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Journal of biomedical Science and engineering 2013年第3期6卷 277-279页

作者： Bangtao Liu Min Luo Minjun Li Xiaoyu Kang Chenghu Zhang Department of biomedical engineering Chengdu Medical College Chengdu China Department of biomedical engineering Luzhou Medical College Luzhou China

This paper expounds professional characteristics of biomedical engineering in our school, and analyses some problems lying in it, emphatically discusses advantages and the problems combining biomedical engineering with the medical courses in order to offer targeted solutions. It summarizes the results and problems so as to provide reference value to a new major.

关键词： biomedical engineering Connotationt Talents Cultivation Specialty Construction

Biomimetic microchannel network with functional endothelium formed by sacrificial electrospun fibers inside 3D gelatin methacryloyl(GelMA)hydrogel models

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Journal of Zhejiang University-Science A(Applied Physics & engineering) 2024年第1期25卷 79-96页

作者： Haoyu SUN Haiyang MA Li WANG Yang LIU Tian HOU Wenjie TANG Qing YU Meiwen AN Meiling WEN Institute of biomedical engineering College of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan030024China

Three-dimensional(3D)hydrogel models play a crucial role in tissue engineering for promoting tissue regeneration.A biomimetic microchannel network system in the 3D hydrogel model is necessary for optimal cellular function.This report describes the preparation of a biomimetic hydrogel scaffold with an internal microchannel network,using electrospinning techniques and the sacrificial template method for 3D cell culture.Microchannels and cavities were created within the gelatin methacryloyl(GelMA)hydrogel by sacrificing polyvinyl alcohol(PVA)electrospun fibers(>10µm),resulting in the creation of microvessel-like channels.Mechanical characterizations,swelling properties,and biodegradation analysis were conducted to investigate the feasibility of a biomimetic microchannel network hydrogel scaffold for 3D cell culture applications.Compared to pure GelMA hydrogel,the hydrogel with microchannels promoted cell proliferation,adhesion,and endothelial tube formation.Moreover,the results confirmed that the biomimetic microchannel network scaffold had a major impact on the distribution and arrangement of human umbilical vein endothelial cells(HUVECs)and can enable the formation of artificial microvasculature by the culture of HUVECs and cell media perfusion.

关键词： Biomimetic scaffold Photocrosslinking Microchannel network Tissue engineering Artificial microvascular

Unveiling protein corona composition:predicting with resampling embedding and machine learning

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Regenerative Biomaterials 2024年第1期3卷 27-33页

作者： Rong Liao Yan Zhuang Xiangfeng Li Ke Chen Xingming Wang Cong Feng Guangfu Yin Xiangdong Zhu Jiangli Lin Xingdong Zhang College of Biomedical Engineering National Engineering Research Centre for BiomaterialsSichuan UniversityChengdu610065China

Biomaterials with surface nanostructures effectively enhance protein secretion and stimulate tissue regeneration.When nanoparticles(NPs)enter the living system,they quickly interact with proteins in the body fluid,forming the protein corona(PC).The accurate prediction of the PC composition is critical for analyzing the osteoinductivity of biomaterials and guiding the reverse design of NPs.However,achieving accurate predictions remains a significant challenge.Although several machine learning(ML)models like Random Forest(RF)have been used for PC prediction,they often fail to consider the extreme values in the abundance region of PC absorption and struggle to improve accuracy due to the imbalanced data distribution.In this study,resampling embedding was introduced to resolve the issue of imbalanced distribution in PC data.Various ML models were evaluated,and RF model was finally used for prediction,and good correlation coefficient(R^(2))and root-mean-square deviation(RMSE)values were obtained.Our ablation experiments demonstrated that the proposed method achieved an R^(2) of 0.68,indicating an improvement of approximately 10%,and an RMSE of 0.90,representing a reduction of approximately 10%.Furthermore,through the verification of label-free quantification of four NPs:hydroxyapatite(HA),titanium dioxide(TiO_(2)),silicon dioxide(SiO_(2))and silver(Ag),and we achieved a prediction performance with an R^(2) value>0.70 using Random Oversampling.Additionally,the feature analysis revealed that the composition of the PC is most significantly influenced by the incubation plasma concentration,PDI and surface modification.

