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clinical pharmacology of Bamboo Grass Extract and Its Constituent Compound,Coenzyme Q10

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Clinical Pharmacology of Bamboo Grass Extract and Its Consti...

Progress of clinical pharmacology

中国中西医结合学会微循环2008学术大会

作者： Kimura I Tsuneki H Sasaoka T Department of Food and Nutrition Science Toyama Collegeand Departmentt of clinical pharmacology University of ToyamaJapan

Background:Bamboo grass leaves (Sasa kurilensis MAKINO et SHIBATA) have been used as traditional food additives in *** extracts are reported to show anti- sepsis,anti-HIV activity,anti-inflammatory,and radical scavenging,and anti-bacterial lignin-like activities(1).The extract contains an endogenous antioxidant coenzyme

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Progress of clinical pharmacology

clinical pharmacology IN CHINA SOME SUGGESTIONS BASED UPON EXPERENCE IN GREAT BRITAIN

全国新药临床试验GCP水平提高研讨班

作者： Qi Huimimn Institute of clinical pharmacology Peking University

Dramatic Increase of life expectancy US life expectancy at birth: 1900: 47 years Today: 77 years In Western Europe: 1970-1990 6 more years In the Czech Republic: 1990-2000 3 more years Pharmaceuticals Keep People At Work Longer Lives with Innovative Medicines "How Much Do Innovative Medicines Contribute?" Positive relationship across diseases between new drug share and mortality reduction 1970-1991 reduction in mortality: > 45% due to new drug share 19 diseases with the highest relative utilization of new drugs: 73% fewer lives lost 19 diseases with the lowest relative utilization of new drugs: only 13% fewer lives lost the mortality reduction was 5 times greater when new drugs were used

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中国临床药理学杂志 1985年第1期 2-7页

作者： C.T.DOLLERY Professor of clinical pharmacology Royal Postgraduate Medical School(University of London) B.Sc.M.B. Ch.B. F.R.C.P.

When my friend and colleague Dr Li Jia-Tai of the Institute of clinicalpharmacology in Beijing suggested that I might write an article containing somesuggestions about the development of clinical pharmacology in China... 详细信息

关键词： clinical pharmacology IN CHINA SOME SUGGESTIONS BASED UPON EXPERENCE IN GREAT BRITAIN

A Brief Review of the clinical pharmacology Expansion Cohorts in FIH Oncology Trials

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A Brief Review of the Clinical Pharmacology Expansion Cohort...

P05 How to improve the teaching of clinical pharmacology

2018年中国药理学会定量药理学专业委员会学术年会

作者： Qiuyang Zhang Tingting Yao Yan Ren Department of clinical pharmacology BeiGene (Shanghai) Co.Ltd

Background The use of expansion cohorts in first-in-human(FIH) trials has become a seamless strategy for improving the efficiency of novel drug development especially in oncology therapeutic *** purpose of conducting these expansion cohorts can be assessing anti-tumor activity in a diseaseand/or population-specific setting,evaluating alternative doses or schedules,exploring potential biomarker and collecting clinical pharmacology information to optimize later phase dosing *** a new FDA draft guidance was published to emphasize the advantage of conducting multiple expansion cohorts in FIH trials drug development,with the goal of making highly effective drugs widely available to the public as quickly as possible

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中国药理通讯 2006年第2期23卷 16-17页

作者： Hua Ding Zi-ying Wang Hui-qing Liu Xin-bing Wei Institute of pharmacology School of Medicine ShandongUniversity 44 West Wen Hua Road Jinan 250012 China

clinical pharmacology plays an important role for medical students as well as clinical doctors to grasp the medication principle of efficacy, economy, and specification so as to realize drug therapy to be safe and rational. In order to improve the teaching quality, we have organized clinical pharmacology teaching in great consideration. First, teaching of clinical pharmacology is performed by the co-endeavour of both the basic pharmacology teachers and clinical doctors. The chapters of basic principles, clinical pharmacology of the aged, perinatal pharmacology, adverse drug reactions and drug induced diseases are performed by basic pharmacology teachers, while the drug therapies of various diseases are performed by clinical doctors. Such arrangement can educe both the teachers and the doctors' specialities greatly. And secondly, we have exploited suitable clinical pharmacology experiments, such as investigation of adverse drug reactions, practice of filling adverse drug reactions report forms, determination of the pharmacokinetic parameters of drugs in volunteers, observation of methods for new drugs' pharmacokinetic research and therapeutic drug monitoring and so on. In the end, we have improved the classic method for examination. We choose such questions with fairly depth and width and correlate with clinic for the exam as to develop the students' ability of analyzing and solving problems.

关键词：临床药理学教育方法高等教育

PREDICTION OF THE THERAPEUTIC EFFECTIVENESS OF NEW DRUGS FROM clinical pharmacology STUDIES

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中国临床药理学杂志 1988年第2期4卷 101-104页

作者： Jan Koch-Weser M.D. clinical Research F.Hoffmann-LA Roche & Co.Ltd.Switzerland

The development of new drugs for therapeutic purposes has become very expensive and time-consuming in American and European *** is estimated that on the average 50 to 100 million dollars and 10 or more years from the time of patenting are required to make a new drug available for general prescription. Every new drug needs to be charac-

关键词： PREDICTION OF THE THERAPEUTIC EFFECTIVENESS OF NEW DRUGS FROM clinical pharmacology STUDIES

The clinical pharmacology of Propofol:A Brief Review

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Open Journal of Anesthesiology 2013年第8期3卷 367-373页

作者： Mohamed Abo El Hamd Department of Pharmaceutical Analytical Chemistry Faculty of Pharmacy Al-Azhar University Assiut Egypt Department of clinical Pharmacy Division of Analytical Research for Pharmacoinformatics Doctoral Course of Pharmaceutical Sciences Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan

The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that substantial portions of the text came from other published papers. The scientific community takes a very strong view on this matter, and the OJAnes treats all unethical behavior such as plagiarism seriously. This paper published in Vol.3 No. 8, 367-373(pages), 2013, has been removed from this site.

关键词： Propofol Pharmacokinetics Pharmacodynamics

P27 The Establishment of a New Experiment in clinical pharmacology Teaching

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中国药理通讯 2006年第2期23卷 32-32页

作者： Zi-ying Wang Hua Ding Ping Liu Xiu-mei Zhang Institute of pharmacology School of Medicine Shandong University 44 West Wen Hua Road Jinan 250012 China

clinical pharmacology is a newly emerging subject which is based on basic pharmacology and clinical medicine. It' s very important for training valid and good doctors and pharmaceutists. Rencently many universities in China have required clinical pharmacology as a special necessary course for medical and pharmacy students. But the experimental teaching in clinical pharmacology is not so wide till now in China. We have established a new clinical experiment as "Determination of the pharmacokinetic parameters of Ciprofloxacin in healthy young volunteers". The experiment was carried out with 10 healthy young volunteers after single oral administration of lOOmg Ciprofloxacin. Urine samples were collected then centrifuged at different time after administration. UV-spectrophotometry method was used to determine the concentration of Ciprofloxacin in urine. The pharmacokinetic parameters following oral administration of tested Ciprofloxacin in healthy young volunteers can be obtained by the formula that the elimination of Ciprofloxacin is conformed to one-compartment model. This method is rapid, accurate, sensitive and the most important, very convenient, it' s very suitable for experimental teaching in clinical pharmacology. This new clinical experiment can be widely spread through all the medical and pharmaceutical universities.

关键词：教育方法药理学实验研究临床

clinical pharmacology relevant to older adults with cardiovascular disease

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Journal of Geriatric Cardiology 2015年第3期12卷 192-195页

作者： Jorge A Brenes-Salazar Laith Alshawabkeh Kenneth E Schmader Joseph T Hanlon Daniel E Forman Department of Medicine Division of Cardiovascular Diseases Mayo Clinic Rochester MN USA Department of Medicine Division of Cardiovascular Medicine University of lowa Iowa City IA USA Department of Medicine Division of Geriatrics Duke University School of Medicine Durham NC USA Departments of Medicine (Division of Geriatric Medicine) Pharmacy and Epidemiology University of Pittsburgh Geriatric Research Education and Clini- cal Center and Center for Health Equity Research and Promotion VA Pittsburgh Health System Pittsburgh PA USA Department of Medicine (Divisions of Geriatric Medicine and Cardiology) University of Pittsburgh Medical Center Geriatric Research Education and Clinical Center VA Pittsburgh Health System Pittsburgh PA USA

1 Introduction Although older adults are generally among the highest users of cardiovascular medications, they are typically underrepresented or excluded from most efficacy and safety trials. Drug developers are usually reluctant to include many senior adults in randomized controlled clinical trials in part due to their high prevalence of multiple comorbidities, frailty, and polypharmacy; and to age-related pharmacokinetic and pharmacodynamic complexities. Consequently, there is often insufficient high quality evidence-based data to inform pharmacologic management of common cardiovascular conditions on older adults. In the absence of data, clinicians often rely on conceptual principles regarding metabolism and drug-drug interactions to minimize adverse drug events, but this is often not well-substantiated or standardized. A related challenge is poor cardiovascular medication adherence among older adults, and its detrimental impact on their health outcomes. In this brief review we highlight some aspects of these topics.

关键词： Metabolism Pharmacokinetics Pharmacodynamics Polypharmacy