检索结果-南通市图书馆

Global Research Progress on Municipal Waste and Future Prospect Based on the Cross-national Comparisons

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Geographical science 2024年第2期34卷 250-264页

作者： ZHANG Yuxin LIU Xiaoqian YAN Xiaoxia MA Sike MAO Weiyun college of applied Arts and science of Beijing Union University Beijing 100191China

Due to the acceleration of urbanization,the municipal waste(MW)problem has transformed into a global challenge for urb-an *** elucidate historical trends,current focal points,and future directions in MW research,we conducted a bibliometric analysis and employed knowledge graph visualization to scrutinize a total of 34212 articles,which were published between 1991 and 2021 in the Web of science(WoS)core *** results indicated that current major research themes encompass waste classifica-tion and recycling,waste management and public behavior,waste disposal methods and technologies,as well as environmental impact and *** has been a shift in the research focus from the environmental impacts of waste incineration to sustainable manage-ment related issues.A comparison of research from six typical countries revealed the differences in research priorities and techniques *** from the USA and Britain initiated MW research earlier than other countries and investigated management issues in depth,such as public behavior and willingness to ***,Japanese,German,and Swedish scholars conducted extensive studies on advanced waste treatment technologies,such as disposal and recycling,risk assessment,and waste-to-energy *** scholars placed particular emphasis on end-of-pipe treatments and their associated environmental *** and poten-tial future frontiers were identified by burst detection *** with high value of burst index(BI)worldwide are food waste and circular *** scholars have put great efforts on waste environmental impact and its recycling technologies,while we’re expecting to further investigating vulnerable ***,this study contributes to bridging the regional gap of scientific research among different countries and fostering international collaboration.

关键词： bibliometrics municipal waste(MW) CiteSpace hotspot prediction burst index(BI) sustainability cross-national comparison Web of science(WoS)

Transcranial Magneto-Acoustic Stimulation Attenuates Synaptic Plasticity Impairment through the Activation of Piezo1 in Alzheimer’s Disease Mouse Model

在线全文

学校读者我要写书评

暂无评论

Research 2024年第1期2023卷 81-95页

作者： Fangxuan Chu Ruxin Tan Xin Wang Xiaoqing Zhou Ren Ma Xiaoxu Ma Ying Li Ruixu Liu Chunlan Zhang Xu Liu Tao Yin Zhipeng Liu Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Tianjin Institutes of Health science Tianjin301600China Neuroscience Center Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing100730China

The neuropathological features of Alzheimer’s disease include amyloid *** emerging evidence suggests that Piezo1,a mechanosensitive cation channel,plays a critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure,but the importance of Piezo1-mediated mechanotransduction in brain functions is less ***,apart from mechanical stimulation,Piezo1 channels are strongly modulated by *** assume that Piezo1 may play a role in converting mechanical and electrical signals,which could induce the phagocytosis and degradation of Aβ,and the combined effect of mechanical and electrical stimulation is superior to single mechanical ***,we design a transcranial magneto-acoustic stimulation(TMAS)system,based on transcranial ultrasound stimulation(TUS)within a magnetic field that combines a magnetoacoustic coupling effect electric field and the mechanical force of ultrasound,and applied it to test the above hypothesis in 5xFAD *** tests,in vivo electrophysiological recordings,Golgi–Cox staining,enzyme-linked immunosorbent assay,immunofluorescence,immunohistochemistry,real-time quantitative PCR,Western blotting,RNA sequencing,and cerebral blood flow monitoring were used to assess whether TMAS can alleviate the symptoms of AD mouse model by activating Piezo1.

