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Risk of second primary cancers after testicular cancer in East and West Germany： a focus on contralateral testicular cancers

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Asian Journal of Andrology 2014年第2期16卷 285-289,I0010,I0011页

作者： Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang Institute of Clinical Epidemiology Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) common cancer registry of berlin Berlin Saarland cancer registry Saarbrucken Institute of Medical Epidemiology Biostatistics and Informatics Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Germany Division of cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD Department of Epidemiology Scfloof of Public Heaftfl Boston University Boston MA USA.

Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was to estimate the risk of developing second primary cancers including the risk associated with primary histologic type （seminoma and non-seminoma） among testicular cancer survivors in Germany. We identified 16 990 and 1401 cases of testicular cancer in population-based cancer registries of East Germany （1961-1989 and 1996-2008） and Saarland （a federal state in West Germany; 1970-2008）, respectively. We estimated the risk of a second primary cancer using standardized incidence ratios （SIRs） with 95% confidence intervals （95% Cls）. To determine trends, we plotted model-based estimated annual SIRs. In East Germany, a total of 301 second primary cancers of any location were observed between 1961 and 1989 （SIR： 1.9; 95% Ch 1.7-2.1）, and 159 cancers （any location） were observed between 1996 and 2008 （SIR： 1.7; 95% Ch 1.4-2.0）. The SIRs for contralateral testicular cancer were increased in the registries with a range from 6.0 in Saarland to 13.9 in East Germany. The SIR for seminoma, in particular, was higher in East Germany compared to the other registries. We observed constant trends in the model-based SIRs for contralateral testicular cancers. The majority of reported SIRs of other cancer sites including histology-specific risks showed low precisions of estimated effects, likely due to small sample sizes. Testicular cancer patients are at increased risk especially for cancers of the contralateral testis and should receive intensive follow-ups.

关键词： cancer registry incidence neoplasms second primary testicular neoplasms

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Incidence and mortality of liver cancer in China in 2011

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Chinese Journal of cancer 2015年第11期34卷 508-513页

作者： Ting-Ting Zuo Rong-Shou Zheng Si-Wei Zhang Hong-Mei Zeng Wan-Qing Chen National Central cancer registry National Cancer Center

Background: Liver cancer is a common cancer with poor prognosis in China. In this study, the national population?based cancer registration data were used to evaluate and analyze liver cancer incidence and mortality in China in 2011 and provide a reference for liver cancer prevention and ***: We collected and evaluated the incidence and mortality data of liver cancer in 2011 from 177 cancer registries with qualiied data. These data were used in the inal analysis including calculating crude, standardized, and truncated incidences and mortalities, and estimated new liver cancer cases and deaths using age?speciic rates and the corresponding populations. The national census in 2000 and Segi's population were used for age?standardized ***: The estimates of new liver cancer cases and deaths were 355,595 and 322,416, respectively, in China in 2011. The crude incidence, age?standardized rate of incidence by Chinese standard population(ASRIC), and age?stand?ardized rate of incidence by world standard population(ASRIW) of liver cancer were 26.39/100,000, 19.48/100,000, and 19.10/100,000, respectively; the crude mortality, age?standardized rate of mortality by Chinese standard popula?tion(ASRMC), and age?standardized rate of mortality by world standard population(ASRMW) of liver cancer were 23.93/100,000,17.48/100,000, and 17.17/100,000, respectively. The incidence and mortality were higher in rural areas than in urban areas and higher in males than in females. The age?speciic incidence and mortality of liver cancer increased greatly with age, particularly after 30 years and peaked at 80–84 or 85+ ***: Liver cancer is a common cancer in China, particularly for males and residents in rural areas. Targeted prevention, early detection, and treatment programs should be carried out.