关键词： nanoparticles protein corona machine learming resampling technique feature analysis

Printability——A key issue in extrusion-based bioprinting

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Journal of Pharmaceutical Analysis 2021年第5期11卷 564-579页

作者： Saman Naghieh Xiongbiao Chen Division of biomedical engineering College of Engineering University of Saskatchewan Department of Mechanical engineering College of Engineering University of Saskatchewan

Three-dimensional(3D) extrusion-based bioprinting is widely used in tissue engineering and regenerative medicine to create cell-incorporated constructs or scaffolds based on the extrusion technique.One critical issue in 3D extrusion-based bioprinting is printability or the capability to form and maintain reproducible 3D scaffolds from bioink(a mixture of biomaterials and cells).Research shows that printability can be affected by many factors or parameters,including those associated with the bioink,printing process,and scaffold design,but these are far from certain.This review highlights recent developments in the printability assessment of extrusion-based bioprinting with a focus on the definition of printability,printability measurements and characterization,and printability-affecting factors.Key issues and challenges related to printability are also identified and discussed,along with approaches or strategies for improving printability in extrusion-based bioprinting.

关键词： Extrusion 3D bioprinting Bioink Printability Tissue engineering

Nanotherapeutic approaches targeting angiogenesis and immune dysfunction in tumor microenvironment

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Science China(Life Sciences) 2018年第4期61卷 380-391页

作者： Sadaf Hameed Pravin Bhattarai Zhifei Dai Department of biomedical engineering College of Engineering Peking University

Tumor microenvironment(TME) comprising cellular and non-cellular components is a major source of cancer hallmarks.Notably, angiogenesis responsible for normal physiological remodeling process can otherwise harness vessel abnormalities during tumorigenesis eliciting severe therapeutic inefficiency. Currently, FDA approved antiangiogenic drugs have only shown modest clinical success owing to tumor hypoxia, antiangiogenic therapeutic resistance, and limited knowledge in understanding TME. In order to overcome these limitations, targeting angiogenesis combined with immunosuppressive TME could offer potential therapeutic opportunities. Indeed, these therapeutic approaches can be further revisited with the advent of nanotechnology that can target the key cellular components of TME and tumor cells more precisely. Synergetic targeting without eliciting systemic toxicity achieved by integration of antiangiogenic and immunotherapy in a single nanoplatform is vital for therapeutic success. In this review, we will discuss the most promising nanotechnological advancements oriented to modulate the immunosuppressive TME in association with antiangiogenic therapy that has gained immense popularity in cancer treatment.

关键词：微型环境免疫力指向肿瘤机能障碍癌症治疗治疗学 TME

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Electroactive chitosan-aniline pentamer hydrogel for peripheral nerve regeneration

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Frontiers of Materials Science 2022年第3期16卷 159-169页

作者： Deqiang MIAO Ya Li Zhongbing HUANG Yulin WANG Min DENG Xiaohui LI College of Biomedical Engineering Sichuan UniversityChengdu 610065China

Electroactive hydrogels could guide the regeneration of nerves and promote their functional recovery.An aniline pentamer-crosslinked chitosan(CS-AP)hydrogel with better electroactivity and degradation was fabricated by the carbodiimide method,and then injected into the repair site of sciatic nerve damage,with its gelation time,tensile strength,and conductivity reaching 35 min,5.02-6.69 MPa,and from 2.97×10^(-4) to 3.25×10^(-4) S-cm^(-1),respectively,due to the cross-linkage and well-distribution of AP.There was better cytocompativility of CS-AP hydrogel on nerve cells.The results of the in vivo repair indicated that CS-AP10 hydrogel induced the capillaries formation and the repair of sciatic nerve defect,and re-innervated gastrocnemius muscle in the CS-AP10 group were obviously better than other experimental groups,due to the electroactivity of CS-AP and its degradation into fragments.These results indicated the potential application of CS-AP hydrogel in the regeneration and function recovery of peripheral nerve injury.

