检索结果-南通市图书馆

Glucose metabolism profile recorded by flash glucose monitoring system in patients with hypopituitarism during prednisone replacement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2023年第7期14卷 1112-1125页

作者： Min-Min Han Jia-Xin Zhang Zi-Ang Liu Lin-Xin Xu Tao Bai Chen-Yu Xiang Jin Zhang Dong-Qing Lv Yan-Fang Liu Yan-Hong Wei Bao-Feng Wu Yi Zhang Yun-Feng Liu Department of Endocrinology First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina The First Clinical Medical college of Shanxi Medical University Taiyuan 030000Shanxi ProvinceChina Department of general Medicine The Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030000Shanxi ProvinceChina Department of Pharmacology Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Commonly used glucocorticoids replacement regimens in patients with hypopituitarism have difficulty mimicking physiological cortisol rhythms and are usually accompanied by risks of over-treatment,with adverse effects on glucose *** associated with glucose metabolism are established risk factors of cardiovascular events,one of the life-threatening *** To investigate the glycometabolism profile in patients with hypopituitarism receiving prednisone(Pred)replacement,and to clarify the impacts of different Pred doses on glycometabolism and consequent adverse cardiovascular *** Twenty patients with hypopituitarism receiving Pred replacement[patient group(PG)]and 20 normal controls(NCs)were recruited.A flash glucose monitoring system was used to record continuous glucose levels during the day,which provided information on glucose-target-rate,glucose variability(GV),period glucose level,and hypoglycemia occurrence at certain *** β-cell function was also *** on the administered Pred dose per day,the PG was then regrouped into Pred>5 mg/d and Pred≤5 mg/d *** analysis was carried out between the PG and *** Significantly altered glucose metabolism profiles were identified in the *** includes significant reductions in glucose-target-rate and nocturnal glucose level,along with elevations in GV,hypoglycemia occurrence and postprandial glucose level,when compared with those in *** analysis indicated more significant glucose metabolism impairment in the Pred>5 mg/d group,including significantly decreased glucose-target-rate and nocturnal glucose level,along with increased GV,hypoglycemia occurrence,and postprandial glucose *** regard to islet β-cell function,PG showed significant difference in homeostasis model assessment(HOMA)-β compared with that of NCs;a notable difference in HOMA-βwas identified in Pred>5 mg/d group when compared with those of NCs;as for Pred

关键词： Hypopituitarism Prednisone Flash glucose monitoring system Glucose-target-rate Glucose variability Period glucose level

SARS-CoV-2 hijacks cellular kinase CDK2 to promote viral RNA synthesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第1期8卷 302-313页

作者： Saisai Guo Xiaobo Lei Yan Chang Jianyuan Zhao Jing Wang Xiaojing Dong Qian Liu Zixiong Zhang Lidan Wang Dongrong Yi Ling Ma Quanjie Li Yongxin Zhang Jiwei Ding Chen Liang Xiaoyu Li Fei Guo Jianwei Wang Shan Cen Department of Immunology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryKey Laboratory of Major Diseases in ChildrenMinistry of EducationBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Lady Davis Institute Jewish General HospitalMcGill UniversityMontrealQCCanada CAMS Key Laboratory of Antiviral Drug Research Chinese Academy of Medical Sciences&Peking Union Medical SciencesBeijingChina

The coronavirus disease 2019(COVID-19)pandemic has devastated global *** key host factors essential for SARS-CoV-2 RNA replication is expected to unravel cellular targets for the development of broad-spectrum antiviral drugs which have been quested for the preparedness of future viral ***,we have identified host proteins that associate with nonstructural protein 12(nsp12),the RNA-dependent RNA polymerase(RdRp)of SARS-CoV-2 using a mass spectrometry(MS)-based proteomic *** the candidate factors,CDK2(Cyclin-dependent kinase 2),a member of cyclin-dependent kinases,interacts with nsp12 and causes its phosphorylation at T20,thus facilitating the assembly of the RdRp complex consisting of nsp12,nsp7 and nsp8 and promoting efficient synthesis of viral *** crucial role of CDK2 in viral RdRp function is further supported by our observation that CDK2 inhibitors potently impair viral RNA synthesis and SARS-CoV-2 *** together,we have discovered CDK2 as a key host factor of SARS-CoV-2 RdRp complex,thus serving a promising target for the development of SARS-CoV-2 RdRp inhibitors.

