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Impact of Long-Term Treatment with OROS Methylphenidate on Pubertal Development in Adolescents with adhd

Open Journal of Psychiatry 2014年第2期4卷 147-152页

作者： Paul Hammerness Daniel Geller Gagan Joshi Anna Georgiopoulos Robert Doyle Thomas Spencer Carter Petty Laura Mahoney Joseph Biederman clinical and research program in pediatric psychopharmacology and adult adhd Massachusetts General Hospital Boston USA

The objective of this study was to examine whether stimulants impact pubertal development in adolescent Attention Deficit Hyperactivity Disorder (adhd), an understudied subject. Pubertal staging data were collected during a 2-year open study of extended release methylphenidate in adolescents (N = 111) with adhd. Tanner stages were compared to national estimates. The sample was primarily male, Caucasian, and a mean age of 14.8 years at baseline. The baseline Tanner stage for 70% of subjects was consistent with chronological age. For the majority of subjects who reached 12 - 20 months (N = 25) or 24 months (N = 21) endpoints, the Tanner stage at respective endpoints was consistent with age. We found that progression in Tanner stage was not associated with OROS MPH duration or dose (p > 0.10). Long-term treatment with extended release methylphenidate did not appear to adversely impact pubertal development in this sample of adolescents with adhd.

关键词： Methylphenidate Puberty Development Adolescents adhd

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Acceptability of an adjunct equine-assisted activities and therapies program for veterans with posttraumatic stress disorder and/or traumatic brain injury

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Journal of Integrative Medicine 2020年第2期18卷 169-173页

作者： Louisa Sylvia Emerson West Allyson M.Blackburn Carina Gupta Eric Bui Tara Mahoney Geraldine Duncan Edward C.Wright Simon Lejeune Thomas J.Spencer Home Base:A Red Sox Foundation and Massachusetts General Hospital program Massachusetts General HospitalCharlestownMA 02129USA Harvard Medical School BostonMA 02115USA Dauten Family Center for Bipolar Treatment Innovation Massachusetts General HospitalBostonMA 02114USA Equine Immersion programsTM USA pediatric psychopharmacology and adult adhd program Massachusetts General HospitalBostonMA 02114USA

Objective: Equine-assisted activities and therapies(EAATs) have been a growing adjunctive integrative health modality, as they allow participants to practice mindfulness, emotional regulation, and self-mastery or self-esteem building skills. Preliminary evidence suggests that these programs may be helpful in reducing posttraumatic stress disorder(PTSD), anxiety, and depressive symptoms. The current study examines the acceptability of integrating an EAAT program as part of a two-week, intensive clinical program for veterans with PTSD and/or traumatic brain injury(TBI).Methods: A family member or support person could accompany veterans and participate in the *** hundred and six participants(veteran n = 62, family n = 44) left the urban environment in an intensive outpatient program(IOP) to attend a two-day, weekend EAAT in rural New Hampshire. Satisfaction surveys were conducted on the last day of the program and examined using thematic ***: The following themes were reported in the surveys: ability of horses to catalyze emotional rehabilitation, effectiveness of immersion in equine-assisted activities, program’s ability to foster interpersonal relationships and necessity of education about PTSD for staff. Participants also reported enjoying the program as highlighted by qualitative feedback, a mean score of 9.76(standard deviation[SD] = 0.61) as reported by veterans and a mean score of 9.91(SD = 0.29) as reported by family members on a 10-point visual analog scale with higher scores indicating a greater overall ***: These data offer preliminary evidence that an adjunct EAAT program is acceptable for veterans with PTSD and/or TBI participating in an IOP.

关键词： Posttraumatic stress disorder Military personnel Traumatic brain injury Complementary and alternative medicine Equine-assisted therapy

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Brain Signaling in Psychiatric Disorders: What Can They Tell Us in the Absence of Behavioral Differences?

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Journal of Behavioral and Brain Science 2015年第8期5卷 333-337页

作者： Jodi M. Gilman James M. Bjork Timothy E. Wilens Center for Addiction Medicine Massachusetts General Hospital Boston MA USA Department of Psychiatry Harvard Medical School Boston MA USA Department of Psychiatry Virginia Commonwealth University Richmond VA USA clinical and research programs in pediatric psychopharmacology Adult ADHD Massachusetts General Hospital Boston MA USA

This is a commentary on the often-observed phenomenon of observing task-based brain signaling differences between clinical populations and healthy control participants in the absence of any behavioral decrements in the clinical group. We offer several explanations for why brain-based differences amid normative performance may be of interest to researchers and clinicians. First, neural processing in the clinical group may not be as efficient as that in the control group. Second, differences in activation could reveal important differences in the cognition behind the (normative) behavior. Third, differences in activation may be prognostic biomarkers of injury or decline. In addition, we contend that similar behavior between groups is important in properly interpreting brain data. Finally, we offer caveats and future directions to further clarify brain mechanisms underlying behavior in clinical populations.

关键词： fMRI Neuroimaging Normative Behavior Normative Performance Neural Efficiency Prognostic Biomarker

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成人注意力不集中和多动症

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美国医学会杂志（中文版） 2005年第5期24卷 294-298页

作者： Timothy E. Wilens Stephen V. Faraone Joseph Biederman 陈益和（译）唐福林（校） clinical research program in pediatric psychopharmacology Massachusetts GeneralHospital and Harvard Medical School Boston Mass Departmentof Epidemiology Harvard School of Public Health Boston Mass 不详

注意力不集中和多动症（attention-deficit／hyperactivity disorder，adhd）是一种患病率较高的疾病，全世界约有3％～9％的学龄儿童和4％的成人患有此病。过去认为，adhd不会延续至成年，但是长期对照随访研究显示，该病存在于相当一... 详细信息

注意力不集中和多动症（attention-deficit／hyperactivity disorder，adhd）是一种患病率较高的疾病，全世界约有3％～9％的学龄儿童和4％的成人患有此病。过去认为，adhd不会延续至成年，但是长期对照随访研究显示，该病存在于相当一部分幼年时被确诊为adhd的成人。

关键词：多动症注意力成人中和 adhd 学龄儿童随访研究患病率

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