1.617.2)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which possesses a remarkable ability to transmit and spread,is currently becoming predominant *** its great harm to human beings,how the Delta variant with T478K,P681R and L452R mutations achieves its ultrafast spread remains *** of SARS-CoV-2 into host cells is mediated by a rapid enzymatic hydrolysis.

关键词： retention massive delta

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Role of tumor necrosis factor alpha-induced protein 6(TNFAIP6)in tumors:a pan-cancer analysis

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Oncology and Translational Medicine 2024年第1期10卷 22-29页

作者： Yang Yang Zhi-Gang Liu Yan-Qi Yang Zhi-Gang Zhang Xiao-Li Wang Yu-Long Li Rui-Fang Sun School of Public Health Shaanxi University of Chinese MedicineXianyangChina Department of Thoracic Surgery Shaanxi Provincial Cancer HospitalXi'an Jiaotong UniversityXi'anChina Department of pathology School of Basic Medical SciencesHealth Science CenterXi'an Jiaotong UniversityXi'anChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineShaanxiChina Department of Gastroenterology Shaanxi Provincial People's HospitalXi'anChina.

Background:There is growing evidence that the gene named tumor necrosis factorα–induced protein 6(TNFAIP6)has an important role in various ***,a systematic pan-cancer analysis of TNFAIP6 is *** we aimed to analyze the expression of TNFAIP6 across multiple cancers and verify its expression during the progression of colon ***:We performed a comprehensive bioinformatics analysis to examine the expression of TNFAIP6 across 27 tumor ***2 was used to evaluate the effect of TNFAIP6 on clinical cancer *** was used to assess TNFAIP6 *** correlation between TNFAIP6 and cancer immune infiltrates was explored using *** CancerSEA database was used to perform functional analysis of *** was used to identify TNFAIP6-related gene enrichment *** was performed to detect TNFAIP6 protein expression in the colon *** addition,the comparative Toxicogenomics Database was searched for known and possible antitumor drugs that may be associated with ***:We found that,in most of the cancers included in this analysis,TNFAIP6 was highly expressed,and there is a distinct relationship between TNFAIP6 expression and cancer ***6 expression is associated with cancer-associated fibroblasts,neutrophils,and endothelial ***6 and similar genes may also be involved in the PID_VEGF_VEGFR_*** revealed an increasing trend of TNFAIP6 protein expression in normal,adenoma,and colon cancer *** known and possible antitumor drugs that may be associated with TNFAIP6 were identified in the comparative Toxicogenomics *** results suggest that a number of drugsmay target TNFAIP6 during cancer treatment,including cisplatin,irinotecan,resveratrol,U 0126,NSC689534,genistein,NSC668394,oxaliplatin,plerixafor,topotecan,vincristine,flutamide,doxorubicin,MRK 003,folic acid,demecolcine,tunicamycin,zoledronic acid,and schizandrin B.

关键词： Cancer IHC Mutation Survival TNFAIP6

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Astrocyte in prion disease: a double-edged sword

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Neural Regeneration Research 2022年第8期17卷 1659-1665页

作者： Waqas Tahir Simrika Thapa Hermann M.Schatzl Department of comparative Biology&Experimental Medicine Faculty of Veterinary MedicineUniversity of CalgaryCalgaryABCanada Calgary Prion Research Unit University of CalgaryCalgaryABCanada Hotchkiss Brain Institute University of CalgaryCalgaryABCanada

Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein(PrPC)into the pathologic isoform *** hallmarks of prion disease are depositions of pathological prion protein PrPSc,neuronal loss,spongiform degeneration and astrogliosis in the *** diseases affect human and animals,there is no effective therapy,and they invariably remain *** a long time,neuronal loss was considered the sole reason for neurodegeneration in prion pathogenesis,and the contribution of non-neuronal cells like microglia and astrocytes was considered less *** evidence suggests that neurodegeneration during prion pathogenesis is a consequence of a complex interplay between neuronal and non-neuronal cells in the brain,but the exact role of these non-neuronal cells during prion pathology is still *** are non-neuronal cells that regulate brain homeostasis under physiological ***,astrocytes can deposit PrPSc aggregates and propagate prions in prion-infected ***,sub-populations of reactive astrocytes that include neurotrophic and neurotoxic species have been identified,differentially expressed in the brain during prion *** the exact role of astrocytes in prion disease is hampered by the lack of in vitro models of prion-infected ***,we established a murine astrocyte cell line persistently infected with mouse-adapted prions,and showed how such astrocytes differentially process various prion *** the complexity of the role of astrocytes in prion pathogenesis,we need more in vitro and in vivo models for exploring the contribution of sub-populations of reactive astrocytes,their differential regulation of signaling cascades,and the interaction with neurons and microglia during prion *** will help to establish novel in vivo models and define new therapeutic targets against prion

