检索结果-南通市图书馆

Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult-and pediatric-onset inflammatory bowel disease in Italy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第29期14卷 4643-4651页

作者： Anna Latiano Orazio Palmieri Maria Rosa Valvano Renata D'Incà Salvatore Cucchiara Gabriele Riegler Anna Maria Staiano Sandro Ardizzone Salvatore Accomando Gian Luigi de Angelis Giuseppe Corritore Fabrizio Bossa Vito Annese U.U. O.O. di Gastroenterologia ed Endoscopia Ospedale IRCCS-CSSSan Giovanni Rotondo (Fg) 71013 Italy Cattedra di Gastroenterologia Università di PadovaPadova 35122 Italy clinica pediatrica università "La Sapienza" Roma 00185 Italy Cattedra di Gastroenterologia Università di NapoliNapoli 80131 Italy clinica pediatrica università di napoli Napoli 80131 Italy Unità di Gastroenterologia Ospedale "Sacco" Milano 20157 Italy clinica pediatrica università di Palermo Palermo 90128 Italy clinica pediatrica università di Parma Parma 43100 Italy

AIM: To investigate gene variants in a large Italian inflammatory bowel disease (IBD) cohort, and to analyze the correlation of sub-phenotypes (including age at diagnosis) and epistatic interaction with other IBD genes. METHODS: Total of 763 patients with Crohn's disease (CD, 189 diagnosed at age diagnosed diatric-onset disease. CONCLUSION: The present study confirms the association of IL23R polymorphisms with IBD, and ATG16L1 with CD, in both adult- and pediatric-onset subsets in our study population.

关键词：肠炎肠溃疡结肠疾病遗传因素

COVID-19 pandemic in the intensive care unit:Psychological implications and interventions,a systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2023年第4期13卷 191-217页

作者： Laura Monti Elisa Marconi Maria Grazia Bocci Georgios Demetrios Kotzalidis Marianna Mazza Carolina Galliani Sara Tranquilli Giovanni Vento Giorgio Conti Gabriele Sani Massimo Antonelli Daniela Pia Rosaria Chieffo UOS Psicologia clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Anestesia RianimazioneTerapia Intensiva e Tossicologia ClinicaDipartimento di Scienze Dell’EmergenzaAnestesiologiche e Della RianimazioneFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Psichiatria clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy NESMOS Department Facoltàdi Medicina e PsicologiaSant’Andrea University HospitalRome 00189Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Psychology UniversitàCattolica del Sacro CuoreRome 00168Italy UOC Neonatologia Dipartimento di Scienze Della Salute Della DonnaDel Bambino e di SanitàPubblicaFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Neonatologia UniversitàCattolica del Sacro CuoreRome 00168Italy UOC Terapia Intensiva pediatrica e Trauma Center Pediatrico Dipartimento di Scienze Dell’EmergenzaAnestesiologiche e Della RianimazioneFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy UOC Terapia Intensiva pediatrica e Trauma Center Pediatrico UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Anesthesiology and Intensive Care Medicine UniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND The coronavirus disease 2019(COVID-19) pandemic produced changes in intensive care units(ICUs) in patient care and health organizations. The pandemic event increased patients’ risk of developing psychological symptoms during and after hospitalisation. These consequences also affected those family members who could not access the hospital. In addition, the initial lack of knowledge about the virus and its management, the climate of fear and uncertainty, the increased workload and the risk of becoming infected and being contagious, had a strong impact on healthcare staff and organizations. This highlighted the importance of interventions aimed at providing psychological support to ICUs, involving patients, their relatives, and the staff;this might involve the reorganisation of the daily routine and rearrangement of ICU staff duties.AIM To conduct a systematic review of psychological issues in ICUs during the COVID-19 pandemic involving patients, their relatives, and ICU staff.METHODS We investigated the PubMed and the clinicalTrials.gov databases and found 65 eligible articles,upon which we commented.RESULTS Our results point to increased perceived stress and psychological distress in staff, patients and their relatives and increased worry for being infected with severe acute respiratory syndrome coronavirus-2 in patients and relatives. Furthermore, promising results were obtained for some psychological programmes aiming at improving psychological measures in all ICU categories.CONCLUSION As the pandemic limited direct inter-individual interactions, the role of interventions using digital tools and virtual reality is becoming increasingly important. All considered, our results indicate an essential role for psychologists in ICUs.

