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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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cGAS-STING: mechanisms and therapeutic opportunities

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Science China Life Sciences 2025年

作者： Mengyuan Zhang Changxin Wu Defen Lu Xing Wang Guijun Shang Shanxi Medical University School and Hospital of stomatology Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials The Key Laboratory of Medical Molecular Cell Biology of Shanxi Province Institutes of Biomedical Sciences Shanxi University college of Life Sciences Shanxi Agricultural University

The cGAS-STING pathway plays a crucial role in the innate immune system by detecting mislocalized double-stranded DNA(dsDNA) in the cytoplasm and triggering downstream signal transduction. Understanding the mechanisms by which cGAS and STING operate is vital for gaining insights into the biology of this pathway. This review provides a detailed examination of the structural features of cGAS and STING proteins, with a particular emphasis on their activation and inhibition mechanisms. We also discuss the novel discovery of STING functioning as an ion channel. Furthermore, we offer an overview of key agonists and antagonists of cGAS and STING, shedding light on their mechanisms of action. Deciphering the molecular intricacies of the cGAS-STING pathway holds significant promise for the development of targeted therapies aimed at maintaining immune homeostasis within both innate and adaptive immunity.

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The Effect of Alumina Content on Fracture Property of All-ceramics Zirconia

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Journal of Wuhan University of Technology(Materials Science) 2013年第1期28卷 73-78页

作者：张东姣 LIAO Yunmao LI Aijie1 XU Zujie SONG Dawei WANG Qi 陈新民 Prosthodontics West China College of Stomatology Sichuan University State Key Laboratory of Oral Diseases West China College of Stomatology Sichuan University

The purpose of the present study was to evaluate the effect ofA1203 content on the fracture property of all-ceramics ZrO2. To improve the all-ceramics ZrO2 restoration mechanics properity ,96 samples containing 0,5,10 and 15 wt% of A1203 particles were prepared by cold isostatic pressing （200 MPa） and 1 550 ℃ sintered .The phase was analyzed by X-ray diffraction analysis and the bulk densities of the samples were made using Archimedes principle. Samples were randomly divided into four groups. In each group, 24 specimens were prepared so that the angle between notch and specimen＇s long axis is 90° and 60°. Notch depths were 1 mm for all samples. Samples were loaded with three-point bending method. 90° cut samples were used to measure fracture toughness while 60°cut samples were used to observe fracture curve by taking points on the fracture extension path under microscope, plotting points on coordinates, generating fitting curve by software ＂Origin＂, and analyzing the microstructure of the specimen fracture surfaces by scanning electron microscopy （SEM）.The results show that the increment ofA1203 has insignificant effect on the densification of all-ceramic *** analysis shows that the specimen is comprised of t-ZrO2 and a- A1203 before fracture while fracture surface is m-ZrO2, t-ZrO2 and a-A1203. ZrO2 containing 10% A1203 has the optimum mechanical properties and unconspicuous crack propagation and distribution. The observations may provide a reference for the materials selection, shaoe design, and production orocess of all-ceramic crown and bridge.

关键词： ZrO2 A1203 all-ceramics notch fracture load fracture curve microstructure

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Cellular response to titanium discs coated with polyelectrolyte multilayer films

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International Journal of Minerals,Metallurgy and Materials 2014年第9期21卷 925-933页

作者： Jing Zhan Qiao-jie Luo Ying Huang Xiao-dong Li Department of stomatology Sir Run Run Shaw Hospital College of Medicine Zhejiang University Department of Oral and Maxillofacial Surgery the Affiliated Stomatology Hospital College of Medicine Zhejiang University

The purpose of this study was to investigate the effects ofpolyelectrolyte multilayer （PEM） coatings on the biological behavior of titanium （Ti） substrates. Collagen type I/hyaluronic acid （Col/HA） and chitosan/hyaluronic acid （Chi/HA） multilayer PEM coatings were introduced onto Ti substrates using layer-by-layer assembly. Contact angle instruments and quartz crystal microbalance were used for film characterization. The results obtained showed that both Col/HA and Chi/HA surfaces had high hydrophilicity and promoted cell adhesion in MC3T3-E1 pre-osteoblast and human gingival fibroblast cells. In addition, the synthesis of function-related proteins and gene expression levels in both MC3T3-E1 and fibroblast cells was higher for the Col/HA coating compared with the Chi/HA coating, indicating better cellular response to the Col/HA coating.