关键词： stimulation Alzheimer Piezo1

Antimicrobial,antibiofilm,angiogenesis,anti-inflammatory,and wound healing activities of zinc nanoparticles green synthesized using Ferula macrecolea extract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 259-268页

作者： Sultan F.Alnomasy Department of medical Laboratories sciences College of Applied Medical SciencesShaqra UniversityAl-Quwayiyah 19257Saudi Arabia

Objective:To assess the antimicrobial,antibiofilm,anti-inflammatory,angiogenic,and wound healing activities of zinc nanoparticles(ZNPs)green synthesized using Ferula macrecolea ***:The green synthesis was conducted using the precipitation ***,the minimum inhibitory concentration(MIC),minimum bactericidal concentration(MBC),and minimum biofilm inhibition concentration 50%(MBIC50)of ZNPs against Staphylococcus aureus(***)and Pseudomonas aeruginosa(***)were *** effects of ZNPs on the gene expressions of Staphylococcus spp.[intracellular adhesion A(icaA)and D(icaD)]and ***(rhlI and rhlR)were investigated using quantitative real-time *** addition,the effects of ZNPs on wound healing,angiogenesis,and anti-inflammatory markers were ***:The green-synthesized ZNPs demonstrated significant antimicrobial efficacy against *** and *** biofilm formation in *** and *** was also inhibited by ZNPs with MBIC50 values of 3.30μg/mL and 2.08μg/mL,***,ZNPs downregulated the expression of biofilm-related genes icaA,icaD,rhlI,and rhlR in the tested *** also demonstrated promising in vitro wound healing effects by promoting fibroblast cell proliferation and wound closure in a dose-dependent manner.A significant increase in the expression of HLA-G5 and VEGF-A genes as well as a marked decrease in the expression of NF-κB,IL-1β,and TNF-αgenes were observed in cells treated with ZNPs compared to the control group(P<0.05).Conclusions:ZNPs display promising antibacterial effects against *** and *** and wound-healing effects by inhibiting biofilm formation,inducing angiogenesis,and reducing ***,further studies must be conducted to specify the accurate mechanisms of action and toxicity of ZNPs.

关键词： Wound healing Antibacterial Angiogenesis Nanomedicine Ferula macrecolea Inflammation

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 173-210页

作者： Md Entaz Bahar Hyun Joon Kim Deok Ryong Kim Department of Biochemistry and Convergence medical sciences and Institute of medical science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea Department of Anatomy and Convergence medical sciences and Institute of medical science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea

Metastatic dissemination of solid tumors,a leading cause of cancer-related mortality,underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis,chemoresistance,and the mechanistic backgrounds of individuals whose cancers are prone to *** most prevalent signaling cascade governed by multi-kinase inhibitors is the mitogen-activated protein kinase(MAPK)pathway,encompassing the RAS–RAF–MAPK kinase(MEK)–extracellular signal-related kinase(ERK)*** kinase is a primary mediator of the MAPK pathway,responsible for the sequential activation of downstream targets,such as MEK and the transcription factor ERK,which control numerous cellular and physiological processes,including organism development,cell cycle control,cell proliferation and differentiation,cell survival,and *** in this signaling cascade are associated with diseases such as *** inhibitors(RAFi)combined with MEK blockers represent an FDAapproved therapeutic strategy for numerous RAF-mutant cancers,including melanoma,non-small cell lung carcinoma,and thyroid ***,the development of therapy resistance by cancer cells remains an important ***,an intracellular lysosome-dependent catabolic recycling process,plays a critical role in the development of RAFi resistance in ***,targeting RAF and autophagy could be novel treatment strategies for RAF-mutant *** this review,we delve deeper into the mechanistic insights surrounding RAF kinase signaling in tumorigenesis and ***,we explore and discuss the ongoing development of next-generation RAF inhibitors with enhanced therapeutic ***,this review sheds light on the functional interplay between RAF-targeted therapies and autophagy in cancer.

