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A deformability-based biochip for precise label-free stratification of metastatic subtypes using deep learning

Microsystems & Nanoengineering 2023年第5期9卷 161-176页

作者： Haojun Hua Shangjie Zou Zhiqiang Ma Wang Guo Ching Yin Fong Bee Luan Khoo city university of hong kong 83 Tat Chee AvenueKowloonHong Kong 999077China hong kong Center for Cerebro-Cardiovascular Health Engineering(COCHE) Hong Kong 999077China city university of hong kong futian-shenzhen research institute Shenzhen 518057China

Cellular deformability is a promising biomarker for evaluating the physiological state of cells in medical *** has emerged as a powerful technique for measuring cellular ***,existing microfluidic-based assays for measuring cellular deformability rely heavily on image analysis,which can limit their scalability for high-throughput ***,we develop a parallel constriction-based microfluidic flow cytometry device and an integrated computational framework(ATMQcD).The ATMQcD framework includes automatic training set generation,multiple object tracking,segmentation,and cellular deformability *** system was validated using cancer cell lines of varying metastatic potential,achieving a classification accuracy of 92.4%for invasiveness assessment and stratifying cancer cells before and after hypoxia *** ATMQcD system also demonstrated excellent performance in distinguishing cancer cells from leukocytes(accuracy=89.5%).We developed a mechanical model based on power-law rheology to quantify stiffness,which was fitted with measured data *** model evaluated metastatic potentials for multiple cancer types and mixed cell populations,even under realworld clinical *** study presents a highly robust and transferable computational framework for multiobject tracking and deformation measurement tasks in *** believe that this platform has the potential to pave the way for high-throughput analysis in clinical applications,providing a powerful tool for evaluating cellular deformability and assessing the physiological state of cells.

关键词： deformability metastatic precise

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AlphaMobileSensing:A virtual testbed for mobile environmental monitoring

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Building Simulation 2023年第7期16卷 1027-1040页

作者： Qi Zhou Haoran Zhong Linyan Li Zhe Wang Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina School of Data Science City University of Hong KongHong KongChina HKUST shenzhen-hong kong Collaborative Innovation research institute FutianShenzhenChina

Environmental monitoring plays a critical role in creating and maintaining a comfortable,productive,and healthy *** upon the advancements of robotics and data processing,mobile sensing demonstrates its potential to address problems regarding cost,deployment,and resolution that stationary monitoring encounters,which therefore has attracted increasing research attentions *** facilitate mobile sensing,two key algorithms are needed:the field reconstruction algorithm and the route planning *** field reconstruction algorithm is to reconstruct the entire environment field from spatially-and temporally-discrete measurements collected by the mobile *** route planning algorithm is to instruct the mobile sensors where the mobile sensor needs to move to for the next *** performance of mobile sensors highly depends on these two ***,developing and testing those algorithms in the real world is expensive,challenging,and *** address these issues,we proposed and implemented an open-source virtual testbed,AlphaMobileSensing,that can be used to develop,test,and benchmark mobile sensing *** aims to help users more easily develop and test the field reconstruction and route planning algorithms for mobile sensing solutions,without worrying about hardware fault,test accidents(such as collision during the test),*** separation of concerns can significantly reduce the cost of developing software solutions for mobile *** versatility and flexibility,AlphaMobileSensing was wrapped up using the standardized interface of OpenAI Gym,and it also provides an interface for loading physical fields that were generated by numerical simulations as virtual test sites to perform mobile sensing and retrieving monitoring *** demonstrated applications of the virtual testbed by implementing and testing algorithms for physical field reconstruction in both static and dynamic indoor thermal en

关键词： mobile sensing environmental monitoring indoor environmental quality environmental field reconstruction

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Nacre-liked material with tough and post-tunable mechanical properties

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Journal of Materials Science & Technology 2022年第19期114卷 172-179页

作者： Zhengyi Mao Mengke Huo Fucong Lyu Yongsen Zhou Yu Bu Lei Wan Lulu Pan Jie Pan Hui Liu Jian Lu Department of Mechanical Engineering City University of Hong KongTat Chee AvenueKowloonHong KongChina cityU-shenzhen futian research institute No.3Binglang RoadFutian DistrictShenzhen 518000China Department of Material Science Engineering City University of Hong KongTat Chee AvenueKowloonHong KongChina hong kong Branch of National Precious Metals Material Engineering research Center City University of Hong KongHong KongChina Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research InstituteGreater Bay Joint DivisionShenyang National Laboratory for Materials ScienceShenzhen 518057China Laboratory of Nanomaterials&Nanomechanics City University of Hong KongHong KongChina

Biomaterials,often imparted time-dependent mechanical properties,which are promising in fields rang-ing from sensors to ***,a facile method was proposed to fabricate post-tunable mechanical properties composites based on hydrogels and ceramic *** wide tunable range of Young’s modulus(27.3 kPa to 3.5 GPa)and ultimate stress(173 kPa to 102 MPa)can be achieved by combining solvent absorption and evaporation process with platelets reinforcement ***,a large fracture toughness(∼32,000 J m^(-2))is obtained as a result of the nacre-liked“brick and mortar”structure introduced by shear force during *** superior flexibility and designability of this material were demonstrated via actuators,portable structure,and *** all,this study provides a new thought to fabricate tough materials with post-tunable mechanical properties.

