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Identifying disappeared historic buildings of port of Callao using georeferencing

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Built Heritage 2023年第4期7卷 1-15页

作者： Diego Javier Celis Estrada Francisco Felipe Quiroz Chueca Ruth Aracelis Manzanares Grados Faculty of Architecture and Design Universidad Privada del NorteLimaPeru Research Group GIADIPS Faculty of Architecture and DesignUniversidad Privada del NorteLimaPeru Department of History Universidad Nacional Mayor de San MarcosLima15081Peru Directorate for Research Innovation and Social ResponsibilityUniversidad Privada del NorteLimaPeru

The port of Callao is important for its varied historical and archaeological heritage,which includes several military buildings that were the main actors and witnesses of the colonial era of Peru(from the 16th century to the country’s independence from Spain early in the 19th century).Despite the studies that have been carried out on the basis of documents and some eventual archaeological excavations,the port’s main monument,namely,the Real Felipe Fortress,continues to hide very important information that could be used to understand the role that the fortress played in numerous historical events throughout the *** main contribution of this study is the use of photogrammetry software and a Geographic Information System(GIS)to examine the Real Felipe *** this way,the nature of the atypical construction within the fortress is *** a result,it is possible to accurately establish the location of the defensive wall that surrounded the ancient city of Callao,as well as its first churches,whose records were lost after being destroyed by the 1746 earthquake and tsunami in Lima,the worst cataclysm registered in the history of Peru and South *** a result,this study demonstrates that technology can be successfully used to establish and validate with great precision the existence of the location of churches that have been built in the port of Callao since the founding of Lima in the 16th *** identification allows architects,engineers and students who are interested in the history of monuments to discover hidden structures and buildings and carry out the necessary restoration and archaeological works,with the aim of recovering the history of the colonial architecture of Callao and other similar cities and ports worldwide.

关键词： georeferencing Viceroyalty of Peru church military buildings port of Callao cultural heritage

Proximal Methods with Bregman Distances to Solve VIP on Hadamard Manifolds with Null Sectional Curvature

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Journal of the Operations Research Society of China 2021年第3期9卷 499-523页

作者： Erik Alex Papa Quiroz Paulo Roberto Oliveira Universidad Nacional Mayor de san Marcos Universidad Privada del NorteLimaPeru PESC-COPPE Federal University of Rio de JaneiroRio de Janeiro CEP 21941-972Brazil

We present an extension of the proximal point method with Bregman distances to solve variational inequality problems(VIP)on Hadamard manifolds with null sectional *** some natural assumptions,as for example,the existence of solutions of the VIP and the monotonicity of the multivalued vector field,we prove that the sequence of the iterates given by the method converges to a solution of the ***,this convergence is linear or superlinear with respect to the Bregman distance.

关键词： Proximal point methods Hadamard manifolds Bregman distances Variational inequality problems Monotone vector field

Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal sanchez fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham claudio Mengoa Hugo Fuentes Paola Montenegro Ebert Poquioma Raul Alatrista claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HER2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HER2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(PclUSION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina

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World Journal of Hepatology 2018年第1期10卷 41-50页

作者： Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva Hepatology and Liver Transplantation Unit Hospital Universitario AustralBuenos Aires 1629Argentina Hepatology Section Liver Transplant ProgramDepartment of Academic ResearchHospital Italiano from Buenos AiresBuenos Aires 1424Argentina sanatorio Trinidad san Isidro Buenos Aires 1642Argentina clínica privada san fernando Buenos Aires 2013Argentina Hepatology and Gastroenterology Hospital BritánicoBuenos Aires 1280Argentina Hepatobiliary Surgery Hospital G RawsonSan Juan 5400Argentina Department of Hepatology and Liver Transplant Program Hospital AlemanBuenos Aires 1118Argentina Department of Hepatology and Liver Transplantation Sanatorio AllendeCórdoba 5016Argentina Hepatology Section Department of MedicineCentro de Educación Médica e Investigaciones Clínicas Norberto Department of Hepatology Hospital Ramos MejíaBuenos Aires 1221Argentina Department of Hepatology Centro Especialidades Medicas Ambulatorias(CEMA)Mar del Plata 7600Argentina Department of Hepatology and Liver Transplantation Clínica de Nefrología de Santa FeSanta Fe 3000Argentina Department of Hepatology and Gastroenterology Hospital C Bonorino UdaondoBuenos Aires 1264Argentina Department of Hepatology and Gastroenterology Hospital CentenarioSanta Fe 2002Argentina

AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical *** A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher *** The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications.

