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Molybdenum and cadmium co-induce necroptosis through Th1/Th2 imbalance-mediated endoplasmic reticulum stress in duck ovaries

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Journal of Environmental Sciences 2024年第8期142卷 92-102页

作者： Ting Cui Xueyan Dai Huiling Guo Dianyun Wang Bingyan Huang Wenjing Pu Xuesheng Chu Caiying Zhang Jiangxi Provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045China

Cadmium(Cd)and excess molybdenum(Mo)pose serious threats to animal *** previous study has determined that Cd and/or Mo exposure can cause ovarian damage of ducks,while the specific mechanism is still *** further investigate the toxic mechanism of Cd and Mo co-exposure in the ovary,forty 8-day-old female ducks were randomly allocated into four groups for 16 weeks,and the doses of Cd and Mo in basic diet per kg were as follows:control group,Mo group(100 mg Mo),Cd group(4 mg Cd),and Mo+Cd group(100 mg Mo+4 mg Cd).Cadmium sulfate 8/3-hydrate(CdSO_(4)·8/3H_(2)O)and hexaammonium molybdate((NH_(4))_(6)Mo_(7)O_(24)·4H_(2)O)were the origins of Cd and Mo,*** the 16th week of the experiment,all ovary tissues were collected for the detection of related *** data indicated that Mo and/or Cd induced trace element disorders and Th1/Th2 balance to divert toward Th1 in the ovary,which activated endoplasmic reticulum(ER)stress and then provoked necroptosis through triggering RIPK1/RIPK3/MLKL signaling pathway,and eventually caused ovarian pathological injuries and necroptosis *** alterations of above indicators were most apparent in the joint *** all,this research illustrates that Mo and/or Cd exposure can initiate necroptosis through Th1/Th2 imbalance-modulated ER stress in duck ovaries,and Mo and Cd combined exposure aggravates ovarian *** research explores the molecular mechanism of necroptosis caused by Mo and/or Cd,which reveals that ER stress attenuation may be a therapeutic target to alleviate necroptosis.

关键词： Molybdenum Cadmium Th1/Th2 imbalance Endoplasmic reticulum stress Necroptosis Ovary

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Cervical cancer prevention in China: where are we now, and what's next?

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Cancer Biology & Medicine 2024年第3期21卷 213-217页

作者： Huijiao Yan Qiankun Wang Youlin Qiao School of population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100730China Department of Cancer Epidemiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China

Cervical cancer(CC) epidemiology CC, the fourth most frequently diagnosed malignancy in women worldwide, is a major global health challenge, particularly in low-resource regions. Approximately 88.1% of the 604,000 CC new cases occurred in low-and middle-income countries in 2020, and more than 90% of the 342,000 CC deaths occurred in low-and middle-income countries in 2020~1.

关键词： prevention Cervical epidemiology

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DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice

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Genes & Diseases 2024年第4期11卷 368-380页

作者： Dafei Chai Xu Wang Praveen Neeli Shan Zhou Xingfang Yu Kanaga Sabapathy Yong Li Department of Medicine Section of Epidemiology and Population SciencesDan L Duncan Comprehensive Cancer CenterBaylor College of MedicineHoustonTX 77030USA Division of Cellular&Molecular Research Humphrey Oei Institute of Cancer ResearchNational Cancer Centre SingaporeSingapore 168583Singapore

tThe tumor suppressor p53 is the most common mutated gene in cancer,with the R175H as the most frequent p53 missense ***,there are currently no approved targeted therapies or immunotherapies against mutant ***,we characterized and inves-tigated a monoclonal antibody(mAb)that recognizes the mutant p53-R175H for its affinity,specificity,and activity against tumor cells in *** then delivered DNA plasmids expres-sing the anti-R175H mAb or a bispecific antibody(BsAb)into mice to evaluate their therapeutic *** results showed that the anti-R175H mAb specifically bound to the p53-R175H an-tigen with a high affinity and recognized the human mutant p53-R175H antigen expressed on HEK293T or MC38 cells,with no cross-reactivity with wild-type *** cultured cells,the anti-R175H mAb showed higher cytotoxicity than the control but did not induce antibody-dependent cellular *** made a recombinant MC38 mouse cell line(MC38-p53-R175H)that overexpressed the human p53-R175H after knocking out the endogenous mutant p53 *** vivo,administration of the anti-R175H mAb plasmid elicited a robust anti-tumor effect against MC38-p53-R175H in *** administration of the anti-R175H BsAb plasmid showed no therapeutic effects,yet potent anti-tumor activity was observed in combination with the anti-PD-1 *** results indicate that targeting specific mutant epitopes using DNA-delivered mAbs or BsAbs presents a form of improved natural immunity derived from tumor-infiltrating B cells and plasma cells against intracellular tumor antigens.

