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Effect of arotinolol on right ventricular function in patients with dilated cardiomyopathy

Journal of Geriatric Cardiology 2007年第3期4卷 170-173页

作者： Hong Yang Li Xu Yongkang Tao Zhimin Xu Xiuqing Du Naqiang Lu Kefei Dou Jinglin Zhao Xianqi Yuan Yanfen Zhao Rongfang Shi Chaomei Fan Key laboratory of clinical trials Research in Cardiovascular Drugs Ministry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Beijing Nuclear Industry Hospital Beijing 100042China. Beijing Nuclear Industry Hospital Beijing 100042China. Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037China Key Laboratory of Clinical Trials Research in Cardiovascular DrugsMinistry of HealthClinical Pharmacology CenterCardiovascular Institute and Fuwai Hospital CAMS and PUMCBeijing 100037Ch

Objective Dilated cardiomyopathy(DCM) is generally considered to be accompanied by both left and right ventricular dysfunction,but most studies only analyze the left ventricular function. In this study,we evaluated the effect of arotinolol on right ventricular function in patients with DCM. Methods Right ventricular ejection fraction(RVEF) and right ventricular diameter(RVD) were measured by two-dimensional echocardiography(2-DE) in 33 DCM patients;RVEF measured by first-pass radionuclide angiography(FPRA) was compared with that by 2-DE. Results The treatment with arotinolol for one year resulted in a reduction in the right ventricular diameter(baseline,23.0 ± 8.3 mm vs after one-year treatment,20.7 ± 5.4 mm;P=0.004 ) and an associated increase in ejection fraction(baseline,36.9 ± 10.3% vs after one-year treatment,45.8 ± 9.6%;P < 0.001 ) ;there is a high correlation between the 2-DE method and radionuclide ventriculographic method. The correlation coefficient is 0.933(P<0.001) . Conclusion Arotinolol therapy could not only improve left ventricular function,but also improve right ventricular function in DCM patients.

关键词： dilated cardiomyopathy arotinolol right ventricular function

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Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi Liang Fei Yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina laboratory for clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Prostate cancer prediction forest algorithm that takes using the random into account transrectal ultrasound findings, age, and serum levels of prostate-specific antigen

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Asian Journal of Andrology 2017年第5期19卷 586-590页

作者： Li-Hong Xiao Pei-Ran Chen Zhong-Ping Gou Yong-Zhong Li Mei Li Liang-Cheng Xiang Ping Feng Institute of clinical trials West China Hospital Sichuan University Chengdu China Department of Epidemiology and biostatistics West China School of Public Health Sichuan University Chengdu China Department of Ultrasound West China Hospital Sichuan University Chengdu China

The aim of this study is to evaluate the ability of the random forest algorithm that combines data on transrectal ultrasound findings, age, and serum levels of prostate-specific antigen to predict prostate carcinoma. Clinico-demographic data were analyzed for 941 patients with prostate diseases treated at our hospital, including age, serum prostate-specific antigen levels, transrectal ultrasound findings, and pathology diagnosis based on ultrasound-guided needle biopsy of the prostate. These data were compared between patients with and without prostate cancer using the Chi-square test, and then entered into the random forest model to predict diagnosis. Patients with and without prostate cancer differed significantly in age and serum prostate-specific antigen levels （P 〈 0.001）, as well as in all transrectal ultrasound characteristics （P 〈 0.05） except uneven echo （P = 0.609）. The random forest model based on age, prostate-specific antigen and ultrasound predicted prostate cancer with an accuracy of 83.10%, sensitivity of 65.64%, and specificity of 93.83%. Positive predictive value was 86.72%, and negative predictive value was 81.64%. By integrating age, prostate-specific antigen levels and transrectal ultrasound findings, the random forest algorithm shows better diagnostic performance for prostate cancer than either diagnostic indicator on its own. This algorithm may help improve diagnosis of the disease by identifying patients at high risk for biopsy.

关键词： diagnosis prostate cancer prostate-specific antigen random forest algorithm transrectal ultrasound characteristics

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Impact of switching from ranibizumab to aflibercept on the number of intravitreous injection and follow up visit in wet AMD:results of real life ELU study

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 252-256页

作者： Frederic Queguiner Kristina Bezirganyan Jean Christophe Courjaret Laurence Curel Guillaume Penaranda Maud Righini Chossegros Ophthalmology and clinical Research Departments Hopital Saint JosephMarseille F-13008France biostatistics Department Alphabio LaboratoryMarseille F-13003France

