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RoBGP:A Chinese Nested Biomedical Named Entity Recognition Model Based on RoBERTa and Global Pointer

Computers, Materials & Continua 2024年第3期78卷 3603-3618页

作者： Xiaohui Cui Chao Song Dongmei Li Xiaolong Qu Jiao Long Yu Yang Hanchao Zhang School of Information Science and Technology Beijing Forestry UniversityBeijing100083China Engineering research Center for Forestry-Oriented Intelligent Information processing of National Forestry and Grassland Administration Beijing100083China division of Biostatistics Department of Population HealthGrossman School of MedicineNew York UniversityNew York10016USA

Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and categorize them into predefined entity *** process can provide basic support for the automatic construction of knowledge *** contrast to general texts,biomedical texts frequently contain numerous nested entities and local dependencies among these entities,presenting significant challenges to prevailing NER *** address these issues,we propose a novel Chinese nested biomedical NER model based on RoBERTa and Global Pointer(RoBGP).Our model initially utilizes the RoBERTa-wwm-ext-large pretrained language model to dynamically generate word-level initial *** then incorporates a Bidirectional Long Short-Term Memory network for capturing bidirectional semantic information,effectively addressing the issue of long-distance ***,the Global Pointer model is employed to comprehensively recognize all nested entities in the *** conduct extensive experiments on the Chinese medical dataset CMeEE and the results demonstrate the superior performance of RoBGP over several baseline *** research confirms the effectiveness of RoBGP in Chinese biomedical NER,providing reliable technical support for biomedical information extraction and knowledge base construction.

关键词： Biomedicine knowledge base named entity recognition pretrained language model global pointer

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Super-high bed sintering for iron ores:behaviors,causes and solutions of horizontal segregation on strand

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Journal of Iron and Steel research(International) 2024年第7期31卷 1590-1596页

作者： Liang-ping Xu Hui-bo Liu Zhong-lin Dong Qiang Zhong Yu-chao Zhao Guang-hui Li School of Minerals processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Horizontal segregation has been a constraint to the development and application of super-high bed *** eliminate the horizontal segregation of super-high bed sintering,several typical sintering machines were sampled and analyzed,and theoretical calculation was made to compare the bed depth and their differences in different areas within the mixture ***,solutions were proposed and applied to a 265 m^(2) sintering *** results showed that the horizontal seg-regation of the 265 m^(2) sintering machine was dominated by particles larger than 8 mm with horizontal segregation degree of 0.48,while 360 and 550 m^(2) sintering machines were affected by 5-8 mm and 1-3 mm particles with horizontal segregation degree of 0.27 and 0.31,*** analysis indicated the different segregation distribution results from the matching of the bed depth of each area within the mixture ***,the horizontal segregation degree not larger than 0.06 was achieved by optimizing the time parameters and the division of three zones on the 265 m^(2) sintering machine.

关键词： Super-high bed sintering Horizontal segregation Feeder Particle distribution Agglomeration

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Three novel umami peptides derived from the alcohol extract of the Pacific oyster(Crassostrea gigas):identification,characterizations and interactions with T1R1/T1R3 taste receptors

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Food Science and Human Wellness 2024年第1期13卷 146-153页

作者： Baifeng Fu Di Wu Shuzhen Cheng Xianbing Xu Ling Zhang Lishu Wang Heshanm REl-Seedi Hanxiong Liu Ming Du School of Food Science and Technology Dalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep processing Dalian Polytechnic UniversityDalian 116034China National Engineering research Center of Seafood Dalian Polytechnic UniversityDalian 116034China division of Hematology and Oncology Department of MedicineMedical College of WisconsinMilwaukee 53226USA division of Pharmacognosy Department of Medicinal ChemistryBiomedical CentreUppsala UniversityUppsala SE-75123Sweden

