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Cuproptosis:A potential therapeutic target in clear cell renal cell carcinoma

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Chinese Medical Journal 2024年第11期137卷 1378-1380页

作者： Yuetong Zhao Jie Li Xiaojie Lu Shuang Wu Yunze Xing Yaxuan Fang Bo Yang Department of Nephrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300381China Department of Nephrology National Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300381China

To the Editor:Copper is a crucial trace element in the body that plays a key role in metabolism and biological *** ions are found in two forms,Cu^(1+)and Cu^(2+),of which Cu^(1+)is the main form stored in *** studies have shown that intracellular copper accumulation can cause oxidative stress and disrupt cellular function.[1]Different from apoptosis,autophagy,pyroptosis,and ferroptosis,cuproptosis is a newly discovered type of cell death in 2022.[2]It is mediated by protein lipoylation with ferredoxin 1(FDX1)in *** most common pathological type of kidney cancer in adults is clear cell renal cell carcinoma(ccRCC),which accounts for 70-80%of all cases of renal cell carcinoma(RCC).[3]Currently,surgical resection is the preferred treatment for RCC,as radiotherapy,chemotherapy,and immunotherapy have shown limited effectiveness in treating ***,cuproptosis induction may offer a new approach for ccRCC treatment.

关键词： metabolism chemotherapy potential

Association of Cytokines with clinical Indicators in Patients with Drug-Induced Liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANg Ting Ting SHEN ge DENg Wen WANg Shi Yu ZHANg Zi Yu LI Xin Xin LU Yao ZHANg Lu LIU Ru Yu CHANg Min WU Shu Ling gAO Yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU Meng Jiao YI Wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:Pge may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

Pharmacokinetic Characterization of Xylazine in goats with Simultaneous Anesthesia Studies

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Journal of Northeast Agricultural university(English Edition) 2024年第2期31卷 86-96页

作者： gao Tiantian Liu Yongti Zhou Lulu Li Yanan Ruan Hongri Wei Chengwei gao Xiang College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Animal clinical teaching hospital Northeast Agricultural UniversityHarbin 150030China

The aim was to study the pharmacokinetics of xylazine as a stable anesthetic in *** this study,goats were injected with xylazine at the rate of 0.3 mL·kg-1 intramusculally,and blood samples were collected at 1,3,5,10,20,30,45,60,90,120,180,and 240 min after administration,*** was extracted by liquid-liquid extraction and separation method,and blood concentration was determined by high performance liquid chromatography(HPLC).The pharmacokinetic characteristics of xylazine in healthy goats were analyzed by pharmacokinetic *** results showed that the chromatographic peak time of xylazine chromatography was 9-11 *** specificity of the method was *** linear correlation coefficient R2 of the standard curve was 0.9982 when the concentration of xylazine was in the range of 10-1×1000 *** pharmacokinetic model of xylazine in goats was a one-chamber model with first-order rate absorption,distribution half-life t1/2Ka was(0.49±0.041)min,elimination half-life t1/2Ke was(23.3±2.5)min,and the peak time(Tp)of the highest concentration was(2.8±0.2)*** total drug clearance CL/F was(0.00016±0.000016)mg·kg-1·min-1(ng·mL-1),and the minimum effective blood concentration was 56.6 ng·mL-1,which was consistent with the clinical anesthetic *** results showed that xylazine had the characteristics of rapid absorption,wide distribution,short peak time,slow clearance rate,and long anesthetic time in goats,which could be used as the basic drug for the development of goat complex anesthetic preparation.

关键词： xylazine anesthesia goat pharmacokinetics

Acupuncture for ischemic stroke:where are we now?

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Acupuncture and Herbal Medicine 2024年第1期4卷 36-55页

作者： Weiming Zhu Qingqing Jia Alberto Cantidio Ferreira Hailun Jiang Jieying Zhang Boxuan Li Menglong Zhang Bifang Zhuo Yuanhao Lyu Junjie Chen Li Li guang Tian Shizhe Deng Zhihong Meng Xuemin Shi graduate School Tianjin University of Traditional Chinese MedicineTianjinChina First teaching hospital Tianjin University of Traditional Chinese MedicineTianjinChina National clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina The Second Affiliated hospital of Shandong university of Traditional Chinese Medicine JinanChina Taos Institute of Traditional Chinese Medicine Recife/PEBrazil

