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A novel mechanism of PHB2-mediated mitophagy participating in the development of Parkinson's disease

Neural Regeneration Research 2024年第8期19卷 1828-1834页

作者： Yongjiang Zhang Shiyi Yin Run Song Xiaoyi Lai Mengmeng Shen Jiannan Wu Junqiang Yan Key Laboratory of Neuromolecular biology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Endoplasmic reticulum stress and mitochondrial dysfunction play important roles in Parkinson s disease,but the regulato ry mechanism remains ***-2(PHB2)is a newly discove red autophagy receptor in the mitochondrial inner membrane,and its role in Parkinson’s disease remains *** kinase R(PKR)-like endoplasmic reticulum kinase(PERK)is a factor that regulates cell fate during endoplasmic reticulum *** is regulated by PERK and is a target of the unfolded protein *** is unclear whether PERK regulates PHB2-mediated mitophagy thro ugh *** this study,we established a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model of Parkinson’s *** used adeno-associated virus to knockdown PHB2 *** res ults showed that loss of dopaminergic neurons and motor deficits were aggravated in the MPTP-induced mouse model of Parkinson’s *** rexpression of PHB2 inhibited these *** also established a 1-methyl-4-phenylpyridine(MPP+)-induced SH-SY5Y cell model of Parkinson’s *** found that ove rexpression of Parkin increased co-localization of PHB2 and microtubule-associated protein 1 light chain 3,and promoted *** addition,MPP+regulated Parkin involvement in PHB2-mediated mitophagy through phosphorylation of *** findings suggest that PHB2 participates in the development of Parkinson’s disease by intera cting with endoplasmic reticulum stress and Parkin.

关键词： endoplasmic reticulum dopaminergic neuron microtubule-associated protein 1 light chain 3 mitophagy oxidative stress Parkin Parkinson’s disease PKR-like endoplasmic reticulum kinase reactive oxygen species prohibitin-2

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Multicolor circularly polarized phosphorescence of axially chiral binuclear platinum(Ⅱ) complexes

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science China Chemistry 2024年第11期67卷 3757-3766页

作者： Jintong Song Rui Zeng Hui Xiao Hailiang Ni Zong-Xiang Xu Haifeng Xiang college of Chemistry and Materials science Sichuan Normal University Department of Chemistry Southern University of Science and Technology college of Chemistry Sichuan University

D-A charge transfer, including through-bond charge transfer and through-space charge transfer between two different electron donors（D） and electron acceptors（A）, is a fundamental and powerful tool to tune the optical properties of organic dyes. Herein,we demonstrate a unique strategy to tune phosphorescence and circularly polarized luminescence properties of axially chiral binuclear Pt（Ⅱ） complexes through long-range charge transfer, even though these molecules have two totally identical segments on either side of the chiral core. The presence of axial chirality would break not only the symmetry of molecular structure and π-conjugation system but also the symmetry of charge distribution for long-range charge transfer. These binaphthyl-based Pt（Ⅱ）complexes bearing coordinated atoms far away from chiral axis exhibit no Pt-Pt interactions but colorful concentrationdependent phosphorescence with quantum yield up to 86.4% and could be applied as emitters in highly efficient solutionprocessed organic light-emitting diodes to achieve luminance, luminance efficiency, power efficiency, external quantum efficiency, and asymmetry factor up to 8.94 × 10～3cd m-2, 41.9 cd A-1, 18.8 lm W-1, 12.6% and 2.98 × 10-3, respectively. Therefore,the present work affords a new and simple way to utilize the inherently asymmetric advantage of chirality for the design of D-Abased organic dyes.

关键词： Pt(II) complexes organic light-emitting diodes circularly polarized phosphorescence axial chirality

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Crystalline cyclic(alkyl)(amino)stannylene via transient stannyne

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science China Chemistry 2024年

作者： Xinfeng Wang Chaopeng Hu Zhihao Lu Liu Leo Liu Department of Chemistry and Research Center for Chemical biology and Omics Analysis College of Science Southern University of Science and Technology

We demonstrate that a bulky cyclic amino ligand, specifically 1,1,3,3-tetraphenylisoindolinyl, can facilitate the formation of a transient stannyne, endowed with adjacent ambiphilic carbon and tin centers. This stannyne, manifesting carbene-like behavior,engages in an unprecedented sequence of reactions, including Buchner ring expansion, [1,3]sigmatropic, and [1,5]-sigmatropic shifts, culminating in the synthesis of a stable cyclic(alkyl)(amino)stannylene. This compound represents the first tin analogue of the well-known cyclic(alkyl)(amino)carbenes. Both the bonding configuration and the formation process of this stannylene are thoroughly analyzed through quantum chemical computations. Our findings pave the way for further synthesis of unusual main group species using bulky isoindolinyl substituents, emphasizing their potential as a versatile tool in synthetic chemistry.

