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Orthogonal Combinatorial Raman Codes Enable Rapid High-Throughput-Out Library Screening of Cell-Targeting Ligands

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Research 2024年第1期2023卷 199-208页

作者： Yuchen Tang Xingxing Zheng Tingjuan Gao China Key Laboratory of Pesticide and Chemical biology of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China

High-throughput assays play an important role in the fields of drug discovery,genetic analysis,and clinical *** super-capacity coding strategies may facilitate labeling and detecting large numbers of targets in a single assay,practically,the constructed large-capacity codes have to be decoded with complicated procedures or are lack of survivability under the required reaction *** challenge results in either inaccurate or insufficient decoding ***,we identified chemical-resistant Raman compounds to build a combinatorial coding system for the high-throughput screening of cell-targeting ligands from a focused 8-mer cyclic peptide *** accurate in situ decoding results proved the signal,synthetic,and functional orthogonality for this Raman coding *** orthogonal Raman codes allowed for a rapid identification of 63 positive hits at one time,evidencing a high-throughput-out capability in the screening *** anticipate this orthogonal Raman coding strategy being generalized to enable efficient high-throughput-out screening of more useful ligands for cell targeting and drug discovery.

关键词： enable throughput allowed

One-Pot Stereoselective Synthesis of Different Fused Multicyclic Iminosugars Based on the Iminium-lon Intermediate

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Chinese Journal of chemistry 2024年第2期42卷 142-150页

作者： Song Xie Jilai Wu Likai Zhou Chao Wei Xiaoliu Li Hua Chen Key Laboratoryof Chemical biology of Hebei Province College of Chemistry and Material ScienceHebei UniversityBaodingHebei 071002China college of chemistry and Chemical Engineering Xingtai UniversityXingtaiHebei 054001China

Different novel fused multicyclic iminosugars were synthesized from D-ribose tosylate,aniline and vinyl ethyl ether by one-pot three-component stereoselective[4+2]reaction at different *** iminium-ion is the key intermediate for the *** a result,several complex fused iminosugars 3a were obtained by aza-Diels-Alder mechanism at 60℃,while a series of aza-C-glycosides 5a were prepared by Mannich reaction at room temperature accompanied by another tetrahydroquinoline-fused iminosugars 4a(tricyclic derivatives)through aza-Diels-Alder *** strategy will help to construct structurally diverse and bioactive iminosugar analogues.

关键词： Fused multicyclic iminosugar Aza-Diels-Alder cycloaddition Mannich reaction Tetrahydroquinoline Multicomponent reactions Enantioselectivity Cyclization

Synthesis of Anti-Pancreatic Cancer Natural Product Majusculamide D and Analogues Reveals a Preliminary Structure-Activity Relationships

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Chinese Journal of chemistry 2024年第6期42卷 605-610页

作者： Xiuhe Zhao Mengxue Lv Xiaonan Xi Yaxin Lu Liang Wang Yue Chen The State Key Laboratory of Medicinal Chemical biology College of PharmacyNankai UniversityTianjin300350 China college of chemistry Nankai UniversityTianjin300071 China

The total synthesis of majusculamide D(1)was achieved from commercially available *** addition,we synthesized eight analogues including three stereoisomers of majusculamide D that differ in the fatty acid *** analogues including a simplified analogue 29 exhibited significant nanomolar-level IC50 values against Panc-1 cells in MTT assays.A preliminary SAR analysis indicated that the hydroxyl group at C10 and C2−C3 unsaturated double bond of majusculamide D were essential in maintaining the high activity against Panc-1 cells and the orientation of C40-Me and C42-Me groups was tolerable.

