检索结果-南通市图书馆

Single atom site conjugated copper polyphthalocyanine assisted carbon nanotubes as cathode for reversible Li-CO_(2) batteries

引用

Nano Research 2022年第5期15卷 4100-4107页

作者： Yunyun Xu Cheng Jiang Hao Gong Hairong Xue Bin Gao Peng Li Kun Chang Xianli Huang Tao Wang Jianping He college of Materials science and Technology Jiangsu Key Laboratory of Electrochemical Energy Storage TechnologiesNanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Chemistry and Materials science College of ScienceNanjing Forestry UniversityNanjing 210037China

Recently,Li-CO_(2) battery has gradually become a research hotspot due to its high discharge capacity,energy density and environmental benefits.However,it has been an important problem for researchers because of its slow decomposition kinetics and difficult to generalize to practical application.Herein,we prepared copper polyphthalocyanine-carbon nanotubes composites(CuPPc-CNTs)by solvothermal in-situ polymerization of copper phthalocyanine on the surface of carbon nanotubes as cathode for reversible Li-CO_(2) batteries,which exhibits a high discharge capacity of 18,652.7 mAh·g^(-1) at current density of 100 mA·g^(-1),1.64 V polarization at 1,000 mA·g^(-1),and a stable cycles number of 160 is close to 1,630 h of charge-discharge process at 200 mA·g^(-1).Copper polyphthalocyanine has highly efficient copper single-atom catalytic sites with excellent CO_(2) adsorption and activation,while carbon nanotubes provide a conductive network.The synergistic effect of the two compounds enables it to have excellent catalytic activity.The density functional theory(DFT)calculation proved that the addition of copper polyphthalocyanine significantly improved the CO_(2) adsorption and activation process.This study provides an opportunity for the research of covalent organic polymers(COPs)single-atom catalyst in Li-CO_(2) battery field.

关键词： copper polyphthalocyanine carbon nanotubes CO_(2)adsorption reversible Li-CO_(2) batteries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effectively Modulating Oxygen Vacancies in Flower‑Likeδ‑MnO_(2)Nanostructures for Large Capacity and High‑Rate Zinc‑Ion Storage

引用

Nano-Micro Letters 2023年第12期15卷 49-67页

作者： Yiwei Wang Yuxiao Zhang Ge Gao Yawen Fan Ruoxin Wang Jie Feng Lina Yang Alan Meng Jian Zhao Zhenjiang Li college of Materials science and Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongPeople’s Republic of China college of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042ShandongPeople’s Republic of China

In recent years,manganese-based oxides as an advanced class of cathode materials for zinc-ion batteries(ZIBs)have attracted a great deal of attentions from numerous researchers.However,their slow reaction kinetics,limited active sites and poor electrical conductivity inevitably give rise to the severe performance degradation.To solve these problems,herein,we introduce abundant oxygen vacancies into the flower-likeδ-MnO_(2)nanostructure and effectively modulate the vacancy defects to reach the optimal level(δ-MnO_(2)-x-2.0).The smart design intrinsically tunes the electronic structure,guarantees ion chemisorption-desorption equilibrium and increases the electroactive sites,which not only effectively accelerates charge transfer rate during reaction processes,but also endows more redox reactions,as verified by first-principle calculations.These merits can help the fabricatedδ-MnO_(2)-x-2.0 cathode to present a large specific capacity of 551.8 mAh g^(-1) at 0.5 A g^(-1),high-rate capability of 262.2 mAh g^(-1) at 10 A g^(-1) and an excellent cycle lifespan(83%of capacity retention after 1500 cycles),which is far superior to those of the other metal compound cathodes.In addition,the charge/discharge mechanism of theδ-MnO_(2)-x-2.0 cathode has also been elaborated through ex situ techniques.This work opens up a new pathway for constructing the next-generation high-performance ZIBs cathode materials.

