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Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 233-243页

作者： Hongmin LU Tiantian GUO Yue ZHANG Dewang LIU Lulu HOU Chengxue MA Mingwei XING college of wildlife and Protected Area Northeast Forestry UniversityHarbin 150040China

Microplastics(MPs)have attracted growing attention worldwide as an increasingly prevalent environmental *** addition,chicken meat is currently the most widely consumed kind of poultry in the global *** demand for chicken is on the rise both at home and *** a result,the safety of chicken raising has also received significant *** lungs play an essential role in the physiological activities of chickens,and they are also the most vulnerable *** injury is difficult to repair after the accumulation of contaminants,and the mortality rate is high,which brings huge economic losses to *** research on the toxicity of MPs has mainly focused on the marine ecosystem,while the mechanisms of toxicity and lung damage in chickens have been poorly ***,this study explored the effects of exposure to polystyrene microplastics(PS-MPs)at various concentrations for 42 d on chicken ***-MPs could cause lung pathologies and ultrastructural abnormalities,such as endoplasmic reticulum(ER)swelling,inflammatory cell infiltration,chromatin agglutination,and plasma membrane ***,PS-MPs increased the expression of genes related to the heat shock protein family(Hsp60,Hsp70,and Hsp90),ER stress signaling(activating) transcription factor 6(ATF0),ATF4,protein kinase RNA-like ER kinase(PERK),and eukaryotic translation initiation factor 2 subunitα(eIF2a),pyroptosis-related genes(NOD)-,LRR-and pyrin domain-containing protein 3(NLRP3),apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),interleukin-1β(IL-1β),cysteinyl aspartate-specific proteinase 1(Caspasel),and gasdermin-D(GSDMD),and the inflammatory signaling pathway(nuclear factor-kB(NF-kB),inducible nitric oxide synthase(iNOS),and cyclooxygenase-2(COX-2).The above results showed that PS-MP exposure could result in lung stress,ER stress,pyroptosis,and inflammation in *** findings provide new scientific clues for further research o

关键词： Polystyrene microplastics Endoplasmic reticulum stress Lung NLRP3 inflammasome Inflammation

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HPLC Fingerprint Combined with Chemometrics and Network Pharmacology for Q-Markers Prediction Analysis of Saposhnikovia divaricata

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Journal of Analysis and Testing 2024年第1期8卷 83-94页

作者： Renguo Zhang Xinjian Liu Tong Wang Jie Yu Mengyuan Wang Jianmin Sun Xueling Yu Na Niu Ligang Chen college of Chemistry Chemical Engineering and Resource UtilizationKey Laboratory of Forest Plant EcologyNortheast Forestry UniversityHarbin 150040China

Saposhnikovia divaricata(SD)has high medicinal and edible value,but relatively little research has been done on its qual-ity markers(Q-markers).To further clarify the Q-markers of SD with their corresponding pharmacodynamic *** this experiment,14 batches of SD were identified and screened for Q-marker candidate components using a combination of HPLC fingerprint with similarity analysis,principal component analysis,hierarchical cluster analysis,and partial least squares discriminant ***,network pharmacology was used to predict Q-markers and core *** results showed that 5-O-methylvisammioside,cimifugin,and prim-O-glucosylcimifugin could be used as Q-markers of SD;while,MAPK1,MAPK3,PIK3CA,JUN,and MAPK8 were the core targets of SD for drug *** further evaluate the bind-ing efficiency of Q-markers,molecular docking of the main active ingredients of SD to the core targets was *** results showed that the compounds bind well to their targets,and binding energies were all less than-5 kcal/*** Q-markers obtained from the screening were closely related to the core target genes,which could achieve therapeutic effects by modulating the relevant signaling *** study offers a reference for the establishment of a set of quality control evaluation system for SD potential Q-markers prediction analysis,and lays the foundation for elucidating the mechanism of actionunderlying itspharmacodynamic substance.

