检索结果-南通市图书馆

Gastric cancer in 2022:Is there still a role for endoscopic ultrasound?

World Journal of Gastrointestinal Endoscopy 2023年第1期15卷 1-9页

作者： Gemma Rossi Maria Chiara Petrone Andrew J Healey Paolo Giorgio Arcidiacono Pancreato-Biliary Endoscopy and Endosonography Division Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSVita Salute San Raffaele UniversityMilan 20132Italy Department of clinical Surgery University of EdinburghRoyal Infirmary of EdinburghEdinburgh EH164SAUnited Kingdom

Gastric cancer(GC)represents the fourth leading cause of cancer death worldwide and many factors can influence its development(diet,geographic area,genetic,Helicobacter pylori or Epstein-Barr virus infections).High quality endoscopy represents the modality of choice for GC *** correct morphologic classification during a high-resolution endoscopy is fundamental for oncologic diagnosis,staging and therapeutic *** its initial introduction in clinical practice the endoscopic ultrasound(EUS)has been considered a valuable tool for tumor(T-)and lymph nodes(N-)staging also in GC,in order to establish the best therapeutic strategy for the patient(e.g.,upfront surgery vs neoadjuvant treatments).EUS tools as elastography,Doppler and contrast administration can improve diagnosis mainly in case of malignant lymph node *** has a marginal role in disease staging but has a fundamental role in case of a pre-endoscopic resection management and in the new era of endoscopic mucosal resection or submucosal dissection as minimally invasive *** and locoregional staging of GC with EUS are a method of inarguable value for the assessment of gastric wall involvement and presence of infiltrated paragastric lymph *** can also have a role in disease restaging in those patients who have undergone neoadjuvant *** can also have a role in the advanced phases of the disease,in facilitating palliative,minimallyinvasive treatments,such as gastroenterostomy or biliary *** review intends to discuss the modern role of EUS in GC topic.

关键词： Gastric cancer Endoscopic ultrasound Endoscopic resection Neoadjuvant chemotherapy Therapeutic endoscopic ultrasound

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ciinical value and cost-effectiveness of minimally invasive distal pancreatectomy

引用

Hepatobiliary Surgery and Nutrition 2020年第2期9卷 205-207页

作者： Andrea Belli Francesco Izzo Giulio Belli Department of Abdominal Oncology HPB Surgical Oncology UnitNational Cancer InstituteFondazione G.Pascale-IRCCSNaplesItaly Department of General and HPB Surgery Loreto Nuovo HospitalNaplesItaly

Minimally invasive pancreatic resection(MIPR)has gained popularity in the last decade and it is currently widely applied with selected indications in highly specialized centres *** pancreatectomy(DP),which lacks of a technical demanding and complex reconstruction phase,is the most suitable pancreatic resection for a minimal invasive approach and is therefore the most performed *** non-randomized studies and meta-analyses suggested that a minimally invasive distal pancreatectomy(MIDP)could improve the short-term postoperative outcomes by reducing the intraoperative blood loss and the postoperative morbidity when compared to open distal pancreatectomy(ODP)(1).MIDP seems also to promote an earlier recovery and a reduction in the length of postoperative stays when compared to ODP without affecting the oncologic ***,the diffusion of MIDP is increasing and a minimally invasive approach is generally recognized as a suitable approach to benign,borderline malignant lesions and to *** value of MIDP for the surgical treatment of pancreatic ductal adenocarcinoma(PDAC)is still under evaluation despite its feasibility and safety in this setting have been demonstrated and similar long-term oncological outcomes were reported by several single and multicentre series(2).The recent published DIPLOMA study,a European retrospective propensity score-matched cohort study on minimally invasive versus open DP for PDAC,raised some concerns in terms of oncological adequacy of MIDP(3).

关键词： centre value distal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment of colorectal cancer in the elderly

引用

World Journal of Gastrointestinal Oncology 2015年第10期7卷 204-220页

作者： Monica Millan Sandra Merino Aleidis Caro Francesc Feliu Jordi Escuder Tani Francesch Colorectal Surgery unit Department of Surgery Joan XXIII University Hospital Department of Medical Oncology Joan XXIII University Hospital and St. Joan de Reus University Hospital Department of Geriatrics and Palliative Care Joan XXIII University Hospital (GiPSS)

Colorectal cancer has a high incidence, and approxi-mately 60% of colorectal cancer patients are older than 70, with this incidence likely increasing in the near future. Elderly patients(> 70-75 years of age) are a very heterogeneous group, ranging from the very fit to the very frail. Traditionally, these patients have often been under-treated and recruited less frequently to clinical trials than younger patients, and thus are underrepresented in publications about cancer treatment. Recent studies suggest that fit elderly patients can be treated in the same way as their younger counterparts, but the treatment of frail patients with comorbidities is still a matter of controversy. Many factors should be taken into account, including fitness for treatment, the wishes of the patient and family, and quality of life. This review will focus on the existing evidence for surgical, oncologic, and palliative treatment in patients over 70 years old with colorectal cancer. Careful patient assessment is necessary in order to individualize treatment approach, and this should rely on a multidisciplinary process. More well-designed controlled trials are needed in this patient population.

