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Morphological changes in the iridocorneal angle and their relationship with intraocular pressure after infantile cataract surgery

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1453-1459页

作者： Dan-Dan Wang Zhang-Liang Li Bing Zhang Zi-Yi Lu Wei-Chen Guan Yun-E Zhao Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National clinical research center for Ocular Disease Wenzhou 325027Zhejiang ProvinceChina

·AIM:To evaluate morphological changes in the iridocorneal angle after pediatric cataract surgery.·METHODS:Children who underwent primary infantile cataract surgery were included and 64 eyes from 41 children,including 18 with unilateral cataracts(18 eyes)and 23 with bilateral cataracts(46 eyes)were *** patients underwent two gonioscopic examinations to evaluate the iridocorneal angle,before the primary lens removal and before the secondary intraocular lens *** anatomical changes in the iridocorneal angle and the relationship between intraocular pressure(IOP)and iridocorneal angle changes were also analyzed.·RESULTS:The iridocorneal angle was wide in 64 eyes before and after *** trabecular meshwork pigmentation,number of iris processes in every quadrant of the iridocorneal angle,and the width of the ciliary body band in the superior and inferior quadrants at the second gonioscopic examination were significantly increased compared to those at the first examination(P<0.001,P<0.05,P<*** P<0.05,respectively).IOP gradually increased at 1 mo after operation,and returned to the preoperative level at 3 ***,IOP still increased significantly at 6 and 12 mo.·CONCLUSION:The main changes after pediatric cataract surgery include an increase in trabecular meshwork pigmentation and number of iris processes,IOP gradually increase and has positive correlation with trabecular meshwork pigmentation and anterior insertion of iris process.

关键词： gonioscopic iridocorneal angle intraocular pressure pediatric cataract surgery

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CSCO guidelines for colorectal cancer version 2024:Updates and discussions

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Chinese Journal of cancer research 2024年第3期36卷 233-239页

作者： Liubo Chen Hanguang Hu Ying Yuan Shanshan Weng Department of Medical Oncology(Key Laboratory of cancer Prevention and Intervention China National Ministry of EducationKey Laboratory of Molecular Biology in Medical SciencesZhejiang ProvinceChina)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China zhejiang Provincial clinical research center for cancer Hangzhou 310009China cancer center Zhejiang UniversityHangzhou 310058China

According to the latest global cancer statistics,colorectal cancer(CRC)is the most common malignancy of the digestive system and the second most lethal among all cancer types(1).In China,CRC is the second most prevalent cancer,following only after lung cancer(2).The first version of the Chinese Society of clinical Oncology(CSCO)guideline was launched in 2017 and has been updated annually based on the latest findings of clinical research,drug accessibility and expert consensus(3-8).Here,we present the main updates of the 2024 version compared to the 2023 version.

关键词： CSCO colorectal cancer

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Trend of glaucoma internal filtration surgeries in a tertiary hospital in China

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 251-259页

作者： Yang Cao Hai-Shuang Lin Hui-Yan Mao Yin Zhao Yan-Qian Xie Shao-Dan Zhang Qi Zhang Pei-Juan Wang Guo-Xing Li Ai-Wu Fang Yuan-Bo Liang The Eye Hospital School of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National clinical research center for Ocular Diseases Wenzhou 325027Zhejiang ProvinceChina

AIM:To evaluate the trend of glaucoma internal filtration surgeries for inpatients between 2015 and 2021 at the Eye Hospital of Wenzhou Medical ***:A review of the medical records of inpatients who had been diagnosed with glaucoma and received antiglaucoma surgery between January 1,2015 and December 31,2021 was *** glaucoma diagnosis in this study included primary open angle glaucoma,primary angleclosure glaucoma,secondary glaucoma,and paediatric *** types of surgeries were categorised as internal filtration,external filtration,and cyclodestruction surgery based on the pathway of aqueous humor *** trend of these glaucoma surgeries in the sample of patients with different types of glaucoma was then ***:The number of patients hospitalised for glaucoma surgery increased yearly,from 752 in 2015 to 1373 in 2021,at the Eye Hospital of Wenzhou Medical *** the patients diagnosed with primary open angle glaucoma,internal filtration surgery increased from 27.40%of the sample to 54.40%of the sample,while external filtration surgery decreased from 71.50%to 44.20%between 2015 and *** paediatric glaucoma,internal filtration surgery increased from 37.50%in 2015 to 88.20%in *** different types of surgeries were performed on the sample of patients with secondary glaucoma,the proportion of internal filtration surgery also showed an increase from 18.20%in 2015 to 40.90%in ***,internal filtration surgery in the patient sample with primary angle-closure glaucoma already accounted for over 70.00%in 2015,and showed a small increase by ***:As surgical technology and surgical experience continue to elevate and improve,the range of glaucoma surgeries are correspondingly *** study find that internal filtration surgeries accounted for an increasing proportion of treatments in the surgical management of glaucoma between 2015 and 2021.