关键词： Mechanical property Post-tunable Hydrogels Fracture toughness

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Entangled photons enabled ultrafast stimulated Raman spectroscopy for molecular dynamics

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Light(Science & Applications) 2024年第8期13卷 1615-1622页

作者： Jiahao Joel Fan Zhe-Yu Ou Zhedong Zhang Department of Physics City University of Hong KongKowloonHong Kong SARChina city university of hong kong Shenzhen Research InstituteShenzhenGuangdongChina

Quantum entanglement has emerged as a great resource for studying the interactions between molecules and *** propose a new scheme of stimulated Raman scattering with entangled photons.A quantum ultrafast Raman spectroscopy is developed for condensed-phase molecules,to monitor the exciton populations and *** results are obtained,showing an entanglement-enabled time-frequency scale not attainable by classical *** Raman signal presents an unprecedented selectivity of molecular correlation functions,as a result of the hong-Ou-Mandel *** work suggests a new paradigm of using an unconventional interferometer as part of spectroscopy,with the potential to unveil advanced information about complex materials.

关键词： materials spectroscopy selectivity

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Effect of morphological gene mutation and decay on energy dissipation behaviour of granular soils

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Journal of Zhejiang university-Science A(Applied Physics & Engineering) 2023年第4期24卷 303-318页

作者： Wei XIONG Qi-min ZHANG Jian-feng WANG Department of Architecture and Civil Engineering City University of Hong KongHong KongChina shenzhen research institute of city university of hong kong Shenzhen 518057China

In this paper,the X-ray micro-computed tomography(X-rayμCT),spherical harmonical-based principal component analysis(SH-PCA),and discrete element method(DEM)were incorporated to generate virtual samples with morphological gene mutation at different length *** samples were subjected to axial compression and constant confining *** effects of multiscale particle morphology on the stress-strain and energy storage/dissipation responses of granular soils were *** is found that:(a)the effects of particle morphology on the initial stiffness,stress-strain,volumetric strain,and frictional energy dissipation behaviours are more pronounced for looser samples than for denser ones;(b)among different length scales,the particle morphology at the local roundness-level outperforms the one at the general form-level in dictating the macro-scale responses of granular soils;(c)the energy dissipation of a granular assemblage is a result of competition between particle morphology and initial void ratio.

关键词： X-ray micro-computed tomography(X-rayμCT) Spherical harmonic analysis(SHA) Discrete element method(DEM) Morphological gene mutation Energy dissipation

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Aggregate Engineering in Supramolecular Polymers via Extensive Non-covalent Networks

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Chinese Journal of Polymer Science 2021年第10期39卷 1310-1318,I0007页

作者： Xin Huang Dong Lv Li-Qing Ai Shuk Han Cheng Xi Yao Department of Biomedical Sciences City University of Hong KongHong Kong 999077China city university of hong kong Shenzhen Research InstituteShenzhen 518075China

Aggregate engineering of non-covalent networks endows supramolecular polymers with thermo-mechanical versatility,stimuli-responsive phase transitions and intrinsic damage-healing ***,most non-covalent networks are vulnerable at elevated temperatures,which suppresses the robustness of supramolecular ***,ureidocytosine(UCy)motifs,which are capable of forming extensive non-covalent networks and thus robust molecular aggregates via multivalent hydrogen bonds and aromatic stackings,are proposed to enable precise programming of the thermo-mechanical *** simulations reveal that the enthalpic contributions from the UCy aggregates play dominant roles to compensate the entropic loss from the redistributions of polymeric spacers and stabilize the non-covalent networks over wide temperature *** aggregate-level strategy offers prospects for applications which require thermo-mechanical versatility of supramolecular polymers,such as 3D printing,microfabrication and damage-healing coating.

