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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Gut microbiota-derived short chain fatty acids are potential mediators in gut inflammation

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animal Nutrition 2022年第1期8卷 350-360页

作者： Muhammad Akhtar Yan Chen Ziyu Ma Xiaolong Zhang Deshi Shi Jawaria AKhan Huazhen Liu Department of Basic veterinary medicine College of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Department of Preventive veterinary medicine College of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Department of veterinary medicine Faculty of Veterinary ScienceUniversity of Veterinary and Animal SciencesLahore54000Pakistan

Gut inflammation is a challenging concern in humans and animals,which disturbs normal growth and leads to severe bowel *** chain fatty acids(SCFA)are the gut microbiota metabolites produced from fermentation of non-digestible carbohydrates,and have been reported to modulate gut *** have been implicated as the potential therapeutic bioactive molecules for gut inflammatory diseases,and could be an alternative to antibiotic growth promoters(AGP).In this review,the existing knowledge about the types of SCFA,the related gut microbes producing SCFA,the roles of SCFA in maintaining gut homeostasis,and how SCFA modulate gut inflammation is *** therapeutic application of SCFA in the treatment of inflammatory bowel disease(IBD)is also highlighted

关键词： Gut microbiota Short chain fatty acid Gut inflammation Gut homeostasis Inflammatory bowel disease

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Direct-fed microbes: A tool for improving the utilization of low quality roughages in ruminants

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Journal of Integrative Agriculture 2015年第3期14卷 526-533页

作者： Mona M Y Elghandour Abdelfattah Z M Salem Jose S Martínez Castaeda Luis M Camacho Ahmed E Kholif Juan C Vázquez Chagoyán Faculty of veterinary medicine and animal science Autonomous University of the State of Mexico Faculty of veterinary medicine and animal science Autonomous University of Guerrero Dairy science Department National Research Centre

For many years, ruminant nutritionists and microbiologists have been interested in manipulating the microbial ecosystem of the rumen to improve production efficiency of different ruminant species. Removal and restriction of antibiotics subtherapeutic uses from ruminant diets has amplified interest in improving nutrient utilization and animal performance and search for more safe alternatives. Some bacterial and fungal microorganisms as a direct-fed microbial（DFM） can be the most suitable solutions. Microorganisms that are commonly used in DFM for ruminants may be classified mainly as lactic acid producing bacteria（LAB）, lactic acid utilizing bacteria（LUB）, or other microorganism＇s species like Lactobacillus, Bifidobacterium, Enterococcus, Streptococcus, Bacillus, Propionibacterium, Megasphaera elsdenii and Prevotellabryantii, in addition to some fungal species of yeast such as Saccharomyces and Aspergillus. A definitive mode of action for bacterial or fungal DFM has not been established; although a variety of mechanisms have been suggested. Bacterial DFM potentially moderate rumen conditions, and improve weight gain and feed efficiency. Fungal DFM may reduce harmful oxygen from the rumen, prevent excess lactate production, increase feed digestibility, and alter rumen fermentation patterns. DFM may also compete with and inhibit the growth of pathogens, immune system modulation, and modulate microbial balance in the gastrointestinal tract. Improved dry matter intake, milk yield, fat corrected milk yield and milk fat content were obtained with DFM administration. However, the response to DFM is not constant; depending on dosages, feeding times and frequencies, and strains of DFM. Nonetheless, recent studies have supported the positive effects of DFM on ruminant performance.

