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A strategy for uncovering germline variants altering anti-tumor CD8 T cell response

Journal of Genetics and Genomics 2023年第5期50卷 353-361页

作者： Vijay Kumar Ulaganathan Martina H.Vasileva Klinik fur dermatologie&Allergology Universitatsmedizin GottingenGottingen 37075Germany Institut fuir Multiple Sklerose Forschung NeuroimmunologieUniversitatsmedizin GottingenGottingen 37075Germany University of Lorraine NGERE UnitFaculte de Medecine9 Avenue de La Foret de HayeVandoeuvre-les-Nancy 54505France

Among many factors known to alter the outcomes of T cell receptor(TCR)-induced proximal signaling,the role of human germline variants in dictating the individuality of the anti-tumor CD8 T cell response has remained challenging to ***,we describe a convenient strategy for molecular and functional characterization of phosphotyrosine-altering non-synonymous single nucleotide variations(pTyr-SNVs)that directly impact TCR-induced proximal phosphotyrosine motif-based signaling *** devise an experimental co-cultivation set-up comprising a C57BL/6 mouse-derived metastatic melanoma cell line engineered to constitutively present ovalbumin(OVA)antigens and retrovirally engineered syngeneic major histocompatibility complex(MHC)Class I restricted OVA TCR-transgenic CD8 T cells(OT-I).Using the synthetic version of pTyr-SNV rs1178800678-G/T-encoding integrin alpha 4(ITGA4)p.S1027I variant as a prototype,we show that under identical TCR stimulation conditions,genetically determined membrane-proximal immunoreceptor tyrosin activation motif(ITAM)results in increased tyrosine phosphorylation of 70 kDa zeta-chain-associated protein(ZAP70)and the levels of cytotoxic effector molecule granzyme B(GZMB),which in turn result in enhanced cytotoxic activity against metastatic melanoma cell *** strategy paves the way for rapid molecular and functional characterization of anti-tumor immune response-linked germline pTyr-SNVs so as to improve our understanding of the genetic basis of individual-to-individual differences in anti-tumor CD8 T cell response.

关键词： Non-synonymous single nucleotide variants(nsSNVs) Membrane-proximal phosphotyrosine signalling motifs Phosphotyrosine-altering non-synonymous single nucleotide variants(pTyr-SNVs) Immunoreceptor tyrosine activation motif(ITAM) CD8 T cells Melanoma B16-F10

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Peri-Orbital Non-Invasive and Painless Skin Tightening-Safe and Highly Effective Use of Multisource Radio-Frequency Treatment Platform

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Journal of Cosmetics, dermatological Sciences and Applications 2015年第3期5卷 206-211页

作者： Isabelle Rousseaux Cabinet de dermatologie Esthetique Lille Cote Sud Loos France

The periorbital area is the third highest-ranking area for cosmetic surgery. However, surgery in this area presents a number of difficulties and safety concerns. First generation Monopolar RF treatments in this area were usually associated with considerable pain and long downtime. In the present clinical study, we used the iFine handpiece of the EndyMed PRO, multi-source phase-controlled radiofrequency (RF) for Non-invasive, pain free, skin rejuvenation of the periorbital area. The study included eleven (11) subjects, treated for periorbital signs of aging (iFine handpiece, EndyMed PRO platform, EndyMed Medical, Caesarea, Israel). The degree of clinical improvement was assessed by the global aesthetic improvement scale (GAIS) and subjects satisfaction by post treatment questionnaires. 91% of patients showed good to excellent improvement as a result of the treatment. Subjects satisfaction showed that 55% of patients reported that they were very satisfied, 45% were satisfied while none were dissatisfied. There were no incidences of infections, scarring, hypopigmentation, or any other serious complications.

关键词： Facial Tightening Radiofrequency EndyMed 3deEP^(■) Periorbital

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间质短距离放射疗法治疗4例原发性皮肤黑素瘤患者(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 26-27页

作者： Mortier L. Mirabel X. Modiano P. 潘敏 clinique de dermatologie H■pital Claude HuriezCHRU de Lillerue Michel Polonovski59037 Lille