关键词： Liver cancer, Incidence, Mortality, China

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The incidences and mortalities of major cancers in China, 2010

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Chinese Journal of cancer 2014年第8期33卷 402-405页

作者： Wan-Qing Chen Rong-Shou Zheng Si-Wei Zhang Hong-Mei Zeng Xiao-Nong Zou National Central cancer registry National Cancer CenterBeijing

To estimate the cancer incidences and mortalities in China in 2010, the National Central cancer registry(NCCR) of China evaluated data for the year of 2010 from 145 qualified cancer registries covering 158,403,248 people(92,433,739 in urban areas and 65,969,509 in rural areas). The estimates of new cancer cases and cancer deaths were 3,093,039 and 1,956,622 in 2010, respectively. The percentage of morphologically verified cases were 67.11%; 2.99% of incident cases were identified through death certification only, with the mortality to incidence ratio of 0.61. The crude incidence was 235.23/100,000(268.65/100,000 in males and 200.21/100,000 in females). The age-standardized rates by Chinese standard population(ASR China) and by world standard population(ASR world) were 184.58/100,000 and 181.49/100,000, respectively, with a cumulative incidence(0-74 years old) of 21.11%. The crude cancer mortality was 148.81/100,000(186.37/100,000 in males and 109.42/100,000 in females). The ASR China and ASR world were 113.92/100,000 and 112.86/100,000, respectively, with a cumulative mortality of 12.78%. Lung, breast, gastric, liver, esophageal, colorectal, and cervical cancers were the most common cancers. Lung, liver, gastric, esophageal, colorectal, breast, and pancreatic cancers were the leading causes of cancer deaths. The coverage of cancer registration has rapidly increased in China in recent years and may reflect more accurate cancer burdens among populations living in different areas. Given the increasing cancer burden in the past decades, China should strengthen its cancer prevention and control.

关键词：癌症发病率中国标准死亡率发生率世界标准 ASR 城市地区农村地区

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Incidence and mortality of colorectal cancer in China, 2011

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Chinese Journal of cancer Research 2015年第1期27卷 22-28页

作者： Shuzheng Liu Rongshou Zheng Meng Zhang Siwei Zhang Xibin Sun Wanqing Chen Department of cancer Epidemiology Henan Cancer Hospital/Institute Affiliated Tumor Hospital of Zhengzhou University National Central cancer registry National Cancer Center

Objective： Colorectal cancer is the third most common type of cancer and the fourth leading cause of cancer-related death in the world. This article provides the most up-to-date overview of colorectal cancer burden in China. Methods： Totally 234 cancer registries submitted data of 2011 to the National Central cancer registry （NCCR）. Qualified data from 177 registries was pooled and analyzed. The crude incidence and mortality rates of colorectal cancer were calculated by age, gender and geographic area. The numbers of new cases and deaths were estimated using the 5-year age-specific cancer incidence/mortality rates and the corresponding populations. China census in 2000 and Segi＇s world population were applied for age standardized rates. Results： The estimate of new cases diagnosed with colorectal cancer of China in 2011 was 310,244 （178,404 for males and 131,840 for females, 195,117 in urban areas and 115,128 in rural areas）, accounting for 9.20% of overall new cancer cases. The crude incidence of colorectal cancer ranked fourth in all cancer sites with rate of 23.03/100,000 （25.83/100,000 for males and 20.08/100,000 for female, 28.25/100,000 in urban areas and 17.54/100,000 in rural areas）. The age-standardized rates by China population and by World population were 16.79/100,000 and 16.52/100,000, respectively. The estimated number of colorectal cancer deaths of China in 2011 was 149,722 （86,427 for males and 63,295 for females, 91,682 in urban areas and 58,040 in rural areas）, accounting for 7.09% of overall cancer deaths. The crude mortality rate for colorectal cancer ranked fifth leading cause of cancer-related death in all cancer sites with rate of 11.11/100,000 （12.51/100,000 for males and 9.64/100,000 for female, 13.27/100,000 in urban areas and 8.84/100,000 in rural areas）. The age-standardized rates by China population and by World population for mortality were 7.77/100,000 and 7.66/100,000, respectively. For both of incidence and mortality, the rates of co