关键词： direct-fed microbial(DFM) mode of action ruminants

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Genome-wide association study for rib eye muscle area in a Large White×Minzhu F_2 pig resource population

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Journal of Integrative Agriculture 2015年第12期14卷 2590-2597页

作者： GUO Yun-yan ZHANG Long-chao WANG Li-xian LIU Wen-zhong College of animal science and veterinary medicine Shanxi Agricultural University Institute of animal science Chinese Academy of Agricultural Sciences

Rib eye muscle area（REMA） is an economically important trait and one of the main selection criteria for breeding in the swine industry. In the genome-wide association study（GWAS）, the Illumina Porcine SNP60 Bead Chip containing 62 163 single nucleotide polymorphisms（SNPs） was used to genotype 557 pigs from a porcine Large White×Minzhu intercross population. The REMA（at the 5th–6th, 10th–11th and the last ribs） was measured after slaughtered at the age of（240±7） d for each animal. Association tests between REMA trait and SNPs were performed via the Genome-Wide Rapid Association using the Mixed Model and Regression-Genomic Control（GRAMMAR-GC） approach. From the Ensembl porcine database, SNP annotation was implemented using Sus scrofa Build 10.2. Thirty-three SNPs on SSC12 and 3 SNPs on SSC2 showed significant association with REMA at the last rib at the chromosome-wide significance level. None of the SNPs of REMA at the 5th–6th rib and only a few numbers of the SNPs of REMA at the 10th–11th ribs were found in this study. The Haploview V3.31 program and the *** R package were used to detect and visualize haplotype blocks and to analyze the association of the detected haplotype blocks with REMA at the last rib. A linkage analysis revealed that 4 haplotype blocks contained 4, 4, 2, and 4 SNPs, respectively. Annotations from pig reference genome suggested 2 genes（NOS2, NLK） in block 1（266 kb）, one gene（TMIGD1） in block 2（348 kb）, and one gene（MAP2K4） in block 3（453 kb）. A functional analysis indicated that MYH3 and MYH13 genes are the potential genes controlling REMA at the last rib. We screened several candidate intervals and genes based on the SNPs location and the gene function, and inferred that NOS2 and NLK genes maybe the main genes of REMA at the last ribs.

关键词： genome-wide association study rib eye muscle area pig SNP

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Expression of Recombinant Human Lysozyme-tachyplesin I(hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity

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Biomedical and Environmental sciences 2013年第4期26卷 319-322页

作者： GAO Yu ZHAO Hong Lei FENG Xin ZHAI Rui Dong ZHU Seng DU Chong Tao SUN Chang Jiang LEI Lian Cheng College of animal science and veterinary medicine Jilin University

Antimicrobial peptides （AMPs） are making headlines in science because they demonstrate superior microbicidal characteristics compared to synthetic and semi-synthetic antibiotics.

关键词： Design hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity Expression of Recombinant Human Lysozyme-tachyplesin I TP

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Sequence analysis for the complete proviral genome of reticuloendotheliosis virus Chinese strain HA9901

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science China(Life sciences) 2006年第2期49卷 149-157页

作者： WANG Yu CUI Zhizhong JIANG Shijin College of animal science and veterinary medicine Shandong Agricultural University Taian 271018 China College of Animal Science and Veterinary Medicine Shandong Agricultural University Taian 271018 China College of Animal Science and Veterinary Medicine Shandong Agricultural University Taian 271018 China

The genomic DNA extracted from chicken embryo fibroblast (CEF) infected with a Chi-nese field isolate HA9901 of reticuloendotheliosis virus (REV) was used as the template to amplify the REV proviral genomic cDNA by PCR with 6 pairs of primers according to published sequences. Six overlapping fragments were amplified, cloned into the TA vector and sequenced, including a fragment which was amplified from the circular proviral cDNA and covering both 5′- and 3′-ends. The complete sequence of the whole genome was established and analyzed with a DNAstar software. Comparisons of the sequence with two other strains demonstrated that the genomes of REV were relatively con-servative, the homogenecity for all genes or LTR fragments of the 3 strains was over 92%, no matter whether they were isolated from different species and regions in different years. But, the homology of Chinese strain HA9901 to a fowl pox virus-associated strain from Chickens was higher than that to strain SNV isolated from ducks.

关键词： reticuloendotheliosis virus, the genomic sequence, homology comparison.