关键词： Colorectal cancer Surgery Chemotherapy Radiotherap

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

clinical characteristics of COVID-19 hospitalized patients associated with mortality:A cohort study in Spain

引用

Infectious Medicine 2022年第2期1卷 81-87页

作者： Manuel Lozano Adina Iftimi Alvaro Briz-Redon Juanjo Peiró Lara Manyes María Otero Mayte Ballester MDolores de las Marinas Juan Carlos Catalá Joséde Andrés Carolina Romero Preventive Medicine and Public Health Food SciencesToxicology and Forensic Medicine DepartmentUniversitat de ValènciaValenciaSpain Epidemiology and Environmental Health Joint Research unit FISABIO−Universitat Jaume I−Universitat de ValènciaValenciaSpain Department of Statistics and Operations Research University of ValenciaValenciaSpain Statistics Office City Council of ValenciaValenciaSpain Department of Anesthesia Critical Care and Pain UnitUniversity General HospitalValenciaSpain Division of Allergy and Immunology University General HospitalValenciaSpain Anesthesia unit-Surgical Specialties Department Valencia University Medical SchoolValenciaSpain Division of Research Methodology European UniversityValenciaSpain

Background:The heterogeneity of patients with COVID-19 may explain the wide variation of mortality rate due to the population characteristics,presence of comorbidities and clinical ***:In this study,we analyzed 5342 patients’recordings and selected a cohort of 177 hospitalized patients with a poor prognosis at an early *** assessed during 6 months their symptomatology,coexisting health conditions,clinical measures and health assistance related to *** Cox proportional hazards models were built to identify the associated factors with mortality ***:We observed that cough and kidney failure triplicate the mortality risk and both bilirubin levels and oncologic condition are shown as the most associated with the demise,increasing in four and ten times the risk,*** clinical characteristics such as fever,diabetes mellitus,breathing frequency,neutrophil-lymphocyte ratio,oxygen saturation,and troponin levels,were also related to mortality risk of in-hospital ***:The present study shows that some symptomatology,comorbidities and clinical measures could be the target of prevention tools to improve survival rates.

关键词： COVID-19 SARS-CoV-2 Respiratory insufficiency Mortality Proportional hazard model Pandemics Coronavirus infections Epidemiology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein-coding genes combined with long noncoding RNA as a novel transcriptome molecular staging model to predict the survival of patients with esophageal squamous cell carcinoma

引用

Cancer Communications 2018年第1期38卷 50-62页

作者： Jin-Cheng Guo Yang Wu Yang Chen Feng Pan Zhi-Yong Wu Jia-Sheng Zhang Jian-Yi Wu Xiu-E Xu Jian-Mei Zhao En-Min Li Yi Zhao Li-Yan Xu Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Chaoshan Area of Guangdong Higher Education Institutes Shantou University Medical CollegeShantouGuangdong 515041P.R.China Department of Biochemistry and Molecular Biology Shantou University Medical CollegeShantouGuangdong 515041P.R.China Departments of Oncology Surgery Shantou Central HospitalAffiliated Shantou Hospital of Sun Yat-Sen UniversityShantouGuangdong 515041P.R.China Institute of oncologic Pathology Shantou University Medical CollegeShantouGuangdong 515041P.R.China Key Laboratory of Intelligent Information Processing Advanced Computer Research CenterState Key Laboratory of Computer ArchitectureInstitute of Computing TechnologyChinese Academy of SciencesBeijing 100190P.R.China

Background:Esophageal squamous cell carcinoma(ESCC)is the predominant subtype of esophageal carcinoma in *** study was to develop a staging model to predict outcomes of patients with ***:Using Cox regression analysis,principal component analysis(PCA),partitioning clustering,Kaplan-Meier analysis,receiver operating characteristic(ROC)curve analysis,and classification and regression tree(CART)analysis,we mined the Gene Expression Omnibus database to determine the expression profiles of genes in 179 patients with ESCC from GSE63624 and GSE63622 ***:Univariate cox regression analysis of the GSE63624 dataset revealed that 2404 protein-coding genes(PCGs)and 635 long non-coding RNAs(lncRNAs)were associated with the survival of patients with *** categorized these PCGs and lncRNAs into three principal components(PCs),which were used to cluster the patients into three *** analysis demonstrated that the predictive ability of PCG-lncRNA PCs when applied to new patients was better than that of the tumor-node-metastasis staging(area under ROC curve[AUC]:0.69 vs.0.65,Pclinical significance for the prognosis prediction of patients with ESCC and may serve as a three-gene staging microarray.