关键词： Znic-ion battery δ-MnO_(2)cathode materials Oxygen vacancy modulation Large specific capacity High-rate capability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Two Stream Fusion Assisted Deep Learning Framework for Stomach Diseases Classification

引用

Computers, Materials & Continua 2022年第11期73卷 4423-4439页

作者： Muhammad Shahid Amin Jamal Hussain Shah Mussarat Yasmin Ghulam Jillani Ansari Muhamamd Attique Khan Usman Tariq Ye Jin Kim Byoungchol Chang Department of Computer science COMSATS University IslamabadWah CampusPakistan Department of Information sciences University of Education Lahore(Multan Campus)Pakistan Department of Computer science HITEC University TaxilaPakistan college of Computer Engineering and sciences Prince Sattam bin Abdulaziz UniversityAl-KharjSaudi Arabia Department of Computer science Hanyang UniversitySeoul04763Korea Center for computational Social science Hanyang UniversitySeoul04763Korea

Due to rapid development in Artificial Intelligence(AI)and Deep Learning(DL),it is difficult to maintain the security and robustness of these techniques and algorithms due to emergence of novel term adversary sampling.Such technique is sensitive to these models.Thus,fake samples cause AI and DL model to produce diverse results.Adversarial attacks that successfully implemented in real world scenarios highlight their applicability even further.In this regard,minor modifications of input images cause“Adversarial Attacks”that altered the performance of competing attacks dramatically.Recently,such attacks and defensive strategies are gaining lot of attention by the machine learning and security researchers.Doctors use different kinds of technologies to examine the patient abnormalities including Wireless Capsule Endoscopy(WCE).However,using WCE it is very difficult for doctors to detect an abnormality within images since it takes enough time while inspection and deciding abnormality.As a result,it took weeks to generate patients test report,which is tiring and strenuous for them.Therefore,researchers come out with the solution to adopt computerized technologies,which are more suitable for the classification and detection of such abnormalities.As far as the classification is concern,the adversarial attacks generate problems in classified images.Now days,to handle this issue machine learning is mainstream defensive approach against adversarial attacks.Hence,this research exposes the attacks by altering the datasets with noise including salt and pepper and Fast Gradient Sign Method(FGSM)and then reflects that how machine learning algorithms work fine to handle these noises in order to avoid attacks.Results obtained on the WCE images which are vulnerable to adversarial attack are 96.30%accurate and prove that the proposed defensive model is robust when compared to competitive existing methods.

关键词： WCE images adversarial attacks FGSM noise salt and pepper noise feature fusion deep learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Concentrations and chemical forms of potentially toxic metals in road-deposited sediments from different zones of Hangzhou, China

引用

Journal of Environmental sciences 2009年第5期21卷 625-631页

作者： ZHANG Mingkui WANG Hao Department of natural Resource science College of Natural Resource and Environmental Sciences Zhejiang University Hangzhou 310029 China Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition Hangzhou 310029 China

The 25 road-deposited sediments were collected from five different land-use zones （industrial, residential, commercial, park, and countryside） in Hangzhou, China. The concentrations of metals （Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, and Zn） in these samples were determined using ICP-AES after digestion with the mixture of HNO3-HF-HC1 （aqua regia）, and chemically fractionated according to the modified BCR （the European Community Bureau of Reference） sequential extraction procedure. The high metal concentration levels were detected in the sample from industrial zone and commercial zone having heavy traffic. While the low metal levels were noted in the street dust sample from residential zone, park, and countryside zone. The mobility sequence based on the sum of the BCR sequential extraction stages was： Zn （80.28%）, Pb （78.68%）, Cd （77.66%）〉 Cu （73.34%）〉 Mn （67.92%）〉 Co （41.66%）〉 Ni （30.36%）〉 Cr （21.56%）, Fe （20.86%）. Correlation analysis and principal component analysis were applied to the data matrix to evaluate the analytical results and to identify the possible pollution sources of metals. Factor analysis showed that these areas were mainly contaminated by three sources, namely lithology, traffic, and industry.

