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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Geochemistry of Neoproterozoic metavolcanic rocks from the Tahtai Logomiti area,Tigrai,Northern Ethiopia:Implication for petrogenesis and tectonic settings

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Acta Geochimica 2025年第1期44卷 128-144页

作者： Azeb Gebremicale Mulugeta Alene Teklay Gidey School of Earth Sciences Mekelle UniversityP.O.Box:231MekelleEthiopia School of Earth Sciences Addis Ababa UniversityP.O.Box:1176Addis AbabaEthiopia Department of Earth Environmental and Planetary SciencesCase Western Reserve UniversityClevelandOHUSA Faculty of Mines Aksum UniversityP.O.Box:1010AksumEthiopia

The Tahtai Logomiti area is characterized by metavolcanic and metavolcaniclastic interbedded with clastic and carbonate metasedimentary rocks of Neoproterozoic *** geological,petrographic,major,and trace elements data were used to evaluate the metamorphism,petrogenesis,and paleo-tectonic setting of the *** field and petrographic observation indicate that the area has undergone greenschist facies *** on mineralogy and geochemical attributes,these metavolcanic rocks are classified as basalt,basaltic-andesite,andesite,and *** moderate degrees of light rare earth element(LREE)enrichment,flat heavy rare earth element(HREE)pattern,and low Nb/Y ratio,represent shallow mantle *** addition to that,the TiO_(2)/Yb ***/Yb diagram,high(La/Yb)N ratio(>3.44),indicates shallow melting and depleted magma ***,the high ratios of(Th/Ta)>3.8,(La/Ta)>38,and low ratios of(Th/La)<1,(Nb/La)<1,and high Pb content would indicate crustal contamination of the *** discrimination diagram and trace element ratios(Nb/Y,La/Sc,La/Y,and La/Th)indicate that the metavolcanic rocks have a calc-alkaline *** addition,the ZrNb-Y and Th-Hf-Ta plots show that the rocks formed under a volcanic-arc *** general petrological and geochemical characteristics of the Tahtai Logomiti metavolcanic rocks suggest that the area is associated with subduction-related arc accretion of the Arabian Nubian Shield.

关键词： Deformation Metamorphism Foliation Calc-alkaline Neoproterozoic Arabian Nubian Shield

Upper limit of normothermic machine preservation of liver grafts from donation after circulatory death yet to be defined

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World Journal of Transplantation 2025年第2期15卷 218-227页

作者： William H Archie Maria Baimas-George Nathanael Haynes Souma Kundu Katheryn Peterson Chase J Wehrle Damien Huckleberry Lon Eskind David Levi Jose R Soto Roger Denny Vincent Casingal Allyson Cochran Erin H Rein Dionisios Vrochides Division of Adominal Transplant Department of SurgeryCarolinas Medical CenterCharlotteNC 28203United States Department of Hepato-Pancreato-Biliary/Liver Transplant Surgery Cleveland Clinic Transplant Research CenterClevelandOH 44195United States Department of Surgery Carolinas Center for Surgical Outcomes ScienceCarolinas Medical CenterCharlotteNC 28203United States

BACKGROUND The normothermic machine perfusion pump(NMPP)could shape the future of *** ex-vivo optimization,NMPP attenuates ischemic insult while replenishing *** understanding of machine perfusion time(MPT)impact and potential clinical benefits is paramount and necessitates *** To investigate the relationship between MPT and post-transplant graft *** Retrospective review of the first 50 donation after circulatory death(DCD)grafts preserved using NMPP in a tertiary institution was *** preser-vation time points,graft parameters,recipient information,and postoperative outcomes were prospectively *** allograft dysfunction(EAD),L-Graft7 score and 90-day outcomes were collected for all *** first 20 re-cipients were allocated into the early group,considered the learning curve population for the *** subsequent 30 were allocated into the late *** were also stratified into cohorts depending on MPT,i.e.,short(16 hours).RESULTS NMPP operational parameters were not predictive of EAD,L-GrAFT7 or 90-day *** early group had significantly less MPT and cold ischemia time than the late group(553 minutes vs 850 minutes,P<0.001)and(127.5 minutes vs 154 minutes,P=0.025),*** had no impact in either *** Increased MPT of DCD liver grafts had no adverse recipient results for the times utilized in this population,indicating its upper limits,likely beyond 24 hours,are not demonstrated within this *** studies are necessary to determine whether longer MPT is beneficial or detrimental to graft function and,if the latter,what is the maximum safe *** studies of the effect of normothermic machine perfusion pump duration on long-term outcomes are also needed.