关键词： Aggregate engineering Damage-healing Extensive non-covalent network Ureidocytosine Supramolecular polymers

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Micro-rocket robot with all-optic actuating and tracking in blood

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Light(Science & Applications) 2020年第1期9卷 1229-1238页

作者： Dengfeng Li Chao Liu Yuanyuan Yang Lidai Wang Yajing Shen Department of Biomedical Engineering City University of Hong Kong999077 Hong KongChina city university of hong kong shenzhen research institute Shenzhen 518057China

Micro/nanorobots have long been expected to reach all parts of the human body through blood vessels for medical treatment or ***,in the current stage,it is still challenging to drive a microrobot in viscous media at high speed and difficult to observe the shape and position of a single microrobot once it enters the ***,we propose a new micro-rocket robot and an all-optic driving and imaging system that can actuate and track it in blood with microscale *** achieve a high driving force,we engineer the microrobot to have a rocket-like tripletube *** to the interface design,the 3D-printed micro-rocket can reach a moving speed of 2.8 mm/s(62 body lengths per second)under near-infrared light actuation in a blood-mimicking viscous glycerol *** also show that the micro-rocket robot is successfully tracked at a 3.2-μm resolution with an optical-resolution photoacoustic microscope in *** work paves the way for microrobot design,actuation,and tracking in the blood environment,which may broaden the scope of microrobotic applications in the biomedical field.

关键词： structure robot driving

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On the validity of microscopic calculations of double-quantum-dot spin qubits based on Fock-Darwin states

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Science China(Physics,Mechanics & Astronomy) 2018年第4期61卷 36-43页

作者： GuoXuan Chan Xin Wang Department of Physics City University of Hong KongHong Kong SARChina city university of hong kong shenzhen research institute Shenzhen 51805Z China

We consider two typical approximations that are used in the microscopic calculations of double-quantum dot spin qubits, namely,the Heitler-London(HL) and the Hund-Mulliken(HM) approximations, which use linear combinations of Fock-Darwin states to approximate the two-electron states under the double-well confinement potential. We compared these results to a case in which the solution to a one-dimensional Schr ¨odinger equation was exactly known and found that typical microscopic calculations based on Fock-Darwin states substantially underestimate the value of the exchange interaction, which is the key parameter that controls the quantum dot spin qubits. This underestimation originates from the lack of tunneling of Fock-Darwin states, which is accurate only in the case with a single potential well. Our results suggest that the accuracies of the current two-dimensional molecularorbit-theoretical calculations based on Fock-Darwin states should be revisited since underestimation could only deteriorate in dimensions that are higher than one.

关键词： spin qubits double quantum dots exchange interaction

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A Simple and Efficient Algorithm to Identify the Chirality of Polymer Knots Based on the Alexander Polynomial

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Chinese Journal of Polymer Science 2024年第12期42卷 2030-2037,I0012页

作者： Qi-Yuan Qiu Yong-Jian Zhu Zhong-Tao Wu Liang Dai Department of Physics City University of Hong KongHong Kong999077China shenzhen research institute City University of Hong KongShenzhen518057China Department of Mathematics The Chinese University of Hong KongHong Kong999077China

Recent experimental observations of knotting in DNA and proteins have stimulated the simulation studies of polymer *** studies usually identify knots in polymer conformations through the calculation of the Alexander ***,the Alexander polynomial cannot directly discriminate knot chirality,while knot chirality plays important roles in many physical,chemical,and biological *** this work,we discover a new relationship for knot chirality and accordingly,develop a new algorithm to extend the applicability of the Alexander polynomial to the identification of knot *** algorithm adds an extra step in the ordinary calculation of the Alexander *** extra step only slightly increases the computational *** correctness of our algorithm has been proved mathematically by *** implication of this algorithm in physical research has been demonstrated by our studies of the tube model for polymer *** this algorithm,we would be unable to obtain the tubes for polymer knots.

关键词： Polymerentanglement Polymer knot Polymerconformation Tubemodel Monte Carlo simulation

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DEM study on effect of particle roundness on biaxial shearing of sand

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Underground Space 2021年第6期6卷 678-694页

作者： Mengmeng Wu Linghong Xiong Jianfeng Wang Department of Architecture and Civil Engineering City University of Hong KongHong KongChina shenzhen research institute of city university of hong kong ShenzhenChina

In this study,discrete element method(DEM)simulations of a biaxial test were used to examine the effect of particle roundness on the mechanical behavior of sands at both the macro and micro ***,a stack of microcomputed tomography images were binarized,segmented,and labeled using advanced image processing and analysis ***,a spherical harmonic(SH)analysis,which involves a complete set of orthogonal functions,was implemented to rebuild the natural particle ***,five templates of virtual particles were built in a DEM simulation,four of which were obtained from SH degrees of 3,8,12,and 15,and one template was an elementary sphere.A flexible membrane was numerically generated to allow the material to deform freely under a prescribed confining ***,the effect of particle roundness on the mechanical properties of granular materials was investigated and *** shear bands were found to intersect,forming an X shape in both the rotation and displacement ***,a lower particle roundness results in higher deviatoric stress and stronger dilation in the volumetric change.A decrease in particle roundness leads to less rotation of particles despite a higher displacement *** addition,a larger SH degree leads to smaller normalized contact forces of the *** implies that decreasing the roundness results in higher anisotropy of the contact forces.

关键词： Grain shape Roundness Flexible membrane Spherical harmonic analysis Discrete element method

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