关键词： titanium surface modification polyelectrolytes multilayer films cellular response

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Preparation and Characterization of Nano-hydroxy apatite/Konjac Glucomannan Composite Scaffolds

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Journal of Wuhan University of Technology(Materials Science) 2010年第3期25卷 484-486页

作者：潘领战陈治清 West China college of stomatology Sichuan University

A novel nano-hydroxyapatite（HA）/konjac glucomannan composite scaffold with high porosity was developed by blending nano-HA particles with konjac glucomannan in alkaline *** scanning electron microscopy,porosity measurement,X-ray diffraction（XRD）,and Fourier transformed infrared（FTIR） spectroscopy were used to analyze the physical and chemical properties of the composite *** pure konjac glucomannan scaffolds and composite scaffolds were similar in their macroscopic morphology,however,the microscopic morphology on porewall surfaces was quite *** diffraction patterns of XRD revealed the presence of konjac glucomannan and HA in the composite *** addition,the results of FTIR also showed the existence of the functional group of *** results reveal that the newly developed nano-HA/konjac glucomannan composite scaffold may serve as a good three-dimensional substrate in bone tissue engineering.

关键词： konjac glucomannan hydroxyapatite microstructure nano scaffold

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Antibacterial Properties of Nano Silver-containing Orthodontic Cements in the Rat Caries Disease Model

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Journal of Wuhan University of Technology(Materials Science) 2015年第6期30卷 1291-1296页

作者：李福军 FANG Ming PENG Yuying ZHANG Jiayin Hospital of stomatology Wuhan University Tieling Health college

The purpose of this study was to evaluate the antibacterial properties of experimental nano silver-containing cements（NSCs） using rat caries disease model. Nano silver base inorganic antibacterial powder was added to the reinforced glass ionomer cement at three different weight ratios to obtain a series of nano silver-containing cements, then two orthodontic cement products and three NSC samples were implanted into rat caries disease model, and their antibacterial properties were evaluated by the scanning electron microscope（SEM）. Moreover, the rat caries disease model were established by inoculating cariogenic bacteria S mutans into antibiotics treated rat mouths and feeding with cariogenic diet. The tested materials were bonded on the surface of the buccal half crowns of the upper fi rst premolar, and then fi xed under the rats＇ front teeth lingual side to acquire enough retention. The SEM results indicated that the growth of streptococcus mutans was very active in group of Transbond XT. One month later, S mutans scattered on the GC Fuji ORTHO LC surface, and then the number signifi cantly increased and arranged in chains after three months. In groups of NSC2, NSC3 and NSC4, the number of S mutans presented the downward trend and tended to disperse individually with the increase of silver nanoparticle content. We may conclude that the incorporation of silver nanoparticle enhanced GC Fuji ORTHO LC the adhesion restrain and killing effect to S mutans.

关键词： nano silver-containing orthodontic cements rat caries disease model antibacterial properties

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Comparisons of Condylar Movements with the Functional Occlusal Clutch and Tray Clutch Recording Methods in CADIAX~ system

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International Journal of Oral Science 2010年第4期2卷 208-214页

作者： Bi-jie Han Hong Kang Lai-kui Liu Xin-zhu Yi Xiao-qing Li Department of Oral Anatomy and Physiology West China College of Stomatology Sichuan University Chengdu China Institute of stomatology Lanzhou University Lanzhou China college of stomatology Nanjing Medical Science University Nanjing China

Aim The purpose of this study is to compare the effects of the two clutches on recording the condylar movement. Methodology Ten subjects （6 women,4 men; mean age 25.4 years） participated in the study. The mandibular move-ment,sagittal condylar inclination angle,and transversal condylar inclination angle of each subject were recorded with the CADIAX？ using the two clutches,respectively. The characteristics of the tracings of the protrusion,opening,and mediotrusion were analyzed with the t-test statistics at α = 0.05 level. The Kappa values were calculated for an assessment of the congruence of the tracings. Results The results showed that the contour,direction,and dimension of the tracings in the two clutches were approxi-mately same,but the tracings determined by the functional occlusal clutch were more regular and congruent. In the group segment recorded with the tray clutch,opening/ closing paths of one subject showed crossed and time curves of three subjects appeared peak-like changes of velocity,but none were statistically different （P0.05）. Conclusion The research suggests that the functional occlusal clutch should be preferred in the evaluation of the mandibular function,as the tracings with the tray clutch are more likely to produce false positive results.