关键词： glaucoma internal filtration surgery inpatient trend

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Primary and secondary postoperative hemorrhage in pediatric tonsillectomy

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World Journal of clinical Cases 2021年第7期9卷 1543-1553页

作者： Bin Xu Hai-Yan Jin Ke Wu Cao Chen Li Li Yang Zhang Wei-Zhong Gu Chao Chen Department of Otorhinolaryngology-Head and Neck Surgery The Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052Zhejiang ProvinceChina Department of Anesthesiology The Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052Zhejiang ProvinceChina Department of Operating Room The Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052Zhejiang ProvinceChina Department of Pathology The Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052Zhejiang ProvinceChina Department of Radiology The Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children's Regional Medical CenterHangzhou 310052Zhejiang ProvinceChina

Tonsillectomy is the most common procedure for treatment of pediatric recurrent acute tonsillitis and tonsillar enlargement that contributes to obstructive sleep apnea hypopnea *** hemorrhage of tonsillectomy is a lifethreatening *** To identify the risk factors that may contribute to primary and secondary postoperative hemorrhage in pediatric *** The clinical data from 5015 children,3443 males and 1572 females,aged 1.92-17.08 years,with recurrent tonsillitis and/or tonsil hypertrophy who underwent tonsillectomy in our hospital from January 2009 to December 2018 were retrospectively *** variables including sex,age,time of onset,diagnosis,method of tonsillectomy,experience of surgeon,time when the surgery started and monthly average air temperature were *** patients with postoperative hemorrhage were classied into two groups,the primary bleeding group and the secondary bleeding group,and their characteristics were compared with those of the nonbleeding group *** analysis was performed by chi-square test with SPSS *** Ninety-two patients had post-tonsillectomy hemorrhage,and the incidence rate of post-tonsillectomy hemorrhage was 1.83%.The mean age was 5.75 *** of primary hemorrhage accounted for approximately 33.70%(31/92),and cases of secondary hemorrhage occurred in 66.30%(61/92).The rate of reoperation for bleeding was 0.92%,and the rate of rehospitalization for bleeding was 0.88%in all *** hemostasis surgery was performed in 6.52%(3/46)of *** method of tonsillectomy(coblation tonsillectomy)and experience of the surgeon(junior surgeon with less than 5 years of experience)were significantly associated with primary hemorrhage(χ^(2)=5.830,P=0.016,χ^(2)=6.621,P=0.010,respectively).Age(over 6 years old)and time of onset(more than a 1-year history)were significantly associated with secondary hemorrhage(χ^(2)=15.242,P=0.000,χ^(2)=4.293,P=0.038,

关键词： Postoperative hemorrhage Tonsillitis Sleep apnea Obstructive Tonsillectomy Child

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Effect of low dose laser cycloplasty on deepening anterior chamber in chronic angle-closure glaucoma

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2011-2017页

作者： Xuan-Li Zheng Hai-Shuang Lin Xiao-Jie Wang Jia-Qian Li Yan-Qian Xie Shao-Dan Zhang Yuan-Bo Liang Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina National clinical research center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To describe the outcome of using low-dose laser cycloplasty(LCP)in chronic angle-closure glaucoma(CACG).METHODS:A retrospective case *** charts of CACG patients who underwent LCP in the Eye Hospital of Wenzhou Medical University were *** main outcomes included intraocular pressure(IOP),the number of glaucoma medication,anterior segment parameters and surgery-related ***:A total of 7 eyes of 7 CACG patients(age 38.9±11.0y)underwent LCP with a mean follow-up of 27.1±13.7mo(range 16-48mo).Following LCP,mean IOP and glaucoma medications decreased from 26.1±6.1 mm Hg with 3.1±1.1 glaucoma medications pre-treatment to 14.9±3.1 mm Hg(P=0.027)with 0.4±1.1 glaucoma medications(P=0.001)at final *** anterior chamber depth(ACD),angle opening distance500 and trabecular-iris angle increased from 1.65±0.33 mm,0.05 mm(range 0-0.30 mm)and 5.1°(range,0-31.97°)at baseline to 1.98±0.43 mm(P=0.073),0.53 mm(range 0.42-0.91 mm,P=0.015),45.9°(range,40.2°-59.4°),(P=0.015)in the long-term follow-up,*** deepening of ACD and reopening of anterior chamber angle(ACA)was observed in 6 eyes(85.7%).CONCLUSION:LCP is a promising treatment option for patients with CACG via reducing IOP and glaucoma medication without serious *** addition,LCP can bring a significant deepening in ACD and reopening of ACA.