关键词： Saposhnikovia divaricata Q-markers Fingerprint Chemometrics Network pharmacology Molecular docking

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Rational molecular engineering towards efficient heterojunction solar cells based on organic molecular acceptors

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Chinese Physics B 2024年第6期33卷 575-587页

作者：张凯彦宋朋马凤才李源作 college of Materials Science and Engineering Northeast Forestry UniversityHarbin 150040China college of Science Northeast Forestry UniversityHarbin 150040China Department of Physics Liaoning UniversityShenyang 110036China

The selection of photoactive layer materials for organic solar cells(OSCs) is essential for the photoelectric conversion *** is well known that chlorophyll is an abundant pigment in nature and is extremely valuable for ***,there is little research on how to improve the efficiency of chlorophyll-based OSCs by matching chlorophyll derivatives with excellent non-fullerene acceptors to form *** in this study we utilize a chlorophyll derivative,Ce_(6)Me_(3),as a donor material and investigate the performance of its heterojunction with acceptor *** density functional theory,the photoelectric performances of acceptors,i ncluding the fullerene derivative PC_(71)BM and the terminal halogenated non-fullerene DTBCIC series,are compared in *** is found that DTBCIC-C1 has better planarity,light absorption,electron affinity,charge reorganization energy and charge mobility than ***_(6)Me_(3) has good energy level matching and absorption spectral complementarity with the investigated acceptor molecules and also shows good electron donor ***,the designed Ce_(6)Me_(3)/DTBCIC interfaces have improved charge separation and reorganization rates(K_(CS)/K_(CR)) compared with the Ce_(6)Me_(3)/PC_(71)BM *** research provides a theoretical basis for the design of photoactive layer materials for chlorophyll-based OSCs.

关键词： organic solar cells density functional theory chlorophyll derivative non-fullerene acceptors

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Multivariate chemical analysis:From sensors to sensor arrays

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Chinese Chemical Letters 2024年第7期35卷 14-24页

作者： Xueling Yu Lixing Fu Tong Wang Zhixin Liu Na Niu Ligang Chen college of Chemistry Chemical Engineering and Resource UtilizationKey Laboratory of Forest Plant EcologyNortheast Forestry UniversityHarbin 150040China

Chemical sensor arrays can obtain more comprehensive analyte information through high-dimensional *** is of great significance in the analysis of multi-component complex *** review summarizes the development and status of chemical sensor *** focused on the design of chemical sensor arrays based on various sensing *** addition,several pattern recognition methods in chemometrics are *** applications of chemical sensor arrays in food monitoring,medical diagnosis,and environmental monitoring are *** on the analysis of the limitations of current sensor array technology,the direction of the array is also *** review aims to help the broad readership understand the research state of chemical sensor arrays and their development prospects.

关键词： Chemical sensor arrays Sensing materials Pattern recognition methods Analytical application

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BACNN: Multi-scale feature fusion-based bilinear attention convolutional neural network for wood NIR classification

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Journal of forestry Research 2024年第4期35卷 202-214页

作者： Zihao Wan Hong Yang Jipan Xu Hongbo Mu Dawei Qi college of Science Northeast Forestry UniversityHarbin 150040People’s Republic of China

Effective development and utilization of wood resources is *** modification research has become an integral dimension of wood science research,however,the similarities between modified wood and original wood render it challenging for accurate identification and classification using conventional image classification ***,the development of efficient and accurate wood classification techniques is *** paper presents a one-dimensional,convolutional neural network(i.e.,BACNN)that combines near-infrared spectroscopy and deep learning techniques to classify poplar,tung,and balsa woods,and PVA,nano-silica-sol and PVA-nano silica sol modified woods of *** results show that BACNN achieves an accuracy of 99.3%on the test set,higher than the 52.9%of the BP neural network and 98.7%of Support Vector Machine compared with traditional machine learning methods and deep learning based methods;it is also higher than the 97.6%of LeNet,98.7%of AlexNet and 99.1%of ***,the classification method proposed offers potential applications in wood classification,especially with homogeneous modified wood,and it also provides a basis for subsequent wood properties studies.