●AIM:To study if one of the two molecules could lead to a lower number of follow up visits and intra-vitreous injection(IVI)with the same efficacy.●METHODS:ELU(or"elected"in French)study is a retrospective study conducted in real life in patients presenting suboptimal response after ranibizumab IVI(phase 1)and secondary switched to aflibercept(phase 2).The number of follow up visits and IVI were compared in both *** acuity(VA)evolution and"switching"reasons were secondary analyzed.●RESULTS:We retrospectively included data of 33 patients(38 eyes)with age-related macular degeneration(AMD;mean age:77±7.7 y).The number of monthly follow up visits[median(Q1;Q3)]:was significantly lower with aflibercept(phase 2),respectively 1.0(0.81;1.49)visits in phase 1,versus 0.79(0.67;0.86)visits in phase *** median number of monthly IVI also significantly decreased in phase 2,respectively 0.67(0.55;0.90)IVI in phase 1,versus 0.55(0.45;0.67)IVI in phase *** mean VA evolution(VA final-VA initial)was similar in both phases,(P>0.05).Whatever the reason for"switching"(loss of efficacy,tachyphylaxis,tolerance problems),there was no incidence on VA evolution over the time.●CONCLUSION:Our results show that switching from ranibizumab to aflibercept in"suboptimal"patients significantly reduce the number of follow up visits and IVI,with a comparable *** decrease in visit number could improve patients’quality of life and reduce surgical risk by reducing the number of injections.

关键词： wet age-related macular degeneration anti-VEGF aflibercept ranibizumab follow up visit intravitreal injection visual acuity

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Proton pump inhibitor use increases mortality and hepatic decompensation in liver cirrhosis

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World Journal of Gastroenterology 2019年第33期25卷 4933-4944页

作者： Marianne Anastasia De Roza Lim Kai Jia Wen Kam Yiong Huak Chan Andrew Kwek Tiing Leong Ang John Chen Hsiang Department of Gastroenterology and Hepatology Changi General HospitalSinghealth 529889Singapore clinical trials and Research Unit Changi General HospitalSinghealth 529889Singapore biostatistics Unit Yong Loo Lin School of MedicineNational University of SingaporeSingapore 160608Singapore

BACKGROUND Proton pump inhibitors(PPIs)are widely prescribed,often without clear *** are conflicting data on its association with mortality risk and hepatic decompensation in cirrhotic ***,PPI users and PPI exposure in some studies have been poorly defined with many confounding *** To examine if PPI use increases mortality and hepatic decompensation and the impact of cumulative PPI dose *** Data from patients with decompensated liver cirrhosis were extracted from a hospital database between 2013 to *** users were defined as cumulative defined daily dose(cDDD)≥28 within a landmark period,after hospitalisation for hepatic *** regression analysis for comparison was done after propensity score *** risk of hepatic decompensation was analysed by Poisson *** Among 295 decompensated cirrhosis patients,238 were PPI users and 57 were *** users had higher mortality compared to non-users[adjusted HR=2.10,(1.20-3.67);P=0.009].Longer PPI use with cDDD>90 was associated with higher mortality,compared to non-users[aHR=2.27,(1.10-5.14);P=0.038].PPI users had a higher incidence of hospitalization for hepatic decompensation[aRR=1.61,(1.30-2.11);P90 increases the risk of mortality.

关键词： Proton pump inhibitor Liver cirrhosis Mortality Hospitalisation Complications Portal hypertension Variceal bleeding Ascites Spontaneous bacterial peritonitis Hepatic encephalopathy

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Development and evaluation of the screening performance of a low-cost high-risk screening strategy for breast cancer

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Cancer Biology & Medicine 2022年第9期19卷 1375-1384页

作者： Yubei Huang Huan Wang Zhangyan Lyu Hongji Dai Peifang Liu Ying Zhu Fengju Song Kexin Chen Department of Cancer Epidemiology and biostatistics 2Department of Breast ImagingTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Molecular Epidemiology of TianjinKey Laboratory of Breast Cancer Prevention and TherapyMinistry of EducationTianjin 300060China

Objective:To develop and evaluate the screening performance of a low-cost high-risk screening strategy for breast cancer in low resource ***:Based on the Multi-modality Independent Screening Trial,6 questionnaire-based risk factors of breast cancer(age at menarche,age at menopause,age at first live birth,oral contraceptive,obesity,family history of breast cancer)were used to determine the women with high risk of breast *** screening performance of clinical breast examination(CBE),breast ultrasonography(BUS),and mammography(MAM)were calculated and compared to determine the optimal screening method for these high risk ***:A total of 94 breast cancers were detected among 31,720 asymptomatic Chinese women aged 45–65 *** to significantly higher detection rates(DRs)and suitable coverage of the population,high risk women were defined as those with any of 6 risk *** high risk women,the DR for BUS[3.09/1,000(33/10,694)]was similar to that for MAM[3.18/1,000(34/10,696)],while it was significantly higher than that for the CBE[1.73/1,000(19/10,959),P=0.002].Compared with MAM,BUS showed significantly higher specificity[98.64%(10,501/10,646)vs.98.06%(10,443/10,650),P=0.001],but no significant differences in sensitivity[68.75%(33/48)vs.73.91%(34/46)],positive prediction values[18.54%(33/178)vs.14.11%(34/241)],and negative prediction values[99.86%(10,501/10,516)vs.99.89%(10,443/10,455)].Further analyses showed no significant difference in the percentages of early stage breast cancer[53.57%(15/28)vs.50.00%(15/30)],lymph node involvement[22.73%(5/22)vs.28.00%(7/25)],and tumor size≥2 cm[37.04%(10/27)vs.29.03%(9/31)]between BUS and *** analyses stratified by breast densities or age at enrollment showed similar ***:The low-cost high-risk screening strategy based on 6 questionnaire-based risk factors was an easy-to-use method to identify women with high risk of breast ***,BUS and MAM had comparable screening