关键词： heavy metals road-deposited sediment BCR sequential extraction multivariate analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Construction of Ultrathin Layered MXene-TiN Heterostructure Enabling Favorable Catalytic Ability for High-Areal-Capacity Lithium-Sulfur Batteries

引用

Nano-Micro Letters 2022年第11期14卷 324-340页

作者： Hao Wang Zhe Cui Shu-Ang He Jinqi Zhu Wei Luo Qian Liu Rujia Zou State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Physics College of ScienceDonghua UniversityShanghai 201620People’s Republic of China

Catalysis has been regarded as an effective strategy to mitigate sluggish reaction kinetics and serious shuttle effect of Li-S batteries.Herein,a spherical structure consists of ultrathin layered Ti_(3)C_(2)T_(x)-TiN heterostructures(MX-TiN)through in-situ nitridation method is reported.Through controllable nitridation,highly conductive TiN layer grew on the surface and close coupled with interior MXene to form unique 2D heterostructures.The ultrathin heterostructure with only several nanometers in thickness enables outstanding ability to shorten electrons diffusion distance during electrochemical reactions and enlarge active surface with abundant adsorptive and catalytic sites.Moreover,the(001)surface of TiN is dominated by metallic Ti-3d states,which ensures fast transmitting electrons from high conductive MX-TiN matrix and thus guarantees efficient catalytic performance.Calculations and experiments demonstrate that polysulfides are strongly immobilized on MX-TiN,meanwhile the bidirectional reaction kinetics are catalytically enhanced by reducing the conversion barrier between liquid LiPSs and solid Li_(2)S_(2)/Li_(2)S.As a result,the S/MX-TiN cathode achieves excellent long-term cyclability with extremely low-capacity fading rate of 0.022%over 1000 cycles and remarkable areal capacity of 8.27 mAh cm^(−2) at high sulfur loading and lean electrolytes.

关键词： Li-S batteries Ultrathin 2D structures Electrochemical catalysis MXenes Ti_(3)C_(2)T_(x)-TiN

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Global,regional and national burdens of bipolar disorders in adolescents and young adults:a trend analysis from 1990 to 2019

引用

General Psychiatry 2024年第1期37卷 122-132页

作者： Yunxi Zhong Yifan Chen Xiaoying Su Meiqi Wang Qixiu Li Ziming Shao Long Sun Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandongChina National Health Commission of China(NHC)Key Laboratory of Health Economics and Policy Research Shandong UniversityJinanShandongChina nstitute of Health and Elderly Care Shandong UniversityJinanShandongChina

Background Bipolar disorder is identified as a cause of severe damage to the physical,psychological and social functioning of adolescents and young adults.Aims The aim of this study is to ascertain the trends in the burden of bipolar disorder among individuals aged 10-24 years at global,regional and national levels from 1990 to 2019.Methods The data analysed in this study were from the Global Burden of Diseases 2019.The numbers,rates per 100000 population,average annual percentage changes(AAPCs)of incidence,prevalence and years lived with disability(YLDs)of bipolar disorder are reported at the global,regional and national levels among individuals aged 10-24 years.Global trends by age,sex and Social Development Index(SDI)were further analysed.Results Globally,the incidence of bipolar disorder among adolescents and young adults increased from 79.21 per 100000 population(95%uncertainty interval(Ul):58.13 to 105.15)in 1990 to 84.97 per 100000 population(95%Ul:61.73 to 113.46)in 2019,AAPC 0.24(95%confidence interval(Cl):0.22 to 0.26).In the past three decades,there has been an increase in incidence,prevalence and YLDs in both males and females.The largest increase in incidence between 1990 and 2019 was observed in those aged 20-24 years old from 51.76 per 100000 population(95%Ul:26.81 to 87.20)in 1990 to 58.37 per 100000 population(95%UI:30.39 to 98.55)in 2019;AAPC 0.42(95%Cl:0.38 to 0.47).By the SDI quintile,the largest increase in incidence was observed in the middle SDl;however,the high SDI countries had the highest incidence.Regionally,the largest increase in incidence was observed in southern Latin America.At the national level,the most pronounced increase in the incidence was in Greenland.Conclusions The global increase in incidence among adolescents and young adults between 1990 and 2019 indicates that strategies to improve their mental health still need to be emphasised.