关键词： Majusculamide D Natural products SAR Anti-pancreatic cancer Lipopentapeptide

Thiol-mediated transportation pathway:an approach for improving tumor penetration of nanomedicines in vivo

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Science China chemistry 2024年第1期67卷 383-389页

作者： Junjie Zhang Weican Sun Xing Wang Senyan Chen Jingying Li Huanghao Yang New Cornerstone Science Laboratory Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education)College of ChemistryFuzhou UniversityFuzhou 350116China Department of chemistry and college of Biological Science and Engineering Fuzhou UniversityFuzhou 350116China

Abnormal tumor microenvironment imposes barriers to tumor penetration of nanomedicine,which remains a major challenge for effective ***,we present disulfide-based nanoparticles that actively penetrate deep tumors in vivo through a thiol-mediated transportation *** achieve active tumor accumulation in vivo,disulfide-based nanoparticles are modified with folic acid units(FA-DBNPs).It is gratifying that FA-DBNPs still enter cells via the thiol-mediated pathway,which facilitates transcellular transportation and tumor penetration both in vitro and in ***,FA-DBNPs exhibit GSH concentration-dependent depolymerization characterization,indicating that the GSH level in tumor tissues regulates the penetration depth of *** from these advantages,FA-DBNPs showed potent anti-tumor activity in mouse models,leading to the significant regression of *** current study lays a foundation that thiol-mediated transportation is a promising approach in nanomedicine design for solid tumor therapy.

关键词： deep penetration thiol-mediated pathway transcellular transportation solid tumor

维普期刊数据库

Multicolor circularly polarized phosphorescence of axially chiral binuclear platinum(Ⅱ) complexes

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Science China chemistry 2024年第11期67卷 3757-3766页

作者： Jintong Song Rui Zeng Hui Xiao Hailiang Ni Zong-Xiang Xu Haifeng Xiang college of chemistry and Materials Science Sichuan Normal University Department of chemistry Southern University of Science and Technology college of chemistry Sichuan University

D-A charge transfer, including through-bond charge transfer and through-space charge transfer between two different electron donors（D） and electron acceptors（A）, is a fundamental and powerful tool to tune the optical properties of organic dyes. Herein,we demonstrate a unique strategy to tune phosphorescence and circularly polarized luminescence properties of axially chiral binuclear Pt（Ⅱ） complexes through long-range charge transfer, even though these molecules have two totally identical segments on either side of the chiral core. The presence of axial chirality would break not only the symmetry of molecular structure and π-conjugation system but also the symmetry of charge distribution for long-range charge transfer. These binaphthyl-based Pt（Ⅱ）complexes bearing coordinated atoms far away from chiral axis exhibit no Pt-Pt interactions but colorful concentrationdependent phosphorescence with quantum yield up to 86.4% and could be applied as emitters in highly efficient solutionprocessed organic light-emitting diodes to achieve luminance, luminance efficiency, power efficiency, external quantum efficiency, and asymmetry factor up to 8.94 × 10～3cd m-2, 41.9 cd A-1, 18.8 lm W-1, 12.6% and 2.98 × 10-3, respectively. Therefore,the present work affords a new and simple way to utilize the inherently asymmetric advantage of chirality for the design of D-Abased organic dyes.

关键词： Pt(II) complexes organic light-emitting diodes circularly polarized phosphorescence axial chirality

Effect of yttrium and manganese addition on catalytic soot combustion activity and anti-high-temperature stability of CeO_(2) catalyst

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Journal of Rare Earths 2024年第2期42卷 334-344,I0004页

作者： Yi Zhu Xingyu Liu Wei Shi Jia Li Changbing Ye Ruimei Fang Huifeng Zhu Shanhu Chen Li Lan college of chemistry biology and Environment Yuxi Normal UniversityYuxi 653100China Institute of biology and Environmental Engineering Yuxi Normal UniversityYuxi 653100China college of Environment and Resources Chongqing Technology and Business UniversityChongqing 400067China college of chemistry and Chemical Engineering Jiangxi Science and Technology Normal UniversityNanchang 330013China college of Materials and Mechatronics Jiangxi Science and Technology Normal UniversityNanchang 330013China

In order to analyze the influence of the addition of yttrium and manganese on the soot combustion performance and high temperature stability of CeO_(2) catalyst,a series of Y/Mn-modified CeO_(2) catalysts were *** effects of structural properties,textural properties,oxygen vacancies,Ce^(3+),surface adsorbed oxygen species,reduction properties and desorption properties of oxygen species on the activity were analyzed by various characterization *** results of the activity test show that the addition of manganese is beneficial to enhancement of the activity,while the addition of yttrium increases the amount of reactive oxygen species,but decreases the *** aging at 700℃,the activity of the CeMn catalyst decreases most sharply,while the catalytic activity of the CeY catalyst can be maintained to a certain ***,the addition of yttrium and manganese at the same time can stabilize the *** fundamental reason is that yttrium and manganese move to the surface of the solid solution after aging,which increases the reduction performance of the catalyst,thus contributing to the increase of *** the activity of CeYMn catalyst decreases after aging at 800℃,it is still higher than that of other catalysts aged at 700℃.

