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Journal of Rare Earths 2024年第7期42卷 1240-1249,I0002页

作者： Ziyao Wang Haitao Fu Xiufeng Zhan Bo Tong Guofeng Ma H.T.(Bert)Hintzen Institute of Innovative science and Technology Shenyang UniversityShenyang110044China college of Mechanical Engineering Shenyang UniversityShenyang110044China Faculty of applied sciences Delft University of Technology2629 JBDelftthe Netherlands

A novel Eu^(2+)-Eu^(3+)co-activated ratiometric thermo-sensitive phosphor was developed and synthesized by solid-state *** valence state of Eu,photoluminescence and thermo-sensitive performance of the phosphor prepared either in ambient air or carbothermally were investigated and *** phosphor shows high sensitivity(Sa=0.0173 K^(-1),S_(r)=0.461%/K)and superior signal discriminability(Δν∼10380 cm^(−1)).The thermo-sensitive performance is subject to the dual effects of different thermo-responses by Eu^(2+)versus Eu^(3+)combined with energy transfer from Eu^(2+)to Eu^(3+),so that the sensitivity of the phosphor in the temperature range presents a non-monotonic *** development of the BaAl_(2)B_(2)O_(7):Eu^(2+),Eu^(3+)phosphor is not only expected to be relevant for application in the field of temperature sensing,but also of reference significance for improving the sensitivity by means of energy transfer between co-activator ions over a wider temperature range of Eu^(2+)-Eu^(3+)co-activated ratiometric thermo-sensitive phosphors.

关键词： Photoluminescence Ratiometric thermo-response Phosphor Eu^(2+)/Eu^(3+) Rare earths

Learning Dual-Layer User Representation for Enhanced Item Recommendation

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Computers, Materials & Continua 2024年第7期80卷 949-971页

作者： Fuxi Zhu Jin Xie Mohammed Alshahrani applied Research Center of Artificial Intelligence Wuhan CollegeWuhan430212China college of Computer science South-Central MINZU UniversityWuhan430074China Unmanned.Company Riyadh11564Saudi Arabia

User representation learning is crucial for capturing different user preferences,but it is also critical challenging because user intentions are latent and dispersed in complex and different patterns of user-generated data,and thus cannot be measured ***-based data models can learn user representations by mining latent semantics,which is beneficial to enhancing the semantic function of user ***,these technologies only extract common features in historical records and cannot represent changes in user ***,sequential feature can express the user’s interests and intentions that change time by *** the sequential recommendation results based on the user representation of the item lack the interpretability of preference *** address these issues,we propose in this paper a novel model with Dual-Layer User Representation,named DLUR,where the user’s intention is learned based on two different layer ***,the latent semantic layer adds an interactive layer based on Transformer to extract keywords and key sentences in the text and serve as a basis for *** sequence layer uses the Transformer model to encode the user’s preference intention to clarify changes in the user’s ***,this dual-layer user mode is more comprehensive than a single text mode or sequence mode and can effectually improve the performance of *** extensive experiments on five benchmark datasets demonstrate DLUR’s performance over state-of-the-art recommendation *** addition,DLUR’s ability to explain recommendation results is also demonstrated through some specific cases.

关键词： User representation latent semantic sequential feature interpretability

A probabilistic model based on the peak-over-threshold approach for risk assessment of airport controllers’performance

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Journal of Safety science and Resilience 2024年第1期5卷 110-118页

作者： Lili Zu Yijie Lu Min Dong college of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing 211106China School of Engineering and applied science George Washington UniversityWashington DC 20052USA college of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Airport tower control plays an instrumental role in ensuring airport ***,obtaining objective,quantitative safety evaluations is challenging due to the unavailability of pertinent human operation *** study introduces a probabilistic model that combines aircraft dynamics and the peak-over-threshold(POT)approach to assess the safety performance of airport *** applied the POT approach to model reaction times extracted from a radiotelephony dataset via a voice event detection *** model couples the risks of tower control and aircraft operation to analyze the influence of human *** data from radiotele-phony communications and the Base of Aircraft Data(BADA)database,we compared risk levels across *** findings revealed heightened airport control risks under low demand(0.374)compared to typical conditions(0.197).Furthermore,the risks associated with coupling under low demand exceeded those under typical de-mand,with the final approach stage presenting the highest risk(4.929×107).Our model underscores the significance of human factors and the implications of mental disconnects between pilots and controllers for safety ***,these consistent findings affirm the reliability of our probabilistic model as an evaluative tool for evaluating the safety performance of airport tower *** results also illuminate the path toward quantitative real-time safety evaluations for airport controllers within the *** recommend that airport regulators focus on the performance of airport controllers,particularly during the final approach stage.