Oyster(Crassostrea gigas),the main ingredient of oyster sauce,has a strong umami *** this study,three potential umami peptides,FLNQDEEAR(FR-9),FNKEE(FE-5),and EEFLK(EK-5),were identified and screened from the alcoholic extracts of the oyster using nano-HPLC-MS/MS analysis,i Umami-Scoring Card Method(i Umami-SCM)database and molecular docking(MD).Sensory evaluation and electronic tongue analysis were further used to confirm their *** threshold of the three peptides ranged from 0.38 to 0.55 mg/m *** with umami receptors T1R1/T1R3 indicated that the electrostatic interaction and hydrogen bond interaction were the main forces ***,the Phe592 and Gln853 of T1R3 were the primary docking site for MD and played an important role in umami *** with two Glu residues at the terminus had stronger umami,especially at the *** results contribute to the understanding of umami peptides in oysters and the interaction mechanism between umami peptides and umami receptors.

关键词： Oyster umami peptides iUmami-SCM Taste characterization Molecular docking

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A robust vector tracking loop structure based on potential bias analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 405-420页

作者： Qiongqiong JIA Yiran LUO Bing XU Li-Ta HSU Renbiao WU Tianjin Key Lab for Advanced Signal processing Civil Aviation University of ChinaTianjin 300300China Interdisciplinary division of Aeronautical and Aviation Engineering The Hong Kong Polytechnic University999077Hong KongChina Department of Geomatics Engineering University of CalgaryCalgary T2N1N4Canada

This paper proposes a robust vector tracking loop structure based on potential bias analysis. The influence of four kinds of biases on the existing two implementations of Vector Tracking Loops(VTLs) is illustrated by theoretical analysis and numerical simulations, and the following findings are obtained. Firstly, the initial user state bias leads to steady navigation solution bias in the relative VTL, while new measurements can eliminate it in the absolute VTL. Secondly, the initial code phase bias is transferred to the following navigation solutions in the relative VTL, while new measurements can eliminate it in the absolute VTL. Thirdly, the user state bias induced by erroneous navigation solution of VTLs can be eliminated by both of the two VTLs. Fourthly,the multipath/NLOS likely affects the two VTLs, and the induced tracking bias in the duration of the multipath/NLOS would decrease the performance of VTLs. Based on the above analysis,a robust VTL structure is proposed, where the absolute VTL is selected for its robustness to the two kinds of initialization biases;meanwhile, the instant bias detection and correction method is used to improve the performance of VTLs in the duration of the multipath/NLOS. Numerical simulations and experimental results verify the effectiveness of the proposed robust VTL structure.

关键词： Global Navigation Satellite System(GNSS) Vector Tracking Loop(VTL) Multipath Non-Line-of-Sight(NLOS) Tracking bias propagation Least Absolute Shrinkage and Selection Operator(LASSO)

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Sea cucumber gut tetrapeptide ameliorates alcoholic gastric damage via restoring mitochondrial dynamics

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Food Science and Human Wellness 2024年

作者： Zhihong Zheng Na Sun Jingqi Yang Zhijie Bao Songyi Lin State Key Laboratory of Marine Food processing and Safety Control School of Food Science and Technology Dalian Polytechnic University National Engineering research Center of Seafood School of Food Science and Technology Dalian Polytechnic University Collaborative Innovation Center of Seafood Deep processing Dalian Polytechnic University Liaoning Engineering research Center of Special Dietary Food Dalian Polytechnic University

This paper aimed to explore the mechanism of tetrapeptide VTPY in improving alcoholic gastric injury. VTPY has the potential to enhance the growth and movement of normal GES-1 cells. Following ethanol-induced impairment， VTPY effectively improved migration of GES-1 and HUVEC cells， enhanced angiogenesis， eliminated cellular and mitochondrial ROS， inhibited excessive mitochondrial division， enhanced F-actin polymerization and mitochondrial respiratory capacity. To counteract excessive mitochondrial fission， VTPY primarily restores the mitochondria dynamics by reducing the expression of Drp1 and Fis1， while increasing Mfn2. Further studies utilizing inhibitors clarifies that the inhibition of excessive mitochondrial fission can markedly reduce F-actin depolymerization， consequently enhancing cell migration. Additionally， VTPY can inhibit the apoptosis pathway by maintaining potential of mitochondrial membrane， preventing the release of mitochondrial cytochrome c， bolstering the levels of Bcl-XL， while reducing the levels of Bax and cleaved-caspase3. Further investigations using inhibitors demonstrates that excessive mitochondrial fission could activate apoptotic pathway. However， VTPY counteracts this effect and enhance cells viability. Further evidence suggests that VTPY effectively improves ulcer index and pathologic changes， relieves inflammation， enhances the balance of oxidation and anti-oxidation， promotes angiogenesis， improves the expression of mitochondrial dynamics factors， blocks apoptotic pathway， and subsequently ameliorates gastric damage in mice through Fis-1/Bcl-2 pathway.

