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Maternal and infant microbiome:next-generation indicators and targets for intergenerational health and nutrition care

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Protein & Cell 2023年第11期14卷 807-823页

作者： Shengtao Gao Jinfeng Wang college of food science&nutritional engineering China Agricultural UniversityBeijing 100083China

Microbes are commonly sensitive to shifts in the physiological and pathological state of their hosts,including mothers and *** this perspective,the microbiome may be a good indicator for diseases during pregnancy and has the potential to be used for perinatal health *** is embodied in the application of microbiome from multi body sites for auxiliary diagnosis,early prediction,prolonged monitoring,and retrospective diagnosis of pregnancy and infant complications,as well as nutrition management and health products developments of mothers and *** we summarized the progress in these areas and explained that the microbiome of different body sites is sensitive to different diseases and their microbial biomarkers may overlap between each other,thus we need to make a diagnosis prudently for those *** on the microbiome variances and additional anthropometric and physical data,individualized responses of mothers and neonates to meals and probiotics/prebiotics were predictable,which is of importance for precise nutrition and probiotics/prebiotics managements and *** a great deal of encouraging performance was manifested in previous studies,the efficacy could be further improved by combining multi-aspect data such as multi-omics and time series analysis in the *** review reconceptualizes maternal and infant health from a microbiome perspective,and the knowledge in it may inspire the development of new options for the prevention and treatment of adverse pregnancy outcomes and bring a leap forward in perinatal health care.

关键词： newborn microbiome disease detection pregnancy management health care products

Assessment and distinction of commercial soy protein isolate product functionalities using viscosity characteristic curves

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Chinese Chemical Letters 2012年第9期23卷 1051-1054页

作者： Jing Ting Xu He Liu Jian Hua Ren Shun Tang Guo college of food science&nutritional engineering China Agricultural UniversityChina Beijing 100083

To simplify the assessment method of soy protein isolate （SPI） functionalities, the viscosity and functionalities of commercial SPI products were studied. Viscosity value （y） increases With increasing concentration （x） and exhibits a highly significant correlation with the exponential equation y = a. ebx. The b values of products are gradually enhanced from dispersion, emulsion and injected to gel type. Products with low b values （〈0.2）, and high dispersivity were dispersion-type. Products having high b values （〉0.4） and gel springiness were gel-type. The other products with centered b value （0.2-0.4）, high solubility and emulsifying capacity were emulsion-type.

关键词： Soy protein isolate Functional properties Viscosity curve

Applications of virus-induced gene silencing for identification of gene function in fruit

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food Quality and Safety 2021年第3期5卷 222-230页

作者： Gangshuai Liu Hongli Li Daqi Fu Laboratory of Fruit Biology College of Food Science&Nutritional EngineeringChina Agricultural UniversityBeijingChina

With the development of bioinformatics,it is easy to obtain information and data about thousands of genes,but the determi nation of the functions of these genes depends on methods for rapid and effective functi on al ***-induced gene sile ncing(VIGS)is a mature method of gene functional identification developed over the last 20 years,which has been widely used in many research fields involving many *** quality formation is a complex biological process,which is closely related to ***,we review the progress and contribution of VIGS to our understanding of fruit biology and its advantages and disadvantages in determining gene function.

关键词： Gene function virus-induced gene silencing fruit viral vector.

Virus-induced Gene Silencing in Eggplant(Solanum melongena)

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Journal of Integrative Plant Biology 2012年第6期54卷 422-429页

作者： Haiping Liu Daqi Fu Benzhong Zhu Huaxue Yan Xiaoying Shen Jinhua Zuo Yi Zhu Yunbo Luo Laboratory of Fruit Biology College of Food Science&Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Eggplant （Solanum melongena） is an economically important vegetable requiring investigation into its various genomic functions. The current limitation in the investigation of genomic function in eggplant is the lack of effective tools available for conducting functional assays. Virus-induced gene silencing （VIGS） has played a critical role in the functional genetic analyses. In this paper, TRV-mediated VIGS was successfully elicited in eggplant. We first cloned the CDS sequence of PDS （PHYTOENE DESATURASE） in eggplant and then silenced the PDS gene. Photo-bleaching was shown on the newly-developed leaves four weeks after agroinoculation, indicating that VIGS can be used to silence genes in eggplant. To further illustrate the reliability of VIGS in eggplant, we selected Chl H, Su and CLA1 as reporters to elicit VIGS using the high-pressure spray method. Suppression of Chl H and Su led to yellow leaves, while the depletion of CLA1 resulted in albino. In conclusion, four genes, PDS, Chl H, Su （Sulfur）, CLA1, were down-regulated significantly by VIGS, indicating that the VIGS system can be successfully applied in eggplant and is a reliable tool for the study of gene function.

