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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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cGAS-STING: mechanisms and therapeutic opportunities

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Science China Life Sciences 2025年

作者： Mengyuan Zhang Changxin Wu Defen Lu Xing Wang Guijun Shang Shanxi Medical University School and Hospital of stomatology Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province Institutes of Biomedical Sciences Shanxi University college of Life Sciences Shanxi Agricultural University

The cGAS-STING pathway plays a crucial role in the innate immune system by detecting mislocalized double-stranded DNA(dsDNA) in the cytoplasm and triggering downstream signal transduction. Understanding the mechanisms by which cGAS and STING operate is vital for gaining insights into the biology of this pathway. This review provides a detailed examination of the structural features of cGAS and STING proteins, with a particular emphasis on their activation and inhibition mechanisms. We also discuss the novel discovery of STING functioning as an ion channel. Furthermore, we offer an overview of key agonists and antagonists of cGAS and STING, shedding light on their mechanisms of action. Deciphering the molecular intricacies of the cGAS-STING pathway holds significant promise for the development of targeted therapies aimed at maintaining immune homeostasis within both innate and adaptive immunity.

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The Effect of Alumina Content on Fracture Property of All-ceramics Zirconia

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Journal of Wuhan University of Technology(Materials Science) 2013年第1期28卷 73-78页

作者：张东姣 LIAO Yunmao LI Aijie1 XU Zujie SONG Dawei WANG Qi 陈新民 Prosthodontics West China College of Stomatology Sichuan University State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University

The purpose of the present study was to evaluate the effect ofA1203 content on the fracture property of all-ceramics ZrO2. To improve the all-ceramics ZrO2 restoration mechanics properity ,96 samples containing 0,5,10 and 15 wt% of A1203 particles were prepared by cold isostatic pressing （200 MPa） and 1 550 ℃ sintered .The phase was analyzed by X-ray diffraction analysis and the bulk densities of the samples were made using Archimedes principle. Samples were randomly divided into four groups. In each group, 24 specimens were prepared so that the angle between notch and specimen＇s long axis is 90° and 60°. Notch depths were 1 mm for all samples. Samples were loaded with three-point bending method. 90° cut samples were used to measure fracture toughness while 60°cut samples were used to observe fracture curve by taking points on the fracture extension path under microscope, plotting points on coordinates, generating fitting curve by software ＂Origin＂, and analyzing the microstructure of the specimen fracture surfaces by scanning electron microscopy （SEM）.The results show that the increment ofA1203 has insignificant effect on the densification of all-ceramic *** analysis shows that the specimen is comprised of t-ZrO2 and a- A1203 before fracture while fracture surface is m-ZrO2, t-ZrO2 and a-A1203. ZrO2 containing 10% A1203 has the optimum mechanical properties and unconspicuous crack propagation and distribution. The observations may provide a reference for the materials selection, shaoe design, and production orocess of all-ceramic crown and bridge.

关键词： ZrO2 A1203 all-ceramics notch fracture load fracture curve microstructure

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Cellular response to titanium discs coated with polyelectrolyte multilayer films

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International Journal of Minerals,Metallurgy and Materials 2014年第9期21卷 925-933页

作者： Jing Zhan Qiao-jie Luo Ying Huang Xiao-dong Li Department of stomatology Sir Run Run Shaw Hospital College of Medicine Zhejiang University Department of Oral and Maxillofacial Surgery the Affiliated Stomatology Hospital College of Medicine Zhejiang University

The purpose of this study was to investigate the effects ofpolyelectrolyte multilayer （PEM） coatings on the biological behavior of titanium （Ti） substrates. Collagen type I/hyaluronic acid （Col/HA） and chitosan/hyaluronic acid （Chi/HA） multilayer PEM coatings were introduced onto Ti substrates using layer-by-layer assembly. Contact angle instruments and quartz crystal microbalance were used for film characterization. The results obtained showed that both Col/HA and Chi/HA surfaces had high hydrophilicity and promoted cell adhesion in MC3T3-E1 pre-osteoblast and human gingival fibroblast cells. In addition, the synthesis of function-related proteins and gene expression levels in both MC3T3-E1 and fibroblast cells was higher for the Col/HA coating compared with the Chi/HA coating, indicating better cellular response to the Col/HA coating.