关键词： Cancer screening breast cancer high risk mammography ultrasonography

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Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway

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Genes & Diseases 2021年第4期8卷 531-544页

作者： Liqin An Qiong Shi Ying Zhu Hao Wang Qi Peng Jinghong Wu Yu Cheng Wei Zhang Yanyu Yi Zihao Bao Hui Zhang Yetao Luo Jiaming Fan Ministry of Education Key laboratory of Diagnostic Medicine Department of Clinical BiochemistrySchool of Laboratory MedicineChongqing Medical UniversityChongqing400016PR China Department of clinical laboratory The Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China clinical Epidemiology and biostatistics Department Department of Pediatric Research InstituteChildren’s Hospital of Chongqing Medical UniversityChongqing400014PR China

Liver is an important organ for regulating glucose and lipid *** studies have shown that bone morphogenetic proteins(BMPs)may play important roles in regu-lating glucose and lipid *** previous studies,we demonstrated that BMP4 signif-icantly inhibits hepatic steatosis and lowers serum triglycerides,playing a protective role against the progression of non-alcoholic fatty liver disease(NAFLD).However,the direct impact of BMP4 on hepatic glucose metabolism is poorly ***,we investigated the regulatory roles of BMP4 in hepatic glucose *** a comprehensive analysis of the 14 types of BMPs,we found that BMP4 was one of the most potent BMPs in promoting hepatic glycogen accumulation,reducing the level of glucose in hepatocytes and effecting the expression of genes related to glucose ***,we demonstrated that BMP4 reduced the hepatic glucose lewels through the activation of mTORC2 signaling pathway in vitro and in ***,our findings strongly suggest that BMP4 may play an essential role in regulating hepatic glucose *** knowledge should aid us to understand the molecular pathogenesis of NAFLD,and may lead to the development of novel therapeutics by exploiting the inhibitory effects of BMPs on hepatic glucose and lipid metabolism.

关键词： BMP4 Glucose metabolism Glycogen accumulation mTORC2 signaling Non-alcoholic fatty liver disease(NAFLD)

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Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data

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Cancer Biology & Medicine 2024年第8期21卷 712-723页

作者： Yu Zhang Chao Sheng Zhangyan Lyu Hongji Dai Fangfang Song Fengju Song Yubei Huang Kexin Chen Department of Epidemiology and biostatistics Key Laboratory of Molecular Cancer EpidemiologyKey Laboratory of Prevention and Control of Human Major DiseasesMinistry of EducationNational Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin Medical UniversityTianjin 300060China

Objective: Few studies have evaluated the benefits of colorectal cancer(CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model(QCancer-10) and a 139-variant polygenic risk score to evaluate the effectiveness of screening on CRC incidence and ***: We applied the integrated model to calculate 10-year CRC risk for 430,908 participants in the UK Biobank, and divided the participants into low-, intermediate-, and high-risk groups. We calculated the screening-associated hazard ratios(HRs) and absolute risk reductions(ARRs) for CRC incidence and mortality according to risk ***: During a median follow-up of 11.03 years and 12.60 years, we observed 5,158 CRC cases and 1,487 CRC deaths, respectively. CRC incidence and mortality were significantly lower among screened than non-screened participants in both the intermediateand high-risk groups [incidence: HR: 0.87, 95% confidence interval(CI): 0.81±0.94;0.81, 0.73±0.90;mortality: 0.75, 0.64±0.87;0.70, 0.58±0.85], which composed approximately 60% of the study population. The ARRs(95% CI) were 0.17(0.11±0.24) and 0.43(0.24±0.61), respectively, for CRC incidence, and 0.08(0.05±0.11) and 0.24(0.15±0.33), respectively, for mortality. Screening did not significantly reduce the relative or absolute risk of CRC incidence and mortality in the low-risk group. Further analysis revealed that screening was most effective for men and individuals with distal CRC among the intermediate to high-risk ***: After integrating both genetic and non-genetic factors, our findings provided priority evidence of risk-stratified CRC screening and valuable insights for the rational allocation of health resources.

关键词： Colorectal cancer screening polygenic risk score incidence mortality

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Pouch size influences clinical outcome of pouch construction after total gastrectomy:A meta-analysis

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World Journal of Gastroenterology 2014年第29期20卷 10166-10173页

作者： Heng-Lei Dong Yu-Bei Huang Xue-Wei Ding Feng-Ju Song Ke-Xin Chen Xi-Shan Hao Department of Epidemiology and biostatistics Tianjin Medical University Cancer Hospital and InstituteNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy Department of Gastric Cancer Surgery Tianjin Medical University Cancer Hospital and InstituteNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy

AIM: To assess the clinical significance of pouch size in total gastrectomy for gastric malignancies.

关键词： Total gastrectomy Gastric cancer Pouch size Systematic review

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