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Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 258-267页

作者： Li-Jun Ji Jin-Yu Hu Yan-Mei Zeng Qian Ling Jie Zou Cheng Chen Liang-Qi He Xiao-Yu Wang Hong Wei Xu Chen Yi-Xin Wang Yi Shao Yao Yu Department of Ophthalmology Dahua HospitalShanghai 200237China Department of Endocrine and Metabolic the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Centre for Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for metabolic DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands School of optometry and vision science Cardiff UniversityCardiffCF244HQWalesUK Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical ***:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29±11.66y)were selected,alongside 21 appropriately matched controls with diabetes mellitus(DM).Voxel-based morphometry(VBM)techniques were employed to identify aberrant functional regions in the *** operating characteristic(ROC)curves were utilized for classification based on the average VBM values of the two groups,and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical ***:Relative to the DM controls,DVH patients exhibited reduced VBM values in the right superior temporal pole,the right superior temporal gyrus,the right medial orbital frontal gyrus,and the left superior frontal ***,ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy,as indicated by the area under the *** average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale(HADS).CONCLUSION:Pathological alterations in four distinct brain regions are observed in patients with DVH,potentially reflecting neuropathological changes associated with this condition.

关键词： diabetic vitreous hemorrhage voxel-based morphometry Hospital Anxiety and Depression Scale brain areas

Predictors of Survival and Relapse among Children Diagnosed with Acute Leukemia in Northen Tanzania

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Open Journal of Pediatrics 2025年第1期15卷 52-65页

作者： Arnold Likiliwike Yotham Gwanika Heronima Joas Aisa Shayo Linda Kissila Esther Majaliwa Department of Pediatrics Kilimanjaro Christian Medical Centre Kilimanjaro Tanzania Department of Oncology Kilimanjaro Christian Medical Centre Kilimanjaro Tanzania Department of Pediatrics Bugando Medical Center Mwanza Tanzania Kilimanjaro clinical Research Institute Kilimanjaro Tanzania

Background: Acute Leukemia is the most common childhood cancer, with two main types: ALL and AML. In Tanzania, recent improvements in treatment and survival have been noted, but the latest data is from 2013. This study will update survival and relapse information from 2013 to 2020 to help enhance future treatment strategies. Methodology: This study was conducted at two tertiary hospitals in Tanzania. The study analyzed data from children diagnosed with Acute Leukemia between January 2015 to December 2020. Patient data were collected via questionnaires and analyzed using STATA software. Results: This study included a total of 95 participants 64 had age less than 10 years and majority were males 56.8%, 55 had duration of symptoms for more than 1 month 66 had ALL, 49 had attained remission, the overall three years survival was 44.2% with those children with no health insurance having high risk of dying, rate of relapse was 18.4%, with those diagnosed with B-ALL having low risk of relapse. Conclusion: This study provides insights into survival and relapse predictors for childhood leukemia in northern Tanzania. It found an overall survival rate of 44.2%, with health insurance and minimal residual disease after induction being key predictors of survival. The relapse rate was 18.4%, with health insurance linked to a lower relapse risk. Health insurance emerged as a strong predictor of better survival, leading to the recommendation that all children should have health insurance. Additionally, the study suggests that policymakers should support the expansion of global health coverage in Tanzania.

关键词： Acute Leukemia Relapse Survival

Bridging the gap:The role of technological advances in shaping gastrointestinal oncological outcomes

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 29-37页

作者： Nuno J G Rama Inês Sousa Division of Colorectal Surgical Leiria Hospital CentreLeiria 2410-021Portugal Department of Surgical Leiria Hospital CentreLeiria 2410-021Portugal

Gastrointestinal(GI)cancers are highly prevalent and considered a major global health *** approach has undergone a remarkable transformation over the past years due to the development of new technologies that enabled better outcomes regarding their diagnosis and *** include artificial intelligence,robotics,next-generation sequencing and personalized ***,the integration of these advances into everyday clinical practice remains complex and challenging as we are still trying to figure out if these innovations tangibly improve oncological outcomes or if the current state of art should remain as the gold standard for the treatment of these ***,there are also some issues regarding ethical subjects,data privacy,finances and *** surgery concept has evolved considerably over the past decades,especially for oncological *** aims to customize medical treatments and to operate on those patients who most likely will benefit from a specific surgical *** the future,to improve GI oncological outcomes,a delicate balance between technological advances adoption and evidence-based care should be *** we move forward,the question will be to harness the power of innovation while keeping up the highest standards of patient care.

关键词： Technology Innovation Gastrointestinal oncology Outcomes Artificial intelligence Precision surgery

Insights from a proteomic atlas of human Alzheimer's disease brain tissue

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Neural Regeneration Research 2025年第3期20卷 799-800页

作者： Tomas Kavanagh Eleanor Drummond Brain and Mind centre and School of Medical Sciences University of SydneyCamperdownNSWAustralia

There is an urgent need to identify new drug targets for Alzheimer's disease(AD). While new immunotherapies show promise, clinical benefit appears low, and side effects are high. A greater understanding of the disease mechanisms driving AD is an essential factor that will facilitate the identification of new, effective drug targets.