*** melanoma has been considered as a radioresistant ***,recent observations regarding radiobiology and clinical response of melanoma have prompted physicians to re-evaluate the role of radiotherapy in the management of ***,radiotherapy is frequently used in the treatment of metastatic melanoma but the role of this therapeutic approach in the primary tumor management is *** report 4 cases of thick primary melanoma treated by interstitial *** *** patients(3 men,1 woman;age:73,74,79,84 years),three with lentigo maligna melanoma and one with nodular melanoma,were treated exclusively by interstitial *** thickness of the 4 tumors was more than 3 *** treatment was chosen either because of the impossibility of conservative surgery or because of a contraindication for general *** follow-up was 48 months [18 to 65 months] and we did not observe any local tumor *** cosmetic and functional results of this therapy were *** four cases illustrate the possibility of obtaining good local control of thick primary melanoma by interstitial brachy therapy where surgery is impossible,although without challenging the standard surgical therapy for primary *** our study,this treatment was used only in one study to treat melanoma *** this case however,interstitial brachy therapy was accompanied by ***,the findings reported here are the first to demonstrate the efficacy of this treatment when used as the sole treatment for primary *** conclusion,where surgery is difficult or impossible,interstitial brachytherapymay be used to treat primary melanoma with excellent local tumor control and a good cosmetic outcome.

关键词：黑素瘤放射疗法恶性雀斑样痣放射生物学局部肿瘤临床反应外科手术抗辐射性月数禁忌证

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Buruli Ulcer: Epidemiological, Clinical and Biological Profile of Patients in the Centre de depistage et de Traitement d’Allada (Benin) from 2010 to 2014

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Journal of Cosmetics, dermatological Sciences and Applications 2019年第2期9卷 67-82页

作者： Bérénice Dégboé Christiane Koudoukpo Mouhaéminath Alimi Ghislain Emmanuel Sopoh Fabrice Akpadjan Roch Christian Johnson Nadège Agbéssi Hugues Adégbidi Félix Atadokpèdé Faculté des Sciences de la Santé Université d’Abomey-Calavi Abomey-Calavi Benin clinique universitaire de dermatologie-vénérologie Centre National Hospitalier et Universitaire Hubert Koutoukou MAGA de Cotonou Cotonou Benin Faculté de Médecine de Parakou Université de Parakou Parakou Benin clinique universitaire de dermatologie-vénérologie Centre Hospitalier Universitaire Départemental du Borgou-Alibori Parakou Bénin Institut Régional de Santé Publique Université d’Abomey-Calavi Ouidah Benin Centre de Dépistage et de traitement de l’ulcère de Buruli (CDTUB) d’Allada Allada Benin Fondation Raoul FOLLEREAU Paris France Centre Inter Facultaire de Formation et de Recherche en Environnement pour le Développement Durable Université d’Abomey-Calavi Abomey-Calavi Benin

Introduction: The objective of our work was to describe the epidemiological, clinical and biological profile of Buruli ulcer in “Centre de Dépistage et de traitement de l’ulcère de Buruli” (CDTUB) in Allada. Methods: A descriptive and retrospective study focused on new cases of Buruli ulcer received in the CDTUB of Allada from 2010 to 2014. The diagnosis of Buruli ulcer was based on epidemiological, clinical and biological arguments. Results: Over 5 years, 274 new cases of Buruli ulcer have been diagnosed. The average age of the patients was 12 years and the sex ratio was 0.8. The average time to first consultation was 45 days. Clinically, 61% had a joint functional limitation. Lesions were ulcerated in 69% of cases, category I (26%), category II (53%), category III (21%) and were present on the lower limbs in 57% of cases. Microscopy was positive in 65.7% of cases and PCR in 78.1% of cases. Microscopy supplemented by PCR confirmed the diagnosis in 81% of cases. Conclusion: The epidemiological, clinical and biological profile of Buruli ulcer in Allada was characterized by a predominant disease in children, a predominance of ulcerated forms and a decisive contribution of PCR to the diagnosis.

关键词： Buruli Ulcer Epidemiology Clinical Profile Biological Confirmation Benin

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系统性红斑狼疮患者发生皱褶部位无菌性脓疱病伴胃肠道中性粒病变1例

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 52-53页

作者： Kerl K. Masouyé I. Lesavre P. L. Borradori 罗素菊徐波 clinique de dermatologie Hpital Cantonal Universitaire Rue Micheli- du- Crest 26 CH- 1211 Genéve Switzerland

Background: Amicrobial pustulosis of the folds is a recently described entity characterized by relapsing pustular lesions involving predominantly the cutaneous folds and the scalp. The disease typically occurs in the context of an autoimmune or systemic disease and should be included within the spectrum of neutrophilic dermatoses. Observation: We describe a patient with a history of systemic lupus erythematosus, who developed amicrobial pustulosis of the folds. Strikingly, the patient also exhibited recurrent oral and gastrointestinal manifestations that paralleled the course of the cutaneous signs. Conclusions: Our observation indicates that, in analogy to the other neutrophilic dermatoses, amicrobial pustulosis of the folds can also be complicated by the development of extracutaneous neutrophilic involvement, knowledge of which is critical for its diagnosis and proper management.