关键词： COVID-19 Intensive care unit Psychological interventions Pandemic Mental health Health care professionals

An extended assessment of bowel habits in a general population

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2004年第5期10卷 713-716页

作者： Gabrio Bassotti Massimo Bellini Filippo Pucciani Renato Bocchini Antonio Bove Pietro Alduini Edda Battaglia Paolo Bruzzi Sezione di Gastroenterologia ed Epatologia Dipartimento di Medicina Clinica e SperimentaleUniversità di Perugia Sezione di Gastroenterologia Dipartimento di Medicina InternaUniversità di Pisa clinica Chirurgica Generale e discipline Chirurgiche Università di Firenze UO di Medicina Polispecialistica Azienda Sanitaria LocaleCesena UO di Gastroenterologia ed Endoscopia digestiva Azienda Ospedaliera"A.Cardarelli"Napoli dipartimento di Fisiopatologia clinica Università di Torino Struttura Complessa di Epidemiologia clinica IST GenovaItaly

AIM:Bowel habits are difficult to study, and most data on defecatory behaviour in the general population have been obtained on the basis of recalled interview. The objective assessment of this physiological function and its pathological aspects continues to pose a difficult challenge. The aim of this prospective study was to objectively assess the bowel habits and related aspects in a large sample drawn from thegeneral population.METHODS: Over a two-month period 488 subjects were prospectively recruited from the general population and asked to compile a daily diary on their bowel habits and associated signs and symptoms (the latter according to Rome Ⅱ criteria). A total of 298 (61%) participants returned a correctly compiled record, so that data for more than 8000 patient-days were available for statistical analysis.RESULTS:The average defecatory frequency was once per day (range of 0.25-3.25) and was similar between males and females.However, higher frequencies of straining at stool (P=0.001), a feeling of incomplete emptying and/or difficult evacuation (P=0.0001), and manual manoeuvres to facilitate defecation (P=0.046) were reported by females as compared to males.CONCLUSION:This study represents one of the first attempts to objectively and prospectively assess bowel habits in a sample of the general population over a relatively long period of time. The variables we analyzed are coherent with the criteria commonly used for the clinical assessment of functional constipation, and can provide a useful adjunt for a better evaluation of constipated patients.

关键词：肠道习性肠道疾病卫生统计影响因子

Treatment of gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第7期20卷 1635-1649页

作者： Michele Orditura Gennaro Galizia Vincenzo Sforza Valentina Gambardella Alessio Fabozzi Maria Maddalena Laterza Francesca Andreozzi Jole Ventriglia Beatrice Savastano Andrea Mabilia Eva Lieto Fortunato Ciardiello Ferdinando De Vita division of Medical Oncology Dipartimento di MedicinaClinica e Sperimentale ‘F. Magrassi-A. Lanzara’Seconda Università degli Studi di Napoli80131 NaplesItaly divisione di Chirurgia Oncologia Dipartimento di Scienze AnestesiologicheChirurgiche e delle EmergenzeSeconda Università degli Studi di Napoli80131 NaplesItaly

The authors focused on the current surgical treatment of resectable gastric cancer,and significance of periand post-operative chemo or chemoradiation.Gastric cancer is the 4thmost commonly diagnosed cancer and the second leading cause of cancer death worldwide.Surgery remains the only curative therapy,while perioperative and adjuvant chemotherapy,as well as chemoradiation,can improve outcome of resectable gastric cancer with extended lymph node dissection.More than half of radically resected gastric cancer patients relapse locally or with distant metastases,or receive the diagnosis of gastric cancer when tumor is disseminated;therefore,median survival rarely exceeds12 mo,and 5-years survival is less than 10%.Cisplatin and fluoropyrimidine-based chemotherapy,with addition of trastuzumab in human epidermal growth factor receptor 2 positive patients,is the widely used treatment in stageⅣpatients fit for chemotherapy.Recent evidence supports the use of second-line chemotherapy after progression in patients with good performance