关键词： CDK2 synthesis drugs

An Introduction of Competing Strategies for English Speaking Contest for Vocational colleges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

海外英语 2012年第1X期 78-79页

作者：郑伟 general Education Division Anhui Post and Telecom Vocational College

English speaking contest for vocational colleges is held once a ***' s not just a competition,but a chance to test contempo rary college students' English speaking ability,and a platform to show their mental *** schools give high attention to this con test by spending much time tutoring students,but there are still many problems of the *** illustrating this competition in 2012,the writer raises some strategies for both training and competing in order to help competitors perform better.

关键词： contestant strategy perform ability presentation i

Multiple Calcifying Epitheliomas of Malherbe’s of Axilla: A Case Report of Rare Variety

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surgical Science 2014年第6期5卷 242-245页

作者： Mushtaq Chalkoo Shahnawaz Ahangar Naseer Awan Mujahid Ahmad Mir Aarif Bashir Nida Shafiq Department of general Surgery Government Medical College Srinagar India

Pilomatrixoma, a rare benign tumour of sebaceous gland is commonly known as calcifying epithelioma of Malherbe or Tricholemmal cyst. We came across even the rarest form of this benign tumour of skin. Our case report was interestingly detected at a higher age group, unusual site of the body, multiple in nature following postoperative incision drainage of abscess in left axilla.

关键词： Epithelioma Axilla Multiple Postsurgical

Effects of purified herbal extract of Salvia miltiorrhiza on lipid profile in hyperlipidemic patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2009年第2期6卷 99-101页

作者： Zuchang Li Ling Zhu Bin Huang Department of Traditional Chinese Medicine China Coal General Hospital Beij＇ing 100028 China college of Chinese Herbal Medicine Beijing University of Chinese Medicine Beijing 100029 China

背景和客观 Hyperlipidemia 是大多数之一为冠的心疾病(CHD ) 的有势力和最好证实的风险因素。净化的鼠尾草植物 miltiorrhiza 摘录(PSME ) 被显示了在动物实验有 hypolipidemic 效果。这研究试图在 hyperlipidemic 病人评估它的 iipids... 详细信息

背景和客观 Hyperlipidemia 是大多数之一为冠的心疾病(CHD ) 的有势力和最好证实的风险因素。净化的鼠尾草植物 miltiorrhiza 摘录(PSME ) 被显示了在动物实验有 hypolipidemic 效果。这研究试图在 hyperlipidemic 病人评估它的 iipids modulating 效果。在这的方法单个窗帘，安慰剂控制了学习， 80 个 hyperlipidemic 病人的类脂化合物侧面以一样的条件被检查。他们随机被划分成二个相等的组(40 个病人创作的各个) 。他们每天，或安慰剂药片被给 PSME 药片(800 mg ) 三次。所有病人被放在 NCEP 类型节食，六个星期以后，类脂化合物侧面被检查。在 PSME 组，的结果总计胆固醇由 27.32 mg/dl (12.3% 减小) 减少了， LDL 胆固醇由 23.13 mg/dl (16.8% 减小) 减少了， HDL 胆固醇由 9.06 mg/dl (11.1%) 增加了，都是统计上重要的。尽管 triglyceride 去了 12.12， mg/dl (5.1%) 而是这不统计上是重要的(P=-0.34 ) 。在安慰剂组没有重要变化 oflipids 层次。结论 PSME 穿上重要有利效果总计胆固醇， LDL 胆固醇，和 HDL 胆固醇并且可以是为治疗 ofatherogenic dyslipidemia 的一个潜在的代理人。

关键词：降血脂作用中药提取物高脂血症患者高密度脂蛋白胆固醇低密度脂蛋白胆固醇丹参纯化

A novel method to detect bacterial resistance to disinfectants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2017年第3期4卷 163-169页

作者： Xiao-Feng He Hui-Jie Zhang Jin-Gui Cao Fang Liu Jian-Kang Wang Wen-Jie Ma Wen Yin Department of Infection Control Air Force General HospitalBeijing 100142China Department of Pharmacy Air Force General HospitalBeijing 100142China Department of Transfusion Medicine Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Ministry of Education Key Laboratory of Diagnostic Medicine College of Laboratory MedicineChongqing Medical UniversityChongqing 400016China

In clinical practice,the important hygienic prevention of bacterial pathogen spread is disinfection of potentially contaminated *** bromide and chlorhexidine acetate are commonly used disinfectants with a broad spectrum of antimicrobial *** is vital to inhibit the spread of pathogen in ***,a large number of pathogens with the decreased antiseptic susceptibility have been isolated from clinical samples which showed an increased minimal inhibitory concentration(MIC)against those *** resistant pathogens are the major causes for nosocomial crossinfections in *** present study demonstrated the utility of Oxford plate assay system in determining the potential disinfectant resistance of *** microbiological assay is based on the inhibitory effect of tested disinfectants upon the strains of Staphylococcus aureus and Escherichia *** analysis of the bioassay results indicated the linear correlation(r=-0.87-0.99,P<0.01)between the diameter of growth inhibition zone and the log dosage of the tested ***,comparison of inhibitory efficacy of benzalkonium bromide upon 29 *** strains isolated from clinical samples by both Oxford plate method and broth dilution method showed that the diameter of growth inhibition zone has significantly negative correlation with the minimal inhibitory concentration(MIC)(r=-0.574,P<0.001).These results suggest that the Oxford plate is a simple and time-saving method in detecting potential clinical disinfectant resistance and its usefulness for routine surveillance of pathogenic resistance to disinfectants warrants further investigation.

