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Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental medicine Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and DetectionSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Psychosomatics and Psychiatry Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009China

The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely ***,we developed a strategy that integrated solid phase extraction based on magnetic Fe_(3)O_(4)coated with polydopamine(Fe_(3)O_(4)@PDA)and direct analysis of mass spectrometry in real time(DART-MS)for quantification of 10 *** systematically investigated the optimal conditions of this strategy to achieve good accuracy and *** with existing magnetic solid phase extraction methods for NTs detection in biological samples,this strategy could adsorb more targets while having similar adsorption efficiencies,and the total process time was reduced by an average of 69.42%.We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic *** addition,an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this *** results highlighted the potential ability of Fe_(3)O_(4)@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

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4-Nitrophenol at environmentally relevant concentrations mediates reproductive toxicity in Caenorhabditis elegans via metabolic disorders-induced estrogen signaling pathway

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Journal of Environmental Sciences 2025年第1期147卷 244-258页

作者： Jia Wang Jiechen Yin Danhong Peng Xiaoqian Zhang Zhouhong Shi Weixi Li Yingchi Shi Mingjun Sun Nan Jiang Beijing Cheng Xingchen Meng Ran Liu Key Laboratory of Environmental medicine Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Obstetrics and Gynecology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009China Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China

4-Nitrophenol(4-NP),as a toxic and refractory pollutant,has generated significant concern due to its adverse ***,the potential toxic effects andmechanism remained *** this study,the reproduction,development,locomotion and reactive oxygen species(ROS)production of Caenorhabditis elegans were investigated to evaluate the 4-NP *** used metabolomics to assess the potential damage *** role of metabolites in mediating the relationship between 4-NP and phenotypes was examined by correlation and mediation analysis.4-NP(8 ng/L and 8μg/L)caused significant reduction of brood size,ovulation rate,total germ cells numbers,head thrashes and body bends,and an increase in ***,the oosperm numbers in uterus,body length and body width were decreased in 8μg/***,36 differential metabolites were enriched in the significant metabolic pathways,including lysine biosynthesis,β-alanine metabolism,tryptophan metabolism,pentose phosphate pathway,pentose and glucuronate interconversions,amino sugar and nucleotide sugar metabolism,starch and sucrose metabolism,galactose metabolism,propanoate metabolism,glycerolipid metabolism,and estrogen signaling *** mechanism of 4-NP toxicity was that oxidative stress caused by the perturbation of amino acid,which had effects on energy metabolism through disturbing carbohydrate and lipid metabolism,and finally affected the estrogen signaling pathway to exert toxic ***,correlation and mediation analysis showed glycerol-3P,glucosamine-6P,glucosamine-1P,UDP-galactose,L-aspartic acid,and uracilwere potential markers for the reproduction and glucose-1,6P2 for developmental *** results provided insight into the pathways involved in the toxic effects caused by 4-NP and developed potential biomarkers to evaluate 4-NP toxicity.

关键词： 4-Nitrophenol Caenorhabditis elegans Metabolomics Pathway analysis

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Association between age at diagnosis of diabetes and ocular disease:Insights from a recent article

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World Journal of Diabetes 2025年第1期16卷 211-216页

作者： Shi-Qi Liu Dong Wang Cheng-Chun Tang Department of Cardiology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina school of medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

In this article,we discuss Ye et al's recent article on the association between age at diabetes diagnosis and subsequent risk of age-related ocular *** study,which utilized United Kingdom Biobank data,highlighted a strong link between early diabetes onset and major eye conditions,such as cataracts,glaucoma,agerelated macular degeneration,and vision loss,independent of glycemic control and disease *** finding challenges the previous belief that diabetic eye disease primarily correlates with *** lifestyles evolve and the age of diabetes diagnosis decreases,understanding this relationship may reveal the complex pathogenesis underlying diabetes-related *** editorial summarizes potential mechanisms connecting the age of diabetes onset with four types of ocular diseases,emphasizing the significance of early diagnosis.