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Sperm cryodamage occurs after rapid freezing phase:flow cytometry approach and antioxidant enzymes activity at different stages of cryopreservation

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Journal of animal science and Biotechnology 2016年第4期7卷 495-503页

作者： L.S.Castro T.R.S.Hamilton C.M.Mendes M.Nichi V.H.Barnabe J.A.Visintin M.E.O.A.Assumpcao laboratory of spermatozoa biology department of animal reproductionschool of veterinary medicine and animal scienceuniversity of sao pauloBrazil laboratory of in vitro fertilization cloning and animal transgenesisdepartment of animal reproductionschool of veterinary medicine and animal scienceuniversity of sao paulosao pauloBrazil laboratory of andrology.department of animal reproduction school of veterinary medicine and animal scienceuniversity of sao paulosao pauloBrazil

Background： In order to improve the efficiency of bovine sperm cryopreservation process, it is important to understand how spermatozoa respond to differences in temperature as well as the ability to recover its own metabolism. The combination between flow cytometry approach and antioxidant enzymes activity allows a more sensible evaluation of sperm cell during cryopreservation. The aim of this study was to evaluate sperm attributes and antioxidant enzymes activity during different stages of cryopreservation process. Semen samples from Holstein bulls （n = 4） were separated in 3 treatments： fresh （37 ℃）; cooled （5 ℃）; and thawed. Evaluation occurred at 0 h and 2 h after incubation. Membrane integrity, mitochondrial membrane potential （MMP） and DNA damages were evaluated by flow cytometry; activities of antioxidant enzymes such as catalase, superoxide dismutase and gluthatione peroxidase were measured by spectrofotometry. Results： There was an increase in the percentage of sperm with DNA damage in the thawed group, compared to fresh and cooled, and for 2 hs of incubation when compared to 0 h. Considering MMP, there was an increase in the percentage of cells with medium potential in thawed group when compared to fresh and cooled groups. Opposingly, a decrease was observed in the thawed group considering high mitochondrial potential. Also in the thawed group, there was an increase on cells with damaged acrosome and membrane when compared to fresh and cooled groups. Significant correlations were found between antioxidant enzymes activity and membrane or mitochondrial parameters. Conclusion： Based on our results, we conclude that cryopreservation affects cellular and DNA integrity and that the critical moment is when sperm cells are exposed to freezing temperature. Also, our study indicates that intracellular antioxidant machinery （SOD and GPX enzymes） is not enough to control cryodamage.

关键词： Bovine DNA integrity JC-1 Sperm viability

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Effects of exogenous enzymes, Lactobacillus acidophilus or their combination on feed performance response and carcass characteristics of rabbits fed sugarcane bagasse

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Journal of Integrative Agriculture 2015年第3期14卷 544-549页

作者： Nahla A Abdel-Aziz Mounir El-Adawy Maria A Mariezcurrena-Berasain Abdelfattah Z M Salem Jaime Olivares-Pérez Ahmed E Kholif Borhami E Borhami Department of animal and Fish Production Faculty of Agriculture Alexandria University Faculty of veterinary medicine and animal science Autonomous University of the State of Mexico Faculty of veterinary medicine and animal science Autonomous University of Guerrero Dairy science Department National Research Centre

The aim of this study was to evaluate the effect of Lactobacillus acidophilus（LAC）, exogenous enzymes of ZAD（exogenous enzyme preparation） or their combination on feed conversion, and dressing of rabbits fed different treatments of sugarcane bagasse（SCB）. Five rations were allotted randomly to five groups of New-Zealand White（NZW） rabbits（n=10） with initial live body weight of（838±42.4） g and 5 weeks of age. Rabbits were fed on diets with different sources of fiber as follows,（i） a control diet composed of 100% berseem hay and 0% SCB,（ii） 50% berseem hay and 50% untreated SCB（USCB）,（iii） 50% berseem hay and 50% SCB treated with L. acidophilus（LAC）,（iv） 50% berseem hay and 50% SCB treated with ZAD（ZAD）, and（v） 50% berseem hay and 50% SCB treated with a combination of LAC＋ZAD（LZ）. Treatments of SCB with L. acidophilus, ZAD and LAC＋ZAD had the highest feed conversion ratio than both USCB and control. The dressing percentage of rabbits that fed the LAC and LZ diets was higher（P〈0.05） compared with that in the other groups. Performance index（PI） for LAC group was improved（P〈0.05） compared to that for the other groups; however, PI for USCB group was the lowest（P〈0.05）. It could be concluded that treating SCB with L. acidophilus, exogenous enzymes of ZAD or their combination improved feed conversion and performance with more positive effects with L. acidophilus than the other treatments.

