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Large mucinous biliary cystadenoma with "ovarian-like"stroma:A case report

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World Journal of Gastroenterology 2006年第23期12卷 3779-3781页

作者： Mircea Beuran Mircea Dan Venter Laura Dumitru Department of Surgery Emergency Clinical HospitalBucharestRomania

Hepatobiliary cystadenomas are rare tumors that are difficult to diagnose preoperatively. They can reach large sizes that make them real intraoperative ＂surprises＂. A 63-year-old woman, presented with a symptomatic huge abdominal cystic mass, underwent complete resection of the mass with safety margins. Histopathological report revealed mucinous hepatic cystadenoma with ＂ovarian- like＂ stroma and areas of sclerohyalinization. The differential diagnosis of the large cystic tumors which occupy the right hemiabdomen must include the biliary cystadenoma; the complete resection of the tumor with safety margins avoids local recurrence, and therefore represents the optimal therapy because of the malignant potential of the disease. The postoperative follow-up includes abdominal ultrasound or CT scan and CA 19-9 measurement.

关键词： Liver Cystic tumour Mucinous cystadenoma Surgery

Autologous cord blood vs individualized supplements in autistic spectrum disorder:CORDUS study results

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World Journal of clinical Pediatrics 2025年第1期14卷 101-112页

作者： Felician A Stancioiu Raluca Bogdan Bogdan Ivanescu Radu Dumitrescu Department of clinical Research Bio-Forum FoundationBucharest 040245BucurestiRomania Department of Pediatrics Medicover Hospital BucharestBucharest 013982BucurestiRomania Doctor MiT Clinic Bucharest 013929BucurestiRomania Department of Anesthesiology and Intensive Therapy Medicover HospitalBucharest 013982BucurestiRomania

BACKGROUND Cellular therapies have started an important new therapeutic direction in autistic spectrum disorder(ASD),and the ample diversity of ASD pathophysiology and the different types of cell therapies prompt an equally ample effort to employ clinical studies for studying the ASD causes and cell *** cells have yielded so far mixed results in clinical trials,and at patient level the results varied from impressive to no *** this context we have administered autologous cord blood(ACB)and a non-placebo,material intervention repre-sented by an individualized combination of supplements(ICS)to ASD *** CORDUS clinical study is a crossover study in which both oral ICS and intravenous ACB were sequentially administered to 56 children;ACB was infused as an inpatient *** efficacy was evaluated pre-treatment and post-treatment at 6 months by an independent psychotherapist with Autism Treatment Evaluation Checklist,Quantitative Checklist for Autism in Toddlers and a 16-item comparative table score,after interviewing the children’s parents and *** and after each intervention participants had a set of blood tests including inflammatory,metabolic and oxidative markers,and the neuronal specific *** No serious adverse reactions were noted during and after cord blood or supplement *** improved evaluation scores in 78%of children with age 3–7-years(n=28),but was much less effective in kids older than 8 years or with body weight of more than 35 kg(n=28;only 11%of children improved scores).ICS yielded better results than ACB in 5 cases out of 28,while in 23 kids ACB brought more improvement than ICS(P<0.05);high initial levels of inflammation and ferritin were associated with no *** individual differences were noted in children's progress,and statistically significant improvements were seen after ACB on areas such as verbalization and social interaction,but not on irritability or

关键词： Autistic spectrum disorder Cord blood Stem cells Neuroinflammation Autologous stem cell treatment Neuronal specific enolase

Fifteen years of bone marrow mononuclear cell therapy in acute myocardial infarction

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World Journal of Stem Cells 2017年第4期9卷 68-76页

作者： Miruna Mihaela Micheu Maria Dorobantu Department of Cardiology Clinical Emergency Hospital of Bucharest014461 BucharestRomania

In spite of modern treatment, acute myocardial infarction(AMI) still carries significant morbidity and mortality worldwide. Even though standard of care therapy improves symptoms and also long-term prognosis of patients with AMI, it does not solve the critical issue, specifically the permanent damage of cardiomyocytes. As a result, a complex process occurs, namely cardiac remodeling, which leads to alterations in cardiac size, shape and function. This is what has driven the quest for unconventional therapeutic strategies aiming to regenerate the injured cardiac and vascular tissue. One of the latest breakthroughs in this regard is stem cell(SC) therapy. Based on favorable data obtained in experimental studies, therapeutic effectiveness of this innovative therapy has been investigated in clinical settings. Of various cell types used in the clinic, autologous bone marrow derived SCs were the first used to treat an AMI patient, 15 years ago. Since then, we have witnessed an increasing body of data as regards this cutting-edge therapy. Although feasibility and safety of SC transplant have been clearly proved, it's efficacy is still under dispute. Conducted studies and meta-analysis reported conflicting results, but there is hope for conclusive answer to be provided by the largest ongoing trial designed to demonstrate whether this treatment saves lives. In the meantime, strategies to enhance the SCs regenerative potential have been applied and/or suggested, position papers and recommendations have been published. But what have we learned so far and how can we properly use the knowledge gained? This review will analytically discuss each of the above topics, summarizing the current state of knowledge in the field.