关键词： Diabetes Age at diagnosis Cataract Glaucoma Age-related macular disease Vision acuity

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Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population

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Journal of Environmental Sciences 2025年第1期147卷 332-341页

作者： Haiyan Jiang Simei Zhang Yaoyao Lin Lin Meng Jiayi Li Wenqing Wang Kaixuan Yang Mingjuan Jin Jianbing Wang Mengling Tang Kun Chen Department of Public Health Fourth Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Public Health Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Department of Public Health National Clinical Research Center for Child Health of Children’s HospitalZhejiang University School of MedicineHangzhou 310058China

Growing evidences showed that heavy metals exposure may be associated with metabolic ***,themechanism underlying arsenic(As)exposure and metabolic syndrome(MetS)risk has not been fully *** we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was *** determined As at baseline and SUA concentration at follow-up in the Yiwu Elderly *** events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident *** investigate the role of SUA in the association between As andMetS,amediation analysiswas *** the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased *** with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95%confidence interval,CI:1.03,2.00).Additionally,blood As was positively associated with SUA,while SUA had significant association with MetS *** mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7%.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults *** analysis indicated that SUA might be a mediator in the association between As exposure and MetS.

关键词： Arsenic(As)exposure Metabolic syndrome(MetS) Serum uric acid(SUA) Cohort study Mediation effect Older adults

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Associations of multiple metals exposure with immunoglobulin levels in pregnant women:Hangzhou Birth Cohort Study

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Journal of Environmental Sciences 2025年第5期151卷 560-572页

作者： Jiena Zhou Lanfei Jin Yexinyi Zhou Kunhong Zhong Kegui Huang Qi Zhang Jun Tang Xue Zhang Lihe Peng Shuai Li Na Lv Dongdong Yu Qinheng Zhu Jing Guo Qiong Luo Guangdi Chen Department of Public Health and Key Laboratory of Reproductive Genetics(Ministry of Education)Women’s HospitalZhejiang University School of MedicineHangzhou 310058China Department of clinical Laboratory Shaw HospitalZhejiang University School of MedicineHangzhou 310018China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051China Jiashan County Center for Disease Control and Prevention JiashanZhejiang 314199China Department of clinical Laboratory Women’s HospitalZhejiang University School of MedicineHangzhou 310020China Department of Obstetrics Women’s HospitalZhejiang University School of MedicineHangzhou 310020China

Metal may affect maternal immune function,but few epidemiological studies have reported the associations between multiple-metal exposure and maternal immunoglobulin(Ig)*** on the Hangzhou Birth Cohort Study,1059 participants were included,and eleven metals in whole blood samples and serum IgA,IgG,IgE and IgM levels were *** regression,quantile-based g-computation(QGC),and Bayesian kernel machine regression(BKMR)models were used to evaluate the *** with the first tertile of metal levels,arsenic(As)was negatively associated with IgE(β=-0.25,95%confidence interval(CI)=-0.48 to-0.02).Moreover,significant associations of manganese(Mn)with IgA,IgG and IgM were demonstrated(β=0.10,95%CI=0.04 to 0.18;β=0.07,95%CI=0.03 to 0.12;β=0.10,95%CI=0.03 to 0.18,respectively).Cadmium(Cd)were associated with higher levels of *** models showed the positive association of the metalmixtures with IgA and IgG,with Mn playing amajor *** and Cd had positive contributions to IgM,while As had negative contributions to *** the BKMR models,the latent continuous outcomes of IgA and IgG showed a significant increase when all the metals were at their 60th percentile or above compared to those at their 50th ***,exposure to metals was associated with maternal Igs,and mainly showed that Mn was associated with increased levels of IgA,IgG and IgM,and As was associated with low IgE levels.

关键词： Metals Immunoglobulin Pregnant woman Quantile-based g-computation (QGC) Bayesian kernel machine regression (BKMR)

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Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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Impact of Spinal Manipulative Therapy on Brain Function and Pain Alleviation in Lumbar Disc Herniation:A Resting-State fMRI Study

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Chinese Journal of Integrative medicine 2025年第2期31卷 108-117页

作者： ZHOU Xing-chen WU Shuang WANG Kai-zheng CHEN Long-hao WEI Zi-cheng LI Tao HUA Zi-han XIA Qiong LYU Zhi-zhen LYU Li-jiang Department of Spine The Third Affiliated Hospital of Zhejiang Chinese Medicine UniversityHangzhou(310053)China Department of Spine The Third School of Clinical MedicineZhejiang Chinese Medicine UniversityHangzhou(310053)China Research Institute of Tuina(Spinal Disease) Zhejiang Chinese Medicine UniversityHangzhou(310053)China