关键词： peripheral nerve regeneration chitosan aniline pentamer electroactive hydrogel capillary formation

Transient stimulated Raman scattering spectroscopy and imaging

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Light(Science & Applications) 2024年第4期13卷 654-663页

作者： Qiaozhi Yu Zhengjian Yao Jiaqi Zhou Wenhao Yu Chenjie Zhuang Yafeng Qi Hanqing Xiong National biomedical Imaging Center College of Future TechnologyPeking UniversityBeijing 100871China biomedical engineering Department College of Future TechnologyPeking UniversityBeijing 100871China

Stimulated Raman scattering(SRS)has been developed as an essential quantitative contrast for chemical imaging in recent years.However,while spectral lines near the natural linewidth limit can be routinely achieved by state-of-the-art spontaneous Raman microscopes,spectral broadening is inevitable for current mainstream SRS imaging methods.This is because those SRS signals are all measured in the frequency domain.There is a compromise between sensitivity and spectral resolution:as the nonlinear process benefits from pulsed excitations,the fundamental time-energy uncertainty limits the spectral resolution.Besides,the spectral range and acquisition speed are mutually restricted.Here we report transient stimulated Raman scattering(T-SRS),an alternative time-domain strategy that bypasses all these fundamental conjugations.T-SRS is achieved by quantum coherence manipulation:we encode the vibrational oscillations in the stimulated Raman loss(SRL)signal by femtosecond pulse-pair sequence excited vibrational wave packet interference.The Raman spectrum was then achieved by Fourier transform of the time-domain SRL signal.Since all Raman modes are impulsively and simultaneously excited,T-SRS features the natural-linewidth-limit spectral line shapes,laser-bandwidth-determined spectral range,and improved sensitivity.With~150-fs laser pulses,we boost the sensitivity of typical Raman modes to the sub-mM level.With all-plane-mirror high-speed time-delay scanning,we further demonstrated hyperspectral SRS imaging of live-cell metabolism and high-density multiplexed imaging with the natural-linewidth-limit spectral resolution.T-SRS shall find valuable applications for advanced Raman imaging.

关键词： scattering excited mutually

3D biofabrication of vascular networks for tissue regeneration:A report on recent advances

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Journal of Pharmaceutical Analysis 2018年第5期8卷 277-296页

作者： M.D.Sarker Saman Naghieh N.K.Sharma Xiongbiao Chen Division of biomedical engineering College of Engineering University of Saskatchewan Department of Mechanical engineering College of Engineering University of Saskatchewan

Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue engineered constructs largely depends on the incorporation of a stable vascular network that eventually anastomoses with the host vasculature to support the various biological functions of embedded cells. In recent years, significant progress has been achieved with respect to extrusion, laser, micro-molding, and electrospinning-based techniques that allow the fabrication of any geometry in a layer-by-layer fashion. Moreover, decellularized matrix, self-assembled structures, and cell sheets have been explored to replace the biopolymers needed for scaffold fabrication. While the techniques have evolved to create specific tissues or organs with outstanding geometric precision, formation of interconnected, functional, and perfused vascular networks remains a challenge. This article briefly reviews recent progress in 3D fabrication approaches used to fabricate vascular networks with incorporated cells, angiogenic factors, proteins, and/or peptides. The influence of the fabricated network on blood vessel formation, and the various features, merits, and shortcomings of the various fabrication techniques are discussed and summarized.

关键词： 3D bioprinting Tissue engineering Vascularization Extrusion Laser-based printing Co-axial printing

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A facial strategy to efficiently improve catalytic performance of CoFe_(2)O_(4) to peroxymonosulfate

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Journal of Environmental Sciences 2022年第6期34卷 1-13页

作者： Lili Gao Jieqiong Deng Tong Li Kai Qi Jiandong Zhang Qun Yi college of Environmental Science and engineering Taiyuan University of TechnologyTaiyuan 030024China College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China