关键词： chronic angle-closure glaucoma low dose laser cycloplasty anterior chamber depth intraocular pressure

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clinical prediction of insufficient vaults after implantable collamer lens implantation

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1300-1306页

作者： Jun Zhu Dan Cheng Xue-Ying Zhu Fen-Fen Li Ye Yang Yu-Feng Ye National clinical research center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(<250μm)after implantable collamer lens(ICL V4c;STAAR Surgical)***:The participants underwent ICL surger... 详细信息

AIM:To determine the factors related to preoperative ocular characters that are predictive of insufficient vault(clinical outcomes were compared between the two *** relationship between the 3-month vault values and preoperative ocular parameters were evaluated by Generalized estimating ***:Sixteen(23 eyes)and 36 patients(63 eyes)were in the low and normal vault groups,*** implantation procedures were uneventful with no cataract formation in the early postoperative *** sulcusto-sulcus lens rise(STSL)and iris ciliary angle(ICA)were correlated with vault at 3mo after *** 0.1 mm increase in STSL was associated with 38.9μm decrease in the postoperative 3-month vault.A rise of 1 degree in ICA is associated with a reduction of 4μm in ***:Eyes with a narrow ciliary sulcus are associated with a higher rate of low vault after ICL implantation,suggesting a need for adjustments to the ICL size in these *** the characteristics of the ciliary sulcus contributes valuable information to predict low vault after surgery.

关键词： insufficient vault implantable collamer lens ciliary body posterior chamber

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Trends in Incidence Rates,Mortality Rates,and Age-Period-Cohort Effects of Female Breast cancer—China,2003-2017

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China CDC weekly 2023年第15期5卷 340-346,I0001页

作者： Kexin Sun Lin Lei Rongshou Zheng Siwei Zhang Hongmei Zeng Shaoming Wang Li Li Ru Chen Bingfeng Han Ji Peng Wenqiang Wei Jie He National Central cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Shenzhen center for Chronic Disease Control Shenzhen CityGuangdong ProvinceChina Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Introduction:This study reported the trends in female breast cancer incidence and mortality rates in China,and analyzed the corresponding age-periodcohort ***:Data from 22 population-based cancer registries in China between 2003 and 2017 were ***-standardized incidence rates(ASIR)and mortality rates(ASMR)were calculated using Segi’s world standard *** regression was employed to evaluate trends,and age-period-cohort effects were examined using the intrinsic estimator ***:The ASIR for female breast cancer exhibited a more rapid increase in rural areas compared to urban areas across all age *** most substantial increase was observed in the 20-34 age group in rural areas[annual percent change(APC)=9.0%,95%confidence interval(CI):7.0%-11.0%,Pcancer incidence and mortality rates in both urban and rural ***,the cohort effect for incidence displayed a slight upward trend for females born between 1983 and 1992 in rural ***:Our study revealed a rapid increase in breast cancer incidence among younger generations and an accelerated mortality rate in older populations residing in rural *** effectively address the growing burden of female breast cancer in China,it is essential to develop and implement targeted intervention strategies.

关键词： mortality Breast younger

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The role of reactive oxygen species in gastric cancer

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cancer Biology & Medicine 2024年第9期21卷 740-753页

作者： Yuqi Wang Jingli Xu Zhenjie Fu Ruolan Zhang Weiwei Zhu Qianyu Zhao Ping Wang Can Hu Xiangdong Cheng College of Pharmaceutical Sciences Zhejiang University of TechnologyHangzhou 310014China Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022China Key Laboratory of Prevention Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang ProvinceHangzhou 310022China zhejiang Provincial research center for Upper Gastrointestinal Tract cancer Zhejiang Cancer HospitalHangzhou 310022China

Gastric cancer(GC)ranks fifth in cancer incidence and fourth in cancer-related mortality *** oxygen species(ROS)are highly oxidative oxygen-derived products that have crucial roles in cell signaling regulation and maintaining internal *** are closely associated with the occurrence,development,and treatment of *** review summarizes recent findings on the sources of ROS and the bidirectional regulatory effects on GC and discusses various treatment modalities for GC that are related to ROS *** addition,the regulation of ROS by natural small molecule compounds with the highest potential for development and applications in anti-GC research is *** aim of the review is to accelerate the clinical application of modulating ROS levels as a therapeutic strategy for GC.