关键词： Colorectal cancer incidence mortality cancer registry China

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cancer Incidence And Mortality in China,2006

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Chinese Journal of cancer Research 2011年第1期23卷 3-9页

作者： Wan-qing Chen Si-wei Zhang Xiao-nong Zou Ping Zhao National Office for cancer Prevention and Control/National Central cancer registry Cancer InstituteChinese Academy of Medical SciencesBeijing 100021China

Objective：To describe the cancer incidence and mortality rates in 2006 and evaluate the cancer burden in ***：cancer registration data in 2006 from 34 cancer registries were collected,evaluated and pooled to calculate cancer incidence and mortality *** data analyses included mortality to incidence ratio（MI）,morphological verification percentage（MV%） and proportion of death certification only（DCO%）.Cumulative incidence and mortality rates were calculated using crude data,age-standardized data,and specific data for cancer site,age,sex and area（urban or rural）.Results：In 2006,34 registries with qualified registration data covered a total population of 59,567,322（46,558,108 in urban areas and 13,009,214 in rural areas）.The crude and age-standardized cancer incidence rates were 273.66 per 100,000 and 190.54 per 100,000,*** crude and age-standardized cancer mortality rates were 175.70 per 100,000 and 117.67 per 100,000,*** of lung,stomach,colon and rectum,liver,and breast in female were the five most common forms of cancer in China,which accounted for 58.99% of all new cancer *** cancer was the leading cause of cancer death,followed by stomach cancer,liver cancer,esophageal cancer and colorectal ***：cancer is still an important public health issue in China with an increasing disease ***,the incidence rates for lung cancer,colorectal cancer and breast cancer were increasing,but those for stomach cancer and esophageal cancer were ***,age-specific incidence rate remained stable,indicating that the aging population was the major source of the increasing cancer burden.

关键词： cancer cancer registration Incidence Mortality

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cancer Incidence and Mortality in China,2007

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Chinese Journal of cancer Research 2012年第1期24卷 1-8页

作者： Wan-qing Chen Hong-mei Zeng Rong-shou Zheng Si-wei Zhang Jie He National Office for cancer Prevention and Control/National Central cancer registry Cancer InstituteChinese Academy of Medical SciencesBeijing 100021China

Objective： cancer incidence and mortality data collected from population-based cancer registries were analyzed to present the overall cancer statistics in Chinese registration areas by age, sex and geographic area in 2007. Methods： In 2010, 48 cancer registries reported cancer incidence and mortality data of 2007 to National Central cancer registry of China. Of them, 38 registries＇ data met the national criteria. Incidence and mortality were calculated by cancer sites, age, gender, and area. Age-standardized rates were described by China and World population. Results： The crude incidence rate for all cancers was 276.16/100,000 （305.22/100,000 for male and 246.46/100,000 for female; 284.71/100,000 in urban and 251.07/100,000 in rural）. Age-standardized incidence rates by China and World population were 145.39/100,000 and 189.46/100,000 respectively. The crude mortality rate for all cancers was 177.09/100,000 （219.15/100,000 for male and 134.10/100,000 for female; 173.55/100,000 in urban and 187.49/100,000 in rural）. Age-standardized mortality rates by China and World population were 86.06/100,000 and 116.46/100,000, respectively. The top 10 most frequently common cancer sites were the lung, stomach, colon and rectum, liver, breast, esophagus, pancreas, bladder, brain and lymphoma, accounting for 76.12% of the total cancer cases. The top 10 causes of cancer death were cancers of the lung, liver, stomach, esophagus, colon and rectum, pancreas, breast, leukemia, brain and lymphoma, accounting for 84.37% of the total cancer deaths. Conclusion： cancer remains a major disease threatening people＇s health in China. Prevention and control should be enhanced, especially for the main cancers.