关键词： RAF insight mechanism

Hybrid rogue waves and breather solutions on the double-periodic background for the Kundu-DNLS equation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第5期76卷 33-48页

作者： DongZhu Jiang Zhaqilao college of Mathematics science Inner Mongolia Normal UniversityHohhot 01022China Center for applied Mathematical science Inner MongoliaHohhot 010022China

In this paper,by using the Darboux transformation(DT)method and the Taylor expansion method,a new nth-order determinant of the hybrid rogue waves and breathers solution on the double-periodic background of the Kundu-DNLS equation is constructed when n is *** and rogue waves can be obtained from this determinant,*** to this,the hybrid rogue waves and breathers solutions on the different periodic backgrounds are given explicitly,including the single-periodic background,the double-periodic background and the plane wave background by selecting different *** addition,the form of the obtained solutions is summarized.

关键词： double-periodic background hybrid rogue waves and breather darboux transformation Kundu-DNLS equation

Impact of next-generation sequencing on antimicrobial treatment in immunocompromised adults with suspected infections

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2024年第2期15卷 105-110页

作者： Jia Li Jiazhen Luo Tao Hu Ling Cheng Weiwei Shang Li Yan Department of Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Emergency Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Tongji medical college Huazhong University of Science and TechnologyWuhan 430030China Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

BACKGROUND:Prompt pathogen identification can have a substantial impact on the optimization of antimicrobial *** objective of the study was to assess the diagnostic value of next-generation sequencing(NGS)for identifying pathogen and its clinical impact on antimicrobial intervention in immunocompromised patients with suspected ***:This was a retrospective *** January and August 2020,47 adult immunocompromised patients underwent NGS testing under the following clinical conditions:1)prolonged fever and negative conventional cultures;2)new-onset fever despite empiric antimicrobial treatment;and 3)afebrile with suspected infections on *** data,including conventional microbial test results and antimicrobial treatment before and after NGS,were *** were analyzed according to documented changes in antimicrobial treatment(escalated,no change,or deescalated)after the NGS ***:The median time from hospitalization to NGS sampling was 19 *** relevant pathogens were detected via NGS in 61.7% of patients(29/47),more than half of whom suffered from fungemia(n=17),resulting in an antimicrobial escalation in 53.2% of patients(25/47)and antimicrobial de-escalation in 0.2% of patients(1/47).Antimicrobial changes were mostly due to the identification of fastidious organisms such as Legionella,Pneumocystis jirovecii,and *** the remaining three cases,NGS detected clinically relevant pathogens also detected by conventional cultures a few days *** antimicrobial treatment was subsequently adjusted according to the susceptibility test ***,NGS changed antimicrobial management in 55.3%(26/47)of patients,and conventional culture detected clinically relevant pathogens in 14.9% of the patients(7/47).CONCLUSION:With its rapid identification and high sensitivity,NGS could be a promising tool for identifying relevant pathogens and enabling rapid appropriate treatment in immunocompromised patients w

关键词： Immunocompromised patients Next-generation sequencing Antimicrobial management

Assessment of tear film parameters post-treatment with commercial eyelid cleaning wipes:a pilot study

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第4期17卷 659-664页

作者： Amal Aldarwesh Ali Almustanyir Raied Fagehi Khalaf Alruways Abdulaziz Bin Turki Mansour Alghamdi Muteb Khalaf Alanazi Balsam Alabdulkader Wafa Alotaibi Mosaad Alhassan Department of Optometry College of Applied Medical SciencesKing Saud UniversityRiyadh 11433Saudi Arabia

AIM:To investigate the short-term effects of commercially available eyelid-cleaning wipes on film ***:This study enrolled 48 healthy participants aged 20-35y(both males and females).Clinical assessment included the Ocular Surface Disease Index(OSDI)questionnaire,non-invasive tear break-up time(NITBUT),tear meniscus height(TMH),and lipid layer pattern(LLP).Based on these initial results,participants were categorized as either non-dry eye or dry *** in each group were randomly allocated to either Blephaclean■or Systane■*** in NITBUT,TMH,and LLP levels before and after lid wipe treatment were ***:The dry eye group exhibited significantly higher OSDI scores and lower NITBUT and TMH levels than in the non-dry eye group(P0.05).Similarly,the LLP levels were significantly improved with Systane■(P<0.001)post-treatment compared to individuals in the non-dry eye ***,the dry eye subjects showed higher posttreatment LLP levels than the untreated group(P<0.02).CONCLUSION:The short-term effects of Systane®eyelid wipes on tear film parameters suggest their effectiveness in dry eye ***,further exploration of their long-term impact is essential to justify their cost effectiveness and efficacy in treating both aqueous deficiency and evaporative dryness.