关键词： Virus-induced gene silencing tobacco rattle virus PHYTOENE DES, ATURASE Solanum melongena

A novel lectin from mushroom Phellodon melaleucus displays hemagglutination activity,and antitumor activity in a B16 melanoma mouse model

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food science and Human Wellness 2023年第5期12卷 1885-1892页

作者： Yuanhui Li Peng Wang Zejun Zhang Qinghong Liu Department of Vegetables College of HorticultureChina Agricultural UniversityBeijing 100193China college of food science&nutritional engineering China Agricultural UniversityBeijing 100193China

A novel lectin(termed PML)was purified from fruiting bodies of the edible mushroom Phellodon melaleucus(division Basidiomycota)by ion exchange,hydrophobic interaction,and gel filtration chromatographies,with overall titer recovery~60%and 20-fold *** displayed hemagglutination activity 13319 units/mg toward rabbit ***-PAGE and gel filtration analyses revealed that PML is a homodimeric lectin with a molecular weight of 28.8 *** hemagglutination activity was not inhibited by various simple sugars or their derivatives,but was enhanced by cations Ca^(2+),Mg^(2+),Zn^(2+),and Cu^(2+).The activity was stable in pH range 6–9 and in the temperature range 20–60°*** dichroism(CD)spectroscopic analysis showed that PML was composed primarily ofβ-sheets with lowα-helix *** a B16 melanoma mouse model,PML treatment significantly inhibited tumor growth,and increased cytokine IL-10 *** findings suggest that PML is a potential anticancer therapeutic agent.

关键词： Phellodon melaleucus Lectin Hemagglutination activity Cytokine IL-10 Antitumor activity

Purification and Characterization of Three Alkaline Endopolygalacturonases from a Newly Isolated Bacillus gibsonii

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过程工程学报 2008年第4期8卷 768-773页

作者：李祖明金波张洪勋白志辉薛文通李鸿玉 Teacher's college of Beijing Union University Research Center for Eco-environmental sciences Chinese Academy of SciencesBeijing100085China college of food science&nutritional engineering China Agricultural UniversityBeijing100083China School of Earth and Environmental science University of Adelaide Research Center for Eco-environmental sciences Chinese Academy of Sciences School of Earth and Environmental science University of AdelaideAdelaide college of food science&nutritional engineering China Agricultural University

A newly isolated Bacillus gibsonii,designated as S-2(CGMCC1215),was cultivated for production of alkaline pectinases utilizing sugar beet pulp as growth *** of three alkaline endopolygalacturonases(endoPGs)from the crude pectinases extract was carried out by ultra-filtration,ammonium sulphate fractionation and ion-exchange chromatography,and their enzyme activities *** three purified alkaline endoPGs,designated as S-I,S-II,and S-III,had a molecular weight about38kDa as determined by *** Km value and optimal temperature for optimal enzyme activities of S-I,S-II and S-III were1.2mg/mL and60℃,0.9mg/mL and55℃,1.1mg/mL and60℃,*** best performances were given at an optimal pH10.5,and sodium polygalacturonate was found to be the best *** isoelectric points of S-I,S-II and S-III were5.4,7.4,and8.2,*** of Tween-80and Tween-20and metal ions such as Mg2+and Ca2+stimulated the activity of S-I,S-II and S-III,whereas S-III was inhibited by Ca2+,and Mn2+and Zn2+ions inhibited the activity of the three enzymes.