关键词： CeO_(2)catalyst Soot catalytic combustion Diesel pollution control Rare earths High temperature stability Low temperature reduction performance

维普期刊数据库

Fe3O4/Fe/FeS Tri-Heterojunction Node Spawning N-Carbon Nanotube Scaffold Structure for High-Performance Sodium-Ion Battery

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Energy & Environmental Materials 2024年第4期7卷 143-152页

作者： Yuan Liu Qing Lin Xiaocui Chen Xufeng Meng Baoxiu Hou Haiyan Liu Shuaihua Zhang Ningzhao Shang Zheng Wang Chaoyue Zhang Jianjun Song Xiaoxian Zhao Department of chemistry College of Science Hebei Agricultural University college of chemistry and Chemical Engineering Qingdao University college of Physics Qingdao University

The Fe-based anode of sodium-ion batteries attracts much attention due to the abundant source,low-cost,and high specific ***,the low electron and ion transfer rate,poor structural stability,and shuttle effect of NaS2intermediate restrain its further ***,the Fe3O4/Fe/FeS tri-heterojunction node spawned N-carbon nanotube scaffold structure（FHNCS） was designed using the modified MIL-88B（Fe） as a template followed by catalytic growth and sulfidation process.

关键词： anode core-shell heterojunction hollow structure sodium ion batteries

Structural engineering of Sb-based electrode materials to enhance advanced sodium-ion batteries

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Rare Metals 2024年第10期43卷 4777-4806页

作者： Zheng Yang Qiao-Ling Kang Rui-Wang Li-Jing Yan Xian-He Meng Ting-Li Ma college of Materials and chemistry Jiliang University

Antimony （Sb） is recognized as a potential electrode material for sodium-ion batteries （SIBs） due to its huge reserves,affordability,and high theoretical capacity(660 mAh·g-1).However,Sb-based materials experience significant volume expansion during cycling,leading to comminution of the active substance and limiting their practical use in ***,the volume expansion issue of Sb-based materials during charging/discharging must be solved to create high-performance *** paper presents a detailed review of structural engineering of Sb-based electrode materials,focusing on the performance effects of different kinds of structures on advanced performance ***,the future development and the challenges of Sb-based materials are *** paper can provide specific perspectives on the structure construction and optimization of Sb-based anode materials so as to promote the rapid development and practical applications of SIBs.

关键词： Sb-based electrode Sodium-ion batteries Structural engineering

Direct Synthesis of α-Aminophosphonates from Amines,Alcohols,and White Phosphorus

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CCS chemistry 2024年第1期6卷 91-99页

作者： Mengpei Bai Yinwei Cao Junwei Huang Yan Liu Guo Tang Yufen Zhao Department of chemistry and Key Laboratory for Chemical biology of Fujian Province College of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujian 361005

Developing practical strategies for the synthesis of organophosphorus compounds(OPCs)from white phosphorus(P_(4))without the use of Cl_(2) and PCl_(3) remains a significant *** first multicomponent oxidative α-phosphonylation of amines with P_(4) and alcohols has been *** the use of copper(Ⅱ)as the catalyst and air as the safe oxidant,structurally sophisticated α-aminophosphonates have been prepared in high ***,this method is also suitable for selective construction of P-O-P *** reaction is characterized by a complete conversion of P_(4).The activation of P_(4) with transition metals often leads to formation of complexes[M_(x)P_(y)]_(n) associated with the deactivation of transition *** breakthrough showcases the potential of transition-metal-catalyzed reactions in elemental phosphorus chemistry.

关键词： white phosphorus P-C bonds dialkyl phosphites aminophosphonates pyrophosphates