关键词： dry eye lid wipes tear break-up time tear meniscus height

Effect of boundary slip on electroosmotic flow in a curved rectangular microchannel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第7期33卷 303-309页

作者：刘勇波 college of Mathematics science Inner Mongolia Normal UniversityHohhot 010022China Inner Mongolia Center for applied Mathematics Hohhot 010022China

The aim of this study is to numerically investigate the impact of boundary slip on electroosmotic flow(EOF) in curved rectangular microchannels. Navier slip boundary conditions were employed at the curved microchannel walls. The electric potential distribution was governed by the Poisson–Boltzmann equation, whereas the velocity distribution was determined by the Navier–Stokes equation. The finite-difference method was employed to solve these two equations. The detailed discussion focuses on the impact of the curvature ratio, electrokinetic width, aspect ratio and slip length on the velocity. The results indicate that the present problem is strongly dependent on these parameters. The results demonstrate that by varying the dimensionless slip length from 0.001 to 0.01 while maintaining a curvature ratio of 0.5 there is a twofold increase in the maximum velocity. Moreover, this increase becomes more pronounced at higher curvature ratios. In addition, the velocity difference between the inner and outer radial regions increases with increasing slip length. Therefore, the incorporation of the slip boundary condition results in an augmented velocity and a more non-uniform velocity distribution. The findings presented here offer valuable insights into the design and optimization of EOF performance in curved hydrophobic microchannels featuring rectangular cross-sections.

关键词： electroosmotic flow(EOF) curved rectangular microchannels slip boundary conditions

Semi-quantitative analysis of the structural evolution of mesophase pitch-based carbon foams by Raman and FTIR spectroscopy

在线全文

学校读者我要写书评

暂无评论

新型炭材料（中英文） 2024年第4期39卷 668-680页

作者： LIU Yue CHANG Sheng-kai SU Zhan-peng HUANG Zu-jian QIN Ji YANG Jian-xiao Hunan Province Key Laboratory for Advanced Carbon Materials and applied Technology College of Materials Science and EngineeringHunan UniversityChangsha410082China

Graphitized carbon foams(GFms)were prepared using mesophase pitch(MP)as a raw material by foaming(450℃),pre-oxidation(320℃),carbonization(1000℃)and graphitization(2800℃).The differences in structure and properties of GFms prepared from different MP precursors pretreated by ball milling or liquid phase extraction were investigated and compared,and semi-quantitative calculations were conducted on the Raman and FTIR spectra of samples at each preparation ***-quantitat-ive spectroscopic analysis provided detailed information on the structure and chemical composition changes of the MP and GFm de-rived from *** with microscopic observations,the change from precursor to GFm was *** results showed that ball milling concentrated the distribution of aromatic molecules in the pitch,which contributed to uniform foaming to give a GFm with a uniform pore distribution and good *** phase extraction helped remove light components while retaining large aromatics to form graphitic planes with the largest average size during post-treatment to produce a GFm with the highest degree of graphitization and the fewest open pores,giving the best compression resistance(2.47 MPa),the highest thermal conductivity(64.47 W/(m·K))and the lowest electrical resistance(13.02μΩ·m).Characterization combining semi-quantitative spectroscopic ana-lysis with microscopic observations allowed us to control the preparation of the MP-derived GFms.

关键词： Mesophase pitch Carbon foams Raman FTIR Graphitization