关键词：系统性红斑狼疮自身免疫性疾病系统性疾病病谱脓疱疹

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Acute lung injury in mechanically ventilated patients with epidermal necrolysis:an exposed-unexposed retrospective cohort study

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Burns & Trauma 2020年第1期8卷 30-33页

作者： S.Lalevée J.Catano S.Ingen-Housz-Oro M.Surenaud J.Tran Van Nhieu F.Schlemmer I.Bendib A.Mekontso-dessap S.Hue N.de Prost Service de dermatologie AP-HPhoital Henri MondorCréteilFrance UniversitéParis Est Créteil INSERM U955IMRBF-94010 CréteilFrance Service de Médecine Intensive Réanimation Hoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France EA7379 EpidermE UPECCréteilFrance Centre de référence des dermatoses bulleuses toxiques et toxidermies graves TOXIBUL CréteilFrance Service d’Anatomopathologie AP-HPhoital Henri MondorCréteilFrance Unitéde Pneumologie Service de Médecine Intensive RéanimationHoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France Groupe de Recherche clinique CARMAS Facultéde Santéde CréteilUniversitéParis Est CréteilCréteil Cedex 94010France AP-HP Département d’Hématologie et d’Immunologie biologiquesGroupe hospitalouniversitaire Chenevier MondorAssistance Publique-Hoitaux de Paris F-94010 CréteilFrance

To the Editor,During the acute phase of epidermal necrolysis(EN,including Stevens-Johnson syndrome and toxic epidermal necrolysis),mucosal lesions involving the tracheo-bronchial tract have been reported[1,2]and approximately one in four EN patients develop acute respiratory failure and require endotracheal intubation and mechanical ventilation(MV)support[3].Asymptomatic respiratory sequelae may be detected on pulmonary function tests after the acute phase in as much as 50%of EN patients,possibly related to pulmonary lesions that occurred at the acute phase[4].

关键词： acute patients respiratory

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伊维菌素成功治疗1例HIV感染患者的螨皮炎

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世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 25-26页

作者： Clyti E. Sayavong K. Chanthavisouk K. 崔荣 Service de dermatologie Institut Guyanais de Dermatologie Tropicale Centre Hospitalier de Cayenne BP 6006 97306 Cayenne France

Introduction. demodex is a saprophyte parasite in mammals. In Man, it is associated with differing clinical profiles (rosacealike dermatitis, folliculitis and blepharitis). We report a case of demodecidosis in an HIV-infected patient that was successfully treated with ivermectin. Case report. A man from Laos, infected by HIV and treated for glandular tuberculosis, presented with a prurigenous eruption on the face and the pre-sternal and interscapular areas. Direct examination of scraped product and histopathological examinations confirmed the diagnosis of demodecidosis. Clinical cure was obtained after 2 single cures of ivermectin a one month’s distance. Discussion. The features of demodecidosis are often similar to those of rosacea. In immunodeficient patients, the semiology remains the same but the eruption is more abundant. During HIV-infection, demodecidosis occurs at the AIDS stage or with a CD4 count lower than 200/mm3. Many anti-dust mite molecules are used to treat the disease but frequently lead to irritation. Administration of a single cure of ivermectin, repeated if necessary, appears to be an interesting alternative to contact anti-dust mite agents.

