检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

难治性部分性癫痫的精神病理学分析

世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 60-61页

作者： De Toffol B. 张玉龙 clinique neurologique CHU Bretonneau 37044 Tours Cedex France

Today, psychopathology in medically refractory partial seizures is well known . Descriptive (syndromic) classifications of both epileptic syndromes and psychi atric disturbances associated with prospective psychiatric status evaluations in resective epilepsy surgery centers in order to prevent poor post surgical outco me have increased our knowledge of the mental status of these patients. Three ma jor categories of psychiatric comorbidities are observed. 1. Specific post ictal syndromes related to seizures (post ictal psychoses and post ictal depressive d isorders). 2. Interictal psychiatric disorders: depression appears to be the mos t prevalent psychiatric condition in medically refractory seizures followed by a nxiety and psychotic states. 3. Psychiatric adverse events of antiepileptic drugs according to the numerous new available drugs. There are no published guidelines. We are challenged both as clinicians and as an academic community. We need to improve identification, b etter utilize existing therapies and promote the development of prospective tria ls devoted to the study of psychiatric status in presurgical evaluation. A psych iatrist must be included in presurgical teams.

关键词：部分性癫痫病理学分析难治性癫痫癫痫症状抗癫痫药物发作期间精神科医生郁症精神障碍外科中心

在线全文

学校读者我要写书评

暂无评论

环孢菌素引起的中毒性神经肌病(法国)

世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 8-9页

作者： Guennoc A.-M. Corcia P. Al-Najjar A. 方伯言 clinique neurologique CHU Bretonneau 2 bisboulevard Tonnellé 37044 Tours Cedex France

Introduction. Cyclosporine is an immunosuppressive treatment whose side effect s limit its usefulness. Among neurological side effects, neuropathies or myopath ies have been reported, specially inpatients given combinations of cyclosporine with co-enzyme A reductase inhibitors. Case report. We report here the case of a 67-year-old woman who developed few months after a kidney graft sensorimotor disorders which progressed rapidly. Since all etiologies of such a disorder wer e ruled out,the hypothesis of toxicity exclusively induced by cyclosporine was s uggested and confirmed by the improvement observed after its withdrawal. Conclus ion. This observation highlights the fact that cyclosporine may induce neuromyop athies even when given alone at the therapeutic dosage.

关键词：环孢菌素肌病感觉运动障碍免疫抑制剂还原酶抑制剂

在线全文

学校读者我要写书评

暂无评论

Vogt-小柳原田综合征

世界核心医学期刊文摘（眼科学分册） 2006年第4期2卷 4-5页

作者： Blanc F. Fleury M. Talmant V. 张磊 clinique neurologique Hpital Civil 1 place de l hpital 67091 Strasbourg France

Introduction:Vogt-Koyanagi-Harada syndrome is a rare, inflammatory disease with manifestations affecting the ocular, central nervous, audito-vestibular, and integumentary systems. Vogt-Koyanagi-Harada syndrome is more frequent in Asia but is also described in Europe. We report three new non asiatic cases of this syndrome. Observations:The three patients had bilateral panuveitis and hypoacusia. Two of them had peripheral facial palsy, two of them had vestibular syndrome and one of them lymphocytic meningitis. In each case we found characteristic HLA II typing and in one case we discovered the simultaneous presence of three auto-antibodies: anti-retina (anti-Arrestin type), anti-choroid and anti-cochlea. These patients were treated by corticosteroids but required an additional treatment by cyclophosphamide (0.8g/m2). The clinical course was favorable with visual sequelae for two and auditory one for one. Discussion:These biological and therapeutic elements and a review of the recent literature are in favor of an autoimmune origin of this syndrome.