关键词： CADIAX temporomandibular joint mandibular movement functional clutch occlusion

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The effect of low fluoride concentrations on microdamage accumulation in mouse tibias under impact loading

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Acta Mechanica Sinica 2015年第6期31卷 944-951页

作者： Qing Luo Nan Chen Yan-Heng Zhou Qi-Guo Rong Department of Orthodontics Peking University School and Hospital of Stomatology college of Engineering Peking University

Microdamage accumulation in bone is one of the mechanisms for energy dissipation during the fracture process. Changes in the ultrastructure and composition of bone constituents due to aging or diseases could affect microdamage accumulation. Low concentration （1 mM） of sodium fluoride （NaF） has been used in this study to investigate the effect of ultrastructural changes on microdamage accumu- lation in mouse tibias following free-fall impact loadings. Twenty-two tibias were divided randomly into control and NaF-treated groups. Free-fall impact loading was conducted twice on each tibia to produce microdamage. The elas- tic modulus of NaF-treated tibias decreased significantly after the impact loadings, while there was no significant difference in the modulus of untreated samples between pre- and post-damage loadings. Microdamage morphology analysis showed that less and shorter microcracks existed in NaF-treated tibias compared with control bones. Meanwhile, more and longer microcracks were observed in tensile regions in untreated samples compared with that in compressive regions, whereas no significant difference was observed between tensile and compressive regions in NaF-treated bones. The results of this study indicate that more energy is required to generate microcracks in NaF-treated bone than in normal bone. A low concentration of fluoride treatment may increase the toughness of bone under impact loading.

关键词： Microdamage accumulation · Fluoridetreatment · Ultrastructural changes · Free-fall impact

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Effects of orthodontic load on the periodontium of autogenously transplanted teeth in beagle dogs

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1025-1032页

作者： Lu LU Hui-fang SUN Han XUE Jing GUO Yang-xi CHEN Department of Orthodontics Stomatology HospitalSchool of StomatologyShandong University Shandong Provincial Key Laboratory of Oral Biomedicine Shandong University Department of Orthodontics West China College of StomatologySichuan University

Objective:To observe the periodontal healing of autogenously transplanted teeth loaded orthodontically after autotransplantation in Beagle ***:Forty-eight teeth were autogenously transplanted,24 of which were loaded postoperatively with orthodontic force at different time points and for different *** healing was evaluated by probing pocket depth(PPD),the expression of relevant proteins,and histomorphometric ***:The dental pockets of loaded and non-loaded teeth were both much deeper after the first postoperative week than before transplantation(P<0.05).Later,the PPD,which was measured after postoperative weeks 1,3,5,9 and 13,gradually became *** expressions of alkaline phosphatase(ALP)and basic fibroblast growth factor(bFGF)were higher in loaded teeth than in non-loaded teeth(P<0.05),and in groups subjected to two weeks duration of loading than in other groups at the same load time point(P<0.05).For the same load duration,the expressions of ALP and bFGF in teeth loaded after postoperative week 4 were higher than those of other treatments(P<0.05).According to histomorphometric analyses,an orthodontic force on transplanted teeth applied after postoperative weeks 4 or 8 for two weeks duration should be favorable for periodontal ***:It is advisable to apply an appropriate magnitude of force on autotransplanted teeth,such as orthodontic force,at appropriate time points and for a suitable duration,to achieve the optimal clinical prognosis following autogenous tooth *** results may serve as a basis for subsequent studies in humans so as to make clinical improvements.

关键词： Autogenous tooth transplantation Periodontium healing Orthodontic load

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Bone-inducing Activity of Biological Piezoelectric Ceramic

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Journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 108-110页

作者：王鹏陈治清 college of stomatology Sichuan University Chengdu 610041 China

To simulate the piezoelectric effect of nature bone, two kinds of biological piezoelectric composite ceramics consisted of hydroxyapatite （ HA ） and lithium sodium potassium niobate （LNK） ceramic of which the ratio of HA/LNK was 1 ： 10 and 5 ： 5（ wt/ wt ） were prepared. Their piezoelectric property and growth of apatite crystal in the ceramics surface were investigated. With the increase of LNK amount, piezoelectric activity increased correspondingly. By immersing the poled piezoelectric ceramics in simulated body fluid （SBF） at 36.5 ℃ for 7, 14, and 21 days, apatite crystal was formed on negatively charged surfaces. After 21 days immersion in SBF, the thickest apatite crystal on the negatively charged surfaces increased to 3. 337 μn. The hotel biological piezoelectric ceramics show an excellent piezoelectric property and superior potential bioactivity.

关键词： biological piezoelectric ceramic piezoelectric constant simulated body fluid

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