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Four development stages of collective intelligence

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Frontiers of Information Technology & Electronic Engineering 2024年第7期25卷 903-916页

作者： Renbin XIAO School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China Key Laboratory of Image Information processing and Intelligent Control Ministry of EducationWuhan 430074China

The new generation of artificial intelligence(AI)research initiated by Chinese scholars conforms to the needs of a new information environment changes,and strives to advance traditional artificial intelligence(AI 1.0)to a new stage of AI *** one of the important components of AI,collective intelligence(CI 1.0),i.e.,swarm intelligence,is developing to the stage of CI 2.0(crowd intelligence).Through in-depth analysis and informative argumentation,it is found that an incompatibility exists between CI 1.0 and CI ***,CI 1.5 is introduced to build a bridge between the above two stages,which is based on biocollaborative behavioral *** 1.5 is the transition from CI 1.0 to CI 2.0,which contributes to the compatibility of the two ***,a new interpretation of the meta-synthesis of wisdom proposed by Qian Xuesen is *** meta-synthesis of wisdom,as an improvement of crowd intelligence,is an advanced stage of bionic intelligence,i.e.,CI *** is pointed out that the dual-wheel drive of large language models and big data with deep uncertainty is an evolutionary path from CI 2.0 to CI 3.0,and some elaboration is *** a result,we propose four development stages(CI 1.0,CI 1.5,CI 2.0,and CI 3.0),which form a complete framework for the development of *** different stages are progressively improved and have good *** to the dominant role of cooperation in the development stages of CI,three types of cooperation in CI are discussed:indirect regulatory cooperation in lower organisms,direct communicative cooperation in higher organisms,and shared intention based collaboration in *** division is the main form of achieving cooperation and,for this reason,this paper investigates the relationship between the complexity of behavior and types of labor ***,based on the overall understanding of the four development stages of CI,the future development direction and research issues of CI are explored.

关键词： Collective intelligence Meta-synthesis of wisdom Incompatibility Labor division Cooperative behavior Collective intelligence emergence Large language model

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Emerging strategies and developments in oxygen reduction reaction using high-performance platinum-based electrocatalysts

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Nano research 2024年第5期17卷 3516-3532页

作者： Asad Ali Aatto Laaksonen Guo Huang Shahid Hussain Shuiping Luo Wen Chen Pei Kang Shen Jinliang Zhu Xiaoyan Ji Energy Engineering Division of Energy ScienceLuleåUniversity of Technology97187 LuleåSweden Department of Materials and Environmental Chemistry Arrhenius LaboratoryStockholm UniversitySE-10691 StockholmSweden Center of Advanced research in Bionanoconjugates and Biopolymers “Petru Poni”Institute of Macromolecular ChemistryIasi 700469Romania State Key Laboratory of Materials-Oriented and Chemical Engineering Nanjing Tech UniversityNanjing 211816China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518060China School of Resources Environment and MaterialsState Key Laboratory of Processing for Non-ferrous Metal and Featured MaterialsGuangxi UniversityNanning 530004China

The global practical implementation of proton exchange membrane fuel cells(PEMFCs)heavily relies on the advancement of highly effective platinum(Pt)-based electrocatalysts for the oxygen reduction reaction(ORR).To achieve high ORR performance,electrocatalysts with highly accessible reactive surfaces are needed to promote the uncovering of active positions for easy mass *** this critical review,we introduce different approaches for the emerging development of effective ORR electrocatalysts,which offer high activity and *** strategies,including morphological engineering,geometric configuration modification via supporting materials,alloys regulation,core-shell,and confinement engineering of single atom electrocatalysts(SAEs),are discussed in line with the goals and requirements of ORR performance *** review the ongoing development of Pt electrocatalysts based on the syntheses,nanoarchitecture,electrochemical performances,and *** eventually explore the obstacles and research directions on further developing more effective electrocatalysts.

