检索结果-南通市图书馆

Obstructive Sleep Apnea Related Symptom Prevalence in Patients with Headache Presented to neurology Outpatient clinic: Results of a Preliminary Study

在线全文

学校读者我要写书评

暂无评论

Neuroscience & Medicine 2014年第4期5卷 177-182页

作者： Yildiz Degirmenci Ege Gulec Balbay Ayhan Ozturk Hulusi Kececi Mehmet Altan neurology Department School of Medicine Duzce University Duzce Turkey Pulmonology Department School of Medicine Duzce University Duzce Turkey neurology Department Mus State Hospital Mus Turkey

Approximately 20% of patients with sleep apnea will have headaches and 25% of patients with other sleep disorders will also experience headaches. We aim to evaluate sleep apnea related symptom prevalence in patient with headache presenting to neurology outpatient clinics. Twenty four patients with headache were asked for sleep apnea symptoms. The prevalence of snoring, excessive daytime sleepiness and witnessed apnea was 33.3%, 20.8% and 4.2%, respectively. Among sleep apnea symptoms, the presence of at least one symptom, at least two symptoms and all three symptoms were 9 (37.5%), 4 (16.7%) and 1 (4.2%), respectively. The frequency of major symptoms of sleep apnea syndrome was high in patient with nonspecific headache. In the light of literature review, in case of a suspicion of sleep disorder in a headache patient, it would be appropriate to question the major symptoms of OSAS, and to refer the patient to a polysomnographic evaluation for an objective diagnosis. This approach would be helpful to improve the quality of life of patients with headache.

关键词： Headache Obstructive Sleep Apne Syndrome neurology Practice

Insula and the Immune System:More than mere Co-existence?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第10期38卷 1271-1273页

作者： Panagiotis Kerezoudis Charles L.Howe Long-Jun Wu Brian N.Lundstrom Jamie J.Van Gompel Department of Neurologic Surgery Mayo ClinicRochesterMNUSA Department of neurology Mayo ClinicRochesterMNUSA

Does the Brain Regulate the Immune System?While long considered to be separate entities,increasing evidence has demonstrated that thebrain and theperipheral immune system interact through bidirectional feedback[1].The brain hosts a vibrant immune environment(*** and perivascular macrophages)that is responsible for maintaining the integrity of the central nervous system[2].In addition,the brain is the central regulator of the rest of the body and its homeostasis.

关键词： Immune homeostasis Ins

Mitochondrial complex Ⅰ as a therapeutic target for Alzheimer’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第2期12卷 483-495页

作者： Eugenia Trushina Sergey Trushin Md Fayad Hasan Department of neurology Mayo ClinicRochesterMN 55905USA Department of Molecular Pharmacology and Experimental Therapeutics Mayo ClinicRochesterMN 55905USA

Alzheimer’s disease(AD),the most prominent form of dementia in the elderly,has no *** focused on the reduction of amyloid beta or hyperphosphorylated Tau protein have largely failed in clinical *** therapeutic targets and strategies are urgently *** data suggest that in response to environmental stress,mitochondria initiate an integrated stress response(ISR)shown to be beneficial for healthy aging and ***,we review data that implicate mitochondrial electron transport complexes involved in oxidative phosphorylation as a hub for small molecule-targeted therapeutics that could induce beneficial mitochondrial ***,partial inhibition of mitochondrial complex I has been exploited as a novel strategy for multiple human conditions,including AD,with several small molecules being tested in clinical *** discuss current understanding of the molecular mechanisms involved in this counterintuitive *** this strategy has also been shown to enhance health and life span,the development of safe and efficacious complex Ⅰ inhibitors could promote healthy aging,delaying the onset of age-related neurodegenerative diseases.

关键词： Mitochondria Mitochondria signaling ComplexⅠinhibitors Alzheimer’s disease Integrated stress response Neuroprotection Mitochondria targeted therapeutics Healthy aging

The proteome of distal nerves: implication in delayed repair and poor functional recovery

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第9期17卷 1998-2006页

作者： Song Guo Raymond M.Moore M.Cristine Charlesworth Kenneth L.Johnson Robert J.Spinner Anthony J.Windebank Huan Wang Department of Neurologic Surgery Mayo ClinicRochesterMNUSA Biomedical Statistics and Informatics Mayo ClinicRochesterMNUSA Proteomics Core Mayo ClinicRochesterMNUSA Department of neurology Mayo ClinicRochesterMNUSA

Chronic denervation is one of the key factors that affect nerve *** axotomy deteriorates the distal nerve stump,causes protein changes,and renders the microenvironment less permissive for *** of these factors/proteins have been individually *** better delineate the comprehensive protein expression profiles and identify proteins that contribute to or are associated with this detrimental effect,we carried out a proteomic analysis of the distal nerve using an established delayed rat sciatic nerve repair *** rats that received immediate repair after sciatic nerve transection served as control,whereas four rats in the experimental group(chronic denervation)had their sciatic nerve repaired after a 12-week *** the rats were sacrificed after 16 weeks to harvest the distal nerves for extracting ***-five micrograms of protein from each sample were fractionated in SDS-PAGE ***-MS/MS analysis was applied to the *** expression levels of nerves on the surgery side were compared to those on the contralateral *** protein with a P value of less than 0.05 and a fold change of 4 or higher was deemed differentially *** the differentially expressed proteins in both groups were further stratified according to the biological processes.A PubMed search was also conducted to identify the differentially expressed proteins that have been reported to be either beneficial or detrimental to nerve *** Pathway Analysis(IPA)software was used for pathway *** results showed that 709 differentially expressed proteins were identified in the delayed repair group,with a bigger proportion of immune and inflammatory process-related proteins and a smaller proportion of proteins related to axon regeneration and lipid metabolism in comparison to the control group where 478 differentially expressed proteins were *** experimental group also had more beneficial proteins that were d