关键词： Safety evaluation Performance Probabilistic model Task demand Airport controller

Current research status of transarterial therapies for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3752-3760页

作者： Mao-Ting Zhou Peng Zhang Qi Mao Xiao-Qin Wei Lin Yang Xiao-Ming Zhang Department of Radiology Interventional Medical CenterScience and Technology Innovation CenterThe Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of medical Imaging North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

With continuous advancements in interventional radiology,considerable progress has been made in transarterial therapies for hepatocellular carcinoma(HCC)in recent years,and an increasing number of research papers on transarterial therapies for HCC have been *** this editorial,we comment on the article by Ma et al published in the recent issue of the World Journal of Gastrointestinal Oncology:“Efficacy and predictive factors of transarterial chemoembolization combined with lenvatinib plus programmed cell death protein-1 inhibition for unresectable HCC”.We focus specifically on the current research status and future directions of transarterial *** the future,more studies are needed to determine the optimal transarterial local treatment for *** the emergence of checkpoint immunotherapy modalities,it is expected that the results of trials of transarterial local therapy combined with systemic therapy will bring new hope to HCC patients.

关键词： Hepatocellular carcinoma Transarterial therapies Transarterial chemoembolization Hepatic artery infusion chemotherapy Transarterial embolization Transarterial radioembolization

Allosteric DNAzyme-based encoder for molecular information transfer

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Chinese Chemical Letters 2024年第7期35卷 235-241页

作者： Minghao Hu Tianci Xie Yuqiang Hu Longjie Li Ting Wang Tongbo Wu School of Pharmacy Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China GI Cancer Research Institute Tongji HospitalHuazhong University of Science and TechnologyWuhan 430030China School of Life science and Technology Wuhan Polytechnic UniversityWuhan 430023China State Key Laboratory of Bioelectronics National Demonstration Center for Experimental Biomedical Engineering EducationSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Dynamic DNA nanotechnology plays a significant role in nanomedicine and information science due to its high programmability based on Watson-Crick base pairing and nanoscale *** DNA machines and networks have been widely used in various fields,including molecular imaging,biosensors,drug delivery,information processing,and logic *** serve as crucial components for information compilation and transfer,allowing the conversion of information from diverse application scenarios into a format recognized and applied by DNA ***,there are only a few encoder designs with DNA ***,the molecular priority encoder is hardly *** this study,we introduce allosteric DNAzyme-based encoders for information *** design of the allosteric domain and the recognition arm allows the input and output to be independent of each other and freely *** pre-packaged mode design achieves uniformity of baseline dynamics and dynamics *** also integrated non-nucleic acid molecules into the encoder through the aptamer design of the allosteric ***,we developed the 2^(n)-n encoder and the EndoⅣ-assisted priority encoder inspired by immunoglobulin's molecular structure and effector *** our knowledge,the proposed encoder is the first enzyme-free DNA encoder with DNA output,and the priority encoder is the first molecular priority encoder in the DNA reaction *** encoders avoid complex operations on a single molecule,and their simple structure facilitates their application in complex DNA circuits and biological scenarios.

关键词： DNAzyme Encoder Nucleic acids DNA circuit DNA strand displacement Dynamic DNA nanotechnology

Harnessing innate immune pathways for therapeutic advancement in cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun Hao Lin Yuheng Liao Hui Yang Ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of medical Neurobiology and MOE Frontiers Center for Brain science and MOE Frontiers Center for Brain science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer

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World Journal of Gastroenterology 2024年第2期30卷 158-169页