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Hydrochemical insights on the signatures and genesis of water resources in a high-altitude city on the Qinghai-Xizang Plateau, South-west China

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Frontiers of Environmental science & Engineering 2024年第7期18卷 123-140页

作者： Jiutan Liu Kexin Lou Zongjun Gao Menghan Tan college of Earth science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Water resources have crucial implications for the steady development of the urban social *** study investigated the hydrochemical signatures and genesis of water resources in the urban area of Lhasa City(UALC).To this end,several analyses,such as ion ratio analysis and correlation analysis,were performed by comprehensively applying mathematical statistics and integrated hydrochemical *** results show relatively low concentrations of major ions in the groundwater and surface water(GSW)of the *** primary anions and cations are HCO3-and Ca2+,reflecting the HCOg-Ca water ***,groundwater exhibits higher concentrations of key chemical components compared to surface *** are weakly alkaline,with pH values of 7.78 and 7.61,respectively,and they have low salinity with average concentrations of total dissolved solids being 190.74 and 112.17 mg/L,*** inputs have minimal influence on the hydrochemical features of GSw,whereas rock weathering is the dominant controlling ***,cation *** a significant *** influencing their hydrochemical *** to the isotope analysis(H and 180),the primary source of recharge for GSW is atmospheric precipitation,with some input from melted ice and ***,GSW samples from the UALC show relatively similar 2H and 18O isotopic compositions,indicating the existence of a discernible hydraulic connection linking the two water *** research findings can serve as a valuable scientific reference and foundation for the sustainable development,effective utilization,and proper safeguarding of regional water resources in high-altitude areas.

关键词： Groundwater and surface water Hydrochemical features Genesis mechanism Water quality Urban area of Lhasa City

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Quantum control based on three forms of Lyapunov functions

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Chinese Physics B 2024年第4期33卷 216-222页

作者：俞国慧杨洪礼 college of Mathematics and Systems science Shandong University of Science and TechnologyQingdao 266590China

This paper introduces the quantum control of Lyapunov functions based on the state distance, the mean of imaginary quantities and state *** this paper, the specific control laws under the three forms are *** is analyzed by the La Salle invariance principle and the numerical simulation is carried out in a 2D test *** calculation process for the Lyapunov function is based on a combination of the average of virtual mechanical quantities, the particle swarm algorithm and a simulated annealing ***, a unified form of the control laws under the three forms is given.

关键词： quantum system Lyapunov function particle swarm optimization simulated annealing algorithms quantum control

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A New Method for Solving Nonlinear Partial Differential Equations Based on Liquid Time-Constant Networks

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Journal of Systems science & Complexity 2024年第2期37卷 480-493页

作者： SUN Jiuyun DONG Huanhe FANG Yong college of Mathematics and Systems science Shandong University of Science and TechnologyQingdao 266590China

In this paper,physics-informed liquid networks(PILNs)are proposed based on liquid time-constant networks(LTC)for solving nonlinear partial differential equations(PDEs).In this approach,the network state is controlled via ordinary differential equations(ODEs).The significant advantage is that neurons controlled by ODEs are more expressive compared to simple activation *** addition,the PILNs use difference schemes instead of automatic differentiation to construct the residuals of PDEs,which avoid information loss in the neighborhood of sampling *** this method draws on both the traveling wave method and physics-informed neural networks(PINNs),it has a better physical ***,the KdV equation and the nonlinear Schr¨odinger equation are solved to test the generalization ability of the *** the best of the authors’knowledge,this is the first deep learning method that uses ODEs to simulate the numerical solutions of PDEs.