关键词： chronic axotomy chronic denervation delayed repair distal nerve functional recovery nerve regeneration peripheral nerve prolonged denervation proteome sciatic nerve sciatic nerve transection

Near-infrared spectroscopy(NIRS)as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome(OSAS):A pilot study

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2014年第2期7卷 143-152页

作者： Zhongxing Zhang Maja Schneider Ursula Fritschi Lsabela Lehner Ramin Khatami Sleep Center Clinic BarmelweidSwitzerland Department of neurology Uniuersity Hospital Zurich University of ZurichSuitzerland

In obstructive sleep apnea syndrome(OSA)the periodic reduction or cessation of breathing dueto narrowing or occlusion of the upper airway during slep leads to an impaired cerebral vascularautoregulation that is associated with an increased cardiovascular risk,including ***-tinuous positive airways pressure(CPAP)therapy at night is the most effective treatment forOSA and has been shown to reduce the cardiovascular risk in OSA ***,there is nosuitable bedside monitoring method evaluating the recovery of cerebral hemodynamics duringCPAP ***-infrared spectroscopy(NiRS)is idelly suited for non-invasive monitoringthe cerebral hemodynamics during sleep due to its properties of local measurement,totally sa feapplication and good tolerance to *** this pilot study,we monitored cerebral hemody-namics during standard CPAP therapy at night in thre patients with severe OSA using *** found periodic oscllations in HbO2,HHb,tisue oxygenation index(TO1)and blood volume(BV)associa ted with periodic apnea events without CPAP in all OSA *** osillationswere eliminated under the optimal CPAP pressures in all *** results sugg ested thatthe recovery of cerebral hemodynamics impaired by apnea events can be evaluated by bedsideNIRS measurements in real time during ll night CPAP *** is a usefi bedsidemonitoring tool to evaluate the treatment elicacy of CPAP therapy in patients with OSA.

关键词： Sleep cerebral hemodynamics hemodynamic oscillations bedside monitoring.

Microglia Research in the 100th Year Since Its Discovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第3期36卷 303-306页

作者： Anthony DUmpierre Long-Jun Wu Department of neurology Mayo ClinicRochesterMN 55905USA Department of Neuroscience Mayo ClinicJacksonvilleFL 32224USA Department of Immunology Mayo ClinicRochesterMN 55905USA

In 1919,Pio del Rio-Hortega first described a class of cells residing in the brain with a tiny soma and branched architecture distinguishable from astrocytes and *** cells,called microglia or mesoglia,have come to be appreciated as resident immune cells in the central nervous system(CNS).In the year 2019,we review the three most recent advances in microglia research in this 100th year since their discovery(Fig.1).We first discuss their transcriptional diversity,which allows us to appreciate the heterogeneity of microglia across species,development,diseases,and brain *** also highlight recent stem cell-based approaches that allow us to study human microglia.

关键词： diseases glia appreciate

A case-based approach to integrative medicine for cardiovascular disease prevention

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2020年第2期18卷 159-162页

作者： Brody Slostad Tejinder Khalsa Kathleen Young Hildalicia Guerra Anjali Bhagra Department of Internal Medicine Mayo ClinicRochesterMinnesota 55904USA Department of Cardiovascular Medicine Mayo ClinicRochesterMinnesota 55904USA Department of neurology Mayo ClinicRochesterMinnesota 55904USA

Cardiovascular disease is commonly encountered in the adult population and has large impacts on morbidity and mortality. The ever-expanding evidence base for the use of integrative medicine in cardiology necessitates providers caring for patients with cardiovascular disease to be familiar with these ***, providers may find it difficult to adequately discuss these therapies in an average office *** a case-based, question-and-answer approach, the authors review some clinically relevant and helpful research that addresses the incorporation of integrative medicine in cardiovascular disease prevention.

关键词： Integrative medicine Coronary artery disease Atrial fibrillation Preventive medicine Cerebrovascular disease

Dual Functions of Microglia in Ischemic Stroke

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2019年第5期35卷 921-933页

作者： Chuan Qin Luo-Qi Zhou Xiao-Tong Ma Zi-Wei Hu Sheng Yang Man Chen Dale B. Bosco Long-Jun Wu Dai-Shi Tian Department of neurology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of neurology Mayo Clinic Rochester MN 55905 USA

Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the brain parenchyma and the neurovascular unit.

关键词： Microglia Inflammation Ischemic stroke Signaling pathways

Getting a Sense of ATP in Real Time

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第7期38卷 834-836页

作者： Anthony D.Umpierre Koichiro Haruwaka Long-Jun Wu Department of neurology Mayo ClinicRochesterMN55905USA Department of Neuroscience Mayo ClinicJacksonvilFL32224USA Department of Immunology Mayo ClinicRochesterMN55905USA

Adenosine 5'-triphosphate(ATP)is a purinergic signal that can be sensed by all major cell classes in the *** is a key signal released during periods of physical damage/injury,inflammation,and neurological events,such as *** ATP signaling in the living brain is complicated by its fast enzymatic degradation,its action at multiple receptors,and its somewhat elusive.

关键词： signal damage somewhat