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Evidence of neurodegeneration in autism spectrum disorder

Translational Neurodegeneration 2013年第1期2卷 113-118页

作者： Janet K Kern David A Geier Lisa K Sykes Mark R Geier Institute of Chronic Illnesses IncorporationSilver SpringMDUSA University of Texas Southwestern Medical Center at Dallas DallasTXUSA comed IncorporationSilver SpringMDUSA

Autism spectrum disorder(ASD)is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and *** of neurological function in ASD,as observed in affected children who have regressed,can be explained as *** there is research evidence of neurodegeneration or progressive encephalopathy in ASD,the issue of neurodegeneration in ASD is still under *** of neurodegeneration in the brain in ASD includes:(1)neuronal cell loss,(2)activated microglia and astrocytes,(3)proinflammatory cytokines,(4)oxidative stress,and(5)elevated 8-oxo-guanosine *** evidence from this review suggests that neurodegeneration underlies the loss of neurological function in children with ASD who have experienced regression and loss of previously acquired skills and abilities,and that research into treatments to address the issue of neurodegeneration in ASD are warranted.

关键词： Autism spectrum disorder(ASD) Autism Neurodegeneration Regression Neuronal cell loss Microglia Oxidative stress Cytokines

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A two-phase study evaluating the relationship between Thimerosal-containing vaccine administration and the risk for an autism spectrum disorder diagnosis in the United States

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Translational Neurodegeneration 2013年第1期2卷 183-194页

作者： David A Geier Brian S Hooker Janet K Kern Paul G King Lisa K Sykes Mark R Geier The Institute of Chronic Illnesses Inc 14 Redgate CtSilver SpringMDUSA Simpson University ReddingCAUSA University of Texas Southwestern Medical Center at Dallas DallasTXUSA comed Inc Silver SpringMDUSA

Background:Autism spectrum disorder(ASD)is defined by standardized criteria of qualitative impairments in social interaction,qualitative impairments in communication,and restricted and stereotyped patterns of behavior,interests,and activities.A significant number of children diagnosed with ASD suffer a loss of previously-acquired skills,which is suggestive of neurodegeneration or a type of progressive encephalopathy with an etiological pathogenic basis occurring after *** date,the etiology of ASD remains under debate,however,many studies suggest toxicity,especially from mercury(Hg),in individuals diagnosed with an *** present study evaluated concerns about the toxic effects of organic-Hg exposure from Thimerosal(49.55%Hg by weight)in childhood vaccines by conducting a two-phased(hypothesis generating/hypothesis testing)study with documented exposure to varying levels of Thimerosal from ***:A hypothesis generating cohort study was undertaken to evaluate the relationship between exposure to organic-Hg from a Thimerosal-containing Diphtheria-Tetanus-acellular-Pertussis(DTaP)vaccine in comparison to a Thimerosal-free DTaP vaccine administered,from 1998 through 2000,for the risk of ASD as reported in the Vaccine Adverse Event Reporting System(VAERS)database(phase I).A hypothesis testing case–control study was undertaken to evaluate the relationship between organic-Hg exposure from Thimerosal-containing hepatitis B vaccines administered at specific intervals in the first six months of life among cases diagnosed with an ASD and controls born between 1991 through 1999 in the Vaccine Safety Datalink(VSD)database(phase II).Results:In phase I,it was observed that there was a significantly increased risk ratio for the incidence of ASD reported following the Thimerosal-containing DTaP vaccine in comparison to the Thimerosal-free DTaP *** phase II,it was observed that cases diagnosed with an ASD were significantly more likely than controls to rece

关键词： Autism Ethylmercury Merthiolate Thimerosal Thiomersal Vaccine

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