关键词： titanium surface modification polyelectrolytes multilayer films cellular response

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Preparation and Characterization of Nano-hydroxy apatite/Konjac Glucomannan Composite Scaffolds

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Journal of Wuhan University of Technology(Materials Science) 2010年第3期25卷 484-486页

作者：潘领战陈治清 West China college of stomatology Sichuan University

A novel nano-hydroxyapatite（HA）/konjac glucomannan composite scaffold with high porosity was developed by blending nano-HA particles with konjac glucomannan in alkaline *** scanning electron microscopy,porosity measurement,X-ray diffraction（XRD）,and Fourier transformed infrared（FTIR） spectroscopy were used to analyze the physical and chemical properties of the composite *** pure konjac glucomannan scaffolds and composite scaffolds were similar in their macroscopic morphology,however,the microscopic morphology on porewall surfaces was quite *** diffraction patterns of XRD revealed the presence of konjac glucomannan and HA in the composite *** addition,the results of FTIR also showed the existence of the functional group of *** results reveal that the newly developed nano-HA/konjac glucomannan composite scaffold may serve as a good three-dimensional substrate in bone tissue engineering.

关键词： konjac glucomannan hydroxyapatite microstructure nano scaffold

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Comparisons of Condylar Movements with the Functional Occlusal Clutch and Tray Clutch Recording Methods in CADIAX~ system

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International Journal of Oral Science 2010年第4期2卷 208-214页

作者： Bi-jie Han Hong Kang Lai-kui Liu Xin-zhu Yi Xiao-qing Li Department of Oral Anatomy and Physiology West China College of Stomatology Sichuan University Chengdu China Institute of stomatology Lanzhou University Lanzhou China college of stomatology Nanjing Medical Science University Nanjing China

Aim The purpose of this study is to compare the effects of the two clutches on recording the condylar movement. Methodology Ten subjects （6 women,4 men; mean age 25.4 years） participated in the study. The mandibular move-ment,sagittal condylar inclination angle,and transversal condylar inclination angle of each subject were recorded with the CADIAX？ using the two clutches,respectively. The characteristics of the tracings of the protrusion,opening,and mediotrusion were analyzed with the t-test statistics at α = 0.05 level. The Kappa values were calculated for an assessment of the congruence of the tracings. Results The results showed that the contour,direction,and dimension of the tracings in the two clutches were approxi-mately same,but the tracings determined by the functional occlusal clutch were more regular and congruent. In the group segment recorded with the tray clutch,opening/ closing paths of one subject showed crossed and time curves of three subjects appeared peak-like changes of velocity,but none were statistically different （P0.05）. Conclusion The research suggests that the functional occlusal clutch should be preferred in the evaluation of the mandibular function,as the tracings with the tray clutch are more likely to produce false positive results.

关键词： CADIAX temporomandibular joint mandibular movement functional clutch occlusion

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Antibacterial Properties of Nano Silver-containing Orthodontic Cements in the Rat Caries Disease Model

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Journal of Wuhan University of Technology(Materials Science) 2015年第6期30卷 1291-1296页

作者：李福军 FANG Ming PENG Yuying ZHANG Jiayin Hospital of stomatology Wuhan University Tieling Health college

The purpose of this study was to evaluate the antibacterial properties of experimental nano silver-containing cements（NSCs） using rat caries disease model. Nano silver base inorganic antibacterial powder was added to the reinforced glass ionomer cement at three different weight ratios to obtain a series of nano silver-containing cements, then two orthodontic cement products and three NSC samples were implanted into rat caries disease model, and their antibacterial properties were evaluated by the scanning electron microscope（SEM）. Moreover, the rat caries disease model were established by inoculating cariogenic bacteria S mutans into antibiotics treated rat mouths and feeding with cariogenic diet. The tested materials were bonded on the surface of the buccal half crowns of the upper fi rst premolar, and then fi xed under the rats＇ front teeth lingual side to acquire enough retention. The SEM results indicated that the growth of streptococcus mutans was very active in group of Transbond XT. One month later, S mutans scattered on the GC Fuji ORTHO LC surface, and then the number signifi cantly increased and arranged in chains after three months. In groups of NSC2, NSC3 and NSC4, the number of S mutans presented the downward trend and tended to disperse individually with the increase of silver nanoparticle content. We may conclude that the incorporation of silver nanoparticle enhanced GC Fuji ORTHO LC the adhesion restrain and killing effect to S mutans.

关键词： nano silver-containing orthodontic cements rat caries disease model antibacterial properties

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The influence of four dual-cure resin cements and surface treatment selection to bond strength of fiber post

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International Journal of Oral Science 2014年第1期6卷 56-60页

作者： Chang Liu Hong Liu Yue-Tong Qian Song Zhu Su-Qian Zhao college and Hospital of stomatology Jilin University Clinical Medical college Jilin University

In this study, we evaluate the influence of post surface pre-treatments on the bond strength of four different cements to glass fiber posts. Eighty extracted human maxillary central incisors and canines were endodontically treated and standardized post spaces were prepared. Four post pre-treatments were tested：（i） no pre-treatment （NS, control）, （ii） sandblasting （SA）, （iii） silanization （SI） and （iv） sandblasting followed by silanization （SS）. Per pre-treatment, four dual-cure resin cements were used for luting posts： DMG LUXACORE Smartmix Dual, Multilink Automix, RelyX Unicem and Panavia F2.0. All the specimens were subjected to micro push-out test. Two-way analysis of variance and Tukey post hoc tests were performed （α=0.05） to analyze the data. Bond strength was significantly affected by the type of resin cement, and bond strengths of RelyX Unicem and Panavia F2.0 to the fiber posts were significantly higher than the other cement groups. Sandblasting significantly increased the bond strength of DMG group to the fiber posts.