Acupuncture is an effective treatment for ischemic stroke(IS)and plays a key role in neurological rehabilitation after *** can improve the clinical symptoms of various complications after IS,including motor dysfunction,swallowing disorders,speech disorders,cognitive impairment,depression,insomnia,and ***,the mechanisms underlying the effects of acupuncture in IS remain *** evidence suggests that acupuncture may exert neuroprotective effects through neuroplasticity(neurogenesis and synaptogenesis),angiogenesis,cell proliferation and apoptosis,and regulation of oxidative stress,inflammation,and *** studies should be conducted to improve the high-quality evidence-based system of acupuncture intervention for IS,by focusing on the clinical and basic research design,increasing the sample size,standardizing and quantifying the standards of acupuncture operations,using multidisciplinary techniques and methods to systematically explore the key targets of acupuncture intervention for IS,and reveal the efficacy and mechanism of acupuncture in the treatment of IS.

关键词： Acupuncture Curative effect Electroacupuncture Ischemic stroke Mechanism Review

The role of corneal endothelium in macular corneal dystrophy development and recurrence

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Science China(Life Sciences) 2024年第2期67卷 332-344页

作者： Bi-Ning Zhang Benxiang Qi Chunxiao Dong Bin Zhang Jun Cheng Xin Wang Suxia Li Xiaoyun Zhuang Shijiu Chen Haoyun Duan Dewei Li Sujie Zhu guoyun Li Yihai Cao Qingjun Zhou Lixin Xie Eye Institute of Shandong First Medical university Qingdao Eye Hospital of Shandong First Medical UniversityQingdao 266071China State Key laboratory Cultivation Base Shandong Provincial Key Laboratory of OphthalmologyQingdao 266071China School of Ophthalmology Shandong First Medical UniversityQingdao 250021China Department of Medicine Qingdao UniversityQingdao 266071China Eye Institute of Shandong First Medical university Eye Hospital of Shandong First Medical University(Shandong Eye Hospital)Jinan 250021China Department of Ophthalmology School of Clinical MedicineWeifang Medical UniversityWeifang 261072China Institute of Translational Medicine College of MedicineQingdao UniversityQingdao 266071China Key laboratory of Marine Drugs of Ministry of Education Shandong Provincial Key Laboratory of Glycoscience and GlycotechnologySchool of Medicine and PharmacyOcean University of ChinaQingdao 266071China laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China Department of Microbiology Tumor and Cell BiologyBiomedicumKarolinska InstitutetStockholm 17177Sweden

Macular corneal dystrophy(MCD)is a progressive,bilateral stromal dystrophic disease that arises from mutations in carbohydrate sulfotransferase 6(CHST6).Corneal transplantation is the ultimate therapeutic solution for MCD ***,postoperative recurrence remains a significant *** conducted a retrospective review of a clinical cohort comprising 102 MCD patients with 124 eyes that underwent either penetrating keratoplasty(PKP)or deep anterior lamellar keratoplasty(DALK).Our results revealed that the recurrence rate was nearly three times higher in the DALK group(39.13%,9/23 eyes)compared with the PKP group(10.89%,11/101 eyes),suggesting that surgical replacement of the corneal endothelium for treating MCD is advisable to prevent postoperative *** experimental data confirmed the robust m RNA and protein expression of CHST6 in human corneal endothelium and the rodent homolog CHST5 in mouse *** knockdown of wild-type Chst5 in mouse corneal endothelium(AC^(siChst5)),but not in the corneal stroma,induced experimental MCD with similar extracellular matrix synthesis impairments and corneal thinning as observed in MCD *** carrying Chst5 point mutation also recapitulated clinical phenotypes of MCD,along with corneal endothelial *** injection of wild-type Chst5 rescued the corneal impairments in AC^(siChst5)mice and retarded the disease progression in Chst5 mutant ***,our study provides new mechanistic insights and therapeutic approaches for MCD treatment by highlighting the role of corneal endothelium in MCD development.

关键词： macular corneal dystrophy recurrence corneal endothelium keratan sulfate penetrating keratoplasty

Study on sex differences and potential clinical value of threedimensional computerized tomography pelvimetry in rectal cancer patients

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World Journal of gastrointestinal Oncology 2024年第3期16卷 773-786页

作者： Xiao-Cong Zhou Fei-Yue Ke gaurav Dhamija Hao Chen Qiang Wang Department of Colorectal Surgery The Dingli Clinical Institute of Wenzhou Medical University(Wenzhou Central Hospital)Wenzhou 325000Zhejiang ProvinceChina Postgraduate Training Base Alliance of Wenzhou Medical university Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina School of International Studies Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Radiology The Dingli Clinical Institute of Wenzhou Medical University(Wenzhou Central Hospital)Wenzhou 325000Zhejiang ProvinceChina