关键词： Long non-coding RNA Protein-coding gene Esophageal squamous cell carcinoma Overall survival Staging model Transcriptome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

关于Del Chiaro及同事应用磁共振做胰腺癌筛查的报道

引用

临床与病理杂志 2016年第8期36卷 1073-1078页

作者： Yì-Xiáng J.Wáng Jing-Shan Gong Romaric Loff roy 王毅翔 Department of Imaging and Interventional Radiology Faculty of MedicineThe Chinese University of Hong Kong Prince of Wales HospitalShatin Department of Radiology Shenzhen People's HospitalSecond Clinical Medicine College of Jinan University Department of Vascular Oncologic and Interventional RadiologyLe2i UMR CNRS 6306University of Dijon School of MedicineBocage Teaching Hospital 香港中文大学医学院

胰腺癌是一种致命的疾病，其发病率和病死率几乎一样。在西方国家5年存活率为4%，是所有癌症类型中最低的[1]。在中国胰腺癌为恶性肿瘤死亡原因的第六位，总累积5年存活率为1%~3%[2-3]。中国胰腺癌患病危险因素类似于西方国家[2-3]。通... 详细信息

胰腺癌是一种致命的疾病，其发病率和病死率几乎一样。在西方国家5年存活率为4%，是所有癌症类型中最低的[1]。在中国胰腺癌为恶性肿瘤死亡原因的第六位，总累积5年存活率为1%~3%[2-3]。中国胰腺癌患病危险因素类似于西方国家[2-3]。通过影像学偶然发现的胰腺癌生存期似乎有所增加[4-6]。最近基因测序证据[7-8]表明，胰腺癌从基因癌变开始到转移期胰腺癌需要15年时间。20世纪90年代之前，胰腺癌可以是一种遗传性疾病这点没有被广泛认识，而现在知道在某些基因异常的个体，如BRCA2、p16、遗传性非息肉性大肠癌、家族性胰腺炎和Peutz-Jeghers综合征的个人都较易患胰腺癌[9-14]。然而胰腺癌只有10%的患者有已知的危险因素，其他90%的癌症目前未有已知的风险因素[4-12]。

关键词：胰腺癌 Peutz-Jeghers综合征遗传性非息肉性大肠癌 Del 癌筛查磁共振遗传性疾病应用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nutritional Screening in a University Hospital:Comparison between oncologic and Non-oncologic Patients

引用

Food and Nutrition Sciences 2015年第1期6卷 75-82页

作者： Selma F.C.Cunha Lidiane S.Tanaka Roberta G.Salomao Danielle M.Macedo Thatiane D.Santos Fernanda M.Peria Division of clinical Nutrition Department of Internal MedicineSchool of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil Parenteral and Enteral Nutrition Team of clinical Hospital School of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil Division of Oncology Department of Internal MedicineSchool of Medicine of Ribeirao PretoUniversity of Sao PauloRibeirao PretoBrazil

Background & Aims: We compared the screening nutritional data of patients with malignant and non-malignant disease, and classified their nutritional risk according to the primary tumor’s site. Methods: Subjective Global Assessment was applied to 3008 patients within 48 h of admission to a public university. Subjects were divided into oncologic Group (n = 576) or Non-oncologic Group (n = 2432) according to the presence of neoplasms or other diseases respectively. These data were compared by the t-student test and classic chi-square test, with statistical significance set at p oncologic Group presented a higher prevalence of weight loss (60.3% vs. 49.3%), quantitative (40.7% vs. 28.5%) and qualitative (16.4% vs. 7.6%) alterations in the food intake pattern, gastrointestinal symptoms and muscle waste (23.2% vs. 13.2%) as compared to the Non-oncologic Group. Also, there was a higher prevalence of nutritional disturbances in the oncologic Group, with 49.5% of the subjects moderately (or suspected to be malnourished) and 12.7% severely mal-nourished. Severe malnourishment was mainly observed in patients with head and neck (25%), upper digestive tract (21.9%) and soft tissue and bones (17.9%) tumors. Conclusion: When compared to other hospitalized patients, patients with neoplastic disease were in higher nutritional risk.