关键词： exogenous enzymes feed conversion Lactobacillus acidophilus rabbit sugarcane bagasse

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Perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle

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Journal of animal science and Biotechnology 2019年第1期10卷 56-66页

作者： Thiago Martins Guilherme Pugliesi Mariana Sponchiado Angela M.Gonella-Diaza Oscar A.Ojeda-Rojas Frederich D.Rodriguez Roney S.Ramos Andrea C.Basso Mario Binelli Department of animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo Department of Nutrition and animal Production School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo University Corporation of Huila ABS Global In Vitro Brasil Department of animal sciences University of Florida

Background: A major,unresolved issue is how the uterine microenvironment determines pregnancy success in *** implantation,conceptus development depends on the uterine secretome(i.e.,histotroph).Despite its pivotal role,little is known about the dynamics of histotroph synthesis and changes in composition throughout the early diestrus and the relevance to pregnancy *** hypothesize that disturbances on histotroph composition affect the establishment of *** was to disturb histotroph composition at early diestrus and verify the effects on:(Exp.1) timing to restore its composition; and(Exp.2) pregnancy rate after multiple-embryo *** cycle of multiparous Nelore cows were synchronized and estrus was considered d 0(D0) of the *** was through flushing each uterine horn with 30 m L of DMPBS and collecting the resulting uterine luminal flushing(ULF) on D1; D4; D7; D1 + D4 + *** group remained *** Exp.1,ULF was collected on D7.5 from all animals and used for quantification of total protein concentration and abundance of *** Exp.2,three in vitro-produced embryos were transferred to the uterine horn ipsilateral to the ovary containing the CL on D7.5 and pregnancy was checked on D25 by ***: In Exp.1,ULF collection on D4 or D7 increased(1.5-to 2.2-folds) the total protein concentration and albumin *** collection on D1 did not alter(P > 0.10) these *** Exp.2,ULF collected on D4 or D7 decreased pregnancy rates to approximately half of that measured in the remaining ***: Subtle perturbations imposed to the native intrauterine milieu,such as those caused by a single,low-volume collection of ULF,profoundly disturbs intrauterine composition and pregnancy *** least 4 d were necessary for the uterus to recover its composition and the functional capacity to carry post-implantation gestation.

关键词： Albumin Embryo Histotroph Protein

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Two new phenylethanoid glycosides and a new secoiridoid glycoside from the roots of Picrorhiza scrophulariiflora

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Chinese Chemical Letters 2010年第9期21卷 1103-1106页

作者： Lian Chun Zou Zhi Hui Yan Tong Fei Zhu Hua Xiang Da Cheng Wang Xu Ming Deng collegeof animal science and veterinary medicine Jilin University Changchun 130062 China Teaching Center of Basic Courses Jilin University Changchun 130062 China Chongqing Medical and Pharmaceutical College Chongqing 400030 China

Two new phenylethanoid glycosides,named scroside H（1）,scroside I（2）,and a new secoiridoid glycoside,named picrogentioside I（3）,have been isolated from the underground parts of Picrorhiza *** structures were eluc... 详细信息

关键词： Picrorhiza scrophulariiflora Phenylethanoid glycoside Secoiridoid glycoside

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