关键词： Normothermic machine pump perfusion Liver transplant Donation after circulatory death Ex-vivo perfusion Ischemic cholangiopathy

Oversampling-Enhanced Feature Fusion-Based Hybrid ViT-1DCNN Model for Ransomware Cyber Attack Detection

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1667-1695页

作者： Muhammad Armghan Latif Zohaib Mushtaq Saifur Rahman Saad Arif Salim Nasar Faraj Mursal Muhammad Irfan Haris Aziz Department of Computer and Information System Cleveland State UniversityOhio44115USA Department of Electrical Electronics and Computer SystemsCollege of Engineering and TechnologyUniversity of SargodhaSargodha40100Pakistan Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Saudi Arabia Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa31982Saudi Arabia Department of Mechanical Industrial and Energy System EngineeringUniversity of SargodhaSargodha40100Pakistan

Ransomware attacks pose a significant threat to critical infrastructures,demanding robust detection *** study introduces a hybrid model that combines vision transformer(ViT)and one-dimensional convolutional neural network(1DCNN)architectures to enhance ransomware detection *** common challenges in ransomware detection,particularly dataset class imbalance,the synthetic minority oversampling technique(SMOTE)is employed to generate synthetic samples for minority class,thereby improving detection *** integration of ViT and 1DCNN through feature fusion enables the model to capture both global contextual and local sequential features,resulting in comprehensive ransomware *** on the UNSW-NB15 dataset,the proposed ViT-1DCNN model achieved 98%detection accuracy with precision,recall,and F1-score metrics surpassing conventional *** approach not only reduces false positives and negatives but also offers scalability and robustness for real-world cybersecurity *** results demonstrate the model’s potential as an effective tool for proactive ransomware detection,especially in environments where evolving threats require adaptable and high-accuracy solutions.

关键词： Ransomware attacks cybersecurity vision transformer convolutional neural network feature fusion encryption threat detection

Co-optimization approach to post-storm recovery for interdependent power and transportation systems

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Journal of Modern Power Systems and Clean Energy 2019年第4期7卷 688-695页

作者： Yinyin GE Lili DU Hongxing YE Case Western Reserve University ClevelandUSA University of Florida GainesvilleUSA cleveland State University ClevelandUSA

The power and transportation systems are urban interdependent critical infrastructures(CIs).During the post-disaster restoration process,transportation mobility and power restoration process are interdependent,and their functionalities significantly affect the well-beings of other urban ***,to enhance the resilience of urban CIs,successful recovery strategies should promote CI function cooperatively and synergistically to distribute goods and services *** paper develops an integrative framework that addresses the challenges of enhancing the recovery efficiency of urban power and transportation systems in short-term recovery ***,the post-storm recovery process is considered as a scheduling problem with the constraints representingcrew dispatch,equipment and fuel *** propose a new framework for co-optimizing the recovery scheduling of power and transportation systems,respecting precedency requirement and network *** advantages and benefits of co-optimized recovery scheduling are validated in a testing system.

关键词： Co-optimization Interdependent critical infrastructure(CI) Power system Resilience Transportation system

Liver transplantation in patients with incidental hepatocellular carcinoma/cholangiocarcinoma and intrahepatic cholangiocarcinoma： a single-center experience

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Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 264-270页

作者： Mohammed Elshamy Naftali Presser Abdulrahman Y Hammad Daniel J Firl Christopher Coppa John Fung Federico N Aucejo Hepatobiliary and Transplant Surgery Digestive Disease and Surgery Institute Cleveland Clinic Cleveland OH USA Imaging Institute Cleveland Clinic Cleveland OH USA

BACKGROUND： Reports of fiver transplantation （LT） in patients with mixed hepatocellular carcinoma/cholangiocarcinoma （HCC/CC） and intrahepatic cholangiocarcinoma （ICC） are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC. METHODS： From a prospectively maintained database, we performed cohort analysis. We identified 13 patients who underwent LT with explant pathology revealing HCC/CC or ICC. RESULTS： The observed recurrence rate post-LT was 31% （4/13） and overall survival was 85%, 51%, and 51% at 1, 3 and 5 years, respectively. Disease-free survival was 68%, 51%, and 41% at 1, 3 and 5 years, respectively. In our cohort, four patients would have qualified for exception points based on updated HCC Organ Procurement and Transplantation Network imaging guidelines. CONCLUSIONS： Lesions which lack complete imaging characteristics of HCC may warrant pre-LT biopsy to fully elucidate their pathology. Identified patients with early HCC/CC or ICC may benefit from LT if unresectable. Additionally, incorporating adjunctive perioperative therapies such as in the case of patients undergoing LT with hilar cholangiocarcinoma may improve outcomes but this warrants further investigation.