关键词： Wood classification Near infrared spectroscopy Bilinear network SE module Anti-noise algorithm

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Three-dimensional forest foodscape in large herbivores’habitat based on UAV with LiDAR detection

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Integrative Zoology 2024年第2期19卷 343-346页

作者： Heng BAO Guangshun JIANG college of wildlife and Protected Area Northeast Forestry UniversityHarbinChina Feline Research Center of National forestry and Grassland Administration HarbinChina Research Center for northeast Asia Biodiversity Conservation HarbinChina

Traditionally,wildlife habitat research mainly extracts two-dimensional habitat ***,they live in three-dimensional space,and the three-dimensional structure of the forest ecosystem is an important factor affecting the composition of the mammal community(Fig.1a,b),and the three-dimensional structure of the forest also determines the behavior pattern of wildlife multidimensional habitat selection or use(Flaspohler et al.2010;Palminteri et al.2012;Müller et al.2014).For instance,forest structure determines the vertical distribution of annual edible shoots,fruits,or seed nuts resources in space,providing additional ecological niches for frugivores,rodents,and other species,and then leading to niche differentiation of wild animals in vertical space utilization,thus increasing species coexistence(*** et al.2023).

关键词： habitat forest dimensional

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Method for Detecting Industrial Defects in Intelligent Manufacturing Using Deep Learning

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Computers, Materials & Continua 2024年第1期78卷 1329-1343页

作者： Bowen Yu Chunli Xie college of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin150040China

With the advent of Industry 4.0,marked by a surge in intelligent manufacturing,advanced sensors embedded in smart factories now enable extensive data collection on equipment *** analysis of such data is pivotal for ensuring production safety,a critical factor in monitoring the health status of manufacturing *** defect detection techniques,typically limited to specific scenarios,often require manual feature extraction,leading to inefficiencies and limited versatility in the overall *** research presents an intelligent defect detection methodology that leverages deep learning techniques to automate feature extraction and defect localization *** proposed approach encompasses a suite of components:the high-level feature learning block(HLFLB),the multi-scale feature learning block(MSFLB),and a dynamic adaptive fusion block(DAFB),working in tandem to extract meticulously and synergistically aggregate defect-related characteristics across various scales and hierarchical *** have conducted validation of the proposed method using datasets derived from gearbox and bearing *** empirical outcomes underscore the superior defect detection capability of our *** demonstrates consistently high performance across diverse datasets and possesses the accuracy required to categorize defects,taking into account their specific locations and the extent of damage,proving the method’s effectiveness and reliability in identifying defects in industrial components.

关键词： Industrial defect detection deep learning intelligent manufacturing

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Single-atom photo-catalysts:Synthesis,characterization,and applications

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Nano Materials Science 2024年第3期6卷 284-304页

作者： Siqi Li Ziwang Kan He Wang Jiaxiao Bai Yunyi Liu Song Liu Yingjie Wu college of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin150040China School of Medicine and Health Harbin Institute of TechnologyHarbin150001China

Single-atom catalysts(SACs)are gaining popularity in catalytic reactions due to their nearly 100%atomic utilization and defined active sites,which provide great convenience for studying the catalytic mechanism of ***,SACs still present challenges such as complex formation processes,low loading and easy agglomeration of ***,we systematically discuss the synthesis methods for SACs,including coprecipitation,impregnation,atomic layer deposition,pyrolysis and Anti-Ostwald ripening *** techniques for characterizing single-atom catalysts(SACs)are described in *** utilization of individual atoms in various photocatalytic reactions and their mechanisms of action in different reactions are *** purpose of this review is to introduce single-atom synthesis methods,characterization techniques,specific catalytic action and their applications in the direction of photocatalysis,and to provide a reference for the industrialization of photocatalytic single-atoms,which is currently impossible,in the hope of promoting further development of photocatalytic single-atoms.