关键词： Clinical technology Disinfectants resistance Inhibitory efficacy Oxford plate method Staphylococcus aureus

Liver transplantation for unresectable colorectal metastasis:a new hope

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2020年第5期9卷 665-668页

作者： Andre Gorgen Tommy Ivanics Gonzalo Sapisochin Multi-Organ Transplant Program Division of General SurgeryUniversity Health NetworkToronto General HospitalTorontoCanada

Despite recent advances in medical and surgical treatments,surgical resection remains the only curative option for patients with colorectal liver metastasis(CRLM).Unfortunately,only a minority of patients with CRLM are candidates for liver *** 5-year survival of patients with liver-only disease and deemed unresectable is difficult to quantify but likely ranges around 5 to 10%.Since 2013,a few studies have shown that liver transplantation(LT)is feasible for selected patients with unresectable CRLM(1,2).Recently,the Oslo University Hospital LT group has published their latest results with modified selection criteria and should be congratulated for their ***,the evidence available is still *** example,currently,there is a lack of robust evidence supporting the widespread use of LT for CRLM outside Norway,a particular region in terms of graft scarcity.

关键词： metastasis colorectal likely

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

三唑类的化学和生物活性进展(英文)

中国天然药物 2013年第5期11卷 456-465页

作者： Jagdish K. Sahu1 Swastika Ganguly Atul Kaushik Institute of Professional studies college of Pharmacy Department of Pharmaceutical Sciences Birla Institute of Technology

In recent years,heterocyclic compounds,analogs,and derivatives have attracted strong interest due to their useful biological and pharmacological *** small and simple triazole nucleus is present in compounds aimed at evaluating new entities that possess anti-microbial,anti-tumor,antitubercular,anti-convulsant,anti-depressant,antimalarial,and anti-inflammatory *** display a broad range of biological activities and are found in many potent,biologically active compounds,such as trazodone(antidepressant drug),rizatriptan(antimigrane drug),hexaconazole(antifungal drug) and alprazolam(hyptonic,sedative and tranquilizer drug).So far,modifications of the triazole ring have proven highly effective with improved potency and lesser *** present review highlights the recently synthesized triazoles possessing important biological activities.

关键词： Triazoles Antifungal Antitubercular Anticancer Antiviral Anticonvulsant Anti-inflammatory Antidepressant Antimalarial

Quantum-safe cryptography:crossroads of coding theory and cryptography

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第1期65卷 95-115页

作者： Jiabo WANG Ling LIU Shanxiang LYU Zheng WANG Mengfan ZHENG Fuchun LIN Zhao CHEN Liuguo YIN Xiaofu WU Cong LING Beijing National Research Center for Information Science and Technology Tsinghua University Department of Software Engineering Shenzhen University college of Cyber Security Jinan University School of Information Science and Engineering Southeast University Department of Electrical and Electronic Engineering Imperial College London National Engineering Research Center of Communications and Networking Nanjing University of Posts and Telecommunications

We present an overview of quantum-safe cryptography(QSC) with a focus on post-quantum cryptography(PQC) and information-theoretic security. From a cryptographic point of view, lattice and code-based schemes are among the most promising PQC solutions. Both approaches are based on the hardness of decoding problems of linear codes with different metrics. From an information-theoretic point of view, lattices and linear codes can be constructed to achieve certain secrecy quantities for wiretap channels as is intrinsically classical-and quantum-safe. Historically, coding theory and cryptography are intimately connected since Shannon’s pioneering studies but have somehow diverged later. QSC offers an opportunity to rebuild the synergy of the two areas, hopefully leading to further development beyond the NIST PQC standardization process. In this paper, we provide a survey of lattice and code designs that are believed to be quantum-safe in the area of cryptography or coding theory. The interplay and similarities between the two areas are discussed. We also conclude our understandings and prospects of future research after NIST PQC standardisation.

关键词： post-quantum cryptography lattice-based cryptography code-based cryptogarphy information-theoretic security lattice reduction lattice codes linear codes