关键词： adolescent bipolar young

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polymyxin resistance caused by large-scale genomic inversion due to IS26 intramolecular translocation in Klebsiella pneumoniae

引用

药学学报:英文版 2023年第9期13卷 3678-3693页

作者： Haibin Li Lang Sun Han Qiao Zongti Sun Penghe Wang Chunyang Xie Xinxin Hu Tongying Nie Xinyi Yang Guoqing Li Youwen Zhang Xiukun Wang Zhuorong Li Jiandong Jiang Congran Li Xuefu You Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Bioactive Substance and Function of natural Medicines Institute of Materia MedicaChinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100050China

Polymyxin B and polymyxin E(colistin)are presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales,Acinetobacter baumannii,and Klebsiella pneumoniae.Yet resistance to this last-line drugs is a major public health threat and is rapidly increasing.Polymyxin S2(S2)is a polymyxin B analogue previously synthesized in our institute with obviously high antibacterial activity and lower toxicity than polymyxin B and colistin.To predict the possible resistant mechanism of S2for wide clinical application,we experimentally induced bacterial resistant mutants and studied the preliminary resistance mechanisms.Mut-S,a resistant mutant of K.pneumoniae ATCC BAA-2146(Kpn2146)induced by S2,was analyzed by whole genome sequencing,transcriptomics,mass spectrometry and complementation experiment.Surprisingly,large-scale genomic inversion(LSGI)of approximately 1.1 Mbp in the chromosome caused by IS26mediated intramolecular transposition was found in Mut-S,which led to mgrB truncation,lipid A modification and hence S2resistance.The resistance can be complemented by plasmid carrying intact mgrB.The same mechanism was also found in polymyxin B and colistin induced drug-resistant mutants of Kpn2146(Mut-B and Mut-E,respectively).This is the first report of polymyxin resistance caused by IS26 intramolecular transposition mediated mgrB truncation in chromosome in K.pneumoniae.The findings broaden our scope of knowledge for polymyxin resistance and enriched our understanding of how bacteria can manage to survive in the presence of antibiotics.

关键词： Klebsiella pneumoniae Polymyxin resistance mgrB IS26 Whole genome sequencing Structural variation Inversion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Macrophage membrane-coated nanovesicles for dual-targeted drug delivery to inhibit tumor and induce macrophage polarization

引用

Bioactive Materials 2023年第5期23卷 69-79页

作者： Xin Huang Lutong Wang Haoyu Guo Weiyue Zhang Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Background:Immunosuppressive M2 macrophages in the tumor microenvironment(TME)can mediate the therapeutic resistance of tumors,and seriously affect the clinical efficacy and prognosis of tumor patients.This study aims to develop a novel drug delivery system for dual-targeting tumor and macrophages to inhibit tumor and induce macrophage polarization.Methods:The anti-tumor effects of methyltransferase like 14(METTL14)were investigated both in vitro and in vivo.The underlying mechanisms of METTL14 regulating macrophages were also explored in this study.We further constructed the cyclic(Arg-Gly-Asp)(cRGD)peptide modified macrophage membrane-coated nanovesicles to co-deliver METTL14 and the TLR4 agonist.Results:We found that METTL14 significantly inhibits the growth of tumor in vitro.METTL14 might downregulate TICAM2 and inhibit the Toll-like receptor 4(TLR4)pathway of macrophages,meanwhile,the combination of METTL14 and the TLR4 agonist could induce M1 polarization of macrophages.Macrophage membrane-coated nanovesicles are characterized by easy modification,drug loading,and dual-targeting tumor and macrophages,and cRGD modification can further enhance its targeting ability.It showed that the nanovesicles could improve the in vivo stability of METTL14,and dual-target tumor and macrophages to inhibit tumor and induce M1 polarization of macrophages.Conclusions:This study anticipates achieving the dual purposes of tumor inhibition and macrophage polarization,and providing a new therapeutic strategy for tumors.