关键词： oxygen reduction reaction(ORR) Pt-based electrocatalysts proton exchange membrane fuel cells(PEMFCs) morphology and alloys strategies single atom electrocatalysts(SAEs)

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Boosting Fischer-Tropsch Synthesis via Tuning of N Dopants in TiO_(2)@CN-Supported Ru Catalysts

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Transactions of Tianjin University 2024年第1期30卷 90-102页

作者： Xincheng Li Yunhao Liu Dejian Zhao Shuaishuai Lyu Jingwei Ye Xiaoshen Li Peipei Wu Ye Tian Yingtian Zhang Tong Ding Song Song Qingpeng Cheng Xingang Li State Key Laboratory of Chemical Engineering Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Haihe Laboratory of Sustainable Chemical TransformationsTianjin Key Laboratory of Applied Catalysis Science and EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Zhejiang Institute of Tianjin University Shaoxing 312300China Sinopec research Institute of Petroleum processing Co. LTDBeijing 100083China Physical Sciences and Engineering division Advanced Membranes and Porous Materials(AMPM)CenterKing Abdullah University of Science and Technology(KAUST)23955-6900 ThuwalSaudi Arabia

Nitrogen(N)-doped carbon materials as metal catalyst supports have attracted signifi cant attention,but the eff ect of N dopants on catalytic performance remains unclear,especially for complex reaction processes such as Fischer-Tropsch synthesis(FTS).Herein,we engineered ruthenium(Ru)FTS catalysts supported on N-doped carbon overlayers on TiO_(2)*** regulating the carbonization temperatures,we successfully controlled the types and contents of N dopants to identify their impacts on metal-support interactions(MSI).Our fi ndings revealed that N dopants establish a favorable surface environment for electron transfer from the support to the Ru ***,pyridinic N demonstrates the highest electron-donating ability,followed by pyrrolic N and graphitic *** addition to realizing excellent catalytic stability,strengthening the interaction between Ru sites and N dopants increases the Ru^(0)/Ru^(δ+)ratios to enlarge the active site numbers and surface electron density of Ru species to enhance the strength of adsorbed ***,it improves the catalyst’s overall performance,encompassing intrinsic and apparent activities,as well as its ability for carbon chain ***,the as-synthesized Ru/TiO_(2)@CN-700 catalyst with abundant pyridine N dopants exhibits a superhigh C_(5+)time yield of 219.4 mol CO/(mol Ru·h)and C_(5+)selectivity of 85.5%.

关键词： Fischer-Tropsch synthesis N-doped carbon materials Ruthenium catalyst Pyridinic N Metal-N interaction

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Excipient effect on antimicrobial activity of Cinnamon (Cinnamomum zelylanicum album) oil, Thyme (Thymus vulgaris) oil and Ajowan (Trachyspermum ammi) oil

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Infectious Diseases research 2024年第1期5卷 27-31页

作者： Bhoj R Singh Shiv Varan Singh Ravikant Agarwal Akanksha Yadav division of Epidemiology ICAR-Indian Veterinary Research InstituteBareilly 243122India division of Bacteriology and Mycology ICAR-Indian Veterinary Research InstituteBareilly 243122India division of Livestock Products Technology ICAR-Indian Veterinary Research InstituteBareilly 243122India.