关键词： Vogt-小柳原田综合征淋巴细胞性脑膜炎视网膜抗体周围面神经麻痹全葡萄膜炎中枢神经炎性疾病听力减退自身抗体患者

视网膜电图及解剖学异常提示Lewy体痴呆患者的视网膜病变

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(神经病学分册) 2006年第2期 48-49页

作者： Devos D. Tir M. Maurage C.A. 樊慧婷 clinique neurologique Hpital R. Salengro CHU F-59037 Lille Cedex France.Dr

The authors used flash electroretinography to demonstrate dysfunction of the photopic and scotopic retina in patients with dementia with Lewy bodies and visual hallucinations (VHs)-compared with patients with Parkinson disease, patients without VHs, and controls. The retinal dysfunction may be related to slight alteration of the photoreceptors and numerous pale inclusions in the outer plexiform layer found at the post mortem examination, suggesting a specific retinopathy.

关键词：视网膜电图眼科检查痴呆患者 Lewy 病变

传染性骨髓病:临床、血清学和预后类型(法国)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 50-51页

作者： Ramirez C. De Seze J. Delalande S. 雷翀 clinique neurologique H.opital R. Salengro CHRU de Lille 59037 Lille Cedex France

Introduction. Serological confirmation of an infectious acute myelitis injury is difficult to confirm as it is sometimes due to a post-infectious etiology. Objectives. The aim of this study was to define the clinical, biological and pr ognostic patterns of infectious myelitis. Patients and methods. This retrospecti ve study included 153 subjects hospitalized in the department of neurology betwe en 1993 and 2002 for treatment of a noncompressive acute myelopathy. Biological confirmation of recent infection was obtained in 12 patients (8 p. 100). Results . An infectious syndrome, beginning prior to the neurological symptoms, was foun d in 67 percent of patients. The clinical symptoms were severe with loss of sens oromotor and sphincter functions and ascending spinal cord dysfunction (acute tr ansverse myelopathy). Spinal cord MRI showed extended centromedullar high intens ity signals with rapid and complete regression. CSF analysis cell count was abov e 30/mm3 with hyperproteinorachia, in 75 percent and 58 percent of patients resp ectively. CSF electrophoresis did not detect oligoclonal bands. Clinical outcome was good in all patients except one, however sphincter disorders recovered slow ly. Discussion. Our study illustrates a stereotypical clinical, biological and p rognostic pattern for infectious acute myelitis. These findings contribute signi ficantly to therapeutic decision making and establishing prognosis at the initia l phase of acute myelopathy.

关键词：骨髓病血清学急性骨髓炎括约肌功能横断性脊髓病退行性变近期感染生物学证据感染性

假性癫痫发作患者的精神并发症:在视频EEG中心实施的回顾性研究(法)

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2006年第5期2卷 59-59页

作者： Mondon K De Toffol B Praline J 谢琰臣 clinique neurologique Hpital Bretonneau 2 boulevard Tonnellé 37044 Tours Cedex France

Introduction. Pseudoseizures involve a group of paroxysmal behavioral symptoms mimicking an epileptic seizure, but without modifications of cerebral electrical activity. Patients and method. In this retrospective study focusing on mental disorders, 37 patients with pseudoseizures were recorded during video-EEG procedure. Results. According to DSM-IV criteria, 70 percent of the patients had at least one mental disorder when evaluated. Diagnoses were, in decreasing order of frequency: post-traumatic stress disorders, other anxious disorders, somatoform disorders, dissociative disorders, and mood disorders. Conclusion. The strong association between pseudoseizures and post-traumatic stress disorders is discussed. Our results argue in favor of a systematic evaluation of psychiatric comorbidity.

关键词：假性癫痫发作癫痫患者精神并发症回顾性 EEG 视频应激性疾病精神异常 DSM-Ⅳ 行为症状

格林-巴利综合征伴幻觉与onirism:被低估的伴随症状(法国)

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 55-55页

作者： Le Rhun E. De Sèze J. Stojkovic T. 王晓琳 clinique neurologique Hpital Roger Salengro CHRU de Lille 59037 Lille Cedex France

Introduction. Guillain-Barré Syndrome (GBS) is generally related to perip heral nervous system involvement, but certain variants with central nervous syst em manifestations have been described. Case report. In the present study we repo rt 2 patients with GBS associated with hallucinations and onirism. Two men (age 64 and 49 years) presented GBS without proven infectious origin who required int ensive care because of respiratory problems. The disease progressed and manifest ations of encephalitis (hallucinations and onirism) appeared. The sensorimotor s igns and encephalitis manifestations evolved in parallel with full recovery in t he first patient and death after 11 months of intensive care in the second. Conc lusion. GBS may be associated with stereotypic central nervous system symptoms, mimicking delirium tremens. The manifestations would be related to the severity of the initial period, but not to long-term prognosis.