关键词： Photocatalysis Single atom Catalytic mechanism

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ChMYB1-ChbHLH42-ChTTG1 module regulates abscisic acidinduced anthocyanin biosynthesis in Cerasus humilis

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Horticultural Plant Journal 2024年第1期10卷 51-65页

作者： Xiaolong Ji Zhe Li Mingyu Zhang Shaoyu Lang Xingshun Song State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbinHeilongjiang 150040China Department of Genetics College of Life ScienceNortheast Forestry UniversityHarbinHeilongjiang 150040China

Cerasus humilis is a kind of economic fruit tree peculiar to China,which is widely used in the food,landscape,and pharmaceutical *** are a phenolic metabolite that plays an essential role in fruit ***,the regulatory network of *** in anthocyanin biosynthesis is still *** this study,the R2R3-MYB transcription factor ChMYB1 was isolated from the full genome of the *** one-hybrid,dual-luciferase assays,and GUS staining showed that ChMYB1 significantly increased anthocyanin contents in *** fruit by promoting the expression of ChCHS and ChUFGT by binding MBS(MYB-binding elements).ChMYB1 interacted with ChbHLH42and ChTTG1 to form the MBW complex and further enhanced the expression of *** addition,abscisic acid(ABA)treatment promoted the expression of ChMYB1 and anthocyanin accumulation in *** ***,ABA treatment enhanced the interaction between ChMYB1 and ***,ChABI5 inhibited the interaction between ChMYB1 and *** data elucidated the primary molecular mechanism of anthocyanin biosynthesis in *** fruit,deepening the understanding of the regulatory network affecting anthocyanin metabolism in edible fruit crops.

关键词： Cerasus humilis Anthocyanin ChMYB1 Fruit ABA

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Three-dimensional porous In_(2)O_(3) arrays for self-powered transparent solar-blind photodetectors with high responsivity and excellent spectral selectivity

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Nano Research 2024年第5期17卷 4471-4477页

作者： Nana Zhang Xinyu Gao Haoran Guan Simin Sun Jiaming Liu Zhitao Shao Qiyue Gao Yuan Zhang Ruyu Sun Guang Yang Feng Gao Wei Feng college of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040China Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025China

Transparent solar-blind ultraviolet photodetectors(SBUV PDs)have extensive applications in versatile scenarios,such as optical ***,it is still challenging to simultaneously achieve high responsivity,high transparency,and satisfying self-powered ***,we demonstrated high-performance,transparent,and self-powered photoelectrochemical-type(PEC)SBUV PDs based on vertically grown ultrathin In_(2)O_(3) nanosheet arrays(NAs)with a three-dimensional(3D)porous *** 3D porous structure simultaneously improves the transmittance in the visible light region,accelerates interfacial reaction kinetics,and promotes photogenerated carrier *** performance of In_(2)O_(3) NAs photoanodes exceeds most reported self-powered PEC SBUV PDs,exhibiting a high transmittance of approximately 80%in the visible light region,a high responsivity of 86.15 mA/W for 254 nm light irradiation,a fast response speed of 15/18 ms,and good multicycle *** In_(2)O_(3) NAs also show excellent spectral selectivity with an ultrahigh solar-blind rejection ratio of 1319.30,attributed to the quantum confinement effect induced by the ultrathin feature(2-3 nm).Furthermore,In_(2)O_(3) NAs photoanodes show good capability in underwater optical *** work demonstrated that a 3D porous structure is a powerful strategy to synchronously achieve high responsivity and transparency and provides a new perspective for designing high-performance,transparent,and self-powered PEC SBUV PDs.

关键词： In_(2)O_(3) three-dimensional porous transparent photoelectrochemical solar-blind photodetectors

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