关键词： Nutritional Screening Malnutrition Subjective Global Assessment Hospital Setting Neoplasia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Survival after laparoscopic versus open resection for colorectal liver metastases

引用

Hepatobiliary Surgery and Nutrition 2021年第1期10卷 134-135页

作者： Davit L.Aghayan Åsmund Avdem Fretland Bjørn Edwin The Intervention Centre Oslo University Hospital-RikshospitaletOsloNorway Institute of clinical Medicine Medical FacultyUniversity of OsloOsloNorway Department of Surgery N1 Yerevan State Medical University after M.HeratsiYerevanArmenia Department of HPB Surgery Oslo University Hospital-RikshospitaletOsloNorway

Laparoscopic liver surgery has become standard of care in many specialized centers worldwide(1,2).Despite its well-known advantages over open approach in surgical outcomes,the evidence supporting its advantages in lon... 详细信息

关键词： Survival liver surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of ferroptosis in esophageal cancer and corresponding immunotherapy

引用

World Journal of Gastrointestinal Oncology 2023年第7期15卷 1105-1118页

作者： Xin Fan Yan-Ting Fan Hui Zeng Xi-Qi Dong Min Lu Zhi-Yuan Zhang Department of Otolaryngology-Head and Neck Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina The First clinical Medical College Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Stomatology The Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Emergency Medicine Shangrao Hospital Affiliated to Nanchang UniversityShangrao 334000Jiangxi ProvinceChina

Esophageal cancer(EC)is one of the most common digestive system malignancies in the *** combined modality treatment of EC is usually surgery and radiation therapy,however,its clinical efficacy for advanced patients is relatively ***,a new type of iron-dependent programmed cell death,is different from apoptosis,necrosis and *** recent years,many studies have further enlightened that ferroptosis plays an essential role in the occurrence,development and metastasis of *** ferroptosis stimulates a new direction for further exploration of oncologic treatment ***,ferroptosis has a critical role in the immune microenvironment of *** paper reviews the mechanism of ferroptosis and the ferroptosis research progress in the treatment of *** further elaborate the interaction between ferroptosis and immunotherapy,and the related mechanisms of ferroptosis participation in the immunotherapy of EC,so as to provide new directions and ideas for the treatment of EC.

关键词： Esophageal cancer Ferroptosis Immunotherapy Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment-Plan Comparison of Three Advanced Radiation Treatment Modalities for Fractionated Stereotactic Radiotherapy to the Head and Neck

引用

International Journal of Medical Physics, clinical Engineering and Radiation Oncology 2019年第2期8卷 106-120页

作者： He Wang James N. Yang Xiaodong Zhang Jing Li Steven J. Frank Zhongxiang Zhao Dershan Luo Xiaorong Zhu Congjun Wang Samuel Tung Adam S. Garden David I. Rosenthal Clifton David Fuller Gary Brandon Gunn Amol J. Ghia Jay P. Reddy Shaan M. Raza Franco De Monte Mark S. Chambers Paul D. Brown Shirley Su Jack Phan Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of oncologic Dentistry Prosthodontics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The Mayo Clinic Rochester MN USA

Purpose: Fractionated stereotactic radiosurgery (FSRS) can be given with at least three modalities: Gamma Knife, with the noninvasive frameless extend system (GKE);linear accelerator-based volumetric modulated arc therapy (VMAT);and intensity-modulated proton therapy (IMPT). We extracted treatment plans for patients who had received FSRS with GKE for recurrent skull base or intracranial tumors, created corresponding plans for VMAT and IMPT, and compared the quality of the three sets of plans. Methods and materials: Plans were extracted for 9 patients with recurrent malignant skull-base tumors (n = 6) or large intracranial tumors (n = 3) who had received FSRS with GKE (median dose 24 Gy in 3 fractions) in 2013 through 2015. Plans for VMAT were generated with a TrueBeam STx LINAC machine using 6-MV photons, and plans for IMPT were generated with multi-field optimization. The optimized VMAT and IMPT plans were normalized to achieve the best possible target coverage while meeting the same dose-volume constraints on organs at risk (OARs) as the GKE plans. Plans were evaluated on the basis of target coverage, conformity index, homogeneity index, gradient index, and treatment efficiency. Results: The median target volume was 10.2 cm3 (range 1.9 - 33.8 cm3). The VMAT and IMPT plans met all OAR constraints, and target coverage and conformity were comparable among all plans. VMAT and IMPT plans showed significantly better target uniformity and treatment delivery efficiency (P P Conclusion: FSRS for skull base and large intracranial lesions delivered by VMAT and IMPT can achieve comparable target coverage, conformity, and sparing of critical structure as the GKE while providing superior target uniformity and treatment delivery efficiency. The GKE had superior high-dose gradients outside the target and thus better protected surrounding normal structures.

关键词： Gamma Knife Extend System Stereotactic Radiosurgery Volumetric Modulated Arc Therapy Intensity-Modulated Proton Therapy Spot Scanning Proton Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：