关键词： onirism 精神错乱中枢系统重症监护感觉运动完全康复中枢神经系统进展过程周围神经系统感染源

FRAMIG 2000:法国的偏头痛医疗状况

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 37-37页

作者： Lucas C. Chaffaut C. Artaz M.-A. Lantéri-Minet M. 夏峰 clinique neurologique H.opital Salengro C.H.R.U. 59037 Lille France

FRAMIG 2000 is a population-based survey of medical and therapeutic managemen t of migraine in France. A total of 312 migraine sufferers were first identified from a representative sample of 4689 adult subjects using a validated questionn aire based on the IHS migraine diagnostic criteria and administered by telephone . Subjects were then interviewed using a branching questionnaire and a computer -assisted interview technique. Although 80%were self-aware of their migrainou s state, 82%of migraine sufferers had no medical follow-up for migraine. The p roportion of migraine sufferers who did not consult decreased slightly with incr easing migraine-related disability (from 87%for subjects in MIDAS grade I to 6 8%for those in MIDAS grade IV). Migraine sufferers declared to effectively cont rol only four attacks out of 10 after the first intake of the usual treatment. O nly 6%of subjects in the survey received a prophylactic treatment for migraine whereas 22%were in MIDAS grade III or IV. These data show that the burden of mi graine does not result from a deficit in diagnosis but instead from a deficit in patient information on the proper use of current effective treatments of migrai ne.

关键词： FRAMIG 2000 医疗状况头痛发作数据显示问卷调查

Blood–brain barrier dysfunction in intensive care unit

在线全文

学校读者我要写书评

暂无评论

Journal of Intensive Medicine 2023年第4期3卷 303-312页

作者： Loic Le Guennec Nicolas Weiss Département de neurologie Sorbonne UniversitéAP-HP Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreUnitéde Médecine Intensive Réanimationàorientation neurologiqueParis 75013France Groupe de Recherche clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE(GRC-RESPIRE)Sorbonne Université Paris 75013France Brain Liver Pitié-Salpêtrière(BLIPS)Study Group INSERM UMR_S 938Centre de recherche Saint-AntoineMaladies métaboliquesBiliaires et fibro-inflammatoire du foieInstitute of Cardiometabolism and Nutrition(ICAN)Paris 75013France

The central nervous system is characterized by a peculiar vascularization termed blood–brain barrier(BBB),which regulates the exchange of cells and molecules between the cerebral tissue and the whole *** dysfunction is a life-threatening condition since its presence corresponds to a marker of severity in most diseases encountered in the intensive care unit(ICU).During critical illness,inflammatory response,cytokine release,and other phenomena activating the brain endothelium contribute to alterations in the BBB and increase its permeability to solutes,cells,nutrients,and ***,patients in the ICU are often old,with underlying acute or chronic diseases,and overly medicated due to their critical condition;these factors could also contribute to the development of BBB *** accurate diagnostic approach is critical for the identification of the mechanisms underlying BBB alterations,which should be rapidly managed by *** methods were developed to investigate the BBB and assess its ***,in humans,exploration of the BBB requires the use of indirect *** and biochemical methods can be used to study the abnormal passage of molecules through the *** this review,we describe the structural and functional characteristics of the BBB,present tools and methods for probing this interface,and provide examples of the main diseases managed in the ICU that are related to BBB dysfunction.

关键词： Blood–brain barrier ICU hepatic encephalopathy Delirium Extracorporeal membrane oxygenation(ECMO) Acute bacterial meningitis