关键词： BsAb Cytotoxicity mAb Mutant p53 PD-1 R175H

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Coverage and determinants of infant postnatal care in Nigeria: A population-based cross-sectional study

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儿科学研究(英文) 2024年第1期08卷 27-36页

作者： Egbewale Bolaji Emmanuel Oyedeji Olusola Bump Jesse Sudfeld Christopher Robert Department of Global Health and population Takemi Program in International Health Harvard T. H. Chan School of Public Health Boston Massachusetts USA Department of Community Medicine College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Nigeria Department of Pediatrics and Child Health College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Nigeria

Importance: In 2019, Nigeria had the largest number of under-5 child deaths globally and many of these deaths occurred within the first week of life. The World Health Organization recommends infant postnatal care (PNC) attendance to support newborn survival; however, utilization of PNC is known to be low in many ***: This study examined coverage and individual-level determinants of infant PNC attendance in ***: Nigeria Demographic Health Survey (NDHS) 2018 data were used to evaluate infant PNC coverage and determinants. Infant PNC was defined as receipt of care within 2 days of birth. Children delivered up to 2 years before the 2018 NDHS were included. We examined predictors of infant PNC with modified Poisson regression models to estimate relative risks (RRs).Results: The national coverage of infant PNC was 37.3% (95% confidence interval [CI]: 35.8%–38.7%). Significant heterogeneity in PNC attendance existed at state and regional levels. Facility delivery was strongly associated with the uptake of PNC (RR: 6.07; 95% CI: 5.60–6.58). Greater maternal education, maternal employment, urban residence, female head of household, and greater wealth were also associated with an increased likelihood of PNC ***: The uptake of infant PNC is low and interventions are urgently needed to promote equity in access and increase demand for PNC in Nigeria.

关键词： Infant postnatal care Epidemiology Coverage Determinants Nigeria

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Quercetin Alleviates Lipopolysaccharide-Induced Cardiac Inflammation via Inhibiting Autophagy and Programmed Cell Death

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Biomedical and Environmental Sciences 2024年第1期37卷 54-70页

作者： YU Jin Hai HU Guo Liang GUO Xiao Quan CAO Hua Bin XIA Zhao Fei AMIN Buhe Jiangxi Provincial Key Laboratory for Animal Health Institute of Animal Population HealthCollege of Animal Science and TechnologyJiangxi Agricultural UniversityNanchang 330045JiangxiChina Internal Medicine Laboratory Department of Veterinary Clinical MedicineCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100091China Department of Cancer Surgery Beijing Shijitan Hospital Affiliated with Capital Medical UniversityBeijing 100038China

Objective The aim of this study is to explore the potential modulatory role of quercetin against Endotoxin or lipopolysaccharide(LPS)induced septic cardiac *** Specific pathogen-free chicken embryos(n=120)were allocated untreated control,phosphate buffer solution(PBS)vehicle,PBS with ethanol vehicle,LPS(500 ng/egg),LPS with quercetin treatment(10,20,or 40 nmol/egg,respectively),Quercetin groups(10,20,or 40 nmol/egg).Fifteenday-old embryonated eggs were inoculated with abovementioned solutions via the allantoic *** embryonic day 19,the hearts of the embryos were collected for histopathological examination,RNA extraction,real-time polymerase chain reaction,immunohistochemical investigations,and Western *** They demonstrated that the heart presented inflammatory responses after LPS *** LPS-induced higher mRNA expressions of inflammation-related factors(TLR4,TNFα,MYD88,NF-κB1,IFNγ,IL-1β,IL-8,IL-6,IL-10,p38,MMP3,and MMP9)were blocked by quercetin with three *** significantly decreased immunopositivity to TLR4 and MMP9 in the treatment group when compared with the LPS *** significantly decreased protein expressions of TLR4,IFNγ,MMP3,and MMP9 when compared with the LPS *** treatment prevented LPS-induced increase in the mRNA expression of Claudin 1 and ZO-1,and significantly decreased protein expression of claudin 1 when compared with the LPS *** significantly downregulated autophagyrelated gene expressions(PPARα,SGLT1,APOA4,AMPKα1,AMPKα2,ATG5,ATG7,Beclin-1,and LC3B)and programmed cell death(Fas,Bcl-2,CASP1,CASP12,CASP3,and RIPK1)after LPS *** significantly decreased immunopositivity to APOA4,AMPKα2,and LC3-II/LC3-I in the treatment group when compared with the LPS *** significantly decreased protein expressions of AMPKα1,LC3-I,and *** significantly decreased the protein expression to CASP1 and CASP3 by immunohistochemical investigation or