Cobalt iron spinel(CoFe_(2)O_(4)) has been considered as a good heterogeneous catalysis to peroxymonosulfate(PMS) in the degradation of persistent organic pollutants due to its magnetic properties and good chemical stability. However, its catalytic activity needs to be further improved. Here, a facial strategy, “in-situ substitution”, was adopted to modify CoFe_(2)O_(4) to improve its catalytic performance just by suitably increasing the Co/Fe ratio in synthesis process. Compared with CoFe_(2)O_(4), the newly synthesized Co_(1.5)Fe_(1.5)O_(4), could not only significantly improve the degradation efficiency of phenol, from 50.69 to 93.6%, but also exhibited more effective mineralization ability and higher PMS utilization. The activation energy advantage for phenol degradation using Co_(1.5)Fe_(1.5)O_(4)was only 44.2 k J/mol, much lower than that with CoFe_(2)O_(4)(127.3 k J/mol). A series of related representations of CoFe_(2)O_(4) and Co_(1.5)Fe_(1.5)O_(4) were compared to explore the possible reasons for the outstanding catalytic activity of Co_(1.5)Fe_(1.5)O_(4). Results showed that Co_(1.5)Fe_(1.5)O_(4)as well represented spinel crystal as CoFe_(2)O_(4)and the excess cobalt just partially replaced the position of iron without changing the original structure. Co_(1.5)Fe_(1.5)O_(4) had smaller particle size(8.7 nm), larger specific surface area(126.3 m^(2)/g), which was more favorable for exposure of active sites. Apart from the superior physical properties, more importantly, more reactive centers Co(Ⅱ) and surface hydroxyl compounds generated on Co_(1.5)Fe_(1.5)O_(4), which might be the major reason. Furthermore, Co_(1.5)Fe_(1.5)O_(4) behaved good paramagnetism, wide range of pH suitability and strong resistance to salt interference, making it a new prospect in environmental application.

关键词： CoFe_(2)O_(4) Co_(1.5)Fe_(1.5)O_(4) In-situ substitution Peroxymonosulfate(PMS) Advanced oxidation processes(AOPs)

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Whisker of biphasic calcium phosphate ceramics: Osteoimmunomodulatory behaviors

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Nano Research 2022年第10期15卷 9169-9182页

作者： Jinjie Wu Cong Feng Menglu Wang Hongfeng Wu Xiangdong Zhu Xiangfeng Li Xuening Chen Xingdong Zhang National engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China

Immune systems play a critical role in the regulation of bone formation and homeostasis,which arouses a growing interest in the development of biomaterials that can modulate both immune response and osteogenesis.In this study,biphasic calcium phosphate(BCP)ceramics were modified with different whiskered surface,and their effects on macrophage polarization and functional status were investigated.The results showed that compared to BCP-W ceramics with long and solid whiskers,BCPHW ceramics with short and hollow whiskers surface were conducive to protein adsorption and macrophage elongation.Furthermore,BCP-HW ceramics down-regulated the expression of M1 macrophage markers(Il1β,Tnfα,and iNos),promoted the expression of M2 macrophage markers(Il10 and Arg)and growth factors(Tgfβ1 and Bmp2),which might be attributed to the differential integrin expression regulated by different whisker structures.The conditioned medium derived from the supernatant of macrophage/whiskered ceramic co-culture was further used to culture MC3T3-E1 pre-osteoblasts to evaluate the effects of whiskered ceramic-mediated macrophage secretion on osteogenesis in vitro.Compared with BCP-W ones,the secretion pattern induced by BCP-HW ceramics could promote the expression of bone markers in pre-osteoblasts,which might due to the activation of intracellular signaling cascades like BMP/Smad and TGF-β/Smad signaling pathways.A murine intramuscular implantation model suggested that after implantation for 1,2,and 3 weeks,BCP-HW ceramics drove the switch of macrophages to ARG+wound-healing M2 phenotype,while BCP-W ceramics increased the proportion of iNOS+M1 inflammatory macrophages.At 2 months,only BCP-HW could induce ectopic bone formation.Taken together,these results indicated that BCP ceramics with hollow whiskers were capable of creating a proper inflammatory microenvironment to induce bone formation.These whiskered BCP ceramics with good osteo-immunomodulatory capacity hold promise in serving as bone grafts to achieve desired bone repair and regenerat

关键词： whisker macrophage polariztion osteoinduction biphasic calcium phosphate surface structure