关键词： Hepatocellular carcinoma Etiology Fatty liver South America

Gastric myeloid sarcoma:A case report

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World Journal of clinical Oncology 2021年第10期12卷 960-965页

作者： Patricia Rioja Jackeline Macetas Jorge Luna-Abanto Indira Tirado-Hurtado Daniel J Enriquez Department of Oncology Medicine Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru Department of Surgical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru Universidad privada san Juan Bautista Filial Chincha 11702Peru Universidad privada san Juan Bautista Lima 15000Peru

BACKGROUND Myeloid sarcoma(MS)is a rare hematologic malignancy defined as an extramedullary tumor of immature granulocytic *** can occur as primary or de novo and be associated with myelodysplasia or myeloproliferative *** most frequent locations are the skin,lymph nodes and *** case of a patient with a diagnosis of primary granulocytic de novo gastric MS is *** SUMMARY A 19-year-old female patient with MS,whose abdominal computed tomography showed a bulky tumor of 16.5 cm in the gastric chamber with infiltration in the retroperitoneal,pancreatic and bile duct region;the histological study showed gastric mucosa diffusely infiltrated by mononucleated cells and the immunohistochemistry expressed *** receiving induction chemotherapy based on the 3+7 regimen(daunorubicin/cytarabine),the patient developed severe hematological toxicity and neutropenic typhlitis which required a prolonged medical *** presented a rapid disease *** she received supportive treatment,the patient *** Gastric primary de novo MS is a rare and aggressive course neoplasm,fostering knowledge is very important to decide its management and to promote more approaches focused on understanding this pathology and its particularities in our population.

关键词： Myeloid sarcoma Granulocytic sarcoma Stomach Chemotherapy Peru Case report

PIK3CA mutation in non-metastatic triple-negative breast cancer as a potential biomarker of early relapse:A case report

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World Journal of clinical Oncology 2021年第8期12卷 702-711页

作者： Guillermo Arturo Valencia Patricia Rioja Zaida Morante Jhajaira M Araujo Heberth Daniel Vallejos Henry Guerra Henry L Gomez Department of Medical Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru Escuela de Medicina Humana Universidad Privada San Juan BautistaLima 15067Peru Department of Medical Oncology Russian Scientific Center of Radiology and RadiotherapyKonkovo 117485MoscowRussia Department of Pathology Instituto Nacional de Enfermedades NeoplásicasLima 15000Peru

BACKGROUND Currently,the detection of PIK3CA mutations is of special interest in personalized medicine because it is frequently found in triple-negative breast cancer(TNBC).The PI3KCA mutation is an independent negative prognostic factor for survival in metastatic breast cancer,and its prognostic value in liquid biopsy as a biomarker of treatment and early relapse is under investigation,both for metastatic disease and neoadjuvant scenario with curative *** SUMMARY A 54-year-old female patient with TNBC clinical stage IIIA,who,after receiving neoadjuvant chemotherapy(based on anthracyclines and taxanes),surgery,radiotherapy,and adjuvant capecitabine,was detected with a PI3KCA mutation in tissue and peripheral blood(ctDNA in liquid biopsy).After 10 mo,the patient had disease relapse of left cervical node *** The detection of PIK3CA mutation in TNBC after neoadjuvant treatment might be associated with early relapse or rapid disease progression.

关键词： Triple-negative breast cancer PIK3CA mutation Liquid biopsy Early relapse Biomarker Case report