关键词： Quercetin Lipopolysaccharide Inflammation Autophagy Programmed cell death Myocardiocytes permeability

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Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action(EQIA)study:a national cohort study in China from 2017 to 2019

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Frontiers of Medicine 2024年第2期18卷 315-326页

作者： Wei Cheng Jieqing Chen Xudong Ma Jialu Sun Sifa Gao Ye Wang Longxiang Su Lu Wang Wei Du Huaiwu He Yujie Chen Zunzhu Li Qi Li Jianhua Sun Hongbo Luo Jinbang Liu Guangliang Shan Bing Du Yanhong Guo Dawei Liu Chang Yin Xiang Zhou on behalf of the China National Critical Care Quality Control Center-the ECMO quality improvement action(EQIA)study Department of Critical Care Medicine State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China Information Center Department/Department of Information Management State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical SciencesBeijing100730China Department of Medical Administration National Health Commission of the People’s Republic of ChinaBeijing100044China School of population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Department of Epidemiology and Biostatistics Institute of Basic Medicine SciencesChinese Academy of Medical Sciences(CAMS)&School of Basic MedicinePeking Union Medical CollegeBeijing100730China National Institute of Hospital Administration National Health Commission of the People’s Republic of ChinaBeijing100044China 不详

This cohort study was performed to explore the influence of intensive care unit(ICU)quality on in-hospital mortality of veno-venous(V-V)extracorporeal membrane oxygenation(ECMO)-supported patients in *** study involved all V-V ECMO-supported patients in 318 of 1700 tertiary hospitals from 2017 to 2019,using data from the National Clinical Improvement System and China National Critical Care Quality Control *** quality was assessed by quality control indicators and capacity *** the 2563 V-V ECMO-supported patients in 318 hospitals,a significant correlation was found between ECMO-related complications and *** reintubation rate within 48 hours after extubation and the total ICU mortality rate were independent risk factors for higher in-hospital mortality of V-V ECMO-supported patients(cutoff:1.5%and 7.0%;95%confidence interval:1.05–1.48 and 1.04–1.45;odds ratios:1.25 and 1.23;P=0.012 and P=0.015,respectively).Meanwhile,the V-V ECMO center volume was a protective factor(cutoff of≥50 cases within the 3-year study period;95%confidence interval:0.57–0.83,odds ratio:0.69,P=0.0001).The subgroup analysis of 864 patients in 11 high-volume centers further strengthened these ***,ICU quality may play an important role in improving the prognosis of V-V ECMO-supported patients.

关键词： veno-venous extracorporeal membrane oxygenation in-hospital mortality high-volume centers quality control intensive care unit capacity parameters

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A 12-month follow-up study of discharged patients with acute pancreatitis:An acute condition with prolonged sequela

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Chinese Medical Journal 2024年第2期137卷 250-252页

作者： Hanyue Ding Jiayuan Dai Jiaye Lin Liang Gong Han Sun Kai Song Feng Xie Dong Wu Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China School of population Medicine and Public Health Peking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China JC School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative RegionChina Emergency Department Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China Department of Health Research Methods Evidence and ImpactMcMaster UniversityHamiltonCanada Centre for Health Economics and Policy Analysis McMaster UniversityHamiltonCanada State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical ScienceBeijing 100730China Clinical Epidemiology Unit International Clinical Epidemiology NetworkBeijing 100730China