关键词：净化方法细菌隔离方法果胶酶

In vitro digestibility of soybean β-conglycinin hydrolysates

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Chinese Chemical Letters 2013年第7期24卷 585-587页

作者： Jian-Hua Ren Shun-Tang Guo college of food science and nutritional engineering China Agricultural University

The in vitro digestibility of alcalase enzymatic hydrolysates of β-conglycinin was studied. The results showed that the zeta potentials of β-conglycinin hydrolysates decreased and their electronegativity increased when digested with pepsin and trypsin. Furthermore, the content of peptides with molecular weight from 10 kDa to 20 kDa remained stable, while those with higher molecular weight （〉20 kDa） decreased, and those with lower molecular weight （〈10 kDa） increased. The proportion of highly hydrophobic peptides decreased in the process of the in vitro digestion, but no significant change in the surface hydrophobicity indices of digestion products was observed （P 〈 0.05）. These results indicate that the β-conglycinin hydrolysates were degraded through in vitro digestion, but the degree of degradation was relatively low. Peptides with molecular weight from 10 kDa to 20 kDa in the β-conglycinin hydrolysates resisted the digestion by pepsin and trypsin and they remained stable during the in vitro digestion processes.

关键词： β-Conglycinin hydrolysates In vitro digestion Digestibility

Bumblebees with the socially transmitted microbiome:A novel model organism for gut microbiota research

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Insect science 2022年第4期29卷 958-976页

作者： Zi-Jing Zhang Hao Zheng college of food science and nutritional engineering China Agricultural UniversityBeijingChina

Eusocial bumble and honey bees are important pollinators for global ecology and the agricultural *** both the bumble and honey bees possess similar and host-restricted gut microbiota,they differ in aspects of morphology,autonomy,physiology,behavior,and life *** social bee gut bacteria exhibit host specificity that is likely a result of long-term *** unique life cycle of bumblebees is key for the acquisition and development of their gut microbiota,and affects the strain-level diversity of the core bacterial *** on bumblebee gut bacteria show that they retain less functional capacity for carbohydrate metabolism compared with that of the *** discuss the potential roles of the bumblebee gut microbiota against pathogenic threats and the application of host-specific probiotics for *** the advantages of the bumblebee microbiome,including the simple structure and host specificity,and the ease of manipulating bumblebee colonies,we propose that bumblebees may provide a valuable system for understanding the general principles of host-microbe interactions,gut-brain axis,and vertical transmission.

关键词： bumblebee gut microbiota host-microbe interaction model organism

Lycopene Accumulation Affects the Biosynthesis of Some Carotenoid-related Volatiles Independent of Ethylene in Tomato

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Journal of Integrative Plant Biology 2008年第8期50卷 991-996页

作者： Hongyan Gao Hongliang Zhu Yi Shao Anjun Chen Chengwen Lu Benzhong Zhu Yunbo Luo college of food science and nutritional engineering China Agricultural University Beijing 100083 China

For elucidating the regulatory mechanism of ethylene on carotenoid-related volatiles （open chain） compounds and the relationship between lycopene and carotenoid-related volatiles, transgenic tomato fruits in which ACC synthase was suppressed were used. The transgenic tomato fruit showed a significant reduction of lycopene and aroma volatiles with low ethylene production. 6-methyl-5-hepten-2-one, 6-methyl-5-hepten-2-ol and geranylacetone, which were suspected to be lycopene degradation products, were lower than those in wild type tomato fruits. In order to identify whether lycopene accumulation effects the biosynthesis of some carotenoid-related volatiles independent of ethylene in tomato or not, the capability of both wild type and transgenic tomato fruits discs to convert lycopene into carotenoid-related volatiles was evaluated. The data showed that external lycopene could convert into 6-methyl-5-hepten-2-one and 6-methyl-5-hepten-2-ol in vivo, indicating that the strong inhibition of ethylene production had no effect on enzymes in the biosynthesis pathway of some carotenoid-related volatUes. Therefore, in ACS-suppression transgenic tomato fruits, the low levels of 6-methyl- 5-hepten-2-one, 6-methyl-5-hepten-2-ol was due to decreased lycopene accumulation, not ethylene production. Ethylene only affected the accumulation of lycopene, and then indirectly influenceed the level of lycopene-related volatiles.

关键词： aroma volatiles ethylene lycopene tomato