关键词： Alzheimer’s disease astrocytes central nervous system Creutzfeldt-Jakob disease glial cells neurodegeneration prion prion disease prion protein scrapie

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KDM2B promotes cell viability by enhancing DNA damage response in canine hemangiosarcoma

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Journal of Genetics and Genomics 2021年第7期48卷 618-630页

作者： Kevin Christian Montecillo Gulay Keisuke Aoshima Yuki Shibata Hironobu Yasui Qin Yan Atsushi Kobayashi Takashi Kimura Laboratory of comparative pathology Department of Clinical SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Laboratory of Radiation Biology Department of Applied Veterinary SciencesFaculty of Veterinary MedicineHokkaido UniversitySapporoHokkaido 060-0818 Japan Department of pathology Yale School of MedicineNew HavenCT 06510USA

Epigenetic regulators have been implicated in tumorigenesis of many types of cancer;however,their roles in endothelial cell cancers such as canine hemangiosarcoma(HSA)have not been *** this study,we find that lysine-specific demethylase 2 b(KDM2 B)is highly expressed in HSA cell lines compared with normal canine endothelial *** of KDM2 B in HSA cells results in increased cell death in vitro compared with the scramble control by inducing apoptosis through the inactivation of the DNA repair pathways and accumulation of DNA ***,doxycycline-induced KDM2 B silencing in tumor xenografts results in decreased tumor sizes compared with the ***,KDM2 B is also highly expressed in clinical cases of *** hypothesize that pharmacological KDM2 B inhibition can also induce HSA cell death and can be used as an alternative treatment for *** treat HSA cells with GSK-J4,a histone demethylase inhibitor,and find that GSK-J4 treatment also induces apoptosis and cell *** addition,GSK-J4 treatment decreases tumor ***,we demonstrate that KDM2 B acts as an oncogene in HSA by enhancing the DNA damage ***,we show that histone demethylase inhibitor GSK-J4 can be used as a therapeutic alternative to doxorubicin for HSA treatment.

关键词： DNA repair Epigenetics Hemangiosarcoma KDM2B Oncogene

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硒和维生素E缺乏和过量的比较病理学

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中华地方病学杂志 1989年第5期8卷 33+61-74+60页

作者： John F.Van Vleet,Victor J.Ferrans Bethesda Maryland20205 Department of pathology School of Veterinary Medicine Purdue University West Lafayette Indiana47907 pathology Branch National Heart Lung and Blood Institute National Institutes of Health

本文报告了缺硒和维生素 E（简称 Se—VE）动物的病理学改变。Se—VE缺乏病多见于子鸭、猪、羔羊、牛犊、鹌鹑、鼠、猫和鸡雏等动物。以上各种 Se—VE缺乏动物的病理改变不尽相同,但多数动物的主要病理所见为骨骼肌的变性,坏死,肉眼病... 详细信息

本文报告了缺硒和维生素 E（简称 Se—VE）动物的病理学改变。Se—VE缺乏病多见于子鸭、猪、羔羊、牛犊、鹌鹑、鼠、猫和鸡雏等动物。以上各种 Se—VE缺乏动物的病理改变不尽相同,但多数动物的主要病理所见为骨骼肌的变性,坏死,肉眼病变呈白色条纹状,心肌也出现不同程度的坏死。小肠和砂囊的平滑肌也发生坏死,多见于火鸡和鹌鹑等。荷兰猪、鼠的肝脏

关键词：硒维生素 E 病理学

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