关键词： cancer registry Incidence Mortality China

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The incidence and mortality of major cancers in China,2012

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Chinese Journal of cancer 2016年第8期35卷 430-434页

作者： Wanqing Chen Rongshou Zheng Hongmei Zeng Siwei Zhang National Office for cancer Prevention and Control & National Central cancer registry National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College

Background:The National Central cancer registry(NCCR) collected population-based cancer registration data in 2012 from local registries and estimated the cancer incidence and mortality in ***:In the middle of 2015,261 cancer registries submitted reports on new cancer cases and deaths occurred in *** data from 193 registries were used for analysis after *** rates,number of cases,and age-standardized rates stratified by area(urban/rural),sex,age group,and cancer type were calculated according to the national population in ***:The covered population were 198,060,406 from 193 qualified cancer registries(74 urban and 119 rural registries).The major indicators of quality control,percentage of cases morphologically verified(MV%),death certificateonly cases(DCO%),and the mortality to incidence(M/l) ratio,were 69.13%,2.38%,and 0,62,*** was estimated that there were 3,586,200 new cancer cases and 2,186,600 cancer deaths in 2012 in China with an incidence of 264.85/100,000[age-standardized rate of incidence by the Chinese standard population(ASRIC) of 191.89/100,000]and a mortality of 161.49/100,000[age-standardized rate of mortality by the Chinese standard population(ASRMC)of 112.34/100,000].The ten most common cancer sites were the lung,stomach,liver,colorectum,esophagus,female breast,thyroid,cervix,brain,and pancreas,accounting for approximately 77.4% of all new cancer *** ten leading causes of cancer death were lung cancer,liver cancer,gastric cancer,esophageal cancer,colorectal cancer,pancreatic cancer,female breast cancer,brain tumor,leukemia,and lymphoma,accounting for 84.5% of all cancer ***:Continuous cancer registry data provides basic information in cancer control *** cancer burden in China is gradually increasing,both in urban and rural areas,in males and *** cancer prevention and control,such as health education,tobacco control,and cancer screening,should be paid att

关键词：癌症发病率中国标准死亡率质量控制结直肠癌农村地区年龄组脑肿瘤

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Current Status of Human Papillomavirus-Related Head and Neck cancer: From Viral Genome to Patient Care

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Virologica Sinica 2021年第6期36卷 1284-1302页

作者： Haoru Dong Xinhua Shu Qiang Xu Chen Zhu Andreas M.Kaufmann Zhi-Ming Zheng Andreas E.Albers Xu Qian Department of Clinical Laboratory Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China Department of cancer Prevention Cancer Hospital University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022China Clinic for Gynecology Berlin Institute of HealthCharité-Universitätsmedizin BerlinFreie Universität BerlinHumboldt-Universität Zu BerlinBerlin12203Germany Tumor Virus RNA Biology Section HIV Dynamics and Replication ProgramNational Cancer InstituteNational Institutes of HealthFrederickMD21702USA Department of Otolaryngology Head and Neck SurgeryBerlin Institute of HealthCharité-Universitätsmedizin BerlinFreie Universität BerlinHumboldt-Universität Zu BerlinBerlin13353Germany

Human papillomavirus(HPV)infection identified as a definitive human carcinogen is increasingly being recognized for its role in carcinogenesis of human *** to 38%–80%of head and neck squamous cell carcinoma(HNSCC)in oropharyngeal location(OPSCC)and nearly all cervical cancers contain the HPV genome which is implicated in causing cancer through its oncoproteins E6 and *** by the biologically distinct HPV-related OPSCC and a more favorable prognosis compared to HPV-negative tumors,clinical trials on de-escalation treatment strategies for these patients have been *** is therefore raised the questions for the patient stratification if treatment de-escalation is ***,understanding the crosstalk of HPV-mediated malignancy and immunity with clinical insights from the proportional response rate to immune checkpoint blockade treatments in patients with HNSCC is of importance to substantially improve the treatment *** review discusses the biology of HPV-related HNSCC as well as successful clinically findings with promising candidates in the pipeline for future *** the advent of various sequencing technologies,further biomolecules associated with HPV-related HNSCC progression are currently being identified to be used as potential biomarkers or targets for clinical decisions throughout the continuum of cancer care.