Background:Many herbal essential oils are potential antimicrobials but their pharmaceutical utility is restricted due to a lack of suitable excipients to mollify their dermatotoxicity and irritant property,and outcome of their therapeutic use may vary with different diluents ***:Effect of 16 diluents(dimethyl sulfoxide,liquid paraffin,glycerine,oils of mustard,sunflower,rice bran,palm,groundnut,olive,coconut,sesame,avocado,jojoba,castor,linseed and soybean)was assessed on antimicrobial activity of 2%cinnamon(Cinnamomum zelylanicum album),thyme(Thymus vulgaris)and ajowan(Trachyspermum ammi)oils using agar well diffusion *** effect of excipients was evaluated on six Candida albicans,five Escherichia coli,four Acinetobacter lwoffii,two strains each of Staphylococcus aureus,Enterobacter agglomerans,and Enterococcus faecium and one strain each of Acinetobacter calcoaceticus,Escherichia fergusonii,Klebsiella oxytoca,*** ***,Leclercia adecarboxylata,Paenibacillus amylolyticus,Proteus mirabilis,***,Pseudomonas aeruginosa,Raoultella terrigena,Staphylococcus capitis ***,***,***,*** and Streptococcus ***:Thyme oil(2%)maintained it antimicrobial activity on dilution in dimethyl sulfoxide and glycerine,and ajowan oil(2%)completely lost its antibacterial activity in all diluents except dimethyl ***,cinnamon oil partially lost its antimicrobial activity upon dilution in glycerine,vegetable,and mineral oils in comparison to dimethyl *** oil was the best vegetable oil,almost comparable to dimethyl sulfoxide and castor oil was the worst diluent for maintaining antimicrobial activity of cinnamon ***:The study indicated the non-suitability of vegetable oils for pharmaceutical formulations of essential oils except olive oil for dilution of cinnamon oil and glycerol for thyme oil to replace dimethyl sulfoxide as diluent.

关键词： essential oils herbal antimicrobials herbal drug-resistance Bacteria Candida

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Analysis of the effect of the 2021 Semeru eruption on water vapor content and atmospheric particles using GNSS and remote sensing

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Geodesy and Geodynamics 2024年第1期15卷 33-41页

作者： Mokhamad Nur Cahyadi Arizal Bawasir Syachrul Arief Amien Widodo Meifal Rusli Deni Kusumawardani Yessi Rahmawati Ana Martina Putra Maulida Hilda Lestiana Department of Geomatics Engineering Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia research Center of Marine and Earth Science-Technology Directorate of Research and Community ServiceInstitut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Geospatial Education and Training division Geospatial Information Agency(BIG)Cibinong 16911Indonesia Department of Geophysics Engineering Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Department of Mechanical Engineering Andalas UniversityPadang City 25175Indonesia Department of Economics Airlangga UniversitySurabaya 60286Indonesia research Center for Geological Resources National Research and Innovation AgencyJakarta 10340Indonesia

Mount Semeru,an active volcano in East Java,Indonesia,erupted on December 4,2021,following extreme rainfall that caused an avalanche of hot pyroclastic flows and *** tropospheric conditions and dominant particle components in the atmosphere can be monitored using Global Navigation Satellite System(GNSS)technology and remote sensing *** signal propagation delay in Precise Point Positioning(PPP)processing can be used to determine Zenith Tropospheric Delay(ZTD)and Precipitable Water Vapor(PWV)variables so that atmospheric conditions can be *** addition,by using remote sensing satellite data,it is possible to obtain rainfall data with high temporal resolution as well as the dominant particle and gas content values during *** the eruption period,the high value of PWV was dominated by the high intensity of precipitation during the rainy *** rainfall before the eruption caused activity inside the mountain to increase,which occurred in avalanche type *** from that,the atmosphere around Semeru was also dominated by SO_(2)content,which spreaded for tens of ***_(2)content began to be detected significantly by remote sensing sensors on December 7,*** this study,deformation and atmospheric monitoring were also carried out using low-cost GNSS at the Semeru Monitoring Station on September 9-15,*** results of the ZTD and ZWD values show the dominance of the wet component,which is directly proportional to rainfall activity in this period.

关键词： Semeru GNSS Water vapor Rainfall SO_(2)

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