关键词： Gastric cancer reactive oxygen species ROSantitumor therapy natural products pharmacology

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Model for liver hardness using two-dimensional shear wave elastography,durometer,and preoperative biomarkers

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World Journal of Gastrointestinal Surgery 2021年第2期13卷 127-140页

作者： Bing-Jie Ju Ming Jin Yang Tian Xiang Zhen De-Xing Kong Wei-Lin Wang Sheng Yan Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of zhejiang province Hangzhou 310009Zhejiang ProvinceChina research center of Diagnosis and Treatment Technology for Hepatocellular Carcinoma of zhejiang province Hangzhou 310009Zhejiang ProvinceChina clinical Medicine Innovation center of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Disease of zhejiang University Hangzhou 310009Zhejiang ProvinceChina clinical research center of Hepatobiliary and Pancreatic Diseases of zhejiang province Hangzhou 310009Zhejiang ProvinceChina School of Mathematical Sciences Zhejiang UniversityHangzhou 310027Zhejiang ProvinceChina

BACKGROUND Post-hepatectomy liver failure(PHLF)increases morbidity and mortality after liver resection for patients with advanced liver fibrosis and *** liver stiffness using two-dimensional shear wave elastography(2D-SWE)is widely used to evaluate the degree of ***,the 2D-SWE results were not accurate.A durometer measures hardness by quantifying the ability of a material to locally resist the intrusion of hard objects into its ***,the durometer score can only be obtained during *** measure correlations among 2D-SWE,palpation by surgeons,and durometermeasured objective liver hardness and to construct a liver hardness regression *** We enrolled 74 hepatectomy patients with liver hardness in a derivation ***-based liver hardness scores(0-100)were determined through palpation of the liver tissue by ***,liver hardness was measured using a *** coefficients for durometer-measured hardness and preoperative parameters were *** linear regression models were constructed to select the best predictive durometer *** operating characteristic(ROC)curves and univariate and multivariate analyses were used to calculate the best model’s prediction of PHLF and risk factors for PHLF,respectively.A separate validation cohort(n=162)was used to evaluate the *** The stiffness measured using 2D-SWE and palpation scale had good linear correlation with durometer-measured hardness(Pearson rank correlation coefficient 0.704 and 0.729,respectively,P<0.001).The best model for the durometer scale(hardness scale model)was based on stiffness,hepatitis B virus surface antigen,and albumin level and had an R2 value of *** area under the ROC for the durometer and hardness scale for PHLF prediction were 0.807(P=0.002)and 0.785(P=0.005),*** optimal cutoff value of the durometer and hardness scale was 27.38(sensitivity=0.900,specificity=0.660)and

关键词： Hepatectomy Liver Hardness Durometer Two-dimensional shear wave elastography Post-hepatectomy liver failure Liver failure

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Retinal laser photocoagulation and intravitreal injection of anti-VEGF for hemorrhagic retinal arterial microaneurysm

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2041-2048页

作者： Ying Huang Wei-Wei Zheng Ying-Zi Li Zu-Hua Sun Bing Lin National clinical research center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To evaluate the efficacy of retinal laser photocoagulation and intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF)for hemorrhagic retinal arterial macroaneurysm(RAM).METHODS:This was a retrospective clinical *** with hemorrhagic RAM were divided into 4 groups defined by different treatments:a retinal laser photocoagulation therapy monotherapy group,an anti-VEGF intravitreal injection monotherapy group,a laser and anti-VEGF combination therapy group,and an observation *** acuity(VA),central macular thickness(CMT),and retinal hemorrhage area(RHA)were ***:Forty-seven eyes of 47 patients were *** improved and had a significant difference between baseline and final in each treatment group(logMAR;laser group:1.90±0.53 vs 1.05±0.63,P<0.001;anti-VEGF group:1.75±0.63 vs 1.12±0.54,P=0.009;combination group:1.76±0.38 vs 1.01±0.52,P<0.001);however,VA decreased and had no significant difference in observation group(1.63±0.51 vs 1.76±0.61,P=0.660).CMT decreased and had a significant difference between baseline and final in each group(laser group:815.16±310.83 vs 252.05±83.90μm,P<0.001;anti-VEGF group:725.00±290.79 vs 203.56±69.89μm,P=0.001;combination group:595.50±186.51 vs 253.13±55.06μm,P=0.001;observation group:758.88±195.65 vs 267.00±120.90μm,P=0.001).RHA were 28.99±28.15,25.94±11.58,19.64±8.97,and 27.45±13.76 mm^(2) in laser group,anti-VEGF group,combination group and observation group,*** was statistically correlated with final VA(P=0.032)in the observation ***:Both laser and anti-VEGF treatments are effective for hemorrhagic *** therapy reduces the number of injections of *** is a visual prognosis predictor in the natural history of hemorrhagic RAM.

关键词： retinal laser photocoagulation anti-vascular endothelial growth factor retinal arterial macroaneurysm

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