关键词： Human papillomavirus(HPV)integration Molecular diagnostics Oropharyngeal cancer De-Escalation treatment Immunotherapy

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Incidence and mortality of liver cancer in China, 2010

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Chinese Journal of cancer 2014年第8期33卷 388-394页

作者： Kuang-Rong Wei Xia Yu Rong-Shou Zheng Xia-Biao Peng Si-Wei Zhang Ming-Fang Ji Zhi-Heng Liang Zhi-Xiong Ou Wan-Qing Chen cancer Institute Zhongshan Municipal People’s HospitalZhongshan Guangdong National Central cancer registry National Cancer CenterBeijing Digestive Internal Department Zhongshan Municipal People’s HospitalZhongshan Guangdong

Liver cancer is a common malignant tumor in China and a major health concern. We aimed to estimate the liver cancer incidence and mortality in China in 2010 using liver cancer data from some Chinese cancer registries and provide reference for liver cancer prevention and treatment. We collected and evaluated the incidence and mortality data of liver cancer in 2010 from 145 cancer registries, which were included in the 2013 Chinese cancer registry Annual Report, calculated crude, standardized, and truncated incidences and mortalities, and estimated new liver cancer cases and deaths from liver cancer throughout China and in different regions in 2010 from Chinese practical population. The estimates of new liver cancer cases and deaths were 358,840 and 312,432, respectively, in China in 2010. The crude incidence, age-standardized rate by Chinese standard population(ASR China), and age-standardized rate by world standard population(ASR world) were 27.29/100,000, 21.35/100,000, and 20.87/100,000, respectively; the crude, ASR China, and ASR world mortalities were 23.76/100,000, 18.43/100,000, and 18.04/100,000, respectively. The incidence and mortality were the highest in western regions, higher in rural areas than in urban areas, and higher in males than in females. The age-specific incidence and mortality of liver cancer showed a rapid increase from age 30 and peaked at age 80-84 or 85+. Our results indicated that the 2010 incidence and mortality of liver cancer in China, especially in undeveloped rural areas and western regions, were among high levels worldwide. The strategy for liver cancer prevention and treatment should be strengthened.

关键词：中国标准死亡率肝癌世界人口死亡病例恶性肿瘤西部地区农村地区

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Estimates of cancer incidence and mortality in China,2013

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Chinese Journal of cancer 2017年第8期36卷 384-389页

作者： Rongshou Zheng Hongmei Zeng Siwei Zhang Wanqing Chen National Central cancer registry National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China

Introduction: Population-based cancer registration data are collected by the National Central cancer registry in China every year. cancer incident cases and cancer deaths in 2013 were ***: Through the procedure of quality control, reported data from 255 registries were accepted to establish the national database for cancer estimates. Incidences and mortalities were calculated with stratification by area(urban/rural), sex(male/female), age group(0,1-4,5-9,10-14... 80-84, and 85-year-old and above), and cancer *** structure of Segi's population was used for the calculation of age-standardized rates(ASR).Top 10 most common cancers and leading causes of cancer deaths were ***: In 2013,3,682,200 new cancer cases and 2,229,300 cancer deaths were estimated in China based on the pooled data from 255 cancer registries, covering 16.65% of the national population. The incidence was270.59/100,000, with an ASR of 186.15/100,000; the mortality was 166.83/100,000, with an ASR of 108.94/100,*** top 10 most common cancer sites were the lung, stomach, liver, colorectum, female breast, esophagus, thyroid, cervix, brain, and pancreas. The ten leading causes of cancer deaths were lung cancer, liver cancer, gastric cancer, esophageal cancer, colorectal cancer, pancreatic cancer, female breast cancer, brain tumor, leukemia, and ***: cancer leaves serious disease burden in China with high incidence and mortality. Lung cancer was the most common cancer and the leading cause of cancer death in China. Efficient control strategy is needed, especially for major cancers.

关键词： Incidence Mortality cancer registry Epidemiology China

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