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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： Dan Ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged myelin sheaths(remyelination) often fails in MS, leading to neuronal loss and irreversible functional deficits.

关键词： myelin protective diseases

Identifying the priority areas for enhancing the ecosystem services in hilly and mountainous areas of southern China

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Journal of Mountain Science 2022年第2期19卷 338-349页

作者： TIAN Jia-ling PENG Yu HUANG Yi-hang BAI Ting LIU Lian-lin HE Xiao-ao LUO Shi-qian college of life&environmental sciences Minzu University of ChinaBeijing 100081China

Ecosystem services can be enhanced through ecological restoration,industrial structure adjustment,land-use optimization,and agricultural and forestry ecosystem *** ecosystem services in hilly and mountainous areas of southern China are crucially needed to be enhanced since these regions are important ecological functional zones in ***,due to its large area,it is not possible to simultaneously upgrade the ecosystem services for all areas,and therefore,priority areas need to be selected to individually upgrade the ecosystem service *** this study,via an approach of combining remote sensing,geographic information system,and spatial statistics,we identify the priority areas that need to be upgraded based on the analysis of ecological sensitivity,importance of ecosystem service function,and decreased degree in ecosystem *** five counties in hilly and mountainous areas of southern China,only less than 2% of the total area was identified as the first priority area;its land-use compositions were analyzed and recommendations on how to enhance ecosystem service were *** approach overcomes the conflict and contradiction issues associated with identifying priority areas in previous studies and solves the problems of high cost or difficult implementation of priority areas.

关键词： Ecosystem service function Priority area identification Mountainous areas Ecological sensitivity Ecological importance

Fabrication of Ce-ReS_(2)by Molten Salt for Electrochemical Hydrogen Evolution

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Transactions of Tianjin University 2022年第6期28卷 440-445页

作者： Ran Chen Minghai Ma Yi Luo Liping Qian Shunli Wan Shengyou Xu Xinsong She college of life&environmental sciences Huangshan UniversityHuangshan 245041China

Renewable and economical generation of hydrogen via electrochemical methods shows great potential in addressing the energy *** this study,an emerging molten salt method was adopted for the synthesis of a cerium-modifi ed rhenium disulfi de nanosheet for electrical hydrogen evolution *** prepared 1%Ce-doped rhenium disulfi de(ReS_(2))sample showed promoted hydrogen evolution performance in both acid and alkaline electrolytes compared to bare ReS_(2).Generating of abundant defects in ReS_(2)exposed more reaction active ***,adding cerium accelerated the hydrogen evolution ***,this work will off er new insight into developing ReS_(2)-based electrocatalysts for hydrogen evolution reactions.

关键词： Hydrogen Molten salt Ce-doped rhenium disulfi de Defects

Single-cell omics: experimental workflow, data analyses and applications

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Science China life sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song Jiang Congwen Zhu Ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina college of Earth and Planetary sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi Tan Chin-Tong Ong Temasek life sciences Laboratory National University of SingaporeSingapore Department of Biological sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

Postharvest quality and reactive oxygen species metabolism improvement of Coprinus comatus mushroom using allyl isothiocyanate fumigation

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Food Quality and Safety 2022年第4期6卷 466-474页

作者： Enping Zheng Zhihang Zheng Shiya Ren Huabin Zhou Hailong Yang college of life&environmental Science Wenzhou UniversityChashan University TownWenzhouChina

The aim of this study was to evaluate the effect of allyl isothiocyanate(AITC)on the reactive oxygen species(ROS)metabolism and quality of postharvest Coprinus comatus(***).Fresh mushrooms were stored at 4℃with AITC at 5,10,and 20μL/L for 18 d,*** was performed every 3 d,and physicochemical parameters and ROS metabolism related enzymes activities were *** with the control,the application of AITC at 10μL/L significantly(P<0.05)decreased xanthine oxidase activity after 9 d of storage,while it significantly(P<0.05)improved the activities of succinic dehydrogenase,glutathione reductase,peroxidase,catalase,and ascorbate peroxidase in the middle and later stages of ***,the Ca^(2+)-ATPase and superoxide dismutase activities in sample treated by 10μL/L were all significantly(P<0.05)higher than those in the ***,the accumulation trends of malondialdehyde and ROS were retarded and membrane integrity was ***,high-concentration AITC(20μL/L)treatment accelerated the ROS generation and increased electrolyte leakage *** AITC treatments significantly(P<0.05)inhibited the respiration rate during the first 9 d of storage and retarded browning of *** during the storage of 18 *** findings suggested that AITC treatment would be a promising method to maintain *** quality,but the concentrations need to be optimized.

关键词： Coprinus comatus allyl isothiocyanate postharvest reactive oxygen species metabolism

Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao Zhang Zhanyu Li Yijia Lei Baozeng Sun Xiaoyu Yu Zhe Wang college of Chemistry and life Science Changchun University of Technology college of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua Zhao Jiao Wang School of life sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical sciences Chinese Academy of Medical sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

Upper Yellow River air concentrations of organochlorine pesticides estimated from tree bark, and their relationship with socioeconomic indices

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Journal of environmental sciences 2014年第3期26卷 593-600页

作者： Chang He Jun Jin Bailin Xiang Ying Wang Zhaohui Ma college of life and environmental sciences Minzu University of China

Organochlorine pesticide （OCP） concentrations in tree bark from the upper Yellow River region were determined. Total OCP concentrations ranged from 2.7 to 82 ng/g dw, with a mean of 20 ng/g dw. Concentrations of total （E） DDTs （0.49-37 ng/g dw）, HCHs （0.55-4.5 ng/g dw）, and HCB （0.1-1.0 ng/g dw） were much higher than the other OCPs and accounted for 89% of the YOCP concentrations. p,p＇-DDT was the dominant member of the DDT pesticide group and [5-HCH was the dominant HCH isomer. The p,p＇-DDT/p,p＇-DDE and ct-HCH/y-HCH ratios suggested that there were recent DDT and y-HCH releases. OCP concentrations in the air were estimated from the tree bark, and the estimated median 3ZDDTs, EHCHs, and HCB concentrations in the air were 0.09, 0.14, and 0.024 pg/m3, respectively. The relationship between total OCP concentrations and socioeconomic and natural environment indices were assessed using multiple linear regression analysis, and a regression equation including all these factors was obtained. Population density and tertiary industry were the two dominant factors that appeared to affect OCP concentrations in the upper Yellow River region.

关键词： North-western China organohalogen willow vegetation atmosphere persistent organic pollutants (POPs)