关键词： Cell membrane-coated nanovesicles Targeted drug delivery system Tumor microenvironment Macrophage polarization Osteosarcoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Challenges and opportunities in Quaternary palynology

引用

science China Earth sciences 2024年第7期67卷 2148-2161页

作者： Qinghai XU Houyuan LU Zhuo ZHENG college of Geographical sciences Hebei Key Laboratory of Environmental Change and Ecological ConstructionHebei Normal UniversityShijiazhuang 050024China Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China School of Earth sciences and Engineering Sun Yat-sen UniversityZhuhai 519082China

Quaternary palynology plays a pivotal role in investigating global climate change and various other research fields,serving as an essential tool for the quantitative analysis of paleoenvironment changes.However,due to the vast diversity of terrestrial ecosystems and intricate interactions between vegetation,climate,and human activities,further advancements are required in the following aspects within this discipline.(1)The accuracy of classification in pollen morphology and fossil pollen identification needs improvement,particularly at the species level.This represents a significant challenge in present Quaternary palynology.Computer-aided intelligent recognition holds promise as a solution for species identification based on more detail pollen morphology.(2)Most pollen-based vegetation and climate reconstructions overlook the significance of bare ground.Neglecting bare ground can lead to substantial inaccuracies when quantitatively reconstructing past vegetation and climate.(3)While pollen records provide reliable information on paleoclimate changes,current quantitative climate reconstruction models heavily rely on modern pollen datasets derived from present-day vegetation disturbed more or less by human activities.This introduces bias and uncertainties into paleoclimate reconstruction.(4)Although pollen can serve as an indicator of human activities,accurately quantifying the intensity of human influence remains challenging.Improving accurate identification of crop pollen,reconstructing reliable land cover/use data,and integrating multidisciplinary data may enhance the identification and quantification of signals related to human activity in pollen records.

关键词： Quaternary palynology Paleoclimate Paleovegetation Human activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway

引用

science China Life sciences 2024年

作者： Ling Li Lei Lu Ziqi Xiao Jingyi Lv Hefeng Huang Bo Wu Tongjin Zhao Chengtao Li Weimin Wang Hongyan Wang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic Engineering Institute of Reproduction and Development and Children's Hospital Fudan University Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative Biology Fudan University Prenatal Diagnosis Center of Shenzhen Maternity & Child Healthcare Hospital Shanghai Medical college Fudan University Department of Pharmacy College of Life Sciences China Jiliang University

The BMP signaling pathway plays a crucial role in regulating early embryonic development and tissue homeostasis. SMAD6 encodes a negative regulator of BMP, and rare variants of SMAD6 are recurrently found in individuals with birth defects. However, we observed that a subset of rare pathogenic variants of SMAD6 consistently exhibited positive regulatory effects instead of the initial negative effects on the BMP signaling pathway. We sought to determine whether these SMAD6 variants have common pathogenic mechanisms. Here, we showed that pathogenic SMAD6 variants accompanying this functional reversal exhibit similar increases in deamidation. Mechanistically, increased deamidation of SMAD6 variants promotes the accumulation of the BMP receptor BMPR1A and the formation of new complexes, both of which lead to BMP signaling pathway activation. Specifically, two residues, N262 and N404, in SMAD6 were identified as the crucial sites of deamidation, which was catalyzed primarily by glutamine-fructose-6-phosphate transaminase 2(GFPT2). Additionally, treatment of cells harboring SMAD6 variants with a deamidase inhibitor restored the inhibitory effect of SMAD6 on the BMP signaling pathway. Conversely,when wild-type SMAD6 was manually simulated to mimic the deamidated state, the reversed function of activating BMP signaling was reproduced. Taken together, these findings show that deamidation of SMAD6 plays a crucial role in the functional reversal of BMP signaling activity, which can be induced by a subset of various SMAD6 variants. Our study reveals a common pathogenic mechanism shared by these variants and provides a potential strategy for preventing birth defects through deamidation regulation, which might prevent the off-target effects of gene editing.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：