关键词： mixed hepatocellular carcinoma/ cholangiocarcinoma liver transplantation survival outcomes

Antibiotic-coated medical devices: with an emphasis on inflatable penile prosthesis

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Asian Journal of Andrology 2004年第3期6卷 249-257页

作者： R.Abouassaly D.K.Montague K.W.Angermeier Glickman Urological Institute Cleveland Clinic FoundationClevelandOH 44195USAGlickman Urological InstituteCleveland Clinic FoundationClevelandOH 44195USAGlickman Urological InstituteCleveland Clinic FoundationClevelandOH 44195USA

One of the most serious complications associated with the use of the inflatable penile prosthesis is infection. This can lead to significant morbidity for the patient, as well as significant health care costs. A number of methods have been used in attempts at minimizing the infection risk, including applying an antibiotic coating to the medical devise. This review aims to evaluate the effectiveness of these products in preventing clinically significant infections.

关键词： penile prosthesis infection erectile dysfunction therapeutic strategy

Hospital readmission following transjugular intrahepatic portosystemic shunt:a 14-year single-center experience

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Gastroenterology Report 2020年第2期8卷 98-103,I0001页

作者： Catherine F.Vozzo Tavankit Singh Jennifer Bullen Shashank Sarvepalli Arthur McCullough Baljendra Kapoor Department of Internal Medicine Cleveland ClinicClevelandOHUSA Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOHUSA Department of Quantitative Health Sciences Cleveland ClinicClevelandOHUSA Department of Inflammation and Immunity Cleveland ClinicClevelandOHUSA Department of Radiology Cleveland ClinicClevelandOHUSA

Background:Placement of a transjugular intrahepatic portosystemic shunt(TIPS)is a relatively common procedure used to treat complications of portal ***,only limited data exist regarding the hospital-readmission rate after TIPS placement and no studies have addressed the causes of hospital *** therefore sought to identify the 30-day hospital-readmission rate after TIPS placement at our institution and to determine potential causes and predictors of ***:We reviewed our electronic medical-records system at our institution between 2004 and 2017 to identify patients who had undergone primary TIPS placement with polytetrafluoroethylene-covered stents and to determine the 30-day readmission rate among these patients.A series of univariable logistic-regression models were fit to assess potential predictors of 30-day ***:A total of 566 patients were included in the *** 30-day readmission rate after TIPS placement was 36%.The most common causes for readmission were confusion(48%),infection(15%),bleeding(11%),and fluid overload(7%).A higher Model for End-Stage Liver Disease(MELD)score corresponded with a higher rate of readmission(odds ratio associated with each 1-unit increase in MELD score:1.06;95%confidence interval:1.02–1.09;P=0.001).Other potential predictors,including indication for TIPS placement,were not significantly associated with a higher readmission ***:The 30-day readmission rate after TIPS placement with covered stents is high,with nearly half of these readmissions due to hepatic encephalopathy—a known complication of TIPS *** interventions to help reduce the TIPS readmission rate should be prioritized in future research.

关键词： transjugular intrahepatic portosystemic shunt portal hypertension liver cirrhosis hospital readmission

Long-term esophageal and respiratory outcomes in children with esophageal atresia and tracheoesophageal fistula

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Gastroenterology Report 2016年第4期4卷 310-314,I0002页

作者： Richard H.Cartabuke Rocio Lopez Prashanthi N.Thota Department of Internal Medicine Cleveland ClinicClevelandOHUSA Department of Biostatistics Cleveland ClinicClevelandOHUSA Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOHUSA

Objectives:Few studies have evaluated the long-term complications and outcomes of esophageal atresia with or without tracheoesophageal fistula(EA/TEF)beyond *** aim of our study was to characterize the esophageal and respiratory morbidity of EA/TEF through evaluation of clinical symptoms,diagnostic testing and therapeutic intervention at a tertiary care ***:Patients with congenital EA/TEF evaluated from 2011 to 2014 were *** characteristics,type and mode of repair of EA/TEF,clinical symptoms,radiographic,endoscopic,bronchoscopic and medication use data were ***:A total of 43 patients were *** median age of this predominantly Caucasian population was 8 years(interquartile range:3,20).Twenty(62.5%)had type C(EA with distal TEF)***-one(48.8%)patients had heartburn,19(44.1%)had acid regurgitation,and 31(72.1%)had dysphagia to *** swallow in 26 patients revealed strictures in 17(65.4%),dysmotility in 20(76.9%)and recurrent fistulas in four patients(15.4%).Thirty patients underwent upper endoscopy,of which 21(70.0%)had a stricture,and six(20.0%)had recurrent fistula requiring surgical ***(18.6%)patients underwent *** evaluation showed cough and choking in 31(72.1%)patients and dyspnea and wheezing in 32(53.4%)*** respiratory infections were reported in 19(44.2%).*** findings included tracheomalacia in 86.7% and restrictive lung disease in 54.5%of ***:There is a high burden of residual esophageal and pulmonary pathology in patients with EA/*** follow-up is required to monitor both the clinical symptoms and treatment responses.

关键词： esophageal atresia tracheoesophageal fistula gastroesophageal reflux disease(GERD) esophageal dysmotility aspiration pneumonia