BACKgROUND Laparoscopic rectal cancer radical surgery is a complex procedure affected by various ***,the existing literature lacks standardized parameters for the pelvic region and soft tissues,which hampers the establishment of consistent *** To comprehensively assess 16 pelvic and 7 soft tissue parameters through computerized tomography(CT)-based three-dimensional(3D)reconstruction,providing a strong theoretical basis to address challenges in laparoscopic rectal cancer radical *** We analyzed data from 218 patients who underwent radical laparoscopic surgery for rectal cancer,and utilized CT data for 3D pelvic *** anatomical points were carefully marked and measured using advanced 3D modeling *** analyze the pelvic and soft tissue parameters,we emp-loyed statistical methods including paired sample t-tests,Wilcoxon rank-sum tests,and correlation *** The investigation highlighted significant sex disparities in 14 pelvic bone parameters and 3 soft tissue *** demonstrated larger measurements in pelvic depth and overall curvature,smaller measurements in pelvic width,a larger mesorectal fat area,and a larger anterior-posterior abdominal *** contrast,females exhibited wider pelvises,shallower depth,smaller overall curvature,and an increased amount of subcutaneous fat ***,there were no significant sex differences observed in certain parameters such as sacral curvature height,superior pubococcygeal diameter,rectal area,visceral fat area,waist circumference,and transverse abdominal *** The reconstruction of 3D CT data enabled accurate pelvic measurements,revealing significant sex differences in both pelvic and soft tissue *** study design offer potential in predicting surgical difficulties and creating personalized surgical plans for male rectal cancer patients with a potentially“difficult pelvis”,ultimately improving surgical ***

关键词： Computerized tomography Rectal cancer Three-dimensional reconstruction Pelvimetry Sex differences

Application of multidisciplinary in situ simulation training in the treatment of acute ischemic stroke: a quality improvement project

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World Journal of Emergency Medicine 2024年第1期15卷 41-46页

作者： ganying Huang Huijie Yang Huan Yao Xinxin Fan Wenqin Xia Yuansheng Xu Xiaoling Shen Xue Zhao Fourth School of clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Emergency Medicine Departent Hangzhou First People's HospitalHangzhou 310006China

BACKgROUND:Ischemic stroke refers to a disorder in the blood supply to a local area of brain tissue for various reasons and is characterized by high morbidity,mortality,and *** reperfusion of brain tissue at risk of injury is crucial for the treatment of acute ischemic *** purpose of this study was to evaluate comfort levels in managing acute stroke patients with hypoxemia who required endotracheal intubation after multidisciplinary in situ simulation training and to shorten the door-to-image ***:This quality improvement project utilized a comprehensive multidisciplinary in situ simulation exercise.A total of 53 participants completed the two-day in situ simulation *** main outcome was the self-reported comfort levels of participants in managing acute stroke patients with hypoxemia requiring endotracheal intubation before and after simulation training.A 5-point Likert scale was used to measure participant comfort.A paired-sample t-test was used to compare the mean self-reported comfort scores of participants,as well as the endotracheal intubation time and door-to-image time on the fi rst and second days of in situ simulation *** door-to-image time before and after the training was also ***:The findings indicated that in situ simulation training could enhance participant comfort when managing acute stroke patients with hypoxemia who required endotracheal intubation and shorten door-to-image *** the emergency management of hypoxemia or tracheal intubation,the mean post-training self-reported comfort score was signifi cantly higher than the mean pre-training comfort score(hypoxemia:4.53±0.64 vs.3.62±0.69,t=-11.046,Pge time and a decreasing trend in the door-to-image time,which continued after the ***:Our study demonstrates that the implementation of in s

关键词： Ischemic stroke Endotracheal intubation Door-to-image time In situ simulation Multidisciplinary approach

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护士参与抗菌药物管理现状及影响因素研究

International Journal of Nursing Sciences 2024年第1期11卷 91-98,I0002,I0003页

作者：聂慧宇岳丽青彭欢周金平李冰玉曹紫薇 teaching and Research Section of clinical Nursing Xiangya Hospital of Central South UniversityChangshaHunanChina Xiangya School of Nursing Central South UniversityChangshaHunanChina

目的基于能力、机会、动机和行为(capability, opportunity, motivation, and behavior, COM-B )理论,调查我国护士抗菌药物管理(antimicrobial stewardship, AMS)参与水平及其影响因素,为制订有效策略提高AMS护理质量提供参考依据。... 详细信息