Objective:To elucidate how spinal manipulative therapy(SMT)exerts its analgesic effects through regulating brain function in lumbar disc herniation(LDH)patients by utilizing resting-state functional magnetic resonance imaging(rs-f MRI).Methods:From September 2021 to September 2023,we enrolled LDH patients(LDH group,n=31)and age-and sex-matched healthy controls(HCs,n=28).LDH group underwent rs-f MRI at 2 distinct time points(TPs):prior to the initiation of SMT(TP1)and subsequent to the completion of the SMT sessions(TP2).SMT was administered once every other day for 30 min per session,totally 14 treatment sessions over a span of 4 *** did not receive SMT treatment and underwent only one f MRI ***,participants in LDH group completed clinical questionnaires on pain using the Visual Analog Scale(VAS)and the Japanese Orthopedic Association(JOA)score,whereas HCs did not undergo clinical scale *** effects on the brain were jointly characterized using the amplitude of low-frequency fluctuations(ALFF)and regional homogeneity(Re Ho).Correlation analyses were conducted between specific brain regions and clinical ***:Following SMT treatment,pain symptoms in LDH patients were notably alleviated and accompanied by evident activation of effects in the *** comparison to TP1,TP2 exhibited the most significant increase in ALFF values for Temporal_Sup_R and the most notable decrease in ALFF values for Paracentral_Lobule_L(voxelwise P30;FDR correction).Additionally,the most substantial enhancement in Re Ho values was observed for the Cuneus_R,while the most prominent reduction was noted for the Olfactory_R(voxelwise P30;FDR correction).Moreover,a comparative analysis revealed that,in contrast to HCs,LDH patients at TP1 exhibited the most significant increase in ALFF values for Temporal_Pole_Sup_L and the most notable decrease in ALFF values for Frontal_Mid_L(voxelwise P30;FDR correction).Fur

关键词： functional magnetic resonance imaging lumbar disc herniation spinal manipulative therapy pain

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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung Lo Jialiu Zeng Department of clinical Neurosciences University of CambridgeCambridgeUK school of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian school of medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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Promising effects of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome:a double-blinded randomized controlled trial

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Journal of Traditional Chinese medicine 2025年第1期45卷 100-106页

作者： Neda Naimipoor Zahra Bagheri-Hosseinabadi Mohammad Reza Hajizadeh Mitra Abbasifard Mohammad Reza Mirzaei Akram Ghadiri Anari Maryam Mohammad-Sadeghipour Mehdi Mahmoodi Department of clinical Biochemistry School of MedicineRafsanjan University of Medical Sciences Department of Internal medicine School of MedicineAli-Ibn Abi-Talib HospitalRafsanjan University of Medical Sciences Molecular medicine Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical Sciences Diabetes Research Center Shahid Sadoughi University of Medical Sciences Department of clinical Biochemistry Afzalipour School of MedicineKerman University of Medical Sciences Physiology Research Center Institute of NeuropharmacologyKerman University of Medical Sciences

OBJECTIVE: To evaluate the effect of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome(MetS). METHODS: Fifty patients with Met S diagnosis were randomly assigned to the intervention(Persian shallot extract) and the control(placebo) group. Both groups received treatment for three months. Before the study and at the end of the study, 5 mL peripheral blood was taken from each patient. The measured factors included total antioxidant capacity(TAC), superoxide dismutase enzyme(SOD), malondialdehyde, oxidized low-density lipoprotein(Ox-LDL), apolipoprotein H(Apo-H), fasting blood glucose(FBS), total cholesterol, triglycerides, high-density lipoprotein(HDL), LDL, and systolic and diastolic blood pressure. RESULTS: At baseline, the evaluated parameters were not significantly different between the intervention and control groups. At the end of the study, the mean serum levels of malondialdehyde and ox-LDL were significantly lower in the intervention group. The mean FBS, cholesterol, triglycerides, and LDL were significantly lower in the intervention group. The mean TAC and HDL were significantly higher in the intervention group(P < 0.05). Moreover, the intervention group significantly reduced systolic and diastolic blood pressure. No other significant association was observed. CONCLUSION: Persian shallot extract has several beneficial effects in Met S patients, including optimizing oxidative balance, reducing blood pressure, fasting blood sugar, and blood lipid profile.

关键词： antioxidants medicine, Persian metabolic syndrome shallots

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