作者： Yue-Hao Luo Zhe-Cheng Yan Jia-Ying Liu Xin-Yi Li Ming Yang Jun Fan Bo Huang Cheng-Gong Ma Xiao-Na Chang Xiu Nie Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Tumor budding(TB)has emerged as a promising independent prognostic biomarker in colorectal cancer(CRC).The prognostic role of TB has been extensively studied and currently affects clinical decision making in patients with stage I and II ***,existing prognostic studies on TB in stage III CRC have been confined to small retrospective cohort ***,this study investigated the correlation among TB categories,clinicopathological features,and prognosis in stage III-IV CRC to further enhance the precision and individualization of treatment through refined prognostic risk *** To analyze the relationship between TB categories and clinicopathological characteristics and assess their prognostic value in stage III-IV CRC to further refine the prognostic risk stratification of stage III-IV *** The clinical data of 547 CRC patients were collected for this retrospective *** at the front edge of the tumor buds was counted according to the 2016 International Tumor Budding Consensus Conference *** Multivariate Cox proportional hazards regression analysis demonstrated that chemotherapy(P=0.004),clinical stage IV(P<0.001),≥4 regional lymph node metastases(P=0.004),left-sided colonic cancer(P=0.040),and Bd 2-3(P=0.002)were independent prognostic factors in patients with stage III-IV ***,the density of tumor infiltrating lymphocytes was higher in Bd 1 than in Bd 2-3,both in the tumor stroma and its invasive *** TB has an independent predictive prognostic value in patients with stage III-IV *** is recommended to complete the TB report of stage III-IV CRC cases in the standardized pathological report to further refine risk stratification.

关键词： Tumor budding Tumor infiltrating lymphocytes Colorectal cancer Survival analysis Prognosis

Nodule Detection Using Local Binary Pattern Features to Enhance Diagnostic Decisions

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Computers, Materials & Continua 2024年第3期78卷 3377-3390页

作者： Umar Rashid Arfan Jaffar Muhammad Rashid Mohammed S.Alshuhri Sheeraz Akram Faculty of Computer science and Information Technology The Superior UniversityLahore54600Pakistan Intelligent Data Visual Computing Research(IDVCR) Lahore54600Pakistan Department of Computer science National University of TechnologyIslamabad45000Pakistan Department of Radiological sciences and medical Imaging College of AppliedMedical SciencesPrince Sattam Bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Information Systems Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh12571Saudi Arabia

Pulmonary nodules are small, round, or oval-shaped growths on the lungs. They can be benign (noncancerous) or malignant (cancerous). The size of a nodule can range from a few millimeters to a few centimeters in diameter. Nodules may be found during a chest X-ray or other imaging test for an unrelated health problem. In the proposed methodology pulmonary nodules can be classified into three stages. Firstly, a 2D histogram thresholding technique is used to identify volume segmentation. An ant colony optimization algorithm is used to determine the optimal threshold value. Secondly, geometrical features such as lines, arcs, extended arcs, and ellipses are used to detect oval shapes. Thirdly, Histogram Oriented Surface Normal Vector (HOSNV) feature descriptors can be used to identify nodules of different sizes and shapes by using a scaled and rotation-invariant texture description. Smart nodule classification was performed with the XGBoost classifier. The results are tested and validated using the Lung Image Consortium Database (LICD). The proposed method has a sensitivity of 98.49% for nodules sized 3–30 mm.

关键词： Pulmonary nodules segmentation histogram thresholding

Classification of complete 3-dimensional self-shrinkers in the Euclidean space R^(4)

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science China Mathematics 2024年第4期67卷 873-882页

作者： Qing-Ming Cheng Zhi Li Guoxin Wei Department of applied Mathematics Faculty of ScienceFukuoka UniversityFukuoka 814-0180Japan college of Mathematics and Information science Henan Normal UniversityXinxiang 453007China School of Mathematical sciences South China Normal UniversityGuangzhou 510631China

In this paper,we completely classify 3-dimensional complete self-shrinkers with the constant norm S of the second fundamental form and the constant f3in the Euclidean space R^(4),where hij’s are components of the sec... 详细信息

关键词： mean curvature ow self-shrinker the generalized maximum principle

Rapid progress of an iris metastasis from esophageal cancer:a case report and review of literature

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1557-1567页

作者： Meng Xie Xing-Hua Wang Jun-Jie Yang Zi-Xuan Su Jia-Hui Huang Peng-Cheng Li Fa-Gang Jiang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

This case report details a rare instance of rapid iris metastasis from esophageal cancer in a 59-year-old man.A literature review was conducted to explore recent advances in detecting,diagnosing,and treating intraocular metastatic *** emission tomographycomputed tomography played a crucial role in identifying primary sites and systemic *** treatment combined with systemic therapy effectively reduced tumor size,preserved useful vision,and improved the patient’s survival rate.A comparison was made of the characteristics of iris metastases from esophageal cancer and lung cancer,including age,gender,tumor characteristics,and *** challenges associated with diagnosis and treatment are discussed,highlighting the implications for clinical practice.

关键词： iris metastasis esophageal cancer positron emission tomography-computed tomography review