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Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma

四川生理科学杂志 2021年第10期43卷 1816-1816页

作者： Leonard B Bacharier From Monroe Carell Jr. Children's Hospital at Vanderbilt Nashville (L.B.B.) Fundación CIdeA Buenos Aires (J.F.M.) Campbelltown Hospital Campbelltown NSW and Western Sydney University Sydney (C.H.K.) - both in Australia Bambino Gesù Children's Hospital IRCCS Rome (A.G.F.) clinique spécialisée en allergie de la capitale Quebec QC Canada (R.G.) Hospital Vall d'Hebron Barcelona (I.M.) Arizona Allergy and Immunology Research Gilbert (N.J.) Peninsula Research Associates Rolling Hills Estates CA (L.D.S.) Sanofi Bridgewater NJ (X.M. U.K. P.J.R. E.L.) Sanofi Beijing (D.L.) Regeneron Pharmaceuticals Tarrytown NY (Y.Z. F.A.K. Y.D. M.R. D.M.W. G.D.Y. N.A. D.J.L.) Sanofi Chilly-Mazarin France (A.H.K. L.P.M.) and Sanofi Genzyme Cambridge MA (N.P. M.H.).

Background:Children with moderate-to-severe asthma continue to have disease complications despite the receipt of standardof-care *** monoclonal antibody dupilumab has been approved for the treatment of adults and adolescents with asthma as well as with other type 2 inflammatory ***:In this 52-week phase 3,randomized,double-blind,placebo-controlled trial,we assigned 408 children between the ages of 6 and 11 years who had uncontrolled moderate-to-severe asthma to receive a subcutaneous injection of dupilumab(at a dose of 100 mg for those weighing≤30 kg and 200 mg for those weighing>30 kg)or matched placebo every 2 *** the children continued to receive a stable dose of standard background *** primary end point was the annualized rate of severe asthma *** end points included the change from baseline in the percentage of predicted prebronchodilator forced expiratory volume in 1 second(ppFeV1)at week 12 and in the score on the Asthma Control Questionnaire 7 Interviewer-Administered(ACQ-7-IA)at week *** points were evaluated in the two primary efficacy populations who had either a type 2 inflammatory asthma phenotype(≥150 blood eosinophils per cubic millimeter or a fraction of exhaled nitric oxide of≥20 ppb at baseline)or a blood eosinophil count of at least 300 cells per cubic millimeter at baseline.

关键词： millimeter cubic continued

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