关键词： Nonlinear partial differential equations numerical solutions physics-informed liquid networks physics-informed neural networks

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Curation,nomenclature,and topological classification of receptor-like kinases from 528 plant species for novel domain discovery and functional inference

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Molecular Plant 2024年第4期17卷 658-671页

作者： Qian Liu Qiong Fu Yujie Yan Qian Jiang Longfei Mao Long Wang Feng Yu Heping Zheng State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University College of BiologyChangshaHunan 410082China Bioinformatics Center Hunan University College of BiologyChangshaHunan 410082China

Receptor-like kinases(RLKs)are the most numerous signal transduction components in plants and play important roles in determining how different plants adapt to their ecological *** on RLKs has focused mainly on a small number of typical RLK members in a few model *** is an urgent need to study the composition,distribution,and evolution of RLKs at the holistic level to increase our understanding of how RLKs assist in the ecological adaptations of different plant *** this study,we collected the genome assemblies of 528 plant species and constructed an RLK *** this dataset,we identified and characterized 524948 RLK family *** member underwent systematic topological classification and was assigned a gene ID based on a unified nomenclature ***,we identified two novel extracellular domains in some RLKs,designated Xiao and *** analysis of the RLK family revealed that the RLCK-XVII and RLCK-XII-2 classes were present exclusively in dicots,suggesting that diversification of RLKs between monocots and dicots may have led to differences in downstream cytoplasmic *** also used an interaction proteome to help empower data mining for inference of new RLK functions from a global perspective,with the ultimate goal of understanding how RLKs shape the adaptation of different plants to the environments/*** assembled RLK dataset,together with annotations and analytical tools,forms an integrated foundation of multiomics data that is publicly accessible via the metaRLK web portal(http://***).

关键词： RLK RLCK domain signaling pathway receptor-protein interactions

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MoO_(x) nanoclusters on Mo-doped TiO_(2) nanosheets with enhanced singlet oxygen generation and sulfide conversion abilities for photocatalytic aerobic oxidative desulfurization

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science China Chemistry 2024年第1期67卷 408-414页

作者： Suting Xie Xinyu Zhao Dongxiao Wang Huawei Yang Lixia Yang Liangjiu Bai Donglei Wei Wenxiang Wang Ying Liang Hou Chen Shaojun Guo college of Chemistry and Materials science Ludong UniversityYantai 264025China college of Materials science and Engineering Peking UniversityBeijing 100871China

Photocatalytic aerobic oxidation desulfurization(PAODS)is a promising and sustainable alternative to conventional,energyintensive desulfurization techniques for petroleum ***,its development is greatly plagued by the low capability in generating highly reactive oxygen species and sluggish kinetics of sulfide oxidation of reported *** we report a class of MoO_(x)nanocluster decorated on ultrathin Mo-doped TiO_(2)nanosheet(MoO_(x)/MoTiO)catalyst for efficiently facilitating the photocatalytic aerobic oxidation of *** demonstrate that MoO_(x)/MoTiO can not only promote the generation of highly reactive singlet oxygen(^(1)O_(2))but also enhance the aerobic conversion of sulfides,which leads to a record dibenzothiophene oxidation activity of 3.90 mmol g^(-1)h^(-1).The multiple experimental characterizations and density functional theory calculations collectively reveal that the doped-Mo sites can interact with the photogenerated excitons,enabling directly energy transfer generation of^(1)O_(2)through a new exciton modulation mechanism,and the coordination unsaturated MoO_(x)clusters play the role of co-catalyst to enhance the separation of charge carriers,and effectively catalyze the reaction between sulfides and1O_(2)to form sulfones.

关键词： titanium dioxide photocatalytic aerobic oxidation desulfurization dibenzothiophene singlet oxygen

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Supplementation with dimethylglycine sodium salt improves lipid metabolism disorder in intrauterine growth-retarded pigs

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Animal Nutrition 2024年第3期18卷 191-202页

作者： Kaiwen Bai Luyi Jiang Tian Wang School of Biological and Chemical Engineering Zhejiang University of Science and TechnologyHangzhou 310023China college of Animal science and Technology Nanjing Agricultural UniversityNanjing 210095China college of biology and Environmental Engineering Zhejiang Shuren UniversityHangzhou 310023China Institute of Dairy science Ministry of Education Key Laboratory of Molecular Animal NutritionCollege of Animal SciencesZhejiang UniversityHangzhou 310023China