关键词：螨皮炎 HIV感染患者伊维菌素蠕形螨感染肩胛间区眼睑炎细胞计数痒疹直接镜检免疫缺陷患者

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Key rheological properties of hyaluronic acid fillers:from tissue integration to product degradation

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Plastic and Aesthetic Research 2018年第5期5卷 1-8页

作者： Samuel Gavard Molliard Jérémie Bon Bétemps Basste Hadjab David Topchian Patrick Micheels denis Salomon Research and development department Kylane Laboratoires S.A.Plan-les-Ouates 1228Switzerland Dr.David&Associates Private Practice Armadale VIC 3143Australia Dr.Patrick Micheels Private Practice Genève 1206Switzerland clinique Internationale de dermatologie Genève S.A.Private Practice Genève 1201Switzerland

Aim: Over the last 15 years, hyaluronic acid (HA) fillers have become the most popular injectable biomaterial for soft tissue correction. With the increasing number of available HA fillers and the multiplication of facial treatments all over the world, there has been a need from physicians to better understand the HA fillers science. There is especially a growing interest in the science-based evaluation of rheological characteristics which represents an essential tool to guide physicians in the selection of the most appropriate HA fillers, administration techniques and depths of injection for their clinical applications. Methods: Four key rheological parameters (viscosity η, elasticity G', normal force FN and elasticity E') are measured and discussed on five HA fillers. Results: These four key rheological parameters are demonstrated to play a pivotal role, in combination with the cohesivity, for better predicting the clinical behavior of HA fillers at different stages of their lifetime. Conclusion: This article discusses the importance of four key rheological parameters during the main steps of the clinical HA fillers' lifetime, from the product injection to the loss of clinical effects. A better knowledge of these HA fillers' rheological parameters can help the physicians to optimize their aesthetic outcomes, safety and patient satisfaction.

关键词： Hyaluronic acid fillers rheological properties product lifetime tissue integration clinical effects

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Chlorhexidine Digluconate Formulations Used for Skin Antisepsis

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Open Journal of Medical Microbiology 2019年第3期9卷 95-104页

作者： S. Salvatico D. Pereira C. Feuillolay N. Bégeault C. Roques Fonderephar Faculté des Sciences Pharmaceutiques Toulouse France Pierre Fabre dermatologie Lavaur France Laboratoire de Génie Chimique UMR 5503 Faculté des Sciences Pharmaceutiques Université de Toulouse CNRS INPT UPS Toulouse France

Aims: The representativeness of European standards phase 2, step 1 regarding bactericidal and yeasticidal activities was used for the comparison of two marketed antiseptic solutions, one containing chlorhexidine digluconate (0.5%) and the other combining chlorhexidine digluconate (0.25%), benzalkonium chloride (0.025%) and benzylic alcohol (4%). Methods: The bactericidal activity of the antiseptic solutions used pure or diluted was assessed according to the European standards NF EN 13727 and NF EN 13624 for the bactericidal and yeasticidal activity respectively. The contact time was 1 min at 20°C. Interfering substances used correspond to soiling conditions i.e. bovine serum albumin and sheep erythrocytes. A reduction of colony-forming units by ≥5 log10 was deemed to meet the requirements to conclude bactericidal activity and ≥4 log10 for yeasticidal activity. Results: Regarding all the mandatory strains, both solutions are bactericidal and yeasticidal even after a 40% dilution and even under “dirty” conditions. Conclusions: The present study demonstrated the efficient bactericidal and yeasticidal activity of aqueous solutions containing chlorhexidine digluconate either alone at a concentration of 0.5% (w/v) or at a concentration of 0.25% (w/v) when combined with benzalkonium chloride at 0.025% (w/v) and benzylic alcohol 4%. These results have to be considered regarding the respective formulations and potent allergy risks.

关键词： Antiseptic In Vitro Bactericidal Activity In Vitro Yeasticidal Activity Chlorhexidine Benzalkonium Chloride NF EN 13624 NF EN 13727 NF EN 14885

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女性阴部巨大皮脂腺异常增生(法语)

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 39-40页

作者： Masmoudi A. Bouassida S. Ayadi L. 李晓莉 Service de dermatologie EPS Hedi Chaker 3029 Sfax Tunisia

Background. Sebaceous gland hyperplasia is an epithelial tumour with sebaceous differentiation. Genital involvement is rare. In this paper, we report a new case of sebaceous gland hyperplasia of the vulva. Case report. A 27 year-old woman presentedmultiple polypoid lesions of the lower third of left labium majus. The lesions were soft to the touch, measured 5 cm in length and were painless. The cutaneous biopsy confirmed the diagnosis of sebaceous gland hyperplasia of the vulva. Surgical excision was performed in two separate procedures and was successful. Discussion. This case was unusual in terms of the site, the clinical appearance and the weeping seen due to the high concentration of hyperplasic sebaceous glands.

关键词：异常增生大阴唇上皮性肿瘤息肉状生殖器部位损害部位女阴

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