To the Editor:Acute pancreatitis(AP)is the most common gastrointestinal condition that leads to acute hospitalization.[1]The incidence of AP has increased in recent decades,with a current global incidence of 34/100,000,probably due to a rising trend of obesity and gallstone *** is associated with remarkable pain,reduced quality of life(QoL),and even death,thus posing a heavy socioeconomic *** addition,approximately 22%of AP patients experience recurrent AP(RAP)and 10%of AP patients progress to chronic pancreatitis.[2]Petrov and Yadav[3]have,therefore,argued that AP should not be considered as an acute and self-limiting *** and long-term care after AP have drawn widespread attention,which has improved patients’physical and mental health.

关键词： patients pancreatitis acute

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The meta-analyses on effectiveness and safety of colorectal cancer screening

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Chinese Medical Journal 2024年第12期137卷 1471-1473页

作者： Pei Li Xueyang Zeng Zuoxiang Liu Jichun Yang Yueying Li Le Gao Hongmei Zeng Lin Zhang Feng Sun Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Peking Union Medical college Beijing 100005China Centre for Safe Medication Practice and Research Department of Pharmacology and PharmacyLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China School of population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

To the Editor:The colorectal cancer(CRC)is the fourthmost common cause of cancer deaths in China that was treated as a public health threat,accounting for approximately 10%of all the cancer-caused mortalities each year.[1]It usually takes decades to develop from a polyp to full CRC,[2]which allows a time window for detecting precancerous lesions and taking early steps for preventions and treatments.

关键词： colorectal prevention cancer

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Prediction of liquid circulation flow rate in RH degasser:improvement of decarburization at low atmospheric pressure

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Journal of Iron and Steel Research(International) 2024年第7期31卷 1661-1667页

作者： Gu-jun Chen Sheng-ping He college of Materials Science and Engineering Yangtze Normal UniversityChongqing 400044China college of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The two-fluid model coupled with population balance model was used for simulating the gas-liquid flow in the Ruhrstahl-Heraeus(RH)*** predicted circulation flow rate was compared with that measured from a water model experiment to validate the mathematical ***,influence of snorkel immersion depth on liquid circulation flow rate was numerically investigated under an atmospheric pressure of 101 and 84 kPa,*** result indicates that the circulation flow rate of the RH degasser in the high-altitude area was severely reduced because of the decrease in atmospheric ***,increasing the snorkel immersion depth from 0.5 to 0.7 m can compensate for the decrease in atmospheric *** test result indicates that decarburization rate is significantly enhanced by increasing the snorkel immersion *** optimization,the percentage of heats with a final carbon content less than 0.002 wt.%is significantly increased from 22.0%to 96.4%.

关键词： RH degasser Two-fluid model population balance model-Circulation flow rate Decarburization Snorkel immersion depth

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Sex-specific impact on disease outcome and the mutational landscape in essential thrombocythemia:A retrospective cohort study

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Chinese Medical Journal 2024年第12期137卷 1495-1497页

作者： Jia Chen Huan Dong Yang Li Ting Sun Rongfeng Fu Xiaofan Liu Feng Xue Wei Liu Yunfei Chen Mankai Ju Xinyue Dai Ying Chi Wentian Wang Huiyuan Li Renchi Yang Lei Zhang State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin Key Laboratory of Gene Therapy for Blood DiseasesCAMS Key Laboratory of Gene Therapy for Blood DiseasesTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China School of population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

To the Editor:Male sex has been confirmed to be an independent risk factor for survival in patients with essential thrombocythemia(ET).[1,2]Sexual dimorphism significantly contributes to patient heterogeneity,and adopting a sex-informed perspective has emerged as a pioneering paradigm in the field of precision *** the spectrum of sex disparities among patients diagnosed with ET holds substantial scientific ***,sex influences the presentation,disease phenotypes,symptom expression,and clinical outcomes of classical Philadelphia chromosome-negative myeloproliferative neoplasm(MPN).[3,4]The objective of our study was to comprehensively elucidate the impact of sex on ET by exploring disease genotype and phenotype as well as clinical outcomes.

关键词： impact landscape holds

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