This study aims to elucidate the mechanism of lipid metabolism disorder in intrauterine growth retardation(IUGR)pigs and the potential alleviating effects of dimethylglycine sodium salt(DMG-Na).A total of 60 male newborn piglets were selected for this *** each litter,one normal birth weight(NBW)male piglet(1.53±0.04 kg)and two IUGR male piglets(0.76±0.06 kg)were chosen based on their birth *** piglets were divided into three groups for the study:NBW pigs received a PBS gavage and a common basal diet(NBW-C group),IUGR pigs received the same PBS gavage and common basal diet(IUGR-C group),and IUGR pigs received a 70-mg DMG-Na gavage along with a common basal diet supplemented with 0.1%DMG-Na(IUGR-D group).At 150 d of age,all piglets underwent euthanasia by exsanguination following electrical stunning,after which plasma,liver,and longissimus dorsi(LM)samples were promptly *** IUGR-D group demonstrated improvements in plasma parameters(P<0.05),with lower triglyceride and free fatty acid(FFA)values,and hormone levels(P<0.05),with lower growth hormone,insulin,and homeostasis model assessment of insulin resistance *** of lipid metabolism was observed(P<0.05),with lower triglyceride and FFA,and higher hepatic lipase and total lipase values in the liver,and lower triglyceride and FFA values in the *** ETC complexes showed increased levels(P<0.05),including higher complex III values in the liver,and higher complex I,complex III,and complex V values in the *** levels of energy metabolites were noted(P<0.05),with higher NAD^(+),NAD^(+)/NADH,adenosine triphosphate,and mtDNA values,and lower NADH values in the liver and ***,meat quality parameters showed improvement(P<0.05),with higher pH 24 h and a^(*)values,and lower drip loss 48 h,L^(*),and b^(*)*** expressions of lipid metabolism and mitochondrial function-related genes and proteins were upregulated(P<0.05)compared to the IUGR-C *** conclusio

关键词： Intrauterine growth retardation Pig Lipid metabolism Mitochondrial function Dimethylglycine sodium salt

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Enhanced axonal regeneration and functional recovery of the injured sciatic nerve in a rat model by lithium-loaded electrospun nanofibrous scaffolds

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Bio-Design and Manufacturing 2024年第5期7卷 701-720页

作者： Banafsheh Dolatyar Bahman Zeynali Iman Shabani Azita Parvaneh Tafreshi Reza Karimi-Soflou Developmental biology Laboratory School of BiologyCollege of ScienceUniversity of TehranTehran ***Iran Department of Biomedical Engineering Amirkabir University of Technology(Tehran Polytechnic)Tehran ***Iran Department of Molecular Medicine Faculty of Medical BiotechnologyNational Institute of Genetic Engineering and BiotechnologyTehran ***Iran 123

Increasing evidence indicates that engineered nerve grafts have great potential for the regeneration of peripheral nerve injuries(PNIs).While most studies have focused only on the topographical features of the grafts,we have considered both the biophysical and biochemical manipulations in our applied *** achieve this,we fabricated an electrospun nanofibrous scaffold(ENS)containing polylactide nanofibers loaded with lithium(Li)ions,a Wnt/β-catenin signaling *** addition,we seeded human adipose-derived mesenchymal stem cells(hADMSCs)onto this engineered scaffold to examine if their differentiation toward Schwann-like cells was *** further examined the efficacy of the scaffolds for nerve regeneration in vivo via grafting in a PNI rat *** results showed that Li-loaded ENSs gradually released Li within 11 d,at concentrations ranging from 0.02 to(3.64±0.10)mmol/L,and upregulated the expression of Wnt/β-catenin target genes(cyclinD1 and c-Myc)as well as those of Schwann cell markers(growth-associated protein 43(GAP43),S100 calcium binding protein B(S100B),glial fibrillary acidic protein(GFAP),and SRY-box transcription factor 10(SOX10))in differentiated *** the PNI rat model,implantation of Li-loaded ENSs with/without cells improved behavioral features such as sensory and motor functions as well as the electrophysiological characteristics of the injured *** improved function was further validated by histological analysis of sciatic nerves grafted with Li-loaded ENSs,which showed no fibrous connective tissue but enhanced organized myelinated *** potential of Li-loaded ENSs in promoting Schwann cell differentiation of hADMSCs and axonal regeneration of injured sciatic nerves suggests their potential for application in peripheral nerve tissue engineering.

关键词： Stem cell Schwann cell differentiation Electrospun nanofibrous scaffold Lithium ion Nerve regeneration

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