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白介素-6基因的多态性(-174G/C)与心肌梗死和传统的心血管危险因子之间无相关性

世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 43-43页

作者： Lieb W. Pavlik R. Erdmann J. H. Schunkert 孟欣 clin. policlinic for int. med. ii University of Luebeck Ratzeburger Allee 160 23538 Lübeck Germany

Background: Recently, a polymorphism at position-174 (G >C) of the int.rleukin-6(IL-6) promoter was found to be associated with an increased prevalence of myocardial infarction(MI). The aim of the present study was to further investigate the association of the IL-6-174 G/C allele status with specific end organ damage, i.e. myocardial infarction in large population-based samples. Methods: Individuals from two Bavarian samples of MI patients (total n=1322) and the population-based Augsburg MONICA survey(1023 unselected controls) were studied by questionnaire, physical examination, echocardiographical assessment and biochemical analyses. The-174 G/C polymorphism was genotyped using a newly established PCR-RFLP. IL-6 levels were measured in a subset of 574 MI patients. Results: In the population-based sample, the IL-6 genotype was neither associated with traditional cardiovascular risk factors(systolic and diastolic blood pressure, total cholesterol, HDL and LDL cholesterol, body mass index, diabetes mellitus) nor with cardiac structural or functional parameters(left ventricular mass index, ejection fraction, diastolic inflow pattern). Moreover, the genotype distribution of the-174 G/C polymorphism was not different in MI patients(GG: 34.1%; GC: 47.4%; CC: 18.5%) and population-based controls (GG: 32.4%; GC: 48.8%; CC: 18.9%) (p=0.67). IL-6 levels were neither related to the-174 G/C polymorphism (p=0.29) nor to ACE-inhibitor treatment (2.16 with vs. 2.09 pg/ml without ACE-inhibitor, p=0.27). However, patients receiving statins displayed significantly lower IL-6 levels(1.83 vs. 2.32 pg/ml in the group without statins, p< 0.0001). Conclusions: This extensive investigation failed to obtain evidence that the IL-6-174G/C promoter polymorphism affects traditional cardiovascular risk factors or the prevalence of myocardial infarction in a Caucasian sample.

关键词：多态性器官损伤左室重量指数他汀类药物高密度脂蛋白心肌收缩心肌结构亚组启动子射血分数

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溃疡性结肠炎患者“J”形回肠袋肛管吻合重建术后经4周的益生菌干预,其临床症状及内镜下表现的结果

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 57-58页

作者： Laake K.O. Bjφrneklett A. Aamodt G. 李翔 Dept. med./Res. Inst. int. med. Rikshospitalet National University Hospital NO- 0027 Oslo Norway

Objective. Pouchitis is a common and troublesome condition in patients operat ed on with ileal- pouch- anal- anastomosis (IPAA). A disturbed microecology i n the pouch has been suggested as one possible explanation. In a previous double - blind, randomized, controlled study we demonstrated clin.cal improvement of s ymptoms in patients with ulcerative colitis (UC) operated on with IPAA, during i ntervention with live probiotic microbes Lactobacilli and Bifidobacteriae. The a im of the present study was to confirm our previous results in a much larger mat erial, including clin.cal symptoms, faecal flora and endoscopic evaluation, and to compare the results in UC/IPAA patients with those of patients with familial adenomatous polyposis (FAP) with IPAA and UC patients with ileorectal anastomosi s (IRA). Material and methods. Five hundred millilitres of a fermented milk prod uct (Cultura) containing live lactobacilli (La- 5) and bifidobacteriae (Bb- 12 ) was given daily for 4 weeks to 51 UC patients and 10 patients with FAP, operat ed on with IPAA, and six UC patients operated on for IRA. Stool samples were cul tured for examination of lactobacilli, bifidobacteriae, fungi and pH before, dur ing and after int.rvention. Before, during and after int.rvention, endoscopic ev aluation was performed. Categorized symptomatology was examined prospectively using diary cards in addition to an int.rview, before and on the last day of int.rvention. Results. The number of l actobacilli and bifidobacteriae increased significantly during int.rvention in t he UC patients operated on with IPAA and remained significantly increased one we ek after int.rvention. Involuntary defecation, leakage, abdominal cramps and the need for napkins (category I), faecal number and consistency (category ii) and mucus and urge to evacuate stools (category iiI) were significantly decreased du ring int.rvention in the UC/IPAA group. In the FAP group there was a significant decrease in faecal leakage, abdominal

关键词：溃疡性结肠炎回肠袋临床症状随机对照试验不自主排便回肠直肠吻合术痛性痉挛血液学检查粪便样本吻合口漏

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