关键词： air abrasion field emission scanning electron microscope micro push-out bond strength silane surface pre-treatment

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Differentially expressed genes and signalling pathways are involved in mouse osteoblast-like MC3T3-E1 cells exposed to 17-β estradiol

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International Journal of Oral Science 2014年第3期6卷 142-149页

作者： Zhen-Zhen Shang Xin Li Hui-Qiang Sun Guo-Ning Xiao Cun-Wei Wang Qi Gong Department of Prosthodontics College of Stomatology Shandong University Department of stomatology The Affiliated Hospital of Medical College QingdaoUniversity Shandong Provincial Key Laboratory of Oral Biomedicine Shandong University

Oestrogen is essential for maintaining bone mass, and it has been demonstrated to induce osteoblast proliferation and bone *** this study, complementary DNA（cDNA） microarrays were used to identify and study the expression of novel genes that may be involved in MC3T3-E1 cells’ response to 17-b estradiol. MC3T3-E1 cells were inoculated in minimum essential media alpha（a-MEM）cell culture supplemented with 17-b estradiol at different concentrations and for different time periods. MC3T3-E1 cells treated with1028mol？L2117-b estradiol for 5 days exhibited the highest proliferation and alkaline phosphatase（ALP） activity; thus, this group was chosen for microarray analysis. The harvested RNA was used for microarray hybridisation and subsequent real-time reverse transcription polymerase chain reaction（RT-PCR） to validate the expression levels for selected genes. The microarray results were analysed using both functional and pathway analysis. In this study, microarray analysis detected 5 403 differentially expressed genes,of which 1 996 genes were upregulated and 3 407 genes were downregulated, 1 553 different functional classifications were identified by gene ontology（GO） analysis and 53 different pathways were involved based on pathway analysis. Among the differentially expressed genes, a portion not previously reported to be associated with the osteoblast response to oestrogen was identified. These findings clearly demonstrate that the expression of genes related to osteoblast proliferation, cell differentiation, collagens and transforming growth factor beta（TGF-b）-related cytokines increases, while the expression of genes related to apoptosis and osteoclast differentiation decreases, following the exposure of MC3T3-E1 cells to a-MEM supplemented with 17-b estradiol. Microarray analysis with functional gene classification is critical for a complete understanding of complementary intracellular processes. This microarray analysis provides large-scale gene expression

关键词： 17-β estradiol MC3T3-E1 cell microarray signal transduction

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TET1 knockdown inhibits the odontogenic differentiation potential of human dental pulp cells

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International Journal of Oral Science 2016年第2期8卷 110-116页

作者： Li-Jia Rao Bai-Cheng Yi Qi-Meng Li Qiong Xu Guanghua School of stomatology Guangdong Provincial Key Laboratory of Stomatology Sun Yat-sen University Guangzhou China Department of stomatology Nanshan Affiliated Hospital of Guangdong Medical College Shenzhen China

Human dental pulp cells （hDPCs） possess the capacity to differentiate into odontoblast-like cells and generate reparative dentin in response to exogenous stimuli or injury. Ten-eleven translocation 1 （TET1） is a novel DNA methyldioxygenase that plays an important role in the promotion of DNA demethylation and transcriptional regulation in several cell lines. However, the role of TET1 in the biological functions of hDPCs is unknown. To investigate the effect of TET1 on the proliferation and odontogenic differentiation potential of hDPCs, a recombinant shRNA lentiviral vector was used to knock down TET1 expression in hDPCs. Following TET1 knockdown, TET1 was significantly downregulated at both the mRNA and protein levels. Proliferation of the hDPCs was suppressed in the TET1 knockdown groups. Alkaline phosphatase activity, the formation of mineralized nodules, and the expression levels of DSPP and DMP1 were all reduced in the TETl-knockdown hDPCs undergoing odontogenic differentiation. Based on these results, we concluded that TET1 knockdown can prevent the proliferation and odontogenic differentiation of hDPCs, which suggests that TET1 may play an important role in dental pulp repair and regeneration.

关键词： DNA demethylation human dental pulp cell knockdown odontogenic differentiation ten-eleven translocation 1

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