关键词： Alzheimer clinical driving

维普期刊数据库

Inflammatory Bowel Disease and Dementia:Evidence Triangulation from a Meta-Analysis of Observational Studies and Mendelian Randomization Study

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Biomedical and Environmental Sciences 2025年第1期38卷 56-66页

作者： Di Liu Meiling Cao Shanshan Wu Bingli Li Yiwen Jiang Tengfei Lin Fuxiao Li Weijie Cao Jinqiu Yuan Feng Sha Zhirong Yang Jinling Tang Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055GuangdongChina Beijing Key Laboratory of clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseaseBeijing 100050China centre for Precision Medicine Edith Cowan UniversityPerth WA7027Australia clinical Research Center The Seventh Affiliated HospitalSun Yatsen UniversityShenzhen 518107GuangdongChina

Objective Observational studies have found associations between inflammatory bowel disease(IBD)and the risk of dementia,including Alzheimer’s dementia(AD)and vascular dementia(VD);however,these findings are *** remains unclear whether these associations are *** We conducted a meta-analysis by systematically searching for observational studies on the association between IBD and *** randomization(MR)analysis based on summary genome-wide association studies(GWASs)was *** correlation and Bayesian colocalization analyses were used to provide robust genetic *** Ten observational studies involving 80,565,688 participants were included in this *** was significantly associated with dementia(risk ratio[RR]=1.36,95%CI=1.04-1.78;I2=84.8%)and VD(RR=2.60,95%CI=1.18-5.70;only one study),but not with AD(RR=2.00,95%CI=0.96-4.13;I^(2)=99.8%).MR analyses did not supported significant causal associations of IBD with dementia(dementia:odds ratio[OR]=1.01,95%CI=0.98-1.03;AD:OR=0.98,95%CI=0.95-1.01;VD:OR=1.02,95%CI=0.97-1.07).In addition,genetic correlation and co-localization analyses did not reveal any genetic associations between IBD and *** Our study did not provide genetic evidence for a causal association between IBD and dementia *** increased risk of dementia observed in observational studies may be attributed to unobserved confounding factors or detection bias.

关键词： Dementia Inflammatory bowel disease Meta-analysis Observational studies Mendelian randomization Genetic evidence Evidence triangulation

维普期刊数据库

Low-grade chondrosarcoma of the larynx: A case report

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World Journal of clinical Cases 2021年第26期9卷 7805-7810页

作者： Ljiljana Vučković Aleksandra Klisic Aleksandar Filipović Mirko Popović TatjanaĆulafić clinical Center of Montenegro Department of PathologyUniversity of Montenegro-Faculty of MedicinePodgorica 81000Montenegro Primary Health Care Center University of Montenegro-Faculty of MedicinePodgorica 81000Montenegro clinical Center of Montenegro Department of Endocrine SurgeryUniversity of Montenegro-Faculty of MedicinePodgorica 81000Montenegro clinical Center of Montenegro Clinic for Otorhinolaryngology and Maxillofacial SurgeryUniversity of Montenegro-Faculty of MedicinePodgorica 81000Montenegro Department of Pathology Clinical Center of MontenegroPodgorica 81000Montenegro

BACKGROUND Chondrosarcomas of the larynx are malignant tumours that most commonly originate from the hyaline *** of the larynx,the most common type of low-grade tumour,accounts for 1%of all laryngeal *** SUMMARY We present the case of a 60-year-old female patient who developed progressive hoarseness and shortness of breath over a 2-mo *** patient had undergone resection of a laryngeal tumour 14 years before the aforementioned symptoms occurred,and histopathological analysis indicated that it was a *** the assessment of the patient,a submucosal,oval-shaped tumour was detected that was predominantly located on the left side of the larynx and was approximately 6 cm in *** decision to perform left partial vertical laryngectomy was made.A pathohistological diagnosis of low-grade chondrosarcoma was *** the results of pathohistological analysis and the positive margins of the resection,a total laryngectomy was *** the 12-mo follow-up,no local relapse or regional or distant metastases was *** Chondrosarcoma of the larynx must be considered in the differential diagnosis of laryngeal submucosal *** is crucial to carefully sample of tumour tissue,differentiate chondroma and chondrosarcoma,and consider the possibility of malignant changes from chondroma to chondrosarcoma.