目的基于能力、机会、动机和行为(capability, opportunity, motivation, and behavior, COM-B )理论,调查我国护士抗菌药物管理(antimicrobial stewardship, AMS)参与水平及其影响因素,为制订有效策略提高AMS护理质量提供参考依据。方法采用横断面调查法。于2021年11月至2022年1月,选取湖南省的17所三级医院的4514名护士进行调查。在COM-B理论指导下,自行编制护士参与抗菌药物管理问卷(the NurseAMS Engagement Que stionnaire ,NAEQ)。该问卷包括能力(14个条目)、机会(7个条目)、动机(6个条目)和行为(12个条目)4个维度,共39个条目。结果护士NAEQ总分为( 155.08±±27.12)分,得分率为79.5% ,表明护士参与AMS处于中等水平。其中,能力维度得分为(52.33±13.48 )分,机会维度得分为(28.64±5.76)分,动机维度得分为(24.57±4.57)分,行为维度得分为(4953±8.83)分。不同职称、是否兼职感染控制护士、是否知晓AMS团队、是否知晓抗菌药物限定日剂量、科室类型、科室是否配备临床药师、参与抗菌药物培训和医师-护士联合查房的频率等特征不同的护士NAEQ得分比较,差异有统计学意义(P<0.05)。其中初级职称护士的NAEQ得分高于中级职称护士(P<0.05);担任兼职感染控制护士、知晓AMS团队、知晓抗菌药物限定日剂量的护士NAEQ得分高于其他护士(P<0.01);重症监护室和传染病科护士NAEQ得分低于五官科等其他科室的护士(P<0.01);科室配备临床药师的护士NAEQ得分高于未配备或不清楚是否配备临床药师的护士(P<0.01);参与抗菌药物培训和医师-护士联合查房次数较多的护士NAEQ得分高于其他护士(P<0.01)。结论加强教育和培训及改善多学科沟通与协作等多种策略有望提高护士参与AMS的水平。此外,应更多关注中级职称、感染控制经验较少以及特定科室工作的护士。

关键词：抗菌药物管理行为中国医院知识动机护士

重症监护室智慧化管理措施减少临床虚假警报效果的整合性综述

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International Journal of Nursing Sciences 2024年第1期11卷 133-142页

作者：李冰玉岳丽青聂慧宇曹紫薇柴小桠彭彬张恬鸽黄伟红 teaching and Research Section of clinical Nursing Xiangya Hospital of Central South UniversityChangshaHunanChina Xiangya School of Nursing Central South UniversityChangshaHunanChina “Mobile Health”Ministry of Education-China Mobile Joint laboratory Xiangya Hospital of Central South UniversityChangshaHunanChina

目的医疗设备的频繁虚假警报可能导致护土警报疲劳,这可能导致反应行动延迟或错过警报,增加患者不良事件的风险。本综述旨在探讨重症监护室临床警报智慧化管理措施对减少临床虚假警报的应用效果。方法根据Whitmore 和Knaf的方法学框架,... 详细信息

目的医疗设备的频繁虚假警报可能导致护土警报疲劳,这可能导致反应行动延迟或错过警报,增加患者不良事件的风险。本综述旨在探讨重症监护室临床警报智慧化管理措施对减少临床虚假警报的应用效果。方法根据Whitmore 和Knaf的方法学框架,对6个数据库进行系统检索: PubMed, EMBASE,CINAHL,OVID,CochraneLibrary,Scopus,检索从每个数据库建库到2022年12月以英文或中文发表的临床警报的智慧化管理相关文章。采用乔安娜布里格斯研究所的评价工具(JBI-MAStARI)评估研究的质量,并对文献进行数据提取和分析。该研究已在PROSPERO完成注册(CRD42023411552)。结果共纳入7项研究。不同的警报智慧化管理措施有利于减少虚假警报数量和警报的持续时间,缩短护士对重要警报的应答时间,减轻护士的警报疲劳程度。在实践中,应用新的警报管理方式后取得了积极的效果。结论智慧化管理措施可能是警报减少的有效途径,医院迫切需要进行临床警报的智慧化管理。为确保更有效的患者监测、减少警报给护士带来的困扰,未来需要更多与人工智能相结合的警报管理手段,以实现关键警报的准确识别,确保护士对警报准确响应,并真正改善警报频繁的临床医疗环境。

关键词：人工智能临床警报重症监护室护士生理监测安全管理