关键词： Bone marrow stem cells Acute myocardial infarction Cell therapy Cardiac regeneration Remodeling

Moving forward on the pathway of cell-based therapies in ischemic heart disease and heart failure-time for new recommendations?

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World Journal of Stem Cells 2019年第8期11卷 445-451页

作者： Miruna Mihaela Micheu Department of Cardiology Clinical Emergency Hospital of Bucharest Bucharest 014461 Romania

Although substantial advances have been made in treating ischemic heart disease and subsequent heart failure, the overall morbidity and mortality from these conditions remain high. Stem cell-based therapy has emerged as a promising approach for prompting cardiac rejuvenation. Various cell types have been tested in the clinical arena, proving consistent safety results. As for efficiency outcomes, contradictory findings have been reported, partly due to inconsistency in study protocols but also due to poor survival, engraftment and differentiation of transplanted cells in the hostile milieu of the ischemic host tissue. Studies have varied in terms of route of delivery, type and dose of implanted stem cells, patient selection and randomization, and assessment of therapeutic effect. Founded on the main achievements and challenges within almost 20 years of research, a number of official documents have been published by leading experts in the field. Core recommendations have focused on developing and optimizing effective strategies to enrich cell retention and their regenerative potential. Issued consensus and position papers have stemmed from an unmet need to provide a harmonized framework for future research, resulting in improved therapeutic application of cell-based therapies for cardiac regeneration and repair.

关键词： Stem cell therapy Ischemic heart disease Heart failure Cardiac regeneration Recommendations

Surrogate markers of mucosal healing in inflammatory bowel disease:A systematic review

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World Journal of Gastroenterology 2021年第16期27卷 1828-1840页

作者： Monica State Lucian Negreanu Theodor Voiosu Andrei Voiosu Paul Balanescu Radu Bogdan Mateescu Department of Gastroenterology Colentina Clinical HospitalBucharest 020125Romania Department of Gastroenterology Emergency University HospitalBucharest 050098Romania Carol Davila University of Medicine and Pharmacy Bucharest 020021Romania Department of Internal Medicine and Research Methodology Colentina Clinical HospitalBucharest 020125Romania

Mucosal healing(MH)has emerged as a key therapeutic target in inflammatory bowel disease(IBD),and achievement of this goal is documented by endoscopy with ***,colonoscopy is burdensome and invasive,and substitution with an accurate noninvasive biomarker is *** To summarize published data regarding the performance of noninvasive biomarkers in assessing MH in IBD *** We conducted a systematic review of studies that reported the performance of biomarkers in diagnosing MH in patients with *** main outcome measure was to review the diagnostic accuracy of serum and fecal markers that showed promising utility in assessing *** We screened 1301 articles,retrieved 46 manuscripts and included 23 articles for full-text *** majority of the included manuscripts referred to fecal markers(12/23),followed by circulatory markers(8/23);only 3/23 of the included manuscripts investigated combined markers(serum and/or fecal markers).Fecal calprotectin(FC)was the most investigated fecal marker for assessing *** ulcerative colitis,for cutoff levels ranging between 58 mcg/g and 490 mcg/g,the sensitivity was 89.7%-100%and the specificity was 62%-93.3%.For Crohn’s disease,the cutoff levels of FC ranged from 71 mcg/g to 918 mcg/g(sensitivity 50%-95.9%and specificity 52.3%-100%).The best performance for a serum marker was observed for the endoscopic healing index,which showed a comparable accuracy to the measurement of FC and a higher accuracy than the measurement of serum C-reactive *** Several promising biomarkers of MH are emerging but cannot yet substitute for endoscopy with biopsy due to issues with reproducibility and standardization assessing *** ulcerative colitis,for cutoff levels ranging between 58 mcg/g and 490 mcg/g,the sensitivity was 89.7%-100%and the specificity was 62%-93.3%.For Crohn’s disease,the cutoff levels of FC ranged from 71 mcg/g to 918 mcg/g(sensitivity 50%-95.9%and specificity 52.3%-100%).The bes

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Biomarkers Serum Fecal Mucosal healing

Ten-year multicentric retrospective analysis regarding postoperative complications and impact of comorbidities in hemorrhoidal surgery with literature review

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World Journal of clinical Cases 2023年第2期11卷 366-384页

作者： Cosmin Moldovan Elena Rusu Daniel Cochior Madalina Elena Toba Horia Mocanu Razvan Adam Mirela Rimbu Adrian Ghenea Florin Savulescu Daniela Godoroja Florin Botea Department of Medical Surgical Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Witting Clinical HospitalBucharest 010243Romania Department of Preclinic Disciplines Faculty of MedicineTitu Maiorescu University of BucharestBucharest 031593Romania Department of General Surgery Sanador Clinical HospitalBucharest 010991Romania Department of General Surgery Monza Clinical HospitalBucharest 021967Romania Department of Ear Nose and ThroatIlfov County Clinical Emergency HospitalBucharest 022104Romania Department of Orthopedics and Traumatology Elias Emergency University HospitalBucharest 011461Romania Medical Doctoral School Titu Maiorescu University of BucharestBucharest 040317Romania Department of Coloproctology MedLife SA Băneasa HyperclinicBucharest 013693Romania nd Department of Surgery Carol Davila Central Military Emergency University HospitalBucharest 010242Romania Department of Anesthesia Ponderas Academic HospitalBucharest 014142Romania Florin Botea 2nd Department of SurgeryFundeni Clinical InstituteBucharest 022328Romania

BACKGROUND Hemorrhoidal disease(HD)is considered a low-severity pathology by both general population and physicians,but the lengthy conservative therapy and postoperative complications suggest *** To assess the effectiveness of different treatment options,both conservative and surgical,in contrast with some preexisting *** We conducted a retrospective,10-yearlong study between January 2011 and December 2021 in two surgical centers,a private and a state-owned *** compared the efficacy and safety of several treatment options,such as open hemorrhoidectomy,stapled hemorrhoidopexy,rubber band ligation and infrared coagulation in terms of complication rates and types and their correlation with different preexisting comorbidities such as inflammatory bowel disease(IBD),use of anticoagulant medication(AM)and liver *** also conducted a 20-years long PubMed research(1.263 articles)for relevant *** Our study recorded 10940 patients with HD,10241 with conservative and 699 with surgical *** of these,the male-to-female ratio of 1.3,and a peak in age distribution between 59 and 68 years old(32%of patients).For the entire study,we recorded a 90%incidence of immediate pain,immediate bleeding in 1.5%(11 cases),delayed bleeding in 1.0%(7 cases),and 0.6%surgical site *** retention was also present,with 0.2%of patients,anal stricture in 1%and fecal incontinence for 0.5%of patients(4 cases).We recorded no severe complications such as Fournier`s gangrene or rectovaginal *** accounted for 6%of the patients,with ulcerative colitis in 12%and Chron`s disease in 10.5%.6.6%of the patients had AM,determining 4%immediate and 2%delayed bleeding,in surgically treated *** Our study determined that most common complications(pain,urinary retention,bleeding,and stricture)are correlated with each surgical technique and pre-existing comorbidities.

关键词： Retrospective Hemorrhoidal Postoperative Complications Comorbidities

Pursuing meaningful end-points for stem cell therapy assessment in ischemic cardiac disease

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World Journal of Stem Cells 2017年第12期9卷 203-218页

作者： Maria Dorobantu Nicoleta-Monica Popa-Fotea Mihaela Popa Iulia Rusu Miruna Mihaela Micheu Department of Cardiology Clinical Emergency Hospital of Bucharest Carol Davila University of Medicine 'Carol Davila' University of Medicine and Pharmacy Bucharest

Despite optimal interventional and medical therapy, ischemic heart disease is still an important cause of morbidity and mortality worldwide. Although not included in standard of care rehabilitation, stem cell therapy(SCT) could be a solution for prompting cardiac regeneration. Multiple studies have been published from the beginning of SCT until now, but overall no unanimous conclusion could be drawn in part due to the lack of appropriate endpoints. In order to appreciate the impact of SCT, multiple markers from different categories should be considered: Structural, biological, functional, physiological, but also major adverse cardiac events or quality of life. Imaging end-points are among the most used-especially left ventricle ejection fraction(LVEF) measured through different methods. Other imaging parameters are infarct size, myocardial viability and perfusion. The impact of SCT on all of the aforementioned end-points is controversial and debatable. 2 D-echocardiography is widely exploited, but new approaches such as tissue Doppler, strain/strain rate or 3 D-echocardiography are more accurate, especially since the latter one is comparable with the MRI gold standard estimation of LVEF. Apart from the objective parameters, there are also patient-centered evaluations to reveal the benefits of SCT, such as quality of life and performance status, the most valuable from the patient point of view. Emerging parameters investigating molecular pathways such as non-coding RNAs or inflammation cytokines have a high potential as prognostic factors. Due to the disadvantages of current techniques, new imaging methods with labelled cells tracked along their lifetime seem promising, but until now only pre-clinical trials have been conducted in humans. Overall, SCT is characterized by high heterogeneity not only in preparation, administration and type of cells, but also in quantification of therapy effects.

关键词： Stem cell therapy Cardiac imaging techniques Ischemic cardiac disease Cardiac regeneration Endpoints

Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 199-206页

作者： Radu Cristian Poenaru Elena Milanesi Andrei Marian Niculae Anastasia-Maria Dobre Catalina Vladut Mihai Ciocîrlan Daniel Vasile Balaban Vlad Herlea Maria Dobre Mihail Eugen Hinescu Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 050474Romania Department of Radiobiology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Pathology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Gastroenterology Prof.Dr.Agrippa Ionescu Clinical Emergency HospitalBucharest 011356Romania Department of Pathology Fundeni Clinical InstituteBucharest 022258Romania

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11%in the United *** for other types of tumors,such as colorectal cancer,aberrant de novo lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and *** To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid(FA)import into *** A gene expression analysis of FASN,CD36,SLC27A1,SLC27A2,SLC27A3,SLC27A4,SLC27A5,ACSL1,and ACSL3 was performed by qRT-PCR in 24 tumoral PDAC tissues and 11 samples from non-tumoral pancreatic tissues obtained via fine needle aspiration or via surgical *** genes were considered significantly dysregulated between the groups when the p value was27A2(FC=5.66;P=0.033),SLC27A3(FC=2.68;P=0.040),SLC27A4(FC=3.13;P=0.033),ACSL1(FC=4.10;P2.67;P=0.012).We further investigated any possible association between the levels of the analyzed mRNAs and the specific characteristics of the tumors,including the anatomic location,the lymph node involvement,and the presence of metastasis.A significant difference in the expression of SLC27A3(FC=3.28;P=0.040)was found comparing patients with and without lymph nodes involvement with an overexpression of this transcript in 17 patients presenting tumoral cells in the lymph *** Despite the low number of patients analyzed,these preliminary results seem to be *** lipid metabolism through a broad strategy could be a beneficial way to treat this *** in vitro and in vivo s

关键词： Carcinoma Pancreatic ductal Fatty acid transport Gene expression Biomarkers

Acute inferior myocardial infarction in a young man with testicular seminoma:A case report

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World Journal of clinical Cases 2021年第16期9卷 4040-4045页

作者： Alexandru Scafa-Udriste Nicoleta-Monica Popa-Fotea Vlad Bataila Lucian Calmac Maria Dorobantu Department of Cardio-Thoracic University of Medicine and PharmacyBucharest 050474Romania Department of Cardiology Emergency Clinical HospitalBucharest 014461Romania

BACKGROUND Atherosclerosis represents the main cause of myocardial infarction(MI);other causes such as coronary embolism,vasospasm,coronary-dissection or drug use are much rarely encountered,but should be considered in less common clinical *** young individuals without cardiovascular risk factors,the identification of the cause of MI can sometimes be found in the medical history and previous treatments *** SUMMARY We present the case of a 34-year-old man presenting acute inferior ST-elevation MI without classic cardiac risk *** years ago,he suffered from orchidopexy for bilateral cryptorchidism,and was recently diagnosed with right testicular seminoma for which he had to undergo surgical resection and chemotherapy with bleomycin,etoposide and *** after the first chemotherapy treatment,namely on day five,he suffered an acute *** revealed a mild stenotic lesion at the level of the right coronary artery with suprajacent thrombus and vasospasm,with no other significant lesions on the other coronary arteries.A conservative treatment was decided upon by the cardiac team,including dual antiplatelets therapy and anticoagulants with good further *** patient continued the chemotherapy treatment according to the initial plan without other cardiovascular *** In young individuals with no cardiovascular risk factors undergoing aggressive chemotherapy,an acute MI can be caused by vascular toxicity of several anticancer drugs.

关键词： Testicular seminoma Myocardial infarction Non-atherosclerotic causes of myocardial infarction Chemotherapy Case report