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Evaluation of a new nomogram for Ferrara ring segment implantation in keratoconus

International Journal of Ophthalmology(English edition) 2021年第9期14卷 1371-1383页

作者： Joaquín Fernández Cristina Peris-Martínez Antonio Pérez-Rueda Sidi Mohamed Hamida Abdelkader María JoséRoig-Revert David P.Pinero Department of Ophthalmology(Qvision) Vithas Virgen del Mar HospitalAlmeria 04120Spain Department of Ophthalmology Torrecardenas Hospital ComplexAlmeria 04009Spain comea and external diseases unit FISABIO-Oftalmologia Medica(FOM)Valencia 46015Spain Avino Peris Eye Clinic Valencia 46001Spain Department of Surgery OphthalmologyUniversity of ValenciaValencia 46010Spain Department of Optics Pharmacologyand AnatomyUniversity of AlicanteAlicante 03690Spain

AIM:To evaluate the short-term clinical outcomes of Ferrara rings in keratoconus using an optimized nomogram developed after several years of research and retrospective analysis of clinical ***:This prospective longitudinal non-comparative clinical trial evaluated 88 eyes of 88 patients(age 18-62 y)with keratoconus diagnosis from two Spanish *** ring segment(AJL Ophthalmic)implantation was performed in all cases,using the mechanical procedure in 25 eyes(28.4%)and a femtosecond laser-assisted procedure in 63 eyes(71.6%).The ring segments implanted in each case were selected using a new optimized nomogram that considered variables such as anterior corneal asphericity and astigmatism or the discrepancy among astigmatism and coma ***,refractive,corneal topographic,aberrometric,and pachymetric changes after surgery were evaluated during a 3-month ***:The implants induced a significant refractive change as well as an improvement in uncorrected(UDVA)and corrected distance visual acuity(CDVA;P<0.001).Postoperative CDVA of 0.10 log MAR or better was achieved in 28.4%and 46.5%of eyes,*** eyes(2.3%)lost two or more lines of CDVA whereas a total of 53.5%of eyes gained lines of CDVA.A significant central anterior and posterior corneal flattening was induced(P≤0.003),with a significant reduction of anterior(P<0.001)and posterior corneal astigmatisms(P=0.048),and a change in anterior asphericity(P<0.001).Total primary coma(6 mm pupil)change was also statistically significant(preoperative 3.66±3.04μm vs postoperative 2.33±2.26μm,P<0.001).No significant differences were found in the effect of ring segments between cases implanted using the mechanical and femtosecond techniques(P≥0.101).CONCLUSION:The implantation of Ferrara rings based on the nomogram evaluated is safe and effective for promoting a visual rehabilitation in keratoconus,with a relevant control of primary coma aberration.

关键词： intracorneal ring segment Ferrara ring segment femtosecond keratoconus coma aberration

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1798-1804页

作者： Min Wu De-Xuan Kuang Ya-Qi Huang Yu-Run Miao Xiao-Cheng Liu Jie-Jie Dai Department of Ophthalmology Yunnan Key Laboratory for prevention and treatment of eye diseases Yunnan Innovation Team for Cataract and Ocular fundus Disease(2017HC010)Yunnan Eye Institutethe 2^nd People’s Hospital of Yunnan Province(Yunnan Eye Hospitalthe 4 Afiliated Hospital of Kunming Medical University)Kunming 650021Yunnan ProvinceChina Center of Tree Shrew Germ plasm Resources Institute of Medical BiologyChinese Academy of Medical Science and Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research and Development on Severe Infectious DiseasesYunnan Innovation Team of Standardization andApplication Research in Tree ShrewKunming 650118Yunnan ProvinceChina

AIM：To determine the impact of age on the morphology of endothelial cells and central corneal thickness（CCT） in Chinese tree ***：One-hundred and twenty eyes of 60 healthy Chinese tree shrews were *** on age,the tree shrews were divided into four *** general anesthesia,the images of endothelium were acquired using non-contact specular microscope Topcon 3000 *** parameters of corneal endothelial cells were measured by built-in software,including CCT,endothelial cell density（ECD）,percent hexagonality（HG%）,coeffi cient of variability（CV）,size of minimal cell（Smin）,size of maximal cell（Smax）,average cells size（Savg） and size standard deviation（Ssd）.Data were analyzed using STATA *** differences of eight parameters among groups and correlations with age were ***：In all studied animals,the average CCT was 2 4 9.6 ± 2 .29 μ m（202-301 μm）,ECD was 308 0.72 ± 460.76 cells/mm^2（1239.6-4047.6 cells/mm^2） and CV was 29.10±7.60（13.6-54.6）.CV was significantly different among different groups（P〈0.001）.Strong correlation with age was found in ECD,Smax,Savg,Ssd and ***：Cornea of Chinese tree shrews had half CCT of human cornea and similar ECD,CV and size of corneal endothelial *** adult tree shrews had higher ECD,HG% and low ***,Smax,Savg,Ssd and CV correlated with age signifi cantly.

关键词： comea endothelial cells Chinese tree shrew( Tupaia belangeri chinensis) specular microscope age

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