关键词： Chondrosarcoma Low grade Larynx Case report

Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma

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World Journal of Gastroenterology 2009年第26期15卷 3269-3275页

作者： Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi Milorad N Petrovi Dragana P obi Vladimir B Obradovi Institute for Digestive Diseases clinical Center of Serbia Institute for Nuclear Medicine Clinical Center of Serbia Gastroenterology Department Clinical Center Podgorica Gastroenterology Department Clinical Center Kragujevac

AIM： To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography （HRA） in secondary Hodgkin＇s hepatic lymphoma. METHODS： The research included patients with a diagnosis of Hodgkin＇s lymphoma with metastatic focal lesions in the liver and controls. Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal, hepatic and splenic veins were examined. Hepatic perfusion index （HPI） estimated by HRA was calculated. was observed. Lesions were mostly hypoechoic and mixed, solitary or multiple. Some of the patients presented with dilated splenic veins and hepatofugal blood flow. A pulse wave was registered in the centre and at the margins of lymphoma. The average velocity of the pulse wave was higher at the margins （P 〉 0.05）. A continuous venous wave was found only at the margins of lymphoma. There was no linear correlation between lymphoma size and velocity of pulse and continuous wave （r = 390, P 〈 0.01）. HPI was significantly lower in patients with lymphomas than in controls （P 〈 0.05）, pointing out increased arterial perfusion in comparison to portal perfusion. CONCLUSION： Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin＇s hepatic lymphoma and estimation of its intensity. Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions.

关键词： Color Doppler ultrasonography Hodgkin's disease Lymphoma Liver Radionuclide angiography Velocity Hepatic artery Portal vein Blood flow Splenomegaly

Renal effects and safety of tirzepatide in subjects with and without diabetes:A systematic review and meta-analysis

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World Journal of Diabetes 2025年第2期16卷 270-283页

作者： ABM Kamrul-Hasan Shinjan Patra Deep Dutta Lakshmi Nagendra AFM Muntahi-Reza Sanja Borozan Joseph M Pappachan Department of Endocrinology Mymensingh Medical CollegeMymensingh 2200DhakaBangladesh Department of Endocrinology and Metabolism All India Institute of Medical Sciences NagpurNagpur 441108MaharashtraIndia Department of Endocrinology CEDAR Superspeciality ClinicsDwarkaNew Delhi 110075India Department of Endocrinology JSS Medical CollegeJSS Academy of Higher Education&ResearchMysore 570015India Department of Urology Bangabandhu Sheikh Mujib Medical UniversityDhaka 1000Bangladesh Department of Endocrinology Clinical Centre of MontenegroPodgorica 81000Montenegro Faculty of Medicine University of MontenegroPodgorica 81000Montenegro Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS Trust&Manchester Metropolitan UniversityPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology Kasturba Medical CollegeManipal UniversityManipal 576104India

BACKGROUND Type 2 diabetes(T2D),as well as obesity,are risk factors for chronic kidney disease(CKD)and end-stage renal *** renal impacts of glucose-lowering and weight-lowering drugs and their potential benefits in preventing CKD often guide clinicians in choosing them *** limited data based on randomized controlled trials(RCTs)is currently available on the renal effects and safety profile of *** To explore the renal benefits and safety of tirzepatide vs *** RCTs involving patients receiving tirzepatide for any indication in the intervention arm and placebo or active comparator in the control arm were searched through multiple electronic *** co-primary outcomes were percent change from baseline(CFB)in urine albumin-to-creatinine ratio(UACR)and absolute CFB in estimated glomerular filtration rate(eGFR;in mL/min/1.73 m^(2));the secondary outcome was tirzepatide’s renal safety *** web was used to conduct meta-analysis using random-effects *** were presented as mean differences(MD)or risk ratios with 95%confidence *** Fifteen RCTs(n=14471)with mostly low risk of bias(RoB)were *** 26-72 weeks,tirzepatide 10 mg[MD-26.95%(-40.13,-13.76),P0.05 for all vs ***(pooled and separate doses)did not increase the risks of adverse renal events,urinary tract infection,nephrolithiasis,acute kidney injury,and renal cancer compared to the placebo,insulin,and glucagon-like peptide-1 receptor ***

关键词： Tirzepatide Type 2 diabetes Obesity Urine albumin creatinine ratio Estimated glomerular filtration rate Renal safety Acute kidney injury Chronic kidney disease

Antibody-drug conjugates in breast cancer: advances and prospects

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Cancer Biology & Medicine 2025年第02期 83-92页

作者： Zhiqiang Shi Yongjin Lu Qiuchen Zhao Yongsheng Wang Pengfei Qiu Breast Cancer Center Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Shandong First Medical University (Shandong Academy of Medical Sciences) Cancer Research UK Cambridge centre Ph D Programme University of Cambridge

The “Global Cancer Statistics Report 2022” estimates that there were approximately 20 million new cancer cases worldwide, including 9.7 million in females, of which 2.31 million were breast cancer cases1. Breast cancer is the most common malignant tumor in women and one of the leading causes of cancer-related deaths.

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