关键词： Gastric cancer Surgery Radiotherapy Adjuvant chemo

Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第28期22卷 6345-6361页

作者： Vincenzo Sforza Erika Martinelli Fortunato Ciardiello Valentina Gambardella Stefania napolitano Giulia Martini Carminia della Corte Claudia Cardone Marianna L Ferrara Alfonso Reginelli Giuseppina Liguori Giulio Belli Teresa Troiani Oncologia medica Dipartimento di Medicina Clinica e Sperimentale "F. Magrassi e A. Lanzara" Seconda Università degli Studi di Napoli Department of Medical Oncology Biomedical Research Institute INCLIVA University of Valencia Department of Internal and Experimental Medicine Magrassi-Lanzara Institute of Radiology Seconda Università di Napoli Department of Pathology Istituto Nazionale Tumori "Fond. Pascale" - IRCCS Department of General and Hepato-Pancreato-Biliary Surgery S. M. Loreto Nuovo Hospital

The prognosis of patients with metastatic colorectal cancer(m CRC) remain poor despite the impressive improvement of treatments observed over the last 20 years that led to an increase in median overall survival from 6 mo, with the only best supportive care, to approximately 30 mo with the introduction of active chemotherapy drugs and targeted agents. The monoclonal antibodies(mo Abs) cetuximab and panitumumab, directed against the epidermal growth factor receptor(EGFR), undoubtedly represent a major step forward in the treatment of m CRC, given the relevant efficacy in terms of progression-free survival, overall survival, response rate, and quality of life observed in several phase Ⅲ clinical trials among different lines of treatment. However, the anti-EGFR mo Abs were shown only to be effective in a subset of patients. For instance, KRAS and NRAS mutations have been identified as biomarkers of resistance to these drugs, improving the selection of patients who might derive a benefit from these treatments. Nevertheless, several other alterations might affect the response to these drugs, and unfortunately, even the responders eventually become resistant by developing secondary(or acquired) resistance in approximately 13-18 mo. Several studies highlighted that the landscape of responsible alterations of both primary and acquired resistance to anti-EGFR drugs biochemically converge into MEK-ERK and PIK3CA-AKT pathways. In this review, we describe the currently known mechanisms of primary and acquired resistance to anti-EGFR mo Abs together with the various strategies evaluated to prevent, overcame or revert them.

关键词： Metastatic colorectal cancer Epidermal growth factor receptor Resistance Mutation KRAS NRAS BRAF PIK

用聚乙二醇脂质体阿霉素治疗IVB期蕈样霉菌病

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 35-36页

作者： di Lorenzo G di Trolio R Delfino M De Placido S 冯义国李晓莉 dipartimento di Patologia Sistematica Clinica Dermatologica Universit`a di Napoli Federico II Naples Italy

Background:Previous studies have shown that pegylated liposomal doxorubicin(LD)is effective in the treatment of relapsing or recalcitrant cutaneous T-cell lymphoma. Objectives:To evaluate the activity and toxicity of LD in patients with stage IVB mycosis fungoides (MF). Methods:In this retrospective study, we evaluated outcomes and recorded adverse effects in 10 patients with MF (seven men and three women) with extracutaneous involvement. Patients were treated with LD 20 mg m-2 administered intravenously every 4 weeks. Results:All patients received at least two cycles of LD, three patients received four cycles and one patient received six cycles. Three patients (30%) had a partial response and two patients had stable disease. Grade 1-2 leucopenia occurred in three of the 10 patients, and grade 4 leucopenia in one. Three patients had grade 2 palmoplantar erythrodysaesthesia. Conclusions:This study demonstrates that LD is beneficial in terms of activity and toxicity in stage IVB MF. These observations should be verified in larger studies.

关键词：蕈样霉菌病 IVB 白细胞减少症掌跖感觉异常淋巴瘤

家族性噬血细胞淋巴组织细胞增多症:1名双胞胎早产儿在应用免疫化学治疗和来自HLA相同的非亲属供体的骨髓移植后存活

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 21-22页

作者： Rugolotto S. Marradi P.L. Balter R. 郭战宏 clinica pediatrica Policlinico Via delle Menegone 37134 Verona Italy

We describe a premature twin born at 30 wk of gestational age, affected with familial haemophagocytic lymphohistiocytosis. Two different mutations were identified in his DNA: one inherited from the mother and one from the father. Haemophagocytosis had been confirmed in his twin brother, who died soon after birth, as well as in the re-evaluation of the autopsy of his older sister, who died 1 y earlier. At 26 d of age, chemotherapy and immune-suppressive treatment were started according to the HLH-94 protocol. At 6 mo of age, a bone marrow transplant from an HLA-identical, unrelated volunteer was performed. Now at 32 mo of age, the infant is healthy and without signs of graft-versus-host disease. Conclusion: This case report shows that immuno-chemotherapy and allogenic bone marrow transplant are feasible even in premature infants affected with familial haemophagocytic lymphohistiocytosis, which should be ruled out in unknown bleeding disorders of neonates.

关键词：噬血细胞 HLA 亲属供体组织细胞增多症骨髓移植免疫化学族性骨髓来源出生后不明原因出血

积极的生活方式可改善急性心肌梗死老年患者行直接血管成形术的结局

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 13-14页

作者： Rengo G. Galasso G. Piscione F. D. Leosco 马超 dipartimento di Medicina clinica Scienze Cardiovascolari ed Immunologiche Universita Federico II Napoli Italy.Dr.

背景:已知规律的体力活动可改善老年人群中急性心肌梗死(AMI)的结局。本研究旨在评价积极的生活方式对心脏预后的正性作用是否也存在于接受直接经皮冠状动脉腔内成形术(PTCA)的AMI老年患者中。方法:对180例年龄≥70岁、接受直接PTCA治疗... 详细信息

背景:已知规律的体力活动可改善老年人群中急性心肌梗死(AMI)的结局。本研究旨在评价积极的生活方式对心脏预后的正性作用是否也存在于接受直接经皮冠状动脉腔内成形术(PTCA)的AMI老年患者中。方法:对180例年龄≥70岁、接受直接PTCA治疗的AMI患者进行前瞻性研究。根据老年人体力活动量表(PASE)的得分对所有患者在AMI前的体力活动水平进行定量。

关键词：心肌梗死 AM 老年患者结局情节 PTCA

Everolimus plus long-acting somatostatin analogs in thymic epithelial malignancies

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of clinical Oncology 2012年第7期3卷 111-115页

作者： Giovannella Palmieri Carlo Buonerba Piera Federico Luigi Formisano Lucia Nappi Giuseppe di Lorenzo Mirella Marino Vincenzo Damiano dipartimento di Endocrinologia ed Oncologia clinica e Molecolare Università Federico Ⅱ 80131 Napoli Italy Centro Regionale Tumori Rari (Regional Center for Rare Tumors) University Federico Ⅱ 80128 Naples Italy Department of Pathology Regina Elena National Cancer Institute 00144 Rome Italy

Although thymic epithelial tumors(TETs) are rare in the general population, they represent the most frequently diagnosed primary malignant tumor of the anterior mediastinum. Unlike localized disease, metastatic disease is invariably fatal. While several chemotherapy agents have proven to be effective in TETs, somatostatin analogs are the only targeted agents with an established role in this disease. Everolimus is an m TOR inhibitor with multiple application in oncology. In this report, we show for the first time that everolimus was effective in two heavily pretreated patients with advanced TETs, with a progression-free survival longer than 1 year and minimal toxicity